Abstract:
:The effects of N-(aminoiminomethyl)-1, 4-dimethyl-1H-indole-2-carboxamide methanesulfonic acid (SM-20550), a novel potent Na(+)/H(+) exchanger, and nicorandil, a K(+) channel opener with nitrate-like activity, were studied in a myocardial ischemia and reperfusion injury model. Anesthetized rabbits underwent occlusion of the coronary artery (30 min) followed by reperfusion (5 h). Intravenous administration of SM-20550 before ischemia reduced the infarct size by approximately 30-70% in a dose-dependent manner, with a significant reduction in serum creatine phosphokinase activity. Similarly, intravenous administration of nicorandil before ischemia reduced the infarct size by 33% with a significant reduction in serum creatine phosphokinase activity. Moreover, intravenous administration of SM-20550 after ischemia resulted in a significant, approximately 20-40% reduction in the infarct size, but the administration of nicorandil after ischemia did not reduce the infarct size. These results indicate that SM-20550 reduced myocardial necrosis when administered either before or after ischemia.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Yamada K,Matsui K,Satoh K,Kitano M,Yamamoto S,Ohashi Ndoi
10.1016/s0014-2999(00)00610-5keywords:
subject
Has Abstractpub_date
2000-09-15 00:00:00pages
201-12issue
1-2eissn
0014-2999issn
1879-0712pii
S0014-2999(00)00610-5journal_volume
404pub_type
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