Abstract:
:Low levels of serotonin may reduce the density of the serotonin transporter (SERT) by either increasing trafficking or reducing synthesis; a "neuroadaptive response". To determine whether 3,4-methylenedioxymethamphetamine (MDMA)-induced reductions in SERT density could be related to such a mechanism, p-chlorophenylalanine or MDMA was administered to rats, and brain serotonin and SERT density were measured. As expected, both treatments led to serotonin depletion 1, 7 and 14 days later. However, only MDMA reduced SERT density. This observation suggests that MDMA-induced reductions in SERT density do not represent neuroadaptive responses to decreased levels of brain serotonin, but may occur in response to some other stimulus or to the neurotoxic effects of MDMA.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Boot BP,Mechan AO,McCann UD,Ricaurte GAdoi
10.1016/s0014-2999(02)02420-2keywords:
subject
Has Abstractpub_date
2002-10-25 00:00:00pages
239-44issue
2-3eissn
0014-2999issn
1879-0712pii
S0014299902024202journal_volume
453pub_type
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