Characterization of muscarinic receptors in canine bronchial smooth muscle.

abstract：:Pulmonary vascular responses to 5,7-dimethyl-2-ethyl-3-[[2'-[butyloxycarbonyl)amino-sulfonyl]-5'-(3-meth oxybenzyl)-[1,1'-biphenyl]-4-yl]methyl]-3H-imidazo[4,5-b]pyridine (L-163,491), a novel nonpeptide angiotensin agonist, and angiotensin IV, the 3-8 amino acid fragment of angiotensin, were compared with responses to...

journal_title：European journal of pharmacology

authors： Kaye AD,Nossaman BD,Kivlighn S,Ibrahim IN,De Witt BJ,Kadowitz PJ

更新日期：1995-12-12 00:00:00

abstract：:The cerebellum receives indolaminergic fibers influencing Purkinje cell discharges. Data from our laboratories have demonstrated an endogenous release of serotonin (5-HT) and a Na(+)-dependent uptake and Ca(2+)-dependent release of [3H]5-HT from slices, homogenates and synaptosomal fractions of the rat cerebellar mole...

journal_title：European journal of pharmacology

authors： Beas-Zárate C,Morales-Villagran A,Tapia-Arizmendi G,Feria-Velasco A

更新日期：1991-05-30 00:00:00

abstract：:Two major effector systems are frequently implicated in the immune and endothelial cell alternations associated with inflammation. They include the enhanced production of reactive oxygen species and diminished bioavailability of nitric oxide (NO). Importantly, these processes can be regulated by endogenously produced ...

journal_title：European journal of pharmacology

authors： Pekarova M,Kubala L,Martiskova H,Bino L,Twarogova M,Klinke A,Rudolph TK,Kuchtova Z,Kolarova H,Ambrozova G,Kuchta R,Kadlec J,Lojek A

更新日期：2013-08-05 00:00:00

abstract：:Intravenous infusions of sodium nitroprusside (SNP) at doses of 20, 40 or 80 micrograms/kg min-1 for 30 min produced dose-related decrements in blood pressure in conscious rats fitted with indwelling aortic and vena caval catheters. Immediately upon termination of SNP infusions, blood pressure rebounded to levels whic...

journal_title：European journal of pharmacology

authors： Abukhres MM,Ertel RJ,Dixit BN,Vollmer RR

更新日期：1979-10-01 00:00:00

abstract：:Following pretreatment with 6-OH-dopamine, the sympathetic nerve endings of the iris and skeletal muscle of mice and rats were not longer detectable by cytochemistry for noradrenaline. In the same animals, the specific binding of [3H] ouabain to intact soleus muscles was not significantly different from that measured ...

journal_title：European journal of pharmacology

authors： Clausen T,Hansen O,Larsson LI

更新日期：1981-07-10 00:00:00

abstract：:Arvanil is a metabolically stable hybrid between anandamide and capsaicin. The present study was designed to test the role of the vagal pathway in post-arvanil respiratory and blood pressure responses. Respiratory and pressure changes evoked by an intravenous injection of arvanil were investigated in 21 urethane-chlor...

journal_title：European journal of pharmacology

authors： Kopczyńska B

更新日期：2010-09-15 00:00:00

abstract：:Membrane preparations of guinea-pig lung (containing multiple muscarinic receptor subtypes) and heart (containing M2 receptors only) were incubated with either neuraminidase, parainfluenza virus (which contains neuraminidase), or virus plus 2,3-dehydro-2-deoxy-N-acetylneuraminic acid, a neuraminidase inhibitor. None o...

journal_title：European journal of pharmacology

authors： Fryer AD,el-Fakahany EE,Jacoby DB

更新日期：1990-05-31 00:00:00

abstract：:The affinity and intrinsic activity of dopamine receptor agonists were determined at the human dopamine hD21 and hD4.4 receptors. (-)-3-Hydroxy-N-n-propylpiperidine ((-)3-PPP) had an intrinsic activity of 46% and 83%, whereas (+)-N-propylnorapomorphine ((+)-NPA) had intrinsic activities of 61% and 58% at the dopamine ...

journal_title：European journal of pharmacology

authors： Lahti RA,Mutin A,Cochrane EV,Tepper PG,Dijkstra D,Wikström H,Tamminga CA

更新日期：1996-04-22 00:00:00

abstract：:The effects of thyrotropin-releasing hormone (TRH), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) and L-5-hydroxytryptophan (5-HTP) were studied on the monosynaptic reflex (MSR) and the polysynaptic reflex (PSR) in acute and chronic spinal rats. Radioimmunoassay showed that while chronic spinal transection (for 2 weeks)...

journal_title：European journal of pharmacology

authors： Nagano N,Ono H,Ozawa M,Fukuda H

更新日期：1988-05-10 00:00:00

abstract：:Transporter-mediated release of dopamine and the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium (MPP+) was examined in COS cells, a cell line derived from monkey kidney, expressing the rat dopamine transporter. The release of preloaded [3H]MPP+ but not [3H]dopamine was dose-dependently inhibited by cocai...

