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ACTH1-24 counteracts the prolactin-releasing effect of an opioid.

Abstract：

:The administration of the synthetic and stable opioid peptide[D-Ala2,MePhe4,Met(O)5o1]enkephalin (FK 33-824) at the dose of 0.2 mg/kg i.v. induced a rise in plasma levels of prolactin in the rat, an effect which was prevented by 1 mg/kg i.v. of the opiate antagonist naloxone. A simultaneous i.v. injection of 20 microgram/kg i.v. of ACTH1-24 significantly reduced the prolactin releasing effect of FK 33-824, therefore giving further evidence of an in vivo interaction between ACTH-related peptides and opioid peptides.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Ferri S,Cocchi D,Locatelli V,Spampinato S,Muller E

doi

10.1016/0014-2999(82)90009-7

subject

Has Abstract

pub_date

1982-01-22 00:00:00

pages

143-5

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(82)90009-7

journal_volume

77

pub_type

杂志文章

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