当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Role of arachidonic acid in leukotriene B(4)-induced guinea-pig eosinophil homotypic aggregation.

Role of arachidonic acid in leukotriene B(4)-induced guinea-pig eosinophil homotypic aggregation.

Abstract：

:The activation of eosinophils with the lipid mediator, leukotriene B(4), induces their homotypic aggregation. Upon activation with leukotriene B(4), eosinophils release a significant amount of arachidonic acid, a process dependent on the activation of phospholipase A(2). Here, we have evaluated whether arachidonic acid could induce aggregation of eosinophils and whether the release of arachidonic acid mediated the aggregation induced by leukotriene B(4). The exogenous administration of arachidonic acid induced a concentration-dependent eosinophil homotypic aggregation. Pretreatment of eosinophils with a 5-lipoxygenase inhibitor or a leukotriene B(4) receptor antagonist abrogated arachidonic-acid-induced aggregation. Arachidonic acid induced a significant increase in leukotriene B(4) levels and desensitised leukotriene B(4)-induced aggregation in a dose-dependent manner. Moreover, this desensitisation was effectively reversed by a 5-lipoxygenase inhibitor. However, arachidonic acid failed to induce a rise in intracellular Ca(2+) in eosinophils and failed to desensitise these cells to rises in intracellular Ca(2+) induced by leukotriene B(4). Pretreatment of eosinophils with the phospholipase A(2) inhibitor, mepacrine, inhibited the aggregation responses induced by 1 nM leukotriene B(4) by approximately 50% but had no significant effect on the other concentrations of leukotriene B(4) tested (0.1 to 100 nM). In conclusion, arachidonic acid stimulates eosinophil aggregation indirectly via the release of leukotriene B(4). Although a significant amount of arachidonic acid is released in response to activation of eosinophils with leukotriene B(4), the arachidonic acid released does appear to play a major role in mediating leukotriene B(4)-induced eosinophil aggregation.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Teixeira MM,Lindsay MA,Giembycz MA,Hellewell PG

doi

10.1016/s0014-2999(99)00697-4

keywords:

subject

Has Abstract

pub_date

1999-11-19 00:00:00

pages

183-90

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(99)00697-4

journal_volume

384

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Dissociation between post-surgical pain behaviors and spinal Fos-like immunoreactivity in the rat.

    abstract：:Previous studies have demonstrated that Fos-like immunoreactivity is increased in spinal dorsal horn neurons in several pain models, and have suggested that Fos-like immunoreactivity could be used as a marker of neurons activated by painful stimulation. In the present study, we evaluated nociceptive behaviors and spin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.12.019

    authors： Zhu CZ,Nikkel AL,Martino B,Bitner RS,Decker MW,Honore P

    更新日期：2006-02-15 00:00:00

  • Mast cells, brain inflammation and autism.

    abstract：:Increasing evidence indicates that brain inflammation is involved in the pathogenesis of neuropsychiatric diseases. Mast cells (MCs) are located perivascularly close to neurons and microglia, primarily in the leptomeninges, thalamus, hypothalamus and especially the median eminence. Corticotropin-releasing factor (CRF)...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2015.03.086

    authors： Theoharides TC,Stewart JM,Panagiotidou S,Melamed I

    更新日期：2016-05-05 00:00:00

  • Silibinin alleviates high glucose-suppressed osteogenic differentiation of human bone marrow stromal cells via antioxidant effect and PI3K/Akt signaling.

    abstract：:High glucose is one of the possible causes for osteoporosis and fracture in diabetes mellitus. Our previous study showed that silibinin can increase osteogenic effect by stimulating osteogenic genes expression in human bone marrow stem cells (hBMSCs). However, no study has yet investigated the effect of silibinin on o...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2015.09.005

    authors： Ying X,Chen X,Liu H,Nie P,Shui X,Shen Y,Yu K,Cheng S

    更新日期：2015-10-15 00:00:00

  • Dopamine antagonists induce gastric lesions in rats.

