Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice.

abstract：:Choline acetyltransferase activity was measured in rats treated with daily injections of ethanol (0.1 g/kg body wt) and or dexamethasone (1 mg/kg body wt) for 5 consecutive days. Ethanol produced a biphasic reduction of choline acetyltransferase activity in rat cerebral cortex, which at most time points was further de...

journal_title：European journal of pharmacology

authors： Wattanathorn J,Kotchabhakdi N,Casalotti SO,Baldwin BA,Govitrapong P

更新日期：1996-10-10 00:00:00

abstract：:Intravenous administration of 0.3 mg/kg of quinpirole to conscious rabbits that had been pretreated with domperidone caused a marked increase in blood pressure and renal sympathetic nerve activity with a peak at 5-10 min after injection (25% and 3-fold increase, respectively). Spectral analysis of the blood pressure-r...

journal_title：European journal of pharmacology

authors： van den Buuse M,Head GA

更新日期：2000-01-24 00:00:00

abstract：:Prognostic models are used to predict outcome in stroke patients and to stratify treatment groups in clinical trials. No one has previously attempted to use such models in stroke recovery studies in animals. We have now shown the predictive value of assigning stroke severity ratings, based on behaviours displayed in c...

journal_title：European journal of pharmacology

authors： Roulston CL,Callaway JK,Jarrott B,Woodman OL,Dusting GJ

更新日期：2008-04-14 00:00:00

abstract：:Experiments were undertaken to determine the effect of the selective histamine H3 receptor agonist (R)-alpha-methylhistamine on the amplitude of neurally evoked electrodermal (sudomotor) responses in anesthetized cats. (R)-alpha-Methylhistamine produced comparable dose-related depressions of these evoked sympathetic-c...

journal_title：European journal of pharmacology

authors： Koss MC

更新日期：1994-05-12 00:00:00

abstract：:The response to epithelium-derived relaxant factor (EpDRF) released from guinea-pig trachea by acetylcholine was studied in the precontracted rat anococcygeus muscle in a coaxial bioassay system. Acetylcholine caused no relaxation of rat anococcygeus muscle which was precontracted with phenylephrine. When the same mus...

journal_title：European journal of pharmacology

authors： Güc MO,Ilhan M,Kayaalp SO

更新日期：1988-04-13 00:00:00

abstract：:In this study we demonstrate allograft survival in a rat model of renal transplantation using the delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [corrected]. Treatment with 7-(benzospiroindanyl)naltrexone [corrected] caused 50% of the rats to survive longer than 100 days (untreated, 11 +/- 3 days)....

journal_title：European journal of pharmacology

authors： Linner KM,Stickney BJ,Quist HE,Sharp BM,Portoghese PS

更新日期：1998-07-31 00:00:00

abstract：:Detailed antagonist competition curves for [3H]prazosin-labelled binding sites in rat cerebral cortex membranes reveal anomalous binding characteristics. Dihydroergocryptine and indoramine compete in a steep, monophasic manner while WB4101 and phentolamine exhibit shallow competition curves. Computer-assisted analysis...

journal_title：European journal of pharmacology

authors： Morrow AL,Battaglia G,Norman AB,Creese I

更新日期：1985-02-26 00:00:00

abstract：:Evidence has shown that downstream signaling by mu opioid receptor (MOR) agonists that recruit β-arrestin2 may lead to the development of tolerance. Also, it has been suggested that opioid receptor desensitization and cyclic AMP overshoot contributes to the development of tolerance and occurrence of withdrawal, respec...

journal_title：European journal of pharmacology

authors： Obeng S,Yuan Y,Jali A,Selley DE,Zhang Y

更新日期：2018-05-15 00:00:00

abstract：:In this study, we describe the effect of antiepileptic drugs on the production of kynurenic acid in rat cortical slices, and on the activity of kynurenic acid biosynthetic enzymes, kynurenine aminotransferases (KATs I and II) in the brain tissue. Phenobarbital, felbamate, phenytoin and lamotrigine (all at 0.5-3.0 mM) ...

journal_title：European journal of pharmacology

authors： Kocki T,Wielosz M,Turski WA,Urbanska EM

更新日期：2006-07-17 00:00:00

abstract：:Some studies have suggested that drug tolerance observed following repeated benzodiazepine exposure may be associated with the development of a subsensitivity to gamma-aminobutyric acid (GABA) in dorsal raphe and hippocampal neurons. In other areas such as the substantia nigra such subsensitivity has not been found. T...

journal_title：European journal of pharmacology

authors： Hutchinson MA,Smith PF,Darlington CL

更新日期：1996-04-22 00:00:00

abstract：:The association between cocaine administration and induction of oxidative stress in different brain regions suggests that oxidative damage is an important factor participating in cocaine disruption of normal central nervous system functions. In order to deal with this topic, brain penetrating exogenous antioxidants we...

