Antiarrhythmic action and protection of ischaemia myocardium after beta-blockade with bevantolol.

abstract：:Previous work from our laboratory has indicated that ovine prolactin can produce a rapid stimulation (within 1 h) of dopamine release from nigrostriatal and mesolimbic dopaminergic neurons of male rats. In the present experiment we attempted to determine whether this effect of prolactin was a function of an increase i...

journal_title：European journal of pharmacology

authors： Chen JC,Ramirez VD

更新日期：1989-08-03 00:00:00

abstract：:Endothelial cells from rat brain microvessels, human aortic artery and human umbilical vein were examined, together with ex vivo rat brain capillaries and rat aortic ring sections, for the expression of opioid receptor-like OP-4 mRNA and protein. High levels of mRNA expression and an immunopositive reaction for the re...

journal_title：European journal of pharmacology

authors： Granata F,Potenza RL,Fiori A,Strom R,Caronti B,Molinari P,Donsante S,Citro G,Iacovelli L,De Blasi A,Ngomba RT,Palladini G,Passarelli F

更新日期：2003-12-15 00:00:00

abstract：:Structurally diverse compounds have been shown to possess high affinities for benzodiazepine receptors in their 'diazepam-sensitive' (DS) conformations. In contrast, only the imidazobenzodiazepinone Ro 15-4513 has been shown to exhibit a high affinity for the 'diazepam-insensitive' (DI) conformation of benzodiazepine ...

journal_title：European journal of pharmacology

authors： Wong G,Skolnick P

更新日期：1992-01-14 00:00:00

abstract：:Some cationic antibacterial peptides, with typical amphiphilic α-helical conformations in a membrane-mimicking environment, exhibit anticancer properties as a result of a similar mechanism of action towards both bacteria and cancer cells. We previously reported the cDNA sequence of the antimicrobial peptide ABP-dHC-Ce...

journal_title：European journal of pharmacology

authors： Sang M,Zhang J,Zhuge Q

更新日期：2017-05-15 00:00:00

abstract：:We have previously reported that subacute hypoxia activates lung 15-lipoxygenase (15-LOX), which catalyzes arachidonic acid to produce 15-HETE, leading to constriction of neonatal rabbit pulmonary arteries. Subacute hypoxia suppresses Kv3.4 channel expression and results in an inhibition of whole-cell K(+) currents (I...

journal_title：European journal of pharmacology

authors： Guo L,Tang X,Tian H,Liu Y,Wang Z,Wu H,Wang J,Guo S,Zhu D

更新日期：2008-06-10 00:00:00

abstract：:Morphine produced a dose-dependent increase in the activity of dopamine-containing neurons in the substantia nigra and ventral tegmental area recorded from mouse brain slices in vitro. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects are the result of...

journal_title：European journal of pharmacology

authors： Trulson ME,Arasteh K

更新日期：1985-08-07 00:00:00

abstract：:We report that cloricromene (5-30 microM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I2 analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 micron), acting through a nitric o...

journal_title：European journal of pharmacology

authors： Mollace V,Prosdocimi M,Nisticó G

更新日期：1992-11-10 00:00:00

abstract：:We explored the effects of contractile arrest maintained for 24-72 h in the presence of 2,3-butanedione monoxime or a Ca(2+) channel blocker (nifedipine or verapamil) on contractile activity, Ca(i)(2+) transients, and myofibrillar protein content and ultrastructure in long-term cultures of spontaneously beating adult ...

journal_title：European journal of pharmacology

authors： Horackova M,Byczko Z,Morash B

更新日期：2000-09-22 00:00:00

abstract：:Molecules regulating cell death constitute prominent therapeutic targets. The pro-apoptotic role of serine protease inhibitors prompted us to search for novel modulators of this process. We have tested some recently synthesized antithrombotic compounds for their potential to induce apoptotic cell death. Cell based ana...

journal_title：European journal of pharmacology

authors： Celhar T,Batista Napotnik T,Obreza A,Zega A,Anderluh PS,Kikelj D,Mlinaric-Rascan I

更新日期：2009-01-05 00:00:00

abstract：:Overexpression of Cav3.2 T-type Ca2+ channels in L4 dorsal root ganglion (DRG) participates in neuropathic pain after L5 spinal nerve cutting (L5SNC) in rats. The L5SNC-induced neuropathic pain also involves high mobility group box 1 (HMGB1), a damage-associated molecular pattern protein, and its target, the receptor ...

journal_title：European journal of pharmacology

authors： Tomita S,Sekiguchi F,Kasanami Y,Naoe K,Tsubota M,Wake H,Nishibori M,Kawabata A

更新日期：2020-12-05 00:00:00

abstract：:Prognostic models are used to predict outcome in stroke patients and to stratify treatment groups in clinical trials. No one has previously attempted to use such models in stroke recovery studies in animals. We have now shown the predictive value of assigning stroke severity ratings, based on behaviours displayed in c...