journal_title：European journal of pharmacology

authors： Kitayama S,Morita K,Dohi T

更新日期：1996-08-01 00:00:00

abstract：:We have recently shown that short-term aortic barodenervation diminishes constrictor responses to activation of alpha1-adrenoceptors in rat aortic smooth muscle. This study investigated the potential role of vascular endothelium and its derived vasoactive substances, nitric oxide and prostaglandins, in the reduced alp...

journal_title：European journal of pharmacology

authors： El-Mas MM,Daabees TT,El-Gowelli HM,Abdel-Galil AG

更新日期：1997-10-22 00:00:00

abstract：:The central dopamine system plays a prominent role in the effect of psychostimulants such as methamphetamine, cocaine and nicotine. l-3,4-Dihydroxyphenylalanine (DOPA), a precursor of dopamine, has been proposed as a neurotransmitter in the central nervous system. We have studied the effects of these psychostimulants ...

journal_title：European journal of pharmacology

authors： Izawa J,Yamanashi K,Asakura T,Misu Y,Goshima Y

更新日期：2006-11-07 00:00:00

abstract：:The involvement of spinal glial cells in the nociceptive behaviors induced by 1600 pmol of histamine was determined in mice. Histamine injected intrathecally (i.t.) produced nociceptive behaviors, consisting of scratching, biting and licking. The nociceptive behaviors induced by histamine were significantly suppressed...

journal_title：European journal of pharmacology

authors： Mizoguchi H,Komatsu T,Iwata Y,Watanabe C,Watanabe H,Orito T,Katsuyama S,Yonezawa A,Onodera K,Sakurada T,Sakurada S

更新日期：2011-02-25 00:00:00

abstract：:Interleukin-6 (IL-6) is a key proinflammatory cytokine which plays a central role in the pathogenesis of periodontal disease. Host modulatory agents targeting at inhibiting IL-6, therefore, appear to be beneficial in slowing the progression of periodontal disease and potentially reducing destructive aspects of the hos...

journal_title：European journal of pharmacology

authors： Choi EY,Jin JY,Choi JI,Choi IS,Kim SJ

更新日期：2014-04-15 00:00:00

abstract：:Anaphylaxis during general anaesthesia is a significant clinical challenge for anaesthesiologists. Approximately 50% of perioperative anaphylaxis cases lack the presence of specific IgE antibodies. Mas-related G-protein coupled receptor X2 (MRGPRX2) in humans and its mouse orthologue Mas-related G-protein coupled rece...

journal_title：European journal of pharmacology

authors： Suzuki Y,Liu S,Ogasawara T,Sawasaki T,Takasaki Y,Yorozuya T,Mogi M

更新日期：2020-07-05 00:00:00

abstract：:A series of 26 drugs was tested for in vitro binding to opiate receptors in the presence and absence of 0.1 M NaCl. The results were correlated with assays for in vivo pharmacological potency. Highly significant correlation was found between binding in the presence and absence of sodium ions and analgesic potency. For...

journal_title：European journal of pharmacology

authors： Stahl KD,van Bever W,Janssen P,Simon EJ

更新日期：1977-12-01 00:00:00

abstract：:The role of leukotriene synthesis in the gastrointestinal damage induced by platelet-activating factor (PAF) was examined in the rat. The effects of a 20-min infusion of PAF (100 ng/kg per min) on leukotriene B4 (LTB4) and leukotriene C4 (LTC4) synthesis were examined in samples of the stomach, duodenum, jejunum, ileu...

journal_title：European journal of pharmacology

authors： Wallace JL,MacNaughton WK

更新日期：1988-06-22 00:00:00

abstract：:The LTD4 antagonist, Wy-48,252 (1,1,1-trifluoro-N-[3-(2-quinolinylmethoxy)phenyl]methanesulfonamide), was assessed for its ability to modulate arachidonic acid metabolism in several inflammatory cells. In A23187-stimulated rat neutrophils, Wy-48,252 effectively inhibited the conversion of exogenous [14C]arachidonic ac...

journal_title：European journal of pharmacology

authors： Chang J,Borgeat P,Schleimer RP,Musser JH,Marshall LA,Hand JM

更新日期：1988-03-22 00:00:00

abstract：:A synthetic heptapeptide corresponding to the C-terminal heptapeptide of caerulein but characterized by a nor-leucyl residue replacing the methyonyl residue of caerulein, when given by i.v. infusion (2 mug/kg/h), inhibited by 70-80% pentagastrin (4 mug/kg/h)-stimulated gastric secretion... ...

journal_title：European journal of pharmacology

authors： Agosti A,Missale G,Bertaccini G

更新日期：1976-07-01 00:00:00

abstract：:Endogenous hydrogen sulfide is produced by cystathionine-γ-lyase and cystathionine-β-synthase in a variety of tissues and has recently been implicated in the regulation of cardiac functions. Acceleration of the heart rate in response to catecholamines is impaired in patients with cirrhosis. The present study was aimed...

