A comparative study of electrical field stimulation of the guinea-pig, ferret and marmoset urinary bladder.

abstract：:Cordycepin, (3'-deoxyadenosine), a bioactive compound of Cordyceps militaris, has been shown to exhibit many pharmacological actions, such as anti-inflammatory, antioxidative and anticancer activities. Little is known about the neuroprotective action of cordycepin as well as its molecular mechanisms. In this study, co...

journal_title：European journal of pharmacology

authors： Cheng Z,He W,Zhou X,Lv Q,Xu X,Yang S,Zhao C,Guo L

更新日期：2011-08-16 00:00:00

abstract：:Mutations of p53 in cancer cells not only subvert its antiproliferative properties but can also promote various oncogenic responses through a gain-of-function activity. Pharmacological manipulation of the mutant p53 pathway by specific compounds could be an effective strategy for cancer therapy. We show here that gain...

journal_title：European journal of pharmacology

authors： Zhang G,Li L,Bi J,Wu Y,Li E

更新日期：2020-11-15 00:00:00

abstract：:The effect of genistein, a tyrosine kinase inhibitor, on nitroglycerin-induced relaxation was examined in rat aortic rings contracted by phenylephrine. In rat aortic rings, genistein (10(-5) M and 3x10(-5) M), a tyrosine kinase inhibitor, but not daidzein, an analogue of genistein, increased relaxation induced by nitr...

journal_title：European journal of pharmacology

authors： Satake N,Imanishi M,Shibata S

更新日期：1999-07-21 00:00:00

abstract：:Histamine-induced [3H]inositol monophosphate ([3H]IP1) accumulation in slices of rat cerebral cortex and guinea-pig cerebral cortex and cerebellum was inhibited in a concentration-dependent manner by Ni2+ ions. The effect of Ni2+ on the concentration-response curve for histamine in rat cerebral cortex was consistent w...

journal_title：European journal of pharmacology

authors： Arias-Montaño JA,Young JM

更新日期：1993-05-15 00:00:00

abstract：:Intravenous administration of 0.3 mg/kg of quinpirole to conscious rabbits that had been pretreated with domperidone caused a marked increase in blood pressure and renal sympathetic nerve activity with a peak at 5-10 min after injection (25% and 3-fold increase, respectively). Spectral analysis of the blood pressure-r...

journal_title：European journal of pharmacology

authors： van den Buuse M,Head GA

更新日期：2000-01-24 00:00:00

abstract：:Carbamazepine, a drug effective in pain, seizure, and affective disorders, was screened for its ability to interact with a variety of neurotransmitter and neuromodulator binding sites on brain membranes. The most potent effect was observed on adenosine antagonist ( [3H]DPX) binding to the adenosine receptor (KI = 3.5 ...

journal_title：European journal of pharmacology

authors： Marangos PJ,Post RM,Patel J,Zander K,Parma A,Weiss S

更新日期：1983-09-30 00:00:00

abstract：:Recently, stable gastric pentadecapeptide BPC 157 reversed the high MDA- and NO-tissue values to the healthy levels. Thereby, BPC 157 therapy cured rats with bile duct ligation (BDL) (sacrifice at 2, 4, 6, 8 week). BPC 157-medication (10 μg/kg, 10 ng/kg) was continuously in drinking water (0.16 μg/ml, 0.16 ng/ml, 12 m...

journal_title：European journal of pharmacology

authors： Sever AZ,Sever M,Vidovic T,Lojo N,Kolenc D,Vuletic LB,Drmic D,Kokot A,Zoricic I,Coric M,Vlainic J,Poljak L,Seiwerth S,Sikiric P

更新日期：2019-03-15 00:00:00

abstract：:Osthole is a coumarin extracted from Cnidium monnieri (L.) Cusson. The medicinal plant is widely used in Vietnamese as well as Chinese traditional medicine as a vasodilating and antihypertensive agent. Here we have tested the proposition that the block of Ca(v)1.2 channels is mainly responsible for its vascular activi...

journal_title：European journal of pharmacology

authors： Fusi F,Sgaragli G,Ha le M,Cuong NM,Saponara S

更新日期：2012-04-05 00:00:00

abstract：:We investigated the involvement of dopamine D1 and D2 receptor subtypes in the effects of GBR 12909, a selective dopamine uptake inhibitor, on latent learning in the performance of a water-finding task and on locomotor activity in mice. GBR 12909 (10 and 20 mg/kg) impaired latent learning, and this effect was countera...

journal_title：European journal of pharmacology

authors： Ichihara K,Nabeshima T,Kameyama T

更新日期：1993-04-06 00:00:00

abstract：:The effects of morphine (0.1 mg/kg) and 5-HTP (2 mg/kg) on colonic motility were investigated in dogs fasted for 15-22 h and fitted with two strain gauge transducers on the transverse colon at 8 and 12 cm from the ileo-colonic junction. The effects were compared to those obtained after previous intravenous (i.v.) (0.2...

