Long-term benzodiazepine treatment reduces neuronal responsiveness to cholecystokinin: an electrophysiological study in the rat.

abstract：:Acute administration of fluoxetine (1, 10 and 20 mg/kg i.p.) increased extracellular levels of serotonin (5-hydroxytryptamine, 5-HT) in the frontal cortex, ventral hippocampus and raphe nuclei as measured by in vivo microdialysis in anaesthetized rats. In the frontal cortex, fluoxetine showed a marked dose-response ef...

journal_title：European journal of pharmacology

authors： Malagié I,Trillat AC,Jacquot C,Gardier AM

更新日期：1995-11-14 00:00:00

abstract：:The K562 cell line has been proposed as a useful experimental system to identify anti-tumor compounds acting by inducing terminal erythroid differentiation. K562 cells exhibit a low proportion of hemoglobin-synthesizing cells under standard cell growth conditions, but are able to undergo terminal erythroid differentia...

journal_title：European journal of pharmacology

authors： Brognara E,Lampronti I,Breveglieri G,Accetta A,Corradini R,Manicardi A,Borgatti M,Canella A,Multineddu C,Marchelli R,Gambari R

更新日期：2011-12-15 00:00:00

abstract：:Normal human blood platelets in plasma were incubated at 2 degrees C with tritiated 5-hydroxytryptamine ([3H]5HT), and the specific receptor binding was displaced by the addition of unlabelled 5HT. The kinetic parameters of this binding were established and a two-site model for the platelet 5HT receptor demonstrated. ...

journal_title：European journal of pharmacology

authors： Peters JR,Grahame-Smith DG

更新日期：1980-12-05 00:00:00

abstract：:Recent evidence suggests that polydatin (PD), a resveratrol glucoside, may have beneficial actions on the cardiac hypertrophy. Therefore, the current study focused on the underlying mechanism of the PD anti-hypertrophic effect in cultured cardiomyocytes and in progression from cardiac hypertrophy to heart failure in v...

journal_title：European journal of pharmacology

authors： Dong M,Ding W,Liao Y,Liu Y,Yan D,Zhang Y,Wang R,Zheng N,Liu S,Liu J

更新日期：2015-01-05 00:00:00

abstract：:Local anaesthetics block action potentials in the membranes of excitable cells but their effects on non-excitable cells are less well known. Some local anaesthetics are applied directly onto the skin, and for this reason the effect of procaine (p-aminobenzoic acid diethylamino-etyl ester hydrochloride) and tetracaine ...

journal_title：European journal of pharmacology

authors： Pierzchalska M,Michalik M,Stepień E,Korohoda W

更新日期：1998-10-09 00:00:00

abstract：:Experiments were conducted to explore the effects of Neuropeptide FF acting at spinal and supraspinal sites in models of chronic inflammatory or neuropathic pain and of acute pain. Neuropeptide FF was administered intrathecally (i.t.; 10.0, 25.0 and 50.0 nmol) or intracerebroventricularly (i.c.v.; 10.0, 12.5 and 15.0 ...

journal_title：European journal of pharmacology

authors： Altier N,Dray A,Ménard D,Henry JL

更新日期：2000-11-03 00:00:00

abstract：:To examine whether low concentrations of endothelin-1 potentiate the vasoconstrictor response to adrenergic stimulation, we recorded the isometric response of rings of rabbit pulmonary artery to electrical stimulation and noradrenaline. Endothelin-1 (10(-10) M) potentiated the contractions induced by electrical stimul...

journal_title：European journal of pharmacology

authors： Vila JM,Medina P,Segarra G,Aldasoro M,Noguera I,Lluch S

更新日期：2001-02-16 00:00:00

abstract：:The effects of brief actinomycin D treatment (0.1 microgram/ml, 0.5 h) on inhibition of cell growth and colony formation were studied in synchronized HeLa cells. Cells in late S and G2 phases were found to be maximally sensitive to inhibition of cell growth and colony formation after short exposure to actinomycin D. C...

journal_title：European journal of pharmacology

authors： Wu MH,Yung BY

更新日期：1994-04-04 00:00:00

abstract：:Recent studies show that 8-iso-prostaglandin F(2alpha), a member of F(2)-isoprostane family, acts as a vasoconstrictor via TP receptor activation; and its local release may contribute to an abnormal vasomotor tone associated with hypercholesterolemia. The purpose of this study was to examine whether ramatroban, a TP r...

journal_title：European journal of pharmacology

authors： Ishizuka T,Matsui T,Kurita A

更新日期：2003-05-02 00:00:00

abstract：:In isolated, perfused rabbit ear artery bradykinin, like [Met5]enkephalin and angiotensin II, inhibited neurogenic constrictions in concentrations lower than 10(-8) M without affecting the responses to exogenous norepinephrine. The IC50 value of bradykinin was 1.95 x 10(-10) M. The inhibitory action of bradykinin and ...

