当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Putrescine modulation of acute activation of the beta-adrenergic system in the left atrium of rat.

Putrescine modulation of acute activation of the beta-adrenergic system in the left atrium of rat.

Abstract：

:Endogenous polyamines mediate acute metabolic effects and cardiac hypertrophy associated to beta-adrenoceptor stimulation. The aim of this study is to characterize the role of polyamines on beta-adrenoceptor system mediated responses. To this end, the functional interaction of polyamine modifying drugs on isoproterenol-elicited cardiotonic effect, in isolated left atria of male Wistar rats, and their effects on [(3)H]dihydroalprenolol (DHA) binding on beta-adrenoceptors and on adenylyl cyclase activity of membrane heart were studied. Polyamines interact with beta-adrenoceptors in rat heart, as shown by the displacement of [(3)H]DHA binding. Furthermore, putrescine (but not spermidine or spermine) increased adenylyl cyclase activity, elicited a positive inotropism and increased intracellular cAMP. The putrescine effect on adenylyl cyclase was not antagonized by the beta-adrenoceptors blockers, alprenolol and ICI-118,551, and facilitated the isoproterenol effect. Neither alprenolol, atenolol nor ICI-118,551 antagonized putrescine-elicited positive inotropism. However, the effect was abolished in preparations with desensitized beta-adrenoceptors. alpha-Difluoromethylornithine, an inhibitor of ornithine decarboxylase, antagonized the effect of isoproterenol on inotropism and cAMP increase. In addition, putrescine might elicit effects by mechanisms independent of beta-adrenoceptor system, since in left atria with functional desensitized receptors an interaction with ouabain-elicited cardiotonic effect was observed. These results suggest that putrescine may act as a low affinity agonist on beta-adrenoceptors and modulate acute responses mediated by beta-adrenoceptors. These findings may be of importance in the physiology and in diseases involving cardiac beta-adrenoceptors.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Bordallo C,Cantabrana B,Velasco L,Secades L,Meana C,Méndez M,Bordallo J,Sánchez M

doi

10.1016/j.ejphar.2008.07.069

subject

Has Abstract

pub_date

2008-11-19 00:00:00

pages

68-74

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(08)00859-5

journal_volume

598

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Anxiolytic homophthalazines increase Fos-like immunoreactivity in selected brain areas of the rat.

    abstract：:Nerisopam, an anxiolytic and antipsychotic homophthalazine induces rapid, intense expression of Fos-like immunoreactivity in the rostral, dorsomedial and lateral parts of the striatum in the rat. Fos-positive cells also occurred in the globus pallidus, the olfactory tubercle and in the accumbens nucleus (in the cone a...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01008-x

    authors： Palkovits M,Baffi JS,Berzsenyi P,Horváth EJ

    更新日期：1997-07-16 00:00:00

  • In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.

    abstract：:The aim of the present study was to compare, in chloral-hydrate anaesthetized rats, the alpha(2)-adrenergