Abstract：
:Omeprazole, besides suppressing gastric acid, causes delayed gastric emptying, which may be associated with aggravated dyspeptic symptoms. Effects of omeprazole on small intestinal transit are unknown. In this study, we evaluated in mice if (a) omeprazole affects transit of a meal through the stomach and small intestine and (b) co-treatment with the promotility agent, tegaserod, can prevent the slowing effect of omeprazole. Omeprazole (40-150 mg/kg, i.p. once daily for 5 days) delayed gastric emptying of the meal in a dose-related manner. Small intestinal transit was then evaluated at the lowest dose of omeprazole (40 mg/kg) that did not retard gastric emptying. Such transit was significantly delayed after this dose of omeprazole compared with vehicle-treated controls. When tegaserod (0.10 mg/kg) was administered concomitantly with the omeprazole, small intestinal transit of the meal was not slowed and was not different from controls. These results show that omeprazole reduces aboral transit of luminal contents through the stomach and small bowel of mice and that this delay is reversed by tegaserod.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Cowan A,Earnest DL,Ligozio G,Rojavin MAdoi
10.1016/j.ejphar.2005.05.041keywords:
subject
Has Abstractpub_date
2005-07-04 00:00:00pages
127-31issue
1-2eissn
0014-2999issn
1879-0712pii
S0014-2999(05)00580-7journal_volume
517pub_type
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journal_title：European journal of pharmacology
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