Abstract：
:The effect of chlorogenic acid on the sleep-wakefulness cycle in rats was investigated in comparison with those of caffeic acid (the metabolite of chlorogenic acid) and dihydrocaffeic acid (the metabolite of caffeic acid). A significant prolongation of sleep latency was observed with chlorogenic acid and caffeic acid at a dose of 500 and 200 mg/kg, respectively. On the other hand, no remarkable effects were observed with dihydrocaffeic acid even at a dose of 500 mg/kg. Caffeine caused a significant increase in sleep latency and waking time and decrease in non-rapid eye movement sleep time at a dose of 10 mg/kg. In contrast, chlorogenic acid and its metabolites had no significant effects on each sleep state. From these results, it may be concluded that chrologenic acid caused a mild arousal effect compared with that of caffeine, and the effect of chlorogenic acid may have occurred through its metabolite caffeic acid.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Shinomiya K,Omichi J,Ohnishi R,Ito H,Yoshida T,Kamei Cdoi
10.1016/j.ejphar.2004.09.054keywords:
subject
Has Abstractpub_date
2004-11-19 00:00:00pages
185-9issue
3eissn
0014-2999issn
1879-0712pii
S0014-2999(04)01121-5journal_volume
504pub_type
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journal_title：European journal of pharmacology
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