External ATP antagonizes the effect of potassium channel openers in guinea-pig ventricular papillary muscle.

abstract：:Right ventricular kitten papillary muscles were incubated with dibutyryl adenosine 3',5'-monophosphate (dbcAMP) at varying concentrations as low as 1 X 10(-4)M. A positive inotropic effect was observed with all concentrations of dbcAMP. Concomitant administration of 5 X 10(-4)M monobutyryl guanosine 3',5'-monophosphat...

journal_title：European journal of pharmacology

authors： Wilkerson RD,Paddock RJ,George WJ

更新日期：1976-03-01 00:00:00

abstract：:First line antidepressants are the so-called SSRIs (selective serotonin reuptake inhibitors), e.g. fluvoxamine, fluoxetine, sertraline, paroxetine and escitalopram. Unfortunately, these drugs mostly do not provide full symptom relief and have a slow onset of action. Therefore other antidepressants are also being presc...

journal_title：European journal of pharmacology

authors： Korte SM,Prins J,Krajnc AM,Hendriksen H,Oosting RS,Westphal KG,Korte-Bouws GA,Olivier B

更新日期：2015-04-15 00:00:00

abstract：:The effects of sulfated cholecystokinin octapeptide (CCK-8s) and CCK-8s antagonist, proglumide, given intrathecally (i.t.) on inhibition of the tail-flick and hot-plate paw-licking responses induced by beta-endorphin and morphine given intracerebroventricularly (i.c.v.) were studied in male ICR mice. Both CCK-8s (up t...

journal_title：European journal of pharmacology

authors： Suh HH,Tseng LF

更新日期：1990-04-25 00:00:00

abstract：:The new platinum (II) and palladium (II) complexes (2-4) with ligands 5-(2-hydroxyphenyl)-1,3-dimethyl-4-(dimethoxy)phosphonyl-1H]-pyrazole (1a) and 5-(2-hydroxyphenyl)-1,3-dimethyl-4-methoxycarbonyl-1H]-2-pyrazole (1b) were screened in a search for novel anticancer agents. Thus, alkylating activity, cytotoxicity, abi...

journal_title：European journal of pharmacology

authors： Budzisz E,Krajewska U,Rozalski M,Szulawska A,Czyz M,Nawrot B

更新日期：2004-10-11 00:00:00

abstract：:Our recent study has shown that the intracerebroventricular administration of d-serine, an endogenous and selective agonist for the glycine site of the N-methyl-d-aspartate receptor, alone or in combination with morphine, leads to the potentiation of antinociception on the tail-flick response. Although there is a vari...

journal_title：European journal of pharmacology

authors： Ito K,Yoshikawa M,Maeda M,Jin XL,Takahashi S,Matsuda M,Tamaki R,Kobayashi H,Suzuki T,Hashimoto A

更新日期：2008-05-31 00:00:00

abstract：:The [3H]nitrendipine binding activity of sarcolemmal fragments isolated from aerobically perfused or ischemic rat hearts was studied. After 90 min aerobic perfusion, two populations of binding sites were detected--high affinity sites with KD of 0.24 +/- 0.04 nM and Bmax 313 +/- 110 fmol/mg protein, and low affinity si...

journal_title：European journal of pharmacology

authors： Nayler WG,Dillon JS,Elz JS,McKelvie M

更新日期：1985-09-10 00:00:00

abstract：:N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methyl-benzamide (RHM-1) and N-[2-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethyl]-2-methoxy-5-methylbenzamide (RHM-2), two conformationally flexible benzamide analogues, were radiolabeled with tritium (specific activity=80 Ci/mmol) and the bi...

journal_title：European journal of pharmacology

authors： Xu J,Tu Z,Jones LA,Vangveravong S,Wheeler KT,Mach RH

更新日期：2005-11-21 00:00:00

abstract：:In isolated heart muscle, the compound R56865 (N-[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2- benzothiazolamine) has been shown to protect against intoxication by cardiac glycosides. We studied the influence of R56865 on various membrane currents in single isolated ventricular cardiomyocytes of the guinea-...

journal_title：European journal of pharmacology

authors： Himmel HM,Wilhelm D,Ravens U

更新日期：1990-10-09 00:00:00

abstract：:The effects of MP 518, an acylated 2-chlorobenzylidene hydrazidone derivative with antihypertensive properties were investigated on the Ca current, ICa, recorded under whole-cell patch-clamp in single frog ventricular cells. MP 518 (1-100 microM) had no effect on ICa under control conditions. However, at 10 microM it ...