journal_title：European journal of pharmacology

authors： Bueno L,Fioramonti J

更新日期：1982-08-27 00:00:00

abstract：:In the Brattleboro rat with diabetes insipidus vasopressin V2 receptor mRNA and the mRNA of various adenylyl cyclase (AC) isoforms are moderately reduced compared with those of normal rats. In the present study renal vasopressin V2 receptor mRNA was modestly higher (by 34%), as was expression of AC 5, 6 and 9 mRNAs (u...

journal_title：European journal of pharmacology

authors： Shen T,Laycock J,Suzuki Y,Defer N,Hanoune J

更新日期：1998-01-02 00:00:00

abstract：:Carbocyclic thromboxane A2 (CTA2) constricted rabbit basilar and saphenous arteries. The contractions of the basilar artery, but not those of the saphenous artery, were potently inhibited by the calcium antagonist nimodipine. Selective inhibition of thromboxane-induced vasoconstriction of cerebral vessels may contribu...

journal_title：European journal of pharmacology

authors： Towart R,Perzborn E

更新日期：1981-01-16 00:00:00

abstract：:Hops (Humulus lupulus L.), a major component of beer, contain potentially neuroactive compounds that made it useful in traditional medicine as a sleeping aid. The present study aims to investigate the individual components in hops acting as allosteric modulators in GABAA receptors and bring further insight into the mo...

journal_title：European journal of pharmacology

authors： Benkherouf AY,Logrén N,Somborac T,Kortesniemi M,Soini SL,Yang B,Salo-Ahen OMH,Laaksonen O,Uusi-Oukari M

更新日期：2020-04-15 00:00:00

abstract：:Toll-like receptors (TLRs) play an important role in the recognition of microbial pathogens and induce innate immune responses. The recognition of microbial components by TLRs triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interfero...

journal_title：European journal of pharmacology

authors： Gu GJ,Eom SH,Suh CW,Koh KO,Kim DY,Youn HS

更新日期：2013-12-05 00:00:00

abstract：:The effects of intraperitoneal injections of two opioid antagonists on plasma corticosterone levels in stressed mice was investigated. The effects of the mu-opioid receptor antagonist naloxone was dependent on the dose used. Low doses (0.5 and 1 mg/kg) potentiated the elevation of plasma corticosterone observed in sal...

journal_title：European journal of pharmacology

authors： Kitchen I,Rowan KM

更新日期：1984-05-18 00:00:00

abstract：:Adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, adenine and inosine were injected intradermally into the backs of human volunteers. ATP, ADP and AMP evoked weal and flare responses in the skin in a dose dependent manner. The rank order of potency was ATP greater tha...

journal_title：European journal of pharmacology

authors： Coutts AA,Jorizzo JL,Eady RA,Greaves MW,Burnstock G

更新日期：1981-12-17 00:00:00

abstract：:The role beta-adrenoceptors in the control of venous tone is not clear. This study examines the dose-response effects of isoprenaline, a non-selective beta-adrenoceptor agonist, on mean circulatory filling pressure (MCFP), an index of body venous tone, in conscious and unrestrained rats. Dose-response curves of isopre...

journal_title：European journal of pharmacology

authors： Abdelrahman A,Pang CC

更新日期：1990-11-13 00:00:00

abstract：:Previous results indicated that the rabbit could represent a suitable model for investigations on the functional role of alpha 2-adrenoceptors in fat cells, but the characterization of these receptors was not resolved yet. In the present report, imidazoline compounds were used to attempt a better definition of rabbit ...

journal_title：European journal of pharmacology

authors： Langin D,Paris H,Dauzats M,Lafontan M

更新日期：1990-04-25 00:00:00

abstract：:It has been suggested that morphine-6-glucuronide, a major metabolite of the opioid analgesic morphine, is more potent as an analgesic than the parent drug. This finding appears not to be due to differences in affinity for opioid receptors. Therefore, in the present study the opioid receptor mediated effects of morphi...

journal_title：European journal of pharmacology

authors： Schmidt N,Brune K,Geisslinger G

更新日期：1994-04-01 00:00:00

abstract：:An unbiased conditioned place preference paradigm was used to evaluate the effect of dextro-morphine on the morphine-produced reward in male CD rats. Morphine sulfate (1-10 mg/kg) given intraperitoneally dose-dependently produced the conditioned place preference. Pretreatment with dextro-morphine at a dose from 0.1 to...

