Reduced contractile function after balloon denudation of rat carotid arteries.

abstract：:Corticotropin releasing factor (CRF) is a hypothalamic hormone that also displays autocrine/paracrine roles at peripheral sites. High concentrations of CRF have been identified in endothelial cells and other inflammatory tissues. We investigated the effects of CRF and antagonists in the regulation of prostaglandin syn...

journal_title：European journal of pharmacology

authors： Fleisher-Berkovich S,Rimon G,Danon A

更新日期：1998-07-24 00:00:00

abstract：:We studied the effects of inhaled formoterol (0.75 mg/ml, 60 breaths = 26 micrograms), a long-acting beta 2-adrenoceptor agonist, or of the more short-acting drug, salbutamol (25 mg/ml, 60 breaths = 875 micrograms), on acute airflow obstruction and airway microvascular leakage (MVL) induced by inhaled histamine in ane...

journal_title：European journal of pharmacology

authors： Tokuyama K,Lötvall JO,Löfdahl CG,Barnes PJ,Chung KF

更新日期：1991-01-25 00:00:00

abstract：:There are several inconsistencies in the literature as regards the characteristics of benzamide and butyrophenone binding to dopamine D2-like receptors. The variations observed in Bmax, Kd and Ki values have led to hypotheses, such as the existence of a specific "benzamide binding site' and that dopamine D2 receptors ...

journal_title：European journal of pharmacology

authors： Malmberg A,Jerning E,Mohell N

更新日期：1996-05-06 00:00:00

abstract：:Ouabain- and bumetanide-resistant potassium fluxes were measured in human erythrocytes incubated in a medium containing calcium and a calcium ionophore. Pharmacological concentrations of rat atrial natriuretic peptide stimulated these fluxes. Although human erythrocytes lack atrial natriuretic peptide receptors, our r...

journal_title：European journal of pharmacology

authors： Esparza N,Díez J

更新日期：1989-07-18 00:00:00

abstract：:Skeletal myogenesis comprises myoblast replication and differentiation into striated multinucleated myotubes. Agents that interfere with myoblast replication are important tools for the understanding of myogenesis. Recently, we showed that cholesterol depletion by methyl-β-cyclodextrin (MCD) enhances the differentiati...

journal_title：European journal of pharmacology

authors： Portilho DM,Soares CP,Morrot A,Thiago LS,Butler-Browne G,Savino W,Costa ML,Mermelstein C

更新日期：2012-11-05 00:00:00

abstract：:Intake of nicotine has been related in many cases to acute or chronic hypertension. Using the patch-clamp technique the effect of nicotine on voltage-dependent K+ channel currents in rat tail artery smooth muscle cells was studied. Nicotine at concentrations of 1-100 microM or 0.3-3 mM increased or decreased, respecti...

journal_title：European journal of pharmacology

authors： Tang G,Hanna ST,Wang R

更新日期：1999-01-08 00:00:00

abstract：:The effects of thyrotropin-releasing hormone (TRH), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) and L-5-hydroxytryptophan (5-HTP) were studied on the monosynaptic reflex (MSR) and the polysynaptic reflex (PSR) in acute and chronic spinal rats. Radioimmunoassay showed that while chronic spinal transection (for 2 weeks)...

journal_title：European journal of pharmacology

authors： Nagano N,Ono H,Ozawa M,Fukuda H

更新日期：1988-05-10 00:00:00

abstract：:Phosphodiesterase 2 is one of the phosphodiesterase (PDEs) family members that regulate cyclic nucleotide (namely cAMP and cGMP) concentrations. The present study determined whether PDE2 inhibition could rescue post-traumatic stress disorder (PTSD)-like symptoms. Mice were subjected to single prolonged stress (SPS) an...

journal_title：European journal of pharmacology

authors： Chen L,Liu K,Wang Y,Liu N,Yao M,Hu J,Wang G,Sun Y,Pan J

更新日期：2021-01-15 00:00:00

abstract：:Capsaicin (1-3 microM) and electrical stimulation of mesenteric nerves in the presence of hexamethonium and guanethidine antidromically stimulate extrinsic sensory nerve fibers to produce a specific slow depolarizing response of myenteric neurons and a contractile response of muscles in the isolated guinea-pig ileum, ...

journal_title：European journal of pharmacology

authors： Takaki M,Namba T,Fujii W,Suga H

更新日期：1993-06-11 00:00:00

abstract：:Sibutramine was formerly marketed as an anti-obesity agent. The current study investigated the relationships between monoamine reuptake site occupancy for sibutramine and both its antidepressant-like efficacy and thermogenic effects. Sibutramine's effects on locomotor activity (LMA) and food intake were also evaluated...

journal_title：European journal of pharmacology

authors： Li YW,Langdon S,Pieschl R,Strong T,Wright RN,Rohrbach K,Lelas S,Lodge NJ