journal_title：European journal of pharmacology

authors： Scamps F,Tran G,Rinjard P,Binet P,Miocque M,Vassort G

更新日期：1993-01-15 00:00:00

abstract：:The Kd values of the multiple agonist binding sites in cardiac muscarinic receptors (mAChR) and pD2 values for negative inotropic actions were determined independently and their relation was examined. The guinea-pig cardiac mAChR is known to have three agonist binding sites (super-high (SH), high (H) and low (L) affin...

journal_title：European journal of pharmacology

authors： Mizushima A,Uchida S,Matsumoto K,Osugi T,Kagiya T,Zhou XM,Higuchi H,Yoshida H

更新日期：1985-12-17 00:00:00

abstract：:The effect of regression of left ventricular hypertrophy was studied in deoxycorticosterone-acetate-salt hypertensive rats (DOCA-salt hypertensive rats) treated with tetrandrine. Treatment with tetrandrine (by gastric intubation, 50 mg/kg per day for 9 weeks) lowered systolic blood pressure, left ventricular weight, C...

journal_title：European journal of pharmacology

authors： Xu Y,Rao MR

更新日期：1995-05-04 00:00:00

abstract：:The effects of ketamine on the cholinergic excitatory and inhibitory (Cl component) responses in Aplysia neurons were examined using the iontophoretic application of ACh and the two-microelectrode voltage clamp technique. Ketamine reduced both responses non-competitively to the same extent in a dose-dependent and reve...

journal_title：European journal of pharmacology

authors： Ikemoto Y

更新日期：1986-12-02 00:00:00

abstract：:We have investigated the cardiac and pressor responses to (±)-ephedrine and (-)-ephedrine in pentobarbitone anaesthetized male wistar rats. The tachycardiac responses to (±)- and (-)-ephedrine were similar, but pressor responses to (-)-ephedrine (10 mg/kg) were significantly greater than those to (±)-ephedrine, and fo...

journal_title：European journal of pharmacology

authors： Alsufyani HA,Docherty JR

更新日期：2018-04-15 00:00:00

abstract：:In WI-38 human fibroblasts, interleukin-1 beta and tumour necrosis factor-alpha (TNF-alpha) increased bradykinin B(1) receptor mRNA, which peaked between 2 and 4 h, remaining elevated for 20 h. Binding of the bradykinin B(1) receptor selective ligand [3H]des-Arg(10)-kallidin, also increased, peaking at 4 h and remaini...

journal_title：European journal of pharmacology

authors： Phagoo SB,Yaqoob M,Herrera-Martinez E,McIntyre P,Jones C,Burgess GM

更新日期：2000-06-02 00:00:00

abstract：:Hippocampal rhythmical slow activity (RSA) can be elicited by stimulation of the midbrain reticular formation. All classes of anxiolytic drug so far tested reduce the frequency of this RSA. Anxiolytic barbiturates and benzodiazepines, as opposed to compounds such as buspirone, are thought to act as receptor agonists o...

journal_title：European journal of pharmacology

authors： Coop CF,McNaughton N,Lambie I

更新日期：1991-01-03 00:00:00

abstract：:We examined the effects of the administration of 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-pregna-1,4,9( 11)-triene-3,20-dione, monomethansulfonate (U74389F), a 21-aminosteroid and so-called lazaroid, that is characterized by an inhibitory activity against iron-dependent lipid peroxidation, on ischemi...

journal_title：European journal of pharmacology

authors： Paroni R,De Vecchi E,Lubatti L,Conti E,Beretta C,Rinaldi P,Kienle MG,Trazzi R

更新日期：1995-12-29 00:00:00

abstract：:The antinociceptive effect of nitrous oxide (N(2)O) is dependent on nitric oxide (NO); however, the next step in the pathway activated by NO is undetermined. The present study was conducted to test the hypothesis that a N(2)O action involves sequential activation of NO synthase, soluble guanylyl cyclase and protein ki...

journal_title：European journal of pharmacology

authors： Zhang Y,Quock LP,Chung E,Ohgami Y,Quock RM

更新日期：2011-03-11 00:00:00

abstract：:Cerebral blood flow in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for the continuous recording of flow over periods of several hours. The bi-fluorophenyl-piperazine derivatives, lidoflazine and flunarizine, enhanced the reactive hyperemia elicited by a brief (3...

journal_title：European journal of pharmacology

authors： Phillis JW,DeLong RE,Towner JK

更新日期：1985-06-19 00:00:00

abstract：:Apoptosis or programmed cell death has been suggested as an important mode of neurodegeneration in Alzheimer's disease pathogenesis. The present study explored the neuroprotective effect of 2-ethoxy-4,5-diphenyl-1,3-oxazine-6-one (EDPOO) against H(2)O(2)-induced cell death in rat pheochromocytoma (PC12) cells. We foun...