journal_title：European journal of pharmacology

authors： Wu HE,Schwasinger ET,Terashvili M,Tseng LF

更新日期：2007-05-21 00:00:00

abstract：:The effect of carbachol (10(-3)M) on the membrane potential of rat diaphragm muscle fibres near and remote from the endplate has been investigated by means of a microelectrode technique. In the endplate region a rather slow depolarization was observed followed by spontaneous repolarization. Outside the endplate region...

journal_title：European journal of pharmacology

authors： Mooij JJ,Evers CD,Ras R

更新日期：1976-06-01 00:00:00

abstract：:20(S)-Protopanaxadiol (PPD), a metabolite of ginsenosides, has been demonstrated to possess cytotoxic effects on several cancer cell lines. The molecular mechanism is, however, not well understood. In this study, we have shown that PPD inhibits cell growth and induces apoptosis in human hepatocarcinoma HepG2 cells. PP...

journal_title：European journal of pharmacology

authors： Zhu GY,Li YW,Tse AK,Hau DK,Leung CH,Yu ZL,Fong WF

更新日期：2011-10-01 00:00:00

abstract：:Intracellular recordings were made from myenteric neurons of the guinea-pig duodenum and the responses to local ejection of several substance P (SP) analogs were examined. It was found that senktide (succinyl-[Asp6,Me-Phe8]SP-(6-11)), a selective analog for the NK-3 (SP-N) receptor, was particularly effective in depol...

journal_title：European journal of pharmacology

authors： Hanani M,Chorev M,Gilon C,Selinger Z

更新日期：1988-08-24 00:00:00

abstract：:This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：European journal of pharmacology

authors： He Z,Chen C,Huang L,Liu S,Guo L

更新日期：2008-12-03 00:00:00

abstract：:This study was designed to determine how the contractility of rat detrusor smooth muscle strips changes in the presence of low concentrations of hydrogen peroxide (H(2)O(2)). The strips were dissected from the base of Sprague-Dawley rat bladders and their contractile responses to a cumulative increase in H(2)O(2) conc...

journal_title：European journal of pharmacology

authors： Han JH,Lee MY,Lee SY,Chang IH,Kim HJ,Kim W,Myung SC

更新日期：2010-07-25 00:00:00

abstract：:Plants are a natural source of bioactive compounds such as secondary metabolites. These molecules, also called phytochemicals, are fundamental for plant survival and often show therapeutic properties used for the treatment of human diseases. Asperuloside is a secondary metabolite which belongs to iridoid glycosides an...

journal_title：European journal of pharmacology

authors： Manzione MG,Martorell M,Sharopov F,Bhat NG,Kumar NVA,Fokou PVT,Pezzani R

更新日期：2020-09-15 00:00:00

abstract：:Saturable, high-affinity binding sites for [3H]saxitoxin were identified in equine portal vein smooth muscle membranes. These sites had a dissociation constant of 0.29 nM and a maximal binding capacity of 115 fmol.mg-1 of protein. A similar dissociation constant was obtained with cells prepared from rat portal vein. S...

journal_title：European journal of pharmacology

authors： Mironneau J,Martin C,Arnaudeau S,Jmari K,Rakotoarisoa L,Sayet I,Mironneau C

更新日期：1990-08-10 00:00:00

abstract：:The bisquaternary compound dequalinium has been tested for its ability to inhibit the loss of K+ which angiotensin II causes in guinea-pig hepatocytes and which occurs through apamin-sensitive Ca(2+)-activated K+ (SKCa) channels. Dequalinium blocked angiotensin II-evoked K+ loss with an IC50 of 1.5 +/- 0.1 microM and ...

journal_title：European journal of pharmacology

authors： Castle NA,Haylett DG,Morgan JM,Jenkinson DH

更新日期：1993-05-19 00:00:00

abstract：:We investigated the effects of ginsenosides, the active ingredient of ginseng, on neuronal or muscle-type nicotinic acetylcholine receptor channel activity expressed in Xenopus oocytes after injection of cRNA encoding bovine neuronal alpha3beta4, alpha7 or human muscle alphabetadeltavarepsilon subunits. Treatment with...

journal_title：European journal of pharmacology

authors： Choi S,Jung SY,Lee JH,Sala F,Criado M,Mulet J,Valor LM,Sala S,Engel AG,Nah SY

更新日期：2002-05-03 00:00:00

abstract：:Serotonergic and dopaminergic involvement in hyperthermia induced by a serotonin (5-hydroxytryptamine, 5-HT)-releasing drug, p-chloroamphetamine, was investigated in mice. Neither the 5-HT transporter inhibitor fluoxetine nor the 5-HT depleter p-chlorophenylalanine affected p-chloroamphetamine-induced hyperthermia. Th...

journal_title：European journal of pharmacology

authors： Sugimoto Y,Ohkura M,Inoue K,Yamada J

更新日期：2001-11-02 00:00:00