更新日期：2014-08-15 00:00:00

abstract：:[3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in bovine cerebral cortex. [3H]Rauwolscine binding was reversible, stereospecific, and saturable. Association, dissociation, and saturation studies revealed one site interactions (k -1/k+1 = 1.2 nM,...

journal_title：European journal of pharmacology

authors： Perry BD,U'Prichard DC

更新日期：1981-12-17 00:00:00

abstract：:The aim of this study was to examine the therapeutic effect of oxymatrine, a monomer isolated from the medicinal plant Sophora flavescens Ait, on the hepatic lipid metabolism in non-alcoholic fatty liver (NAFLD) rats and to explore the potential mechanism. Rats were fed with high fructose diet for 8 weeks to establish...

journal_title：European journal of pharmacology

authors： Shi LJ,Shi L,Song GY,Zhang HF,Hu ZJ,Wang C,Zhang DH

更新日期：2013-08-15 00:00:00

abstract：:The rapid breakout of the coronavirus disease of 2019 (COVID-19) has been declared pandemic with serious global concern due to high morbidity and mortality. As we enter the phase beyond limitations there is an urgent need for explicit treatment against COVID-19. To face this immediate global challenge, drug developmen...

journal_title：European journal of pharmacology

authors： Bibi N,Gul S,Ali J,Kamal MA

更新日期：2020-10-15 00:00:00

abstract：:Some behavioural effects of flunitrazepam were investigated in two sets of experiments in C57BL/6 mice. In the first set, flunitrazepam administration (0.025 or 0.05 mg/kg) enhanced the locomotor activity of mice. In the second set, memory impairments were observed following posttraining (immediately or 30 min, but no...

journal_title：European journal of pharmacology

authors： Castellano C,Filibeck U,Pavone F

更新日期：1984-09-03 00:00:00

abstract：:Two inhibitors of the cellular uptake of the endocannabinoid anandamide, (R)-N-oleoyl-(1'-hydroxybenzyl)-2'-ethanolamine and (S)-N-oleoyl-(1'-hydroxybenzyl)-2'-ethanolamine (OMDM-1 and OMDM-2, respectively), were recently synthesized, and their in vitro pharmacological activity described. Here we have assessed their a...

journal_title：European journal of pharmacology

authors： de Lago E,Ligresti A,Ortar G,Morera E,Cabranes A,Pryce G,Bifulco M,Baker D,Fernandez-Ruiz J,Di Marzo V

更新日期：2004-01-26 00:00:00

abstract：:The binding of atrial natriuretic peptide (ANP) to olfactory bulb, pituitary anterior lobe and thymus gland membranes was examined. [125I]ANP (rat, 99-126) bound specifically to the three types of membranes. However, the affinity for ANP receptor in olfactory bulb was much higher than those in either pituitary or thym...

journal_title：European journal of pharmacology

authors： Agui T,Kurihara M,Saavedra JM

更新日期：1989-03-21 00:00:00

abstract：:LK 204-545 ((+/-)-1-(2-(3-(2-cyano-4-(2-cyclopropyl-methoxy-ethoxy)phenoxy)-2-hydro xy-propyl-amino)-ethyl)-3-(4-hydrxy-phenyl) urea), an antagonist that possesses high beta1-/beta2-selectivity in the rat, and a range of cardio-selective and non-selective beta-adrenoceptor antagonists were examined to compare their ra...

journal_title：European journal of pharmacology

authors： Louis SN,Nero TL,Iakovidis D,Jackman GP,Louis WJ

更新日期：1999-02-19 00:00:00

abstract：:Guanosine 3',5'-cyclic monophosphate (cGMP) is an important second messenger in many biological systems including vascular smooth muscle where it mediates relaxation. Cellular levels of cGMP are regulated primarily by three enzymes; nitric oxide (NO) synthase, soluble guanylate cyclase, and cGMP-phosphodiesterase. Bas...

journal_title：European journal of pharmacology

authors： Bina S,Hart JL,Sei Y,Muldoon SM

更新日期：1998-06-19 00:00:00

abstract：:Central monoaminergic neurotransmitters have been implicated in the control of food intake in different animal species but it remains unclear whether these same neurochemical systems effectively regulate feeding behaviour in the genetically obese (ob/ob) mouse. Neuropharmacological studies have demonstrated, for examp...

journal_title：European journal of pharmacology

authors： Currie PJ,Wilson LM

更新日期：1993-03-02 00:00:00

abstract：:The protective potency of ischemic preconditioning decreases with increasing age. A key step in ischemic preconditioning is the opening of mitochondrial Ca(2+) sensitive K(+) (mK(Ca)) channels, which causes mild uncoupling of mitochondrial respiration. We hypothesized that aging reduces the effects of mK(Ca) channel o...