journal_title：European journal of pharmacology

authors： Roulston CL,Callaway JK,Jarrott B,Woodman OL,Dusting GJ

更新日期：2008-04-14 00:00:00

abstract：:The present study was aimed to evaluate the behavioral and biochemical effects of macranthol, a triphenyl lignan isolated from Illicium dunnianum. To this aim, mice were treated with macranthol (10, 20 and 40 mg/kg) and then subjected to the forced swimming test, tail suspension test and chronic unpredictable mild str...

journal_title：European journal of pharmacology

authors： Li J,Geng D,Xu J,Weng LJ,Liu Q,Yi LT

更新日期：2013-05-05 00:00:00

abstract：:Pancreatic adenocarcinoma is a leading cause of cancer death in the United States and represents a challenging chemotherapeutic problem. The pharmacological control of angiogenesis might represent a novel approach to the management of pancreas cancer, since the pathological development of vascular supply is a critical...

journal_title：European journal of pharmacology

authors： Bocci G,Danesi R,Marangoni G,Fioravanti A,Boggi U,Esposito I,Fasciani A,Boschi E,Campani D,Bevilacqua G,Mosca F,Del Tacca M

更新日期：2004-09-13 00:00:00

abstract：:Preparations of cauda epididymides were taken from rats unilaterally vasectomised by medial transection of the vas deferens. Responses of preparations from the operated side to field stimulation (10 pulses, 70 V, 1 ms, 0.1-20 Hz) declined in parallel with decreases in catecholamine fluorescence. There were leftward sh...

journal_title：European journal of pharmacology

authors： Ventura S,DeGaris RM,Pennefather JN

更新日期：1989-12-19 00:00:00

abstract：:Baicalein was a major bioactive flavonoid derived from Radix Scutellariae in Xiao-Chai-Hu-Tang which was commonly used to treat chronic hepatitis and liver fibrosis in China. The aim of this study was to assess whether chronic baicalein administration could prevent liver fibrosis induced by carbon tetrachloride (CCl(4...

journal_title：European journal of pharmacology

authors： Sun H,Che QM,Zhao X,Pu XP

更新日期：2010-04-10 00:00:00

abstract：:Isolated and purified leucocytosis promoting factor (LPF), alternatively described as pertussis toxin, reduced the hypotension after beta 2-adrenoceptor stimulation with salbutamol as well as the negative chronotropic activity induced by the muscarinic receptor stimulant arecoline 4 days after its injection into rats....

journal_title：European journal of pharmacology

authors： De Wildt DJ,De Jong Y,Nijkamp FP,Kreeftenberg JG

更新日期：1986-08-15 00:00:00

abstract：:In the presence of RS-15385-197 to preclude binding to alpha 2-adrenoceptors, [3H]p-aminoclonidine labelled a low affinity high capacity site, (Kd = 127.6 +/- 19.7 nM, Bmax 978 +/- 172 fmol/mg protein) whereas [3H]idazoxan labelled a high affinity low capacity site (Kd = 1.66 +/- 0.28 nM, Bmax 45.3 +/- 11.4 fmol/mg pr...

journal_title：European journal of pharmacology

authors： MacKinnon AC,Stewart M,Olverman HJ,Spedding M,Brown CM

更新日期：1993-02-23 00:00:00

abstract：:Ovarian cancer (OC) is a major cause of cancer-related deaths in women all over the world. The easy metastasis of OC and the problem of radioresistance are serious issues remaining to be overcome. Thus, research on molecular mechanisms underlying is in urgent demand. Long non-coding RNAs (lncRNAs) are a class of RNAs ...

journal_title：European journal of pharmacology

authors： Dou Q,Xu Y,Zhu Y,Hu Y,Yan Y,Yan H

更新日期：2019-06-05 00:00:00

abstract：:When the prostate cancer cells become unresponsive to androgen therapy, resistance to chemotherapy becomes imminent, resulting in high mortality. To combat this situation, lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatum spores, was tested against hormone sensitive (LnCaP)...

journal_title：European journal of pharmacology

authors： Bishayee K,Chakraborty D,Ghosh S,Boujedaini N,Khuda-Bukhsh AR

更新日期：2013-01-05 00:00:00

abstract：:The activation of eosinophils with the lipid mediator, leukotriene B(4), induces their homotypic aggregation. Upon activation with leukotriene B(4), eosinophils release a significant amount of arachidonic acid, a process dependent on the activation of phospholipase A(2). Here, we have evaluated whether arachidonic aci...

journal_title：European journal of pharmacology

authors： Teixeira MM,Lindsay MA,Giembycz MA,Hellewell PG

更新日期：1999-11-19 00:00:00

abstract：:The effects on rat serum prolactin level of the two isomers constituting the racemic form of amisulpride were compared. (S-)-amisulpride induced hyperprolactinemia at lower doses (ED(50) = 0.09 +/- 0.01 mg/kg) than racemic- (ED(50) = 0.24 +/- 0.03 mg/kg) and (R+)-amisulpride (ED(50) = 4.13 +/- 0.05 mg/kg), in accord w...