    abstract：:Gastric lesions were provoked in all rats that had received intraperitoneally a single dose of the dopamine antagonists haloperidol, metoclopramide or domperidone 24 h before. Dose-dependence was demonstrated for haloperidol. This drug induced gastric lesions as early as 90 min after its application. The ulcerogenic e...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(86)90522-4

    authors： Sikirić P,Geber J,Ivanović D,Suchanek E,Gjuris V,Tućan-Foretić M,Mise S,Cvitanović B,Rotkvić I

    更新日期：1986-11-12 00:00:00

  • Effects of AY-22,241 (Actodigin) on electrical and mechanical activity of cardiac tissues.

    abstract：:AY-22,241 (Actodigin) is a new rapid-acting semisynthetic cardiotonic steroid. In experiments on contractility of cat papillary muscle, Actodigin (2 times 10(-7) to 4 times 10(-6) M) produced a dose-dependent positive inotropic effect, a marked increase in the maximum rate of force development, and no change in restin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(75)90316-7

    authors： Gliklich JI,Gaffney R,Rosen MR,Hoffman BF

    更新日期：1975-05-01 00:00:00

  • Evidence for a role of nitric oxide in the corticotropin-releasing factor release induced by interleukin-1 beta.

    abstract：:Interleukin-1 beta stimulates corticotropin-releasing factor (CRF) secretion from the hypothalamus involving the activation of prostaglandins. This study investigated the possibility that nitric oxide (NO) acts as a mediator of interleukin-1-induced CRF release. An in vitro rat hypothalami continuous perifusion system...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(94)00700-h

    authors： Sandi C,Guaza C

    更新日期：1995-02-14 00:00:00

  • Intracerebroventricular injection of N omega-nitro-L-arginine in rats impairs learning in a 14-unit T-maze.

    abstract：:We investigated whether intracerebroventricular (i.c.v.) infusion of the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine (N-Arg), impairs learning in male Sprague-Dawley rats (2-3 months old) in a 14-unit T-maze. Rats were pretrained in one-way active avoidance to a criterion of 13/15 avoidances of foot shock...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01427-1

    authors： Ingram DK,Spangler EL,Kametani H,Meyer RC,London ED

    更新日期：1998-01-02 00:00:00

  • Dopamine D-1 and D-2 receptor agonists and antagonists and neuropeptide-induced excessive grooming.

    abstract：:The administration of the dopamine D-1 receptor antagonist, SCH 23390, but not of the dopamine D-2 receptor antagonist, sulpiride, suppressed the excessive grooming induced by a new environment or by various neuropeptides. In addition, administration of the dopamine D-1 agonist, SK & F 38393, induced excessive groomin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90527-x

    authors： Van Wimersma Greidanus TB,Maigret C,Torn M,Ronner E,Van der Kracht S,Van der Wee NJ,Versteeg DH

    更新日期：1989-12-07 00:00:00

  • Spinal calmodulin inhibitors reduce N-methyl-D-aspartate- and septide-induced nociceptive behavior.

    abstract：:The effect of two calmodulin inhibitors, W-7 (N-(6-aminohexyl)-5-chloro-1-naphtalenesulfonamide) and calmidazolium, on the nociceptive behavior induced by the intrathecal injection of NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-iso xazolepropionic acid) or of septide is described. Lumbar intrat...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01158-8

    authors： Menéndez L,Hidalgo A,Baamonde A

    更新日期：1997-09-17 00:00:00

  • Electrophysiological effect and the gating mechanism of astragaloside IV on L-type Ca(2+) channels of guinea-pig ventricular myocytes.

