Abstract:
:Plants are a natural source of bioactive compounds such as secondary metabolites. These molecules, also called phytochemicals, are fundamental for plant survival and often show therapeutic properties used for the treatment of human diseases. Asperuloside is a secondary metabolite which belongs to iridoid glycosides and is commonly present in the plant family Rubiaceae. In this review we aim to summarize the scientific knowledge on asperuloside, with a special emphasis on its pharmacological properties as anti-viral, anti-malarial, anti-protozoal, anti-tumorigenic, anti-hypertensive, anti-obesity, immunomodulatory, anti-inflammatory and antioxidant agent. Preclinical studies in animal models suggest that asperuloside has therapeutic potential that could be evaluated in humans. However, despite its tangible phytochemical characteristics, no clinical trial has been performed so far. Thus, we hope that this review will facilitate scientific dissemination of asperuloside pharmacological properties and encourage researchers to evaluate both pharmacokinetic and toxicity of asperuloside in animal models. This will be the first step towards clinical studies in humans.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Manzione MG,Martorell M,Sharopov F,Bhat NG,Kumar NVA,Fokou PVT,Pezzani Rdoi
10.1016/j.ejphar.2020.173344subject
Has Abstractpub_date
2020-09-15 00:00:00pages
173344eissn
0014-2999issn
1879-0712pii
S0014-2999(20)30436-2journal_volume
883pub_type
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