journal_title：European journal of pharmacology

authors： Marchese G,Ruiu S,Casti P,Saba P,Gessa GL,Pani L

更新日期：2002-07-19 00:00:00

abstract：:Nitric oxide (NO) has been described to exert various anti-atherogenic actions. However, NO, in some cases, has been shown to stimulate the oxidation of low-density lipoprotein (LDL), which constitute an important triggering event in atherosclerosis. Thus, some NO donors, despite their advantages, might also induce ox...

journal_title：European journal of pharmacology

authors： Jaworski K,Kinard F,Goldstein D,Holvoet P,Trouet A,Schneider YJ,Remacle C

更新日期：2001-08-03 00:00:00

abstract：:The activity of a selective tachykinin NK1 receptor antagonist, PD 154075 ([(2-benzofuran)-CH2OCO]-(R)-alpha-MeTrp-(S)-NHCH(CH3) Ph), was examined in radioligand binding studies, in a [Sar9,Met(O2)11]substance P-induced foot-tapping model in the gerbil, and in cisplatin-induced acute and delayed emesis in the ferret. ...

journal_title：European journal of pharmacology

authors： Singh L,Field MJ,Hughes J,Kuo BS,Suman-Chauhan N,Tuladhar BR,Wright DS,Naylor RJ

更新日期：1997-02-26 00:00:00

abstract：:The effects of the endothelin ET(A), (BQ-123) and endothelin ET(A/B) (PD161721) receptor antagonists were investigated on ischaemia-induced arrhythmias and on the maximum following frequency. The study was carried out in Langendorff perfused rat hearts subjected to coronary artery occlusion in which the severity of ar...

journal_title：European journal of pharmacology

authors： Crockett TR,Scott GA,McGowan NW,Kane KA,Wainwright CL

更新日期：2001-11-30 00:00:00

abstract：:The responsiveness of the guinea-pig esophageal muscularis mucosae to arachidonic acid (AA) and its cyclooxygenase and lipoxygenase metabolites was examined in vitro. AA (0.1-30 microM) produced a concentration-dependent contraction of the muscularis mucosae (mean EC50 +/- S.E.M. = 5.1 +/- 1.0 microM). The contraction...

journal_title：European journal of pharmacology

authors： Kamikawa Y,Fujinuma S,Shimo Y

更新日期：1985-08-07 00:00:00

abstract：:IRL1620, a specific endothelin ETB receptor agonist, induced relaxation followed by contraction in the guinea-pig ileum, as did endothelin-1. Both components of the response were concentration-dependent in the range studied. Repeated administration of IRL1620 induced tachyphylaxis only of the contractile component, wh...

journal_title：European journal of pharmacology

authors： Miasiro N,Karaki H,Paiva AC

更新日期：1995-10-24 00:00:00

abstract：:Currently, little is known about mechanisms underlying passive sensitization-induced nonspecific airway hyperresponsiveness. We sought to determine whether the nonspecific airway hyperresponsiveness observed after passive sensitization involves an increased role of Rho-kinase in airway smooth muscle contraction. In ad...

journal_title：European journal of pharmacology

authors： Schaafsma D,Zuidhof AB,Nelemans SA,Zaagsma J,Meurs H

更新日期：2006-02-15 00:00:00

abstract：:Administration of methyl-beta-carboline-3-carboxamide (FG 7142, 15 mg/kg i.p.) to rats has previously been shown to cause a selective increase in the levels of 3,4-dihydroxy-phenylacetic acid (DOPAC) in the prefrontal cortex and ventral tegmental area (VTA) via an interaction with benzodiazepine receptors. On withdraw...

journal_title：European journal of pharmacology

authors： Ida Y,Roth RH

更新日期：1987-06-04 00:00:00

abstract：:Human adipose tissue-derived stromal cells (hADSCs) demonstrate promising potential in various clinical applications, including the transplantation to regenerate injured or degenerative tissues. The migration of engrafted hADSCs to the correct site of injure is essential for the curative effect of stem cell therapy. W...

journal_title：European journal of pharmacology

authors： Wang H,Liu TQ,Guan S,Zhu YX,Cui ZF

更新日期：2008-12-03 00:00:00

abstract：:Nitric oxide (NO) and prostacyclin (PGI(2)) are two of the most important vasodilators produced by endothelial cells, the regulation of NO on PGI(2) production has not been fully clear yet. Polyaspartoyl.L-arginine (PDR) is an L-arginine residue-rich compound with inhibitory effects of platelet aggregation and thrombo...

journal_title：European journal of pharmacology

authors： Tang Z,Yang J,Liu X,Wang Y,Peng S

更新日期：2008-12-28 00:00:00