journal_title：European journal of pharmacology

authors： Numa R,Baron M,Kohen R,Yaka R

更新日期：2011-01-10 00:00:00

abstract：:In rat neocortical slices activation of glutamate metabotropic receptors with glutamate, quisqualate and 1S,3R-ACPD caused a spike-evoked afterdepolarization which replaced the normal afterhyperpolarization. In some neocortical neurons the afterdepolarization reached action potential threshold causing prolonged self-s...

journal_title：European journal of pharmacology

authors： Greene C,Schwindt P,Crill W

更新日期：1992-07-01 00:00:00

abstract：:Although muscarinic M(2) and M(3) receptors are known to be important for regulation of gastric and small intestinal motility, muscarinic receptor subtypes regulating colonic function remain to be investigated. The aim of this study was to characterize muscarinic receptors involved in regulation of colonic contractili...

journal_title：European journal of pharmacology

authors： Kondo T,Nakajima M,Teraoka H,Unno T,Komori S,Yamada M,Kitazawa T

更新日期：2011-11-16 00:00:00

abstract：:Compound (+)-R,R-D-84 is an optically active trans-hydroxy-substituted derivative of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine (D-164). As a hydroxypiperidine analog of GBR 12935, (+)-R,R-D-84 is a candidate dopamine transporter compound for the treatment of cocaine dependence. The present work addresses ...

journal_title：European journal of pharmacology

authors： Zhen J,Maiti S,Chen N,Dutta AK,Reith ME

更新日期：2004-12-03 00:00:00

abstract：:We recently observed that the 5-hydroxytryptamine (5-HT)(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)-cycloh exanecarboxamide (WAY 100635) enhanced antipsychotic-induced catalepsy, which we hypothesized to be due to a blockade of tonic 5-HT(1A) receptor activation. Here, we ex...

journal_title：European journal of pharmacology

authors： Prinssen EP,Koek W,Kleven MS

更新日期：2000-04-28 00:00:00

abstract：:NTP42 is a novel antagonist of the thromboxane A2 receptor (TP) in development for the treatment of pulmonary arterial hypertension (PAH). Recent studies demonstrated that NTP42 and TP antagonism have a role in alleviating PAH pathophysiology. However, the efficacy of NTP42 when used in combination with existing PAH t...

journal_title：European journal of pharmacology

authors： Mulvaney EP,Reid HM,Bialesova L,Mendes-Ferreira P,Adão R,Brás-Silva C,Kinsella BT

更新日期：2020-12-15 00:00:00

abstract：:Alpha(2A)-Adrenoceptors mediate the antinociceptive effects of alpha(2)-adrenoceptor agonists in mice, and analgesic synergism between noradrenergic and opioidergic mechanisms has been reported to be lacking in mice devoid of functional alpha(2A)-adrenoceptors. We investigated whether the antinociceptive actions of op...

journal_title：European journal of pharmacology

authors： Ozdoğan UK,Lähdesmäki J,Scheinin M

更新日期：2006-01-04 00:00:00

abstract：:The kappa-opioid receptor (kappa Op) from guinea-pig cerebellum membranes has been solubilized in an active form and in good yield (30-40%) with digitonin in 10 mM Tes-KOH buffer, pH 7.4. [3H]Bremazocine (KD = 1.1 nM in the soluble extract) was used to monitor the binding and hydrodynamic characteristics of the digito...

journal_title：European journal of pharmacology

authors： Francés B,Moisand C,Meunier JC

更新日期：1988-05-20 00:00:00

abstract：:Metabotropic glutamate receptors (mGlu receptors), with their unique signaling systems and pharmacological characteristics, have emerged as a new topic in excitatory amino acid research. Among them, the unique distribution of group II mGlu receptors, such as mGlu(2) and mGlu(3) receptors, and the involvement of these ...

journal_title：European journal of pharmacology

authors： Chaki S

更新日期：2010-08-10 00:00:00

abstract：:The steady-state levels and utilization (alpha-MPT-induced disappearance) of noradrenaline (NA) and dopamine (DA) were measured in distinct mouse brain nuclei after acute morphine challenge, in mice rendered tolerant to morphine, and during the naloxone-precipitated morphine withdrawal syndrome. Mouse brain nuclei con...

journal_title：European journal of pharmacology

authors： Kovács GL,Acsai L,Tihanyi A,Telegdy G

更新日期：1983-09-30 00:00:00

abstract：:Spinal 5-HT1A receptor subtypes are involved in regulation of nociception. This study was performed to investigate the effect of stimulation of these receptors on wide dynamic range neurones in the spinal cord. Extracellular single unit recordings of dorsal horn neurones were performed in intact urethane-anaesthetized...