    abstract：:Astragaloside IV (AS-IV) is one of the main active ingredients of Astragalus membranaceus. This study is aimed to investigate AS-IV׳s effects on Ca(2+) channel activity of single cardiomyocytes and single Ca(2+) channels. Whole-cell Ca(2+) currents in freshly dissociated cardiomyocytes were measured using the whole-ce...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2015.03.082

    authors： Zhao M,Shao D,Yu L,Sun X,Wang Y,Hu H,Feng R,Gao Q,Guo F,Hao L

    更新日期：2015-08-05 00:00:00

  • Regulation of blood pressure by L-arginine-nitric oxide pathway within the superior colliculus of rats.

    abstract：:Injection into the superior colliculus of anaesthetised rats of the nitric oxide (NO) synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 1 micromol), but not its inactive enantiomer N(omega)-nitro-D-arginine methyl ester (D-NAME; 1 micromol), significantly (P < 0.01) increased the mean arterial blood p...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)83029-4

    authors： D'Amico M,Rossi F,Warner TD

    更新日期：1997-06-05 00:00:00

  • Histamine H3-receptors modulate nonadrenergic noncholinergic neural bronchoconstriction in guinea-pig in vivo.

    abstract：:We have investigated whether the histamine H3-receptors influence nonadrenergic noncholinergic (NANC) bronchoconstriction in guinea-pig in vivo. Atropine, propranolol, mepyramine and cimetidine were administered to block the effects of beta-adrenoceptor-, acetylcholine, H1- and H2-receptor-mediated responses, respecti...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90872-8

    authors： Ichinose M,Barnes PJ

    更新日期：1989-12-12 00:00:00

  • Viroinformatics approach to explore the inhibitory mechanism of existing drugs repurposed to fight against COVID-19.

    abstract：:The rapid breakout of the coronavirus disease of 2019 (COVID-19) has been declared pandemic with serious global concern due to high morbidity and mortality. As we enter the phase beyond limitations there is an urgent need for explicit treatment against COVID-19. To face this immediate global challenge, drug developmen...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173496

    authors： Bibi N,Gul S,Ali J,Kamal MA

    更新日期：2020-10-15 00:00:00

  • Long-lasting salivation induced by a novel muscarinic receptor agonist SNI-2011 in rats and dogs.

    abstract：:The sialogogic effect of SNI-2011, a novel muscarinic receptor agonist, (+/-)-cis-2-methylspilo [1,3-oxathiolane-5,3'-quinuclidine] hydrochloride, hemihydrate, was compared with that of pilocarpine hydrochloride in a dose range in which the two muscarinic agonists exhibited approximately similar efficacy in eliciting ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01338-1

    authors： Masunaga H,Ogawa H,Uematsu Y,Tomizuka T,Yasuda H,Takeshita Y

    更新日期：1997-11-19 00:00:00

  • Selective blockade of N-methyl-D-aspartate receptor function by the nitric oxide donor, nitroprusside.

    abstract：:The N-methyl-D-aspartate (NMDA) receptor-mediated component of the synaptic response of cerebellar granule cells to mossy fibre stimulation was selectively inhibited by the nitric oxide (NO) donor, nitroprusside (nitroferricyanide). The direct depolarisation of granule cells induced by perfusion of NMDA was similarly ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(91)90021-h

    authors： East SJ,Batchelor AM,Garthwaite J

    更新日期：1991-12-10 00:00:00

  • Recombinant human type II phospholipase A2 lacks edema producing activity in rat.

    abstract：:The rat paw edema-inducing, acute inflammatory activity of four snake venom phospholipase A2S (PLA2) (Naja naja, Naja mocambique mocambique, Crotalus atrox and recombinant Naja naja naja) and of recombinant human type II PLA2 (rh-PLA2) found in rheumatoid synovial fluid, were compared after a bolus subplantar injectio...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(93)90818-3

    authors： Morgan DW,Anderson CM,Meyers KP

    更新日期：1993-04-22 00:00:00

  • Inflexin attenuates proinflammatory responses and nuclear factor-kappaB activation in LPS-treated microglia.