journal_title：European journal of pharmacology

authors： Ansari N,Khodagholi F,Amini M

更新日期：2011-05-11 00:00:00

abstract：:Intracellular recording was used to study the effect of uncouplers of oxidative phosphorylation on miniature endplate potentials (m.e.p.p.s) in skeletal muscles from dystrophic mice and their clinically normal littermates. Control m.e.p.p. frequency in muscles from dystrophic mice was not significantly different from ...

journal_title：European journal of pharmacology

authors： Kelly S,Morgan G,Smith J

更新日期：1988-02-16 00:00:00

abstract：:The effects of serotonin (5-HT) on a beta-adrenergic response were studied, using the voltage clamp technique, in Xenopus laevis oocytes surrounded by their follicular cells. noradrenaline induced marked hyperpolarization, with a specific increase in the permeability of the membrane toward K+. Application of 10 microM...

journal_title：European journal of pharmacology

authors： Fujita R,Tamazawa Y,Barnard EA,Matsumoto M

更新日期：1993-08-24 00:00:00

abstract：:Transporter-mediated release of dopamine and the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium (MPP+) was examined in COS cells, a cell line derived from monkey kidney, expressing the rat dopamine transporter. The release of preloaded [3H]MPP+ but not [3H]dopamine was dose-dependently inhibited by cocai...

journal_title：European journal of pharmacology

authors： Kitayama S,Morita K,Dohi T

更新日期：1996-08-01 00:00:00

abstract：:The present study has examined the functional activity of the 5-HT1D receptor agonist, sumatriptan, and antagonists, GR127935 (2'-methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxyl ic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide), GR55562 (3-[3-(dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridiny...

journal_title：European journal of pharmacology

authors： Walsh DM,Beattie DT,Connor HE

更新日期：1995-12-04 00:00:00

abstract：:Local administration of amitriptyline into the rat hindpaw produces peripheral antinociception; this is reduced by adenosine receptor antagonists and appears to involve endogenous adenosine. The present study used peripheral microdialysis: (a) to determine whether amitriptyline could enhance extracellular tissue level...

journal_title：European journal of pharmacology

authors： Sawynok J,Reid AR,Liu XJ,Parkinson FE

更新日期：2005-08-22 00:00:00

abstract：:Oleuropein (OLE) was found to have anti-inflammatory and anti-oxidant effects. The latest study has shown that it can resist myocardial injury that follows an acute myocardial infarction and can rescue impaired spinal nerve cells. In this study, we investigated the neuroprotective effects of OLE on cerebral ischemia a...

journal_title：European journal of pharmacology

authors： Yu H,Liu P,Tang H,Jing J,Lv X,Chen L,Jiang L,Xu J,Li J

更新日期：2016-03-15 00:00:00

abstract：:Opioid antagonists, naloxone and naltrexone have long been used in clinical practice and research. In addition to their low selectivity, they easily pass through the blood-brain barrier. Quaternization of the amine group in these molecules, (e.g. methylnaltrexone) results in negligible CNS penetration. In addition, zw...

journal_title：European journal of pharmacology

authors： Zádor F,Király K,Váradi A,Balogh M,Fehér Á,Kocsis D,Erdei AI,Lackó E,Zádori ZS,Hosztafi S,Noszál B,Riba P,Benyhe S,Fürst S,Al-Khrasani M

更新日期：2017-08-15 00:00:00

abstract：:Disturbances in oxidative metabolism are involved in many acute and chronic diseases, as well as in several other conditions. The objective of the present study was to examine the relationship between the level of intracellular reactive oxygen species in the peripheral blood granulocytes of mice, as evaluated by 2',7'...

journal_title：European journal of pharmacology

authors： Rammal H,Bouayed J,Soulimani R

更新日期：2010-02-10 00:00:00

abstract：:Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th leading cause of death worldwide. It is believed that an exaggerated inflammatory response to cigarette smoke causes progressive airflow limitation. This inflammation, where macrophages, neutrophils and T lymphocytes ...

journal_title：European journal of pharmacology

authors： Vlahos R,Bozinovski S

更新日期：2015-07-15 00:00:00

abstract：:A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healthy volunteers. The equilibrium dissociation constant for binding by [3H]PK 1...

journal_title：European journal of pharmacology

authors： Gavish M,Weizman A,Karp L,Tyano S,Tanne Z

更新日期：1986-02-18 00:00:00

abstract：:The alpha(2)-adrenoceptor agonist, clonidine, modulates colorectal sensorimotor functions in humans and, given intrathecally, has analgesic effects in the colorectal distension (CRD) model in rats. We tested the effects of systemic clonidine on the visceral pain-related viscerosomatic and autonomic cardiovascular resp...

journal_title：European journal of pharmacology

authors： Brusberg M,Ravnefjord A,Lindgreen M,Larsson H,Lindström E,Martinez V

更新日期：2008-09-04 00:00:00