journal_title：European journal of pharmacology

authors： Gjerstad J,Tjolsen A,Hole K

更新日期：1996-12-30 00:00:00

abstract：:A significant stimulatory action of PGE1 on adenylate cyclase of the particulate membrane preparation of rat heart was observed at 1 X 10(-4) M. PGE1 caused a positive inotropic effect on isolated spontaneously beating rat atria 1 X (10(-5) M, and an increase in atrial cyclic AMP level at 1 X 10(-6) M. PGE2 stimulate...

journal_title：European journal of pharmacology

authors： Kangasaho M,Metsä-Ketelä T,Vapaatalo H

更新日期：1978-11-01 00:00:00

abstract：:Uptake blockers and substrates are likely to recognise a common binding domain on the dopamine neuronal transporter (DAT). Among cations that form ionic gradients at the level of the cellular plasma membrane, Na+ is the only one that can stimulate their binding. The binding stimulation appears over Na+ concentrations ...

journal_title：European journal of pharmacology

authors： Bonnet JJ

更新日期：2003-10-31 00:00:00

abstract：:The effects of nicotine, carbachol, hexamethonium and scopolamine were investigated on distress vocalizations (DBs) of acutely isolated domestic chicks. Nicotine attenuated, while the antimuscarinic scopolamine increased the frequency of separation-induced DVs. Furthermore, the stress attenuating effects of nicotine w...

journal_title：European journal of pharmacology

authors： Sahley TL,Panksepp J,Zolovick AJ

更新日期：1981-06-19 00:00:00

abstract：:The adenosine-receptor modulation of noradrenaline release was compared in prostatic and epididymal portions of rat vas deferens. In both portions, tritium overflow elicited by electrical stimulation (100 pulses/8 Hz) was reduced by the adenosine A(1) receptor agonist, N(6)-cyclopentyladenosine, and enhanced by the no...

journal_title：European journal of pharmacology

authors： Queiroz G,Diniz C,Gonçalves J

更新日期：2002-07-12 00:00:00

abstract：:Acetylsalicylic acid (ASA) causes adverse haemorrhagic reactions in the upper gastrointestinal (GI) tract, and previous results have suggested that combination therapy with 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) could provide protection in this scenario. Based on this hypothesis, our aim was to develop a new...

journal_title：European journal of pharmacology

authors： Varga G,Lajkó N,Ugocsai M,Érces D,Horváth G,Tóth G,Boros M,Ghyczy M

更新日期：2016-06-15 00:00:00

abstract：:Increasing evidence displays that microRNAs (miRNAs) participate in the development of various human malignancies, including esophageal squamous cell carcinoma (ESCC). MicroRNA-33a-5p (miR-33a-5p) has recently been reported to function as a tumor suppressor in many human cancers. However, the expression and role of mi...

journal_title：European journal of pharmacology

authors： Zhang C,Wang L,Yang J,Fu Y,Li H,Xie L,Cui Y

更新日期：2019-10-15 00:00:00

abstract：:We studied the cardiac electrophysiological effects of falipamil, a specific bradycardic agent, in conscious dogs, in comparison with those of alinidine. Sinus rate, corrected sinus recovery time, and Wenckebach point were measured in six intact dogs. Atrial rate, ventricular rate, and atrial effective refractory peri...

journal_title：European journal of pharmacology

authors： Boucher M,Chassaing C,Chapuy E

更新日期：1996-06-13 00:00:00

abstract：:Salvianolic acid B (SalB) is a polyphenolic compound found in Salvia miltiorrhiza Bunge that has several anti-oxidative and anti-inflammatory effects. In the present study, we investigated whether SalB has neuroprotective effects in an amyloid β (Aβ) peptide-induced Alzheimer's disease mouse model. Mice were injected ...

journal_title：European journal of pharmacology

authors： Lee YW,Kim DH,Jeon SJ,Park SJ,Kim JM,Jung JM,Lee HE,Bae SG,Oh HK,Son KH,Ryu JH

更新日期：2013-03-15 00:00:00

abstract：:Endogenous hydrogen sulfide is produced by cystathionine-γ-lyase and cystathionine-β-synthase in a variety of tissues and has recently been implicated in the regulation of cardiac functions. Acceleration of the heart rate in response to catecholamines is impaired in patients with cirrhosis. The present study was aimed...

journal_title：European journal of pharmacology

authors： Babaei-Karamshahlou M,Hooshmand B,Hajizadeh S,Mani AR

更新日期：2012-12-05 00:00:00