Identification of subtypes of [3H]prazosin-labelled alpha 1 receptor binding sites in rat brain.

abstract：:Heme oxygenase is the rate-limiting enzyme in the catabolism of heme to carbon monoxide, bilirubin and free iron. Many cell types express heme oxygenase-2 constitutively while heme oxygenase-1 is induced at sites of inflammation and oxidative stress. In systemic blood vessels, carbon monoxide may have an important hom...

journal_title：European journal of pharmacology

authors： Stanford SJ,Walters MJ,Hislop AA,Haworth SG,Evans TW,Mann BE,Motterlini R,Mitchell JA

更新日期：2003-07-25 00:00:00

abstract：:This study investigated the antinociceptive action of p-chloro-selenosteroid (PCS), administered by intragastric route (i.g.) to mice against acute models. The contribution of adenosinergic, dopaminergic, serotonergic, nitric oxide and opioid systems was investigated. It was evaluated if the administration of PCS trig...

journal_title：European journal of pharmacology

authors： Marcondes Sari MH,Guerra Souza AC,Gonçalves Rosa S,Souza D,Dorneles Rodrigues OE,Wayne Nogueira C

更新日期：2014-02-15 00:00:00

abstract：:Vervet monkeys were pharmacologically treated acutely and with repeated dose loading to alter serotonergic systems to assess the role of serotonin in the regulation of the hypothalamus-pituitary-thyroid axis. Acute L-tryptophan administration failed to alter basal levels of thyroid hormones but did decrease the TRH-in...

journal_title：European journal of pharmacology

authors： Morley JE,Raleigh MJ,Brammer GL,Yuwiler A,Geller E,Flannery J,Hershman JM

更新日期：1980-10-17 00:00:00

abstract：:Canine cerebral arterial strips denuded of endothelium responded to nicotine and transmural electrical stimulation with relaxations, which were abolished by NG-nitro-L-arginine and methylene blue. Magnitudes of relaxation did not differ in the arteries contracted with prostaglandin F2alpha and sumatriptan, an effectiv...

journal_title：European journal of pharmacology

authors： Ayajiki K,Fujioka H,Noda K,Okamura T,Toda N

更新日期：2001-05-18 00:00:00

abstract：:Subcutaneous (s.c.) administration of compound 48/80 (3.0 mg/kg) to conscious rats produced a time-dependent long-lasting increase of plasma renin activity (PRA). A dose-related increase of the hematocrit was also observed after injection of compound 48/80. The onset of the hematocrit increase preceded that of PRA inc...

journal_title：European journal of pharmacology

authors： Izumi H,Ho S,Michelakis AM,Aoki T

更新日期：1985-02-26 00:00:00

abstract：:We have eliminated putative palmitoylation sites in the carboxyl tail of the human dopamine D1 receptor by replacing the two cysteine residues with alanines either separately or together. The wild type and the three mutated dopamine D1 receptors were stably expressed in baby hamster kidney cells and characterized to d...

journal_title：European journal of pharmacology

authors： Jin H,Zastawny R,George SR,O'Dowd BF

更新日期：1997-04-11 00:00:00

abstract：:Acute benzodiazepine administration has been reported to antagonize the effect of cholecystokinin both in the periphery and in the central nervous system. A two-week treatment with either diazepam (5 mg/kg per day) or flurazepam (15 mg/kg per day) markedly reduced the excitatory effect of microiontophoretically applie...

journal_title：European journal of pharmacology

authors： Bouthillier A,De Montigny C

更新日期：1988-06-22 00:00:00

abstract：:Salvianolate is a compound from traditional Chinese medicine widely used in the treatment of various cardiovascular diseases. This study explored the effects of salvianolate on myocardial infarction and used tandem mass tags (TMT) to discover differentially expressed proteins. Male Sprague Dawley rats were randomly di...

journal_title：European journal of pharmacology

authors： Chen C,Zhu P,Yu H,Huang B,Gui M,Lin X,Bai Y

更新日期：2020-12-15 00:00:00

abstract：:We have examined the effects of intrathecally (i.t.) administered CP-96,345, a non-peptide NK1 receptor ligand, on the spinal nociceptive flexor reflex and on the facilitation of this reflex evoked by i.t. substance P (SP), neurokinin A (NKA) and electrical conditioning stimulation of cutaneous C-afferents. CP-96,345 ...

journal_title：European journal of pharmacology

authors： Xu XJ,Dalsgaard CJ,Wiesenfeld-Hallin Z

更新日期：1992-06-17 00:00:00

abstract：:Bupropion is a weakly potent central nervous system (CNS) stimulant that is marketed both as an antidepressant and as an anti-smoking aid. The mechanism(s) by which it produces its effects is not well understood. In the present study, the effect of bupropion was examined in rats trained to discriminate the stimulus ef...

