WITHDRAWN: Decreased HCN1 mRNA in hippocampal area CA1 and neocortex after chronic cerebral hypoperfusion.

abstract：:In normotensive rats, we have previously demonstrated a role of brain mineralocorticoid receptors in blood pressure and renal function control. In the present study, the coordinate cardiovascular and renal effects of brain mineralocorticoid receptor blockade were examined by intracerebroventricular (i.c.v.) administra...

journal_title：European journal of pharmacology

authors： Rahmouni K,Sibug RM,De Kloet ER,Barthelmebs M,Grima M,Imbs JL,De Jong W

更新日期：2002-02-02 00:00:00

abstract：:The aim of the present study was to compare, in chloral-hydrate anaesthetized rats, the alpha(2)-adrenergic properties of the selective 5-HT(1A) receptor agonist, alnespirone (S-20499), with those of buspirone, a 5-HT(1A) receptor agonist exhibiting potent alpha(2)-adrenoceptor antagonist properties via its principal ...

journal_title：European journal of pharmacology

authors： Astier B,Lambás Señas L,Soulière F,Schmitt P,Urbain N,Rentero N,Bert L,Denoroy L,Renaud B,Lesourd M,Muñoz C,Chouvet G

更新日期：2003-01-10 00:00:00

abstract：:More recently, arsenic trioxide (ATO), was integrated into acute promyelocytic leukemia (APL) treatment, showing high efficacy and tolerability in patients with both ATRA-sensitive and ATRA-resistant APL. ATO could induce apoptosis at relatively high concentrations (0.5 to 2.0 micromol/L) and partial differentiation a...

journal_title：European journal of pharmacology

authors： Safa M,Mousavizadeh K,Noori S,Pourfathollah A,Zand H

更新日期：2014-08-05 00:00:00

abstract：:The function of gamma-aminobutyric acid type A receptors (GABA(A) receptors) is enhanced by various clinically important drugs including benzodiazepines that act on an allosteric site formed at the interface between the alpha and gamma subunits. In contrast to classical benzodiazepines, the novel pyrazolopyrimidine in...

journal_title：European journal of pharmacology

authors： Wegner F,Deuther-Conrad W,Scheunemann M,Brust P,Fischer S,Hiller A,Diekers M,Strecker K,Wohlfarth K,Allgaier C,Steinbach J,Hoepping A

更新日期：2008-02-02 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA)-induced pial artery dilation is reversed to vasoconstriction following fluid percussion brain injury (FPI). This study investigated the contribution of activation of protein tyrosine kinase (PTK) and the extracellular signal-regulated kinase (ERK) and p38 isoforms of mitogen-activated prote...

journal_title：European journal of pharmacology

authors： Armstead WM

更新日期：2003-08-08 00:00:00

abstract：:The specific, irreversible binding of [3H]beta-funaltrexamine (beta-FNA) to mu opioid receptors in slices from the corpus striatum and midbrain region containing the ventral tegmentum area (VTA) was accomplished by incubation with [3H]beta-FNA followed by a washing procedure with 1 microM unlabeled naltrexone in the w...

journal_title：European journal of pharmacology

authors： Takahashi M,Portoghese PS,Takemori AE

更新日期：1988-05-10 00:00:00

abstract：:Previous results indicated that the rabbit could represent a suitable model for investigations on the functional role of alpha 2-adrenoceptors in fat cells, but the characterization of these receptors was not resolved yet. In the present report, imidazoline compounds were used to attempt a better definition of rabbit ...

journal_title：European journal of pharmacology

authors： Langin D,Paris H,Dauzats M,Lafontan M

更新日期：1990-04-25 00:00:00

abstract：:We investigated the involvement of angiotensin II and vascular smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) function in the impaired NO-induced relaxation seen in established streptozotocin-induced diabetes. Plasma angiotensin II levels, which were elevated in untreated diabetic rats (vs age-matched...

journal_title：European journal of pharmacology

authors： Taguchi K,Kobayashi T,Hayashi Y,Matsumoto T,Kamata K

更新日期：2007-02-05 00:00:00

abstract：:Isolated rat diaphragms were treated with the oxime HI-6, 25 min after the start of soman exposure for 5, 15, 20 or 25 min. Recovery of neuromuscular transmission (NMT) was smaller and the subsequent spontaneous failure of NMT greater when soman exposure was longer. Diaphragms taken from anaesthetized atropinized soma...

journal_title：European journal of pharmacology

authors： Van Helden HP,Wolthuis OL

更新日期：1983-05-06 00:00:00

abstract：:The effects of baicalein, a flavonoid, and alpha-tocopherol (vitamin E) on lipid peroxidation in rat forebrain homogenates, on free radical scavenging action against diphenyl-p-picrylhydrazyl (DPPH), and on 12-O-tetradecanoylphorbol acetate (TPA)-induced ear edema in mice were studied. Baicalein inhibited lipid peroxi...