journal_title：European journal of pharmacology

authors： Heinen A,Winning A,Schlack W,Hollmann MW,Preckel B,Frässdorf J,Weber NC

更新日期：2008-01-14 00:00:00

abstract：:The novel antiepileptic and neuroprotective drug felbamate (1 mM) caused a marked inhibition of voltage-dependent Na+ currents expressed in Xenopus oocytes upon injection of the cRNA encoding alpha-subunits from rat and human brain. This inhibition was present only if felbamate was perfused on the intracellular side o...

journal_title：European journal of pharmacology

authors： Taglialatela M,Ongini E,Brown AM,Di Renzo G,Annunziato L

更新日期：1996-12-05 00:00:00

abstract：:The effects of alpha 1-adrenergic stimulation on intracellular pH (pHi) and Ca2+ concentration ([Ca2+]i) were investigated in isolated rat cardiomyocytes with fluorescence dyes, BCECF and fura-2, respectively. In the presence of 5 or 25 mM HCO3- norepinephrine (NE) increased pHi in a dose-dependent manner. Intracellul...

journal_title：European journal of pharmacology

authors： Iwakura K,Hori M,Watanabe Y,Kitabatake A,Cragoe EJ Jr,Yoshida H,Kamada T

更新日期：1990-09-04 00:00:00

abstract：:The decrease in blood flow in response to dopamine (DA) injected intraarterially (i.a.) into the femoral or renal vascular beds was examined in the anaesthetised dog. DA or noradrenaline (NA) were 10 times more potent as vasoconstrictor agents in the femoral than in the renal vasculature. In the femoral bed, the DA in...

journal_title：European journal of pharmacology

authors： Duval N,Hicks PE,Langer SZ

更新日期：1985-02-05 00:00:00

abstract：:Deprenyl, used clinically in Parkinson's disease, has multiple pharmacological effects which make it a good candidate to treat neurotoxicity. Thus, we investigated deprenyl's ability to attenuate methamphetamine-induced dopamine neurotoxicity. We also examined deprenyl's effect in changing markers associated with psyc...

journal_title：European journal of pharmacology

authors： Davidson C,Chen Q,Zhang X,Xiong X,Lazarus C,Lee TH,Ellinwood EH

更新日期：2007-11-14 00:00:00

abstract：:The impacts of prenatal propofol on cognition and emotion of offspring remain elusive. In the present study, pregnant rats in the second trimester were anesthetized with propofol. Neuronal apoptosis and proliferation was determined in fetuses and postnatal rats by detecting caspase-3 and BrdU expression. The offspring...

journal_title：European journal of pharmacology

authors： Chen D,Qi X,Zhuang R,Cao J,Xu Y,Huang X,Li Y

更新日期：2019-01-15 00:00:00

abstract：:In addition to S(-)-nicotine, several minor tobacco alkaloids ((+/-)-nornicotine, anabaseine, S(-)-anabasine, and S(-)-N-methylanabasine) are present in tobacco smoke. This study demonstrates that these alkaloids increase fractional 3H release in a concentration-dependent manner from rat striatal slices preloaded with...

journal_title：European journal of pharmacology

authors： Dwoskin LP,Teng L,Buxton ST,Ravard A,Deo N,Crooks PA

更新日期：1995-03-24 00:00:00

abstract：:We assessed the intrinsic activity of the purported selective muscarinic M1 receptor agonist SR 95639A (morpholinoethylamino-3-benzocyclohepta-(5,6-c)-pyridazine) in inducing several receptor-mediated signals. Our results indicate that SR 95639A lacks the ability to activate phosphoinositide hydrolysis in rat cerebral...

journal_title：European journal of pharmacology

authors： Mohamed AS,Forray C,Aly MH,el-Fakahany EE

更新日期：1992-10-01 00:00:00

abstract：:The tachykinins substance P, neurokinin A and neurokinin B are involved in many pathophysiological processes. A reverse transcription-polymerase chain reaction (RT-PCR) assay was used to analyse the expression of TAC1 and TAC3, the genes that encode substance P/neurokinin A and neurokinin B, respectively, and the gene...

journal_title：European journal of pharmacology

authors： Pinto FM,Almeida TA,Hernandez M,Devillier P,Advenier C,Candenas ML

更新日期：2004-06-28 00:00:00

abstract：:The models currently used to assess antinociceptive efficacy in animals are far from ideal. Those procedures that detect both opioid agonists and mixed agonist-antagonists fail to differentiate between them unless the noxious stimulus is adjusted. Furthermore, changes in the sensitivity of the test often result in pos...

journal_title：European journal of pharmacology

authors： Pizziketti RJ,Pressman NS,Geller EB,Cowan A,Adler MW

更新日期：1985-12-10 00:00:00

abstract：:Chlorin derivatives have been known for their biological activities. Especially due to their advanced electron transfer capacity they have been used as photodynamic therapy agent both at clinical and laboratory scales. Photodynamic therapy (PDT) against cancer or an infectious disease aims the development of less side...

journal_title：European journal of pharmacology

authors： Ayaz F,Ocakoglu K

更新日期：2020-04-15 00:00:00