journal_title：European journal of pharmacology

authors： Young R,Glennon RA

更新日期：2002-05-17 00:00:00

abstract：:The bisquaternary compound dequalinium has been tested for its ability to inhibit the loss of K+ which angiotensin II causes in guinea-pig hepatocytes and which occurs through apamin-sensitive Ca(2+)-activated K+ (SKCa) channels. Dequalinium blocked angiotensin II-evoked K+ loss with an IC50 of 1.5 +/- 0.1 microM and ...

journal_title：European journal of pharmacology

authors： Castle NA,Haylett DG,Morgan JM,Jenkinson DH

更新日期：1993-05-19 00:00:00

abstract：:The development of anticonvulsant tolerance with RO 16-6028, a benzodiazepine receptor partial agonist, was assessed in mice using an i.v. infusion of pentylenetetrazol as the convulsive stimulus. In contrast to other benzodiazepines tested previously in this seizure model the anticonvulsant protection afforded by RO ...

journal_title：European journal of pharmacology

authors： Haigh JR,Feely M

更新日期：1988-03-01 00:00:00

abstract：:Endothelin-1 (ET-1) is reported to be the most powerful constrictor of blood vessels known. Atrial natriuretic factor is a potent relaxor of contracted vessels. This study examined the potential interaction between these vasoactive peptides on rabbit aortic rings. ET-1 contracted the rings in a dose-dependent manner w...

journal_title：European journal of pharmacology

authors： Opgenorth TJ,Novosad EI

更新日期：1990-12-04 00:00:00

abstract：:Nitric oxide can exert either protective or damaging effects on the gastric mucosa. To further explore the role of nitric oxide in the modulation of gastric mucosal defense, the effects of intra-arterial administration of the precursor, L-arginine, on susceptibility of the gastric mucosa to damage induced by topically...

journal_title：European journal of pharmacology

authors： Ferraz JG,Tigley A,Wallace JL

更新日期：1994-07-21 00:00:00

abstract：:It has been previously demonstrated that selegiline, an irreversible monoamine oxidase B (MAO-B) inhibitor, potentiates glial reaction to injury and possesses some 'trophic-like' activities which do not depend on the inhibition of MAO-B and which are probably associated with the induction of astrocyte-derived neurotro...

journal_title：European journal of pharmacology

authors： Semkova I,Wolz P,Schilling M,Krieglstein J

更新日期：1996-11-07 00:00:00

abstract：:Early philosophers and psychologists defined and began to describe attention. Beginning in the 1950's, numerous models of attention were developed. This corresponded with an increased understanding of pharmacological approaches to manipulate neurotransmitter systems. The present review focuses on the knowledge that ha...

journal_title：European journal of pharmacology

authors： Burk JA,Blumenthal SA,Maness EB

更新日期：2018-09-15 00:00:00

abstract：:Binding sites for the sigma ligand [3H]di-o-tollylguanidine ([3H]DTG) have been reported to be altered in the brains of genetically dystonic rats. In the present study, selective sigma 1 and sigma 2 assay conditions were utilized in an effort to define which subpopulation of [3H]DTG binding sites is altered in the dys...

journal_title：European journal of pharmacology

authors： Weissman AD,McCann DJ,Lorden JF,Su TP

更新日期：1993-12-07 00:00:00

abstract：:The zebrafish (Danio rerio) has recently become a powerful animal model for cardiovascular research and drug discovery due to its ease of maintenance, genetic manipulability and ability for high-throughput screening. Recent advances in imaging techniques and generation of transgenic zebrafish have greatly facilitated ...

journal_title：European journal of pharmacology

authors： Seto SW,Kiat H,Lee SM,Bensoussan A,Sun YT,Hoi MP,Chang D

更新日期：2015-12-05 00:00:00

abstract：:Acetylcholine caused no relaxation of a rubbed strip from rabbit aorta (RASR) which was precontracted with phenylephrine. When the same strip was taken into epithelium-intact guinea-pig trachea, acetylcholine produced a slow-developing relaxation which was antagonized by atropine but not by propranolol, indomethacin, ...

journal_title：European journal of pharmacology

authors： Ilhan M,Sahin I

更新日期：1986-11-19 00:00:00

abstract：:In the Brattleboro rat with diabetes insipidus vasopressin V2 receptor mRNA and the mRNA of various adenylyl cyclase (AC) isoforms are moderately reduced compared with those of normal rats. In the present study renal vasopressin V2 receptor mRNA was modestly higher (by 34%), as was expression of AC 5, 6 and 9 mRNAs (u...

journal_title：European journal of pharmacology

authors： Shen T,Laycock J,Suzuki Y,Defer N,Hanoune J

更新日期：1998-01-02 00:00:00

abstract：:We studied the effects of interleukin (IL)-1β on DNA synthesis and cell proliferation in primary cultures of adult rat hepatocytes in order to elucidate the mechanisms of its action. Hepatocyte parenchymal cells maintained in a serum-free, defined medium synthesized DNA and proliferated in the presence of IL-1β (3-30 ...