journal_title：European journal of pharmacology

authors： Hara H,Sukamoto T,Ohtaka H,Abe K,Tatumi Y,Saito Y,Suzuki A,Tsukamoto G

更新日期：1992-10-20 00:00:00

abstract：:The effects of morphine (0.1 mg/kg) and 5-HTP (2 mg/kg) on colonic motility were investigated in dogs fasted for 15-22 h and fitted with two strain gauge transducers on the transverse colon at 8 and 12 cm from the ileo-colonic junction. The effects were compared to those obtained after previous intravenous (i.v.) (0.2...

journal_title：European journal of pharmacology

authors： Bueno L,Fioramonti J

更新日期：1982-08-27 00:00:00

abstract：:Adriamycin-induced nephrosis in rats is a commonly used experimental model for pharmacological studies of human chronic renal diseases. Adriamycin-induced apoptosis of renal tubular cells has been reported in adriamycin-treated rats. In addition, prostacyclin (PGI(2)) is known to have various protective effects on man...

journal_title：European journal of pharmacology

authors： Chen CH,Lin H,Hsu YH,Sue YM,Cheng TH,Chan P,Chen TH

更新日期：2006-01-04 00:00:00

abstract：:IRL1620, a specific endothelin ETB receptor agonist, induced relaxation followed by contraction in the guinea-pig ileum, as did endothelin-1. Both components of the response were concentration-dependent in the range studied. Repeated administration of IRL1620 induced tachyphylaxis only of the contractile component, wh...

journal_title：European journal of pharmacology

authors： Miasiro N,Karaki H,Paiva AC

更新日期：1995-10-24 00:00:00

abstract：:A single electroconvulsive shock produced analgesia (expressed as prolongation of hot-plate latency) in Wistar rats 45 min after the shock. The analgesic action was prevented by administration of nifedipine, 5 mg/kg i.p., 15 min before the electroconvulsive shock, while nifedipine injection after electroconvulsive sho...

journal_title：European journal of pharmacology

authors： Antkiewicz-Michaluk L,Michaluk J,Vetulani J

更新日期：1994-03-11 00:00:00

abstract：:The impacts of prenatal propofol on cognition and emotion of offspring remain elusive. In the present study, pregnant rats in the second trimester were anesthetized with propofol. Neuronal apoptosis and proliferation was determined in fetuses and postnatal rats by detecting caspase-3 and BrdU expression. The offspring...

journal_title：European journal of pharmacology

authors： Chen D,Qi X,Zhuang R,Cao J,Xu Y,Huang X,Li Y

更新日期：2019-01-15 00:00:00

abstract：:The hypotensive activity of a series of calcium entry blockers and various other vasodilators was quantified in pentobarbitone-anesthetized rats. Hypotensive activity was correlated linearly with the potency of these vasoactive agents to depress alpha 2-adrenoceptor-induced pressor responses in pithed rats. However, v...

journal_title：European journal of pharmacology

authors： Van Meel JC,Timmermans PB,Van Zwieten PA

更新日期：1983-08-19 00:00:00

abstract：:The stimulation of spinal cannabinoid type 2 (CB(2)) receptors is a suitable strategy for the alleviation of experimental pain symptoms. Several reports have described the up-regulation of spinal cannabinoid CB(2) receptors in neuropathic settings together with the analgesic effects derived from their activation. Besi...

journal_title：European journal of pharmacology

authors： Curto-Reyes V,Boto T,Hidalgo A,Menéndez L,Baamonde A

更新日期：2011-10-01 00:00:00

abstract：:We previously reported that glycoxidized low-density lipoprotein (glycoxidized LDL) enhanced monocyte chemoattractant protein-1 (MCP-1) mRNA expression through activation of nuclear factor-kappaB (NF-kappaB). Here we investigated the effects of dilazep, an anti-platelet agent, and fenofibric acid, an active metabolite...

journal_title：European journal of pharmacology

authors： Sonoki K,Iwase M,Iino K,Ichikawa K,Yoshinari M,Ohdo S,Higuchi S,Iida M

更新日期：2003-08-15 00:00:00

abstract：:The purpose of the present study was to further evaluate the tail-temperature test as a tool to test potential steroidal and non-steroidal compounds for the treatment of hot flushes. Ovariectomized rats were implanted with a temperature sensitive probe. After a recovery period of 5 weeks, the effect of oestradiol (giv...

journal_title：European journal of pharmacology

authors： Berendsen HH,Kloosterboer HJ

更新日期：2003-12-15 00:00:00

abstract：:It has been previously found that the systemic administration of low doses of N-methyl-D-aspartate (NMDA) in mice induces motor depression. The effects of the systemic administration of different doses of NMDA (10, 30 and 60 mg/kg s.c.) on the motor activity and on the in vivo extracellular levels of adenosine in the ...

