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Cholecystokinin facilitates ejaculation in male rats: blockade with proglumide and apomorphine.

Abstract：

:Systemic administration of the active, sulfated form of cholecystokinin-octapeptide (CCK-8S), at a dose known to inhibit dopamine (DA) release, significantly reduced the latency to ejaculate and number of intromissions preceding ejaculation in sexually active male rats. This effect was identical to that reported for low doses of the DA receptor agonist apomorphine, which bind preferentially to presynaptic DA autoreceptors. The facilitatory effect of CCK-8S on ejaculation was blocked by the putative CCK receptor antagonist proglumide and by a presynaptic dose of apomorphine. Blockade of the effect of CCK-8S with a presynaptic dose of apomorphine is consistent with CCK induction of depolarization block in DA neurons. These data suggest that CCK-8S and apomorphine may reduce the ejaculation threshold in sexually active male rats by inhibition of DA release via two different mechanisms of action.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Pfaus JG,Phillips AG

doi

10.1016/0014-2999(87)90549-8

subject

Has Abstract

pub_date

1987-09-23 00:00:00

pages

331-8

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(87)90549-8

journal_volume

141

pub_type

杂志文章

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