journal_title：European journal of pharmacology

authors： Kimura M,Moteki H,Ogihara M

更新日期：2014-12-15 00:00:00

abstract：:The effect of three selective bradykinin B(2) receptor antagonists, MEN11270 (H-DArg-Arg-Pro-Hyp-Gly-Thi-c(Dab-DTic-Oic-Arg)c(7gamma-1 0alpha)), Icatibant (H-DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg-OH), and FR173567 ((E)-3-(6-acetamido-3-pyridyl)-N-[N-[2, 4-dichloro-3-[(2-methyl-8-quinolinyl) oxymethyl] phenyl]-N-me...

journal_title：European journal of pharmacology

authors： Meini S,Patacchini R,Giuliani S,Lazzeri M,Turini D,Maggi CA,Lecci A

更新日期：2000-01-28 00:00:00

abstract：:Berend Olivier has had a long-standing interest in the utility of animal models for a wide variety of therapeutic indications. His work has spanned multiple types of models, blending ethological, or species typical and naturalistic behaviors, along with methodologies based on learned behavior. He has consistently done...

journal_title：European journal of pharmacology

authors： Barrett JE

更新日期：2015-04-15 00:00:00

abstract：:We investigated whether estrogen protects the ischemic myocardium in oophorectomized female rabbits fed with a cholesterol-enriched diet, whether the addition of a progestin compound attenuates the beneficial effect of estrogen and whether raloxifene also limits myocardial necrosis. We treated 32 female oophorectomize...

journal_title：European journal of pharmacology

authors： Sbarouni E,Iliodromitis EK,Bofilis E,Kyriakides ZS,Kremastinos DT

更新日期：2003-04-25 00:00:00

abstract：:Depression is a serious mental disorder that is becoming more common. To better treat patients suffering from this illness, elucidation of the underlying psychopathological and neurobiological mechanisms of depression is needed. Based on the evidence, we sought to investigate the effects of hesperidin in a model of de...

journal_title：European journal of pharmacology

authors： Antunes MS,Jesse CR,Ruff JR,de Oliveira Espinosa D,Gomes NS,Altvater EET,Donato F,Giacomeli R,Boeira SP

更新日期：2016-10-15 00:00:00

abstract：:In urethane-chloralose anesthetised rats the muscle relaxant activity of flupirtine was investigated on the monosynaptic Hoffmann reflex recorded from plantar foot muscles and on the polysynaptic flexor reflex recorded from tibialis muscle. Intraperitoneal (i.p.; 2.5-25 mumol/kg) and intrathecal (i.t.; 33-330 nmol) ad...

journal_title：European journal of pharmacology

authors： Schwarz M,Schmitt T,Pergande G,Block F

更新日期：1995-04-04 00:00:00

abstract：:The pharmacological nature of nicotine-induced contraction in the rat basilar artery is poorly understood. The purpose of this study was to investigate the endothelium dependency and involvement of arachidonic acid metabolites in nicotine-induced contraction in the rat basilar artery. The rat basilar artery was remove...

journal_title：European journal of pharmacology

authors： Ji X,Nishihashi T,Trandafir CC,Wang A,Shimizu Y,Kurahashi K

更新日期：2007-12-22 00:00:00

abstract：:In male Swiss mice, muscimol produced myoclonic jerks. A 3 mg/kg (i.p.) dose induced this response in all of the mice tested and the peak response of 73 jerks per min was observed between 27 and 45 min. Increasing the brain serotonin levels by the administration of 5-hydroxytryptophan (80-160 mg/kg) in combination wit...

journal_title：European journal of pharmacology

authors： Menon MK,Vivonia CA

更新日期：1981-07-17 00:00:00

abstract：:D-amino acid oxidase (DAAO) is an astroglial enzyme abundantly present in the pain sensing regions including brain and spinal cord. There have been studies indicating an upregulation and increased activity of DAAO in different pain models. Furthermore, the upregulation of DAAO also results in the development of morphi...

journal_title：European journal of pharmacology

authors： Sharma J,Kulshrestha R,Singh N,Jaggi AS

更新日期：2019-07-15 00:00:00

abstract：:Lipopolysaccharide (LPS) administration in rats induces a characteristic syndrome termed 'sickness behavior', including profound changes on locomotor activity and circulating stress and inflammatory mediators. The aim of the present investigation was to evaluate whether the behavioral and the peripheral biomarker resp...

journal_title：European journal of pharmacology

authors： Bison S,Razzoli M,Arban R,Michielin F,Bertani S,Carboni L

更新日期：2011-07-01 00:00:00