    abstract：:Activated microglia participate in neuroinflammation which contribute to neuronal damage. Suppression of microglial activation would have therapeutic benefits, which lead to alleviation of the progression of neurodegeneration. In this study, the inhibitory effects of inflexin, a putative antiinflammatory agent isolate...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2010.02.011

    authors： Ko HM,Koppula S,Kim BW,Kim IS,Hwang BY,Suk K,Park EJ,Choi DK

    更新日期：2010-05-10 00:00:00

  • Cytoprotective properties of phenolic antidiarrheic ingredients in cultured astrocytes and neurons of rat brains.

    abstract：:We have previously shown that particular phenolic antidiarrheic ingredients, including 2-methoxy-4-methylphenol (2M4MP) and 2-methoxy-4-ethyphenol (2M4EP), but not 2-methoxyphenol (2MP), significantly inhibit cellular maturation and differentiation of the bone-resorbing osteoclasts with concomitant protection of the b...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.03.034

    authors： Matsushima N,Nakamichi N,Kambe Y,Takano K,Moriguchi N,Yoneda Y

    更新日期：2007-07-12 00:00:00

  • Losartan inhibits the angiotensin II-induced stimulation of the phosphoinositide signalling system in vascular smooth muscle cells.

    abstract：:2-n-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)bip hen yl-4-yl)methyl]imidazole, potassium salt (Losartan) (previous name, DuP 753 or MK 954) is a nonpeptide angiotensin II receptor antagonist. This study was performed to investigate the ability of Losartan to inhibit the angiotensin II-induced stimulatio...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(92)90130-n

    authors： Ko Y,Görg A,Appenheimer M,Wieczorek AJ,Düsing R,Vetter H,Sachinidis A

    更新日期：1992-10-01 00:00:00

  • WITHDRAWN: Decreased HCN1 mRNA in hippocampal area CA1 and neocortex after chronic cerebral hypoperfusion.

    abstract：:This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.11.052

    authors： He Z,Chen C,Huang L,Liu S,Guo L

    更新日期：2008-12-03 00:00:00

  • Modulation of antigen-induced responses by serotonin and prostaglandin E2 via EP1 and EP4 receptors in the peripheral rat lung.

    abstract：:The cyclooxygenase (COX) pathway and prostanoids may critically contribute to the early allergic airway response. In the rat lung, serotonin (5-HT) is a major mediator of antigen-induced contractions. The aim of this study was therefore to examine the relative role of the COX pathway and serotonin for antigen-induced ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2012.11.039

    authors： Larsson-Callerfelt AK,Dahlén SE,Kühl AR,Lex D,Uhlig S,Martin C

    更新日期：2013-01-15 00:00:00

  • Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells.

    abstract：:Transcriptional activation of the human CYP1A1 gene (coding for cytochrome P450 1A1) is mediated by the aryl hydrocarbon receptor. In the present study we have examined interaction of the ginsenoside Rg1 and Rb1 with the carcinogen activation pathway mediated by the aryl hydrocarbon receptor in HepG2 cells. RT-PCR was...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.10.057

    authors： Wang Y,Ye X,Ma Z,Liang Q,Lu B,Tan H,Xiao C,Zhang B,Gao Y

    更新日期：2008-12-28 00:00:00

  • Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells.

    abstract：:Based on the ability of many receptors to amplify NIH 3T3 cells, we developed a high throughput assay of cloned receptor pharmacology. In this assay, receptors are transiently co-expressed with the marker enzyme beta-galactosidase. Receptors that induce cellular proliferation select and amplify the cells that also exp...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(95)00639-7

    authors： Bräuner-Osborne H,Brann MR

    更新日期：1996-01-04 00:00:00

  • Protective effect of verbascoside on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells.