journal_title：European journal of pharmacology

authors： Babaei-Karamshahlou M,Hooshmand B,Hajizadeh S,Mani AR

更新日期：2012-12-05 00:00:00

abstract：:In this study we have investigated the functional activity of GR127935 (2-methyl-1,2,4 oxadiazol-3-yl)-biphenyl-[4-carboxylic acid 4-methoxy-3-(4-methyl-piperazine-1-yl]-amide) at human 5-HT1D alpha and 5-HT1D beta receptors which have been expressed in a Chinese Hamster Ovary (CHO) cell line. Using [35S] GTP gamma S ...

journal_title：European journal of pharmacology

authors： Watson JM,Burton MJ,Price GW,Jones BJ,Middlemiss DN

更新日期：1996-10-31 00:00:00

abstract：:The family of facilitative glucose transporter (GLUT) proteins is responsible for the entry of glucose into cells throughout the periphery and the brain. The expression, regulation and activity of GLUTs play an essential role in neuronal homeostasis, since glucose represents the primary energy source for the brain. Br...

journal_title：European journal of pharmacology

authors： McEwen BS,Reagan LP

更新日期：2004-04-19 00:00:00

abstract：:In cases of severe human scorpion envenoming, lung injury is a common finding and frequently the cause of death. In the rat, two distinct mechanisms account for oedema following the intravenous injection of the venom -- acute left ventricular failure resulting from a massive release of catecholamines and an increase i...

journal_title：European journal of pharmacology

authors： Matos IM,Souza DG,Seabra DG,Freire-Maia L,Teixeira MM

更新日期：1999-07-09 00:00:00

abstract：:Nitric oxide (10 ppm) inhaled by pigs before or during endotoxin shock induced by an infusion of E. coli lipopolysaccharide. Nitric oxide inhalation selectively attenuated pulmonary hypertension during endotoxin infusion without influencing mean arterial blood pressure and cardiac output. Upon cessation of nitric oxid...

journal_title：European journal of pharmacology

authors： Weitzberg E,Rudehill A,Lundberg JM

更新日期：1993-03-16 00:00:00

abstract：:Although accumulated data suggest that calcitonin gene-related peptide (CGRP) produces anabolic effects in skeletal tissue by directly acting on osteogenic cells, neither the distribution of CGRP receptor subtypes nor the associated cellular signaling pathways are well understood. In this study, we have pharmacologica...

journal_title：European journal of pharmacology

authors： Kawase T,Okuda K,Burns DM

更新日期：2003-06-06 00:00:00

abstract：:Histopathological parameters are essential for deciding on adjuvant treatment following breast cancer surgery. We assessed the impact of inter-observer variability on treatment strategy in patients operated for clinically node negative, non-palpable breast carcinomas. In the context of a multicenter randomised control...

journal_title：European journal of pharmacology

authors： Postma EL,Verkooijen HM,van Diest PJ,Willems SM,van den Bosch MA,van Hillegersberg R

更新日期：2013-10-05 00:00:00

abstract：:Adult rats submitted to perinatal protein deprivation (from day 14 of fetal life till 50 days of age) followed by a longer phase of nutritional recovery on balanced laboratory chow, showed a significant decrease of the pressor response elicited by noradrenaline and adrenaline, an effect that persisted after ganglionic...

journal_title：European journal of pharmacology

authors： Del Basso P,Keller EA,Salica C,Orsingher OA

更新日期：1983-01-28 00:00:00

abstract：:To investigate the long-term functional change in the 5-HT(2A) receptor after acute stress, we examined the effect of single footshock on head shake behavior induced by the 5-HT(2A) receptor agent (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) in rats. Head shakes were evoked in a dose-dependent manner by 0...

journal_title：European journal of pharmacology

authors： Izumi T,Suzuki K,Inoue T,Li XB,Maki Y,Muraki I,Kitaichi Y,Hashimoto S,Koyama T

更新日期：2002-10-04 00:00:00

abstract：:Clomipramine is a tricyclic antidepressant for psychiatric disorders that can induce QT prolongation, which may lead to torsades de pointes. Since blockade of cardiac human ether-a-go-go-related gene (hERG) channels is an important cause of acquired long QT syndrome, we investigated the acute effects of clomipramine o...

journal_title：European journal of pharmacology

authors： Jo SH,Hong HK,Chong SH,Won KH,Jung SJ,Choe H

更新日期：2008-09-11 00:00:00

abstract：:Primary cultures of rat cerebellar granule neurons express 5-lipoxygenase, an enzyme from the inflammatory pathway of arachidonic acid. Outside the central nervous system (CNS) 5-lipoxygenase participates in cell proliferation. We hypothesized that 5-lipoxygenase is needed for proliferation of immature cerebellar gran...

journal_title：European journal of pharmacology

authors： Uz T,Manev R,Manev H

更新日期：2001-04-20 00:00:00