journal_title：European journal of pharmacology

authors： Rónai AZ

更新日期：1991-05-30 00:00:00

abstract：:The effects of protein kinase C (PKC) activators on gamma-aminoburyric acid (GABA) rho 1 receptor function were studied in rho 1 -expressing Xenopus oocytes. The PKC activator phorbol 12-myristate 13-acetate (PMA) but not the inactive analog phorbol 12-mono-myristate inhibited the GABA-gated chloride currents. Mezerei...

journal_title：European journal of pharmacology

authors： Kusama T,Sakurai M,Kizawa Y,Uhl GR,Murakami H

更新日期：1995-11-30 00:00:00

abstract：:We report the cloning, molecular characterization, and pharmacological characterization of the canine 5-HT2A and 5-HT2B receptors. The canine and human 5-HT2A receptors share 93% amino acid homology. The canine and human 5-HT2B receptors are also highly conserved (87% homology) with the exception of the carboxyl termi...

journal_title：European journal of pharmacology

authors： Bonaventure P,Nepomuceno D,Miller K,Chen J,Kuei C,Kamme F,Tran DT,Lovenberg TW,Liu C

更新日期：2005-04-25 00:00:00

abstract：:Patients with spinal cord injury (SCI) undergo severe loss of bone mineral below the level of lesion, and data on available treatment options after SCI is scarce. The aim of this work was to investigate the therapeutic effect of cannabidiol (CBD), a non-psychoactive cannabis, on sublesional bone loss in a rat model of...

journal_title：European journal of pharmacology

authors： Li D,Lin Z,Meng Q,Wang K,Wu J,Yan H

更新日期：2017-08-15 00:00:00

abstract：:Autophagy is a lysosomal degradation pathway, which is essential for cell survival, proliferation, differentiation and homeostasis. It is well known that beta-amyloid (Aβ) aggregation is one of key characteristics for Alzheimer's disease (AD), which triggers a complex pathological cascade, leading to neurodegeneration...

journal_title：European journal of pharmacology

authors： Wang C,Zhang X,Teng Z,Zhang T,Li Y

更新日期：2014-10-05 00:00:00

abstract：:Using isolated rabbit gastric glands, the H2-receptor antagonist MK-208 was investigated with respect to its effects on [14C]aminopyrine uptake as an index of gastric acid secretion. In addition to shifting the histamine concentration-response curve to the right in a parallel fashion, the antagonism produced by MK-208...

journal_title：European journal of pharmacology

authors： Shepherd-Rose AJ,Pendleton RG

更新日期：1984-11-13 00:00:00

abstract：:UP 269-6, 5-methyl-7-propyl-8(-)[2'-(1H-tetrazol-5-yl)biphenyl-4- yl)methyl]-1,2,4-triazolo]1,5-c]pyrimidin-2(3H)-one is a novel nonpeptide angiotensin II receptor antagonist. In vivo studies were performed to evaluate UP 269-6 for its angiotensin II antagonistic action. In pithed rats, i.v. administration of UP 269-6...

journal_title：European journal of pharmacology

authors： Cazes M,Provost D,Versigny A,Cloarec A

更新日期：1995-09-15 00:00:00

abstract：:Portulaca oleracea L. is used as a folk medicine in many countries because of its wide range of pharmacological effects. HM-chromanone, isolated from P. oleracea using bioassay-guided fractionation and HPLC, belongs to the homoisoflavonoid group and has been shown to exert several biological effects. In this study, we...

journal_title：European journal of pharmacology

authors： Je JY,Park JE,Seo Y,Han JS

更新日期：2021-02-05 00:00:00

abstract：:The spontaneous and electrically evoked activity was examined in guinea-pig, ferret and marmoset urinary bladder. Electrical field stimulation of detrusor strips in vitro induced a rapid, frequency-dependent contraction with a maximum response at 40 Hz. This contraction was partly decreased by either atropine (0.29 mi...

journal_title：European journal of pharmacology

authors： Moss HE,Burnstock G

更新日期：1985-08-27 00:00:00

abstract：:Three important features must be considered when proposing therapeutic strategies in liver cirrhosis: inflammation, oxidative stress and fibrogenesis. Pirfenidone is a synthetic molecule which oxidative action has not been tested in cirrhosis. Cirrhosis was induced in rats by ligation of the common bile duct or carbon...

journal_title：European journal of pharmacology

authors： Salazar-Montes A,Ruiz-Corro L,López-Reyes A,Castrejón-Gómez E,Armendáriz-Borunda J

更新日期：2008-10-24 00:00:00

abstract：:We examined the influence of streptozotocin-induced diabetes on the growth of cultured rat aortic smooth muscle cells in the presence of interleukin-1 beta. Interleukin-1 beta induced a dose-dependent biphasic effect on proliferation of diabetic and control smooth muscle cells, consistent with the data on [3H]thymidin...