    abstract：:The neuroprotective effects of verbascoside, one of phenylpropanoid glucoside isolated from the Chinese herbal medicine Buddleja officinalis Maxim, on 1-methyl-4-phenylpyridinium ion (MPP(+)) induced apoptosis and oxidative stress in PC12 neuronal cells were investigated. Treatment of PC12 cells with MPP(+) for 48 h i...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(02)02240-9

    authors： Sheng GQ,Zhang JR,Pu XP,Ma J,Li CL

    更新日期：2002-09-13 00:00:00

  • Loop and distal actions of a novel diuretic, M17055.

    abstract：:We investigated the mechanism of action of a novel 'high ceiling' diuretic, M17055, in in vivo clearance studies with anesthetized dogs during water diuresis and in vitro microperfusion studies of isolated rabbit renal tubules. In the clearance study, intravenous infusion of M17055 (1 mg/kg per h) decreased free water...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(93)90863-d

    authors： Shinkawa T,Yamasaki F,Notsu T,Nakakuki M,Nishijima K,Yoshitomi K,Imai M

    更新日期：1993-07-20 00:00:00

  • Celastrol attenuates symptoms of preeclampsia in rats by inhibiting matrix metalloproteinase-9.

    abstract：:Preeclampsia is reported in pregnant women around the world and often causes maternal/fetal mortality and morbidity. In the current study, we assessed the efficacy of celastrol on a rat preeclampsia model induced by Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME). Pregnant rats were administered L-NAME to esta...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2018.04.025

    authors： Xiao S,Zhang M,He Z,Wang D

    更新日期：2018-07-05 00:00:00

  • Lack of dopamine supersensitivity in rats after chronic administration of blonanserin: Comparison with haloperidol.

    abstract：:Long-term treatment with antipsychotic drugs in patients with schizophrenia can lead to dopamine supersensitivity psychosis. It is reported that repeated administration of haloperidol caused dopamine supersensitivity in rats. Blonanserin is an atypical antipsychotic drug with high affinity for dopamine D2, D3 and sero...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2018.04.014

    authors： Hashimoto T,Baba S,Ikeda H,Oda Y,Hashimoto K,Shimizu I

    更新日期：2018-07-05 00:00:00

  • DHA supplementation prevent the progression of NASH via GPR120 signaling.

    abstract：:Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases involving chronic accumulation of fat and inflammation, often leading to advanced fibrosis, cirrhosis and carcinoma. However, the pathological mechanism for this is unknown. GPR120/FFAR4 has been recognized as a functional fatty acid receptor...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.11.046

    authors： Nakamoto K,Shimada K,Harada S,Morimoto Y,Hirasawa A,Tokuyama S

    更新日期：2018-02-05 00:00:00

  • Responses to L-163,491, a nonpeptide angiotensin II mimic, in the pulmonary vascular bed of the cat.

    abstract：:Pulmonary vascular responses to 5,7-dimethyl-2-ethyl-3-[[2'-[butyloxycarbonyl)amino-sulfonyl]-5'-(3-meth oxybenzyl)-[1,1'-biphenyl]-4-yl]methyl]-3H-imidazo[4,5-b]pyridine (L-163,491), a novel nonpeptide angiotensin agonist, and angiotensin IV, the 3-8 amino acid fragment of angiotensin, were compared with responses to...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(95)00486-6

    authors： Kaye AD,Nossaman BD,Kivlighn S,Ibrahim IN,De Witt BJ,Kadowitz PJ

    更新日期：1995-12-12 00:00:00

  • Receptor binding profile of cyclazosin, a new alpha 1B-adrenoceptor antagonist.

    abstract：:The binding profile of cyclazosin, a new prazosin-related alpha 1-adrenoceptor antagonist, at alpha 1-, alpha 2-adrenoceptors, dopamine D2 and 5-HT1A receptors was compared to that of 5-methylurapidil, spiperone, risperidone and other prazosin-related ligands. In addition, cyclazosin was investigated at native and clo...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(95)00471-7

    authors： Giardinà D,Crucianelli M,Melchiorre C,Taddei C,Testa R

    更新日期：1995-12-04 00:00:00