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Effect of propofol on calcium homeostasis in hypoxia-reoxygenated neonatal rat cardiomyocytes.

Abstract：

:Intracellular Ca2+ overload induced by hypoxia-reoxygenation alters Ca2+ homeostasis, which plays an important role in myocardial cell injury. Even though propofol is known as a radical scavenger with Ca2+ channel blocking properties, little is known about cardioprotective effect associated with Ca2+ homeostasis in cardiomyocytes. In the present study, we showed that propofol protects cardiomyocytes against hypoxia-reoxygenation injury. In propofol-treated cardiomyocytes, we observed a decrease in the expression of pro-apoptotic protein Bax, cytochrome c, caspase-3 activation and intracellular Ca2+ content. We also found that propofol treatment enhanced expression of anti-apoptotic protein Bcl-2 and activation of ERK concerned with survival. Propofol attenuated alterations of genes involving Ca2+-regulatory mechanism and significantly modulated abnormal changes of SERCA2a genes in hypoxia-reoxygenated neonatal cardiomyocytes. These results suggest that propofol modulates the expression of genes involved in Ca2+ homeostasis, thereby producing cardioprotective effects through a reduction in apoptotic cell death.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Kim HS,Chang WC,Hwang KC,Choi IG,Park WK

doi

10.1016/j.ejphar.2008.07.027

subject

Has Abstract

pub_date

2008-10-10 00:00:00

pages

139-45

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(08)00742-5

journal_volume

594

pub_type

杂志文章

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