journal_title：European journal of pharmacology

authors： Etienne P,Parés-Herbuté N,Monnier L

更新日期：1996-09-05 00:00:00

abstract：:The bronchial smooth muscle of the rat was examined for contractile responses to excitatory amino acids. The nerve-mediated contraction induced by electrical field stimulation was enhanced by exogenous L-glutamate (L-Glu). The apparent affinity (ED50) of L-Glu was 3.5 +/- 0.1 mM. Both tetrodotoxin and hemicholinium-3 ...

journal_title：European journal of pharmacology

authors： Aas P,Tansø R,Fonnum F

更新日期：1989-05-02 00:00:00

abstract：:Cysteamine (420 mg/kg s.c.) increased gastric acid secretion in rats 3-6 h post-injection; duodenal pH fell from 6.0 +/- 0.2 (S.E.M.) at 0 time to 2.2 +/- 0.3 at 12 h. A high (60-80%) incidence of duodenal ulcerations was observed 18 h after cysteamine injection. Intracisternal (i.c.) administration of bombesin (1 mic...

journal_title：European journal of pharmacology

authors： Hernandez DE,Adcock JW,Nemeroff CB,Prange AJ Jr

更新日期：1982-10-22 00:00:00

abstract：:Intraperitoneal administration of (--)-sulpiride (12 to 50 mg/kg) produced a dose-related decrease in cGMP content in cerebellar cortex, while the (+)-sulpiride (10 microgram), but not after intracerebellar injection. These findings support the contention that (--)-sulpiride modifies cerebellar cGMP levels through and...

journal_title：European journal of pharmacology

authors： Corda MG,Casu M,Biggio G

更新日期：1979-05-01 00:00:00

abstract：:The effects of drugs that inhibit human ether-a-go-go-related gene (HERG) related cardiac potassium channels on the variability of QT duration as a sign of repolarisation instability were evaluated in conscious telemetered dogs. QT duration variability was determined using a beat-to-beat analysis before and after the ...

journal_title：European journal of pharmacology

authors： Schneider J,Hauser R,Andreas JO,Linz K,Jahnel U

更新日期：2005-04-04 00:00:00

abstract：:GABAA and GABAB receptor agonists and antagonists were administered locally in the striatum of intact and kainic acid lesioned rats. (+/-)-Baclofen, a GABAB receptor agonist, significantly decreased the level of extracellular dopamine in the striatum of intact rats. (+/-)-Phaclofen, a GABAB receptor antagonist, increa...

journal_title：European journal of pharmacology

authors： Smolders I,De Klippel N,Sarre S,Ebinger G,Michotte Y

更新日期：1995-09-15 00:00:00

abstract：:This study was designed to investigate the effect and mechanism of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction in rats. Fifty male Wistar rats were randomly divided into five groups: the normal control rats (NC), the high-methionine-diet rats (Met), the high-methionine-diet ra...

journal_title：European journal of pharmacology

authors： Liu DS,Gao W,Liang ES,Wang SL,Lin WW,Zhang WD,Jia Q,Guo RC,Zhang JD

更新日期：2013-08-15 00:00:00

abstract：:Hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor stabilizes hypoxia inducible factor alpha, which increases erythropoietin (EPO) expression via the hypoxia response element. Therefore, PHDs inhibitors have been developed as novel therapeutic agents for anemia. Here, we characterize the in vitro and in viv...

journal_title：European journal of pharmacology

authors： Kato S,Takayama N,Takano H,Koretsune H,Koizumi C,Kunioka EI,Uchida S,Takahashi T,Yamamoto K

更新日期：2018-11-05 00:00:00

abstract：:Tobramycin inhalation therapy is an effective therapy for cystic fibrosis as well as severe bronchiectasis that is colonized with Pseudomonas aeruginosa. The mechanism responsible for the efficacy of tobramycin in the treatment of severe chronic infectious diseases has not been elucidated. We demonstrate that high-dos...

journal_title：European journal of pharmacology

authors： Nakamura S,Yanagihara K,Araki N,Yamada K,Morinaga Y,Izumikawa K,Seki M,Kakeya H,Yamamoto Y,Kamihira S,Kohno S

更新日期：2011-05-20 00:00:00

abstract：:The effects of acute or repeated treatment of male albino BKW mice with caerulein, a cholecystokinin octapeptide (CCK-8) agonist, and with devazepide (MK-329) and L-365,260, antagonists at CCKA ('peripheral') and CCKB ('central') receptors respectively, on motor activity and [propionyl-3H]propionylated-CCK-8 ([3H]pCCK...

journal_title：European journal of pharmacology

authors： Vasar E,Stephenson JD,Meldrum BS

更新日期：1991-09-24 00:00:00

abstract：:Malfunction of the serotonergic system and dysregulation of the hypothalamo-pituitary-adrenocortical axis have been implicated in the pathophysiology of depression. Several studies provide evidence for reciprocal influences between glucocorticoids and 5-HT receptors. The effect of repeated treatment with a high dose o...

journal_title：European journal of pharmacology

authors： Berendsen HH,Kester RC,Peeters BW,Broekkamp CL

更新日期：1996-07-18 00:00:00