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Effect of acute treatment with YM992 on extracellular norepinephrine levels in the rat frontal cortex.

Abstract：

:The effects of acute treatment with (S)-2-[[(7-fluoroindan-4-yl)oxy]methyl]morpholine monohydrochloride (YM992), venlafaxine, fluoxetine and citalopram on extracellular norepinephrine levels were examined in the rat frontal cortex by in vivo microdialysis. YM992 (3, 10, 30 mg/kg, i.p.) dose-dependently increased extracellular norepinephrine levels (3-fold at 10 mg/kg, 5. 5-fold at 30 mg/kg). While venlafaxine and 30 mg/kg fluoxetine also produced significant increases in norepinephrine levels, 30 mg/kg citalopram had no effect. The combined administration of MDL100,907 (a selective 5-HT(2A) receptor antagonist) and citalopram did significantly increase norepinephrine levels compared with either saline or citalopram treatment. Therefore, a synergistic effect due to 5-HT reuptake inhibition and 5-HT(2A) receptor antagonism of YM992 may partly contribute to the increase of extracellular norepinephrine levels. YM992 enhances the neurotransmission of not only 5-HT system but also norepinephrine, and as such may have a preclinical profile different from that of a selective serotonin reuptake inhibitor.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Hatanaka K,Yatsugi S,Yamaguchi T

doi

10.1016/s0014-2999(00)00173-4

keywords:

subject

Has Abstract

pub_date

2000-04-21 00:00:00

pages

31-6

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014299900001734

journal_volume

395

pub_type

杂志文章

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