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Selective blockade of N-methyl-D-aspartate receptor function by the nitric oxide donor, nitroprusside.

Abstract：

:The N-methyl-D-aspartate (NMDA) receptor-mediated component of the synaptic response of cerebellar granule cells to mossy fibre stimulation was selectively inhibited by the nitric oxide (NO) donor, nitroprusside (nitroferricyanide). The direct depolarisation of granule cells induced by perfusion of NMDA was similarly reduced. However, these effects are unlikely to be caused by NO because, inter alia, they could not be replicated by other NO donors whereas ferricyanide was similarly effective.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

East SJ,Batchelor AM,Garthwaite J

doi

10.1016/0014-2999(91)90021-h

subject

Has Abstract

pub_date

1991-12-10 00:00:00

pages

119-21

issue

1-2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(91)90021-H

journal_volume

209

pub_type

杂志文章

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