journal_title：European journal of pharmacology

authors： Melani A,Corsi C,Giménez-Llort L,Martínez E,Ogren SO,Pedata F,Ferré S

更新日期：1999-11-26 00:00:00

abstract：:Using 3H-ligands and radioactive microspheres we studied the binding characteristics and the effects on the distribution of carotid arterial blood flow of n-(3-acetylaminophenyl)piperazine hydrochloride (BEA 1654). The compound had a Ki value of 32 nM (5-HT: 8 nM) on 5-HT1 but no or very weak affinity for 5-HT2, alpha...

journal_title：European journal of pharmacology

authors： Verdouw PD,Jennewein HM,Mierau J,Saxena PR

更新日期：1985-01-08 00:00:00

abstract：:This study addressed the possibility that acetylcholine-induced relaxation in the rabbit aorta is mediated by dual mechanisms: one N omega-nitro-L-arginine (NLA)-sensitive, the other glybenclamide-sensitive. Acetylcholine, nitroglycerin and BRL38227 (lemakalim), an activator of glybenclamide-sensitive potassium channe...

journal_title：European journal of pharmacology

authors： Bellan JA,Longenecker LL,Kadowitz PJ,McNamara DB

更新日期：1993-04-06 00:00:00

abstract：:Concentration-relaxation curves for pinacidil and cromakalim were obtained in isolated guinea-pig tracheas contracted by histamine. Pinacidil produced complete relaxation with an EC50 value of 2.8 microM. The antidiabetic sulfonylurea, glibenclamide (0.1, 1, 10 microM), caused concentration-dependent rightward shifts ...

journal_title：European journal of pharmacology

authors： Nielsen-Kudsk JE,Bang L,Brønsgaard AM

更新日期：1990-05-16 00:00:00

abstract：:The actions of the substituted benzamide derivatives metoclopramide, clebopride, YM-09151-2, tiapride, (+)- and (-)-sulpiride and (+)- and (-)-sultopride, and the dopamine antagonists haloperidol and domperidone, were studied on the responses to field stimulation (0.125-10 Hz) of smooth muscle strips taken from cardia...

journal_title：European journal of pharmacology

authors： Costall B,Naylor RJ,Tan CC

更新日期：1984-06-15 00:00:00

abstract：:The spasmolytic activity of synthetic alpha-human atrial natriuretic peptide (alpha-hANP) and its related peptides was determined in vitro using the chick rectum and the rat aorta. Natriuretic activity was also measured in the anesthetized rat, alpha-hANP-(7-28), with the NH2-terminal hexapeptide truncated, had greate...

journal_title：European journal of pharmacology

authors： Watanabe TX,Noda Y,Chino N,Nishiuchi Y,Kimura T,Sakakibara S,Imai M

更新日期：1988-02-16 00:00:00

abstract：:The vasodilatory role of calcitonin gene-related peptide in activating K+ channels was examined in isolated, suffused human uterine arteries. Calcitonin gene-related peptide produced a concentration-dependent relaxation of norepinephrine (1 microM)-induced contractions. Calcitonin gene-related peptide was antagonized ...

journal_title：European journal of pharmacology

authors： Nelson SH,Suresh MS,Dehring DJ,Johnson RL

更新日期：1993-10-05 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor dysfunctions resulting from the loss of upper (UMNs) and lower (LMNs) motor neurons. While ALS symptoms are coincidental with pathological changes in LMNs and UMNs, the causal relationship between the two is unclear....

journal_title：European journal of pharmacology

authors： Nakagawa Y,Yamada S

更新日期：2021-02-05 00:00:00

abstract：:The aim of this study was to determine the effect of ethanol on cell cycle events during the G(1) and S phases in cultured vascular smooth muscle cells (VSMC). Flow cytometric analysis for the DNA content in rat aortic VSMC indicated that following ethanol treatment, the cell population in the G(0)/G(1) phase increase...

journal_title：European journal of pharmacology

authors： Sayeed S,Cullen JP,Coppage M,Sitzmann JV,Redmond EM

更新日期：2002-06-12 00:00:00

abstract：:Our aim in performing this study was to analyze in vivo the cell death mechanism induced by toxic doses of digitalis compounds on guinea-pig cardiomyocytes. We analyzed three study groups of five male guinea pigs each. Guinea pigs were intoxicated under anesthesia with ouabain or digoxin (at a 50-60% lethal dose); the...

journal_title：European journal of pharmacology

authors： Ramirez-Ortega M,Zarco G,Maldonado V,Carrillo JF,Ramos P,Ceballos G,Melendez-Zajgla J,Garcia N,Zazueta C,Chanona J,Suarez J,Pastelin G

更新日期：2007-07-02 00:00:00

abstract：:Nerve growth factor (NGF) is known to regulate the development and survival of select populations of neurons via its binding/activation of the TrkA and p75(NTR) receptors. However, in some physiological circumstances NGF dysregulation can result in debilitating pathologies, including diabetic neuropathies, interstitia...

journal_title：European journal of pharmacology

authors： Eibl JK,Strasser BC,Ross GM

更新日期：2013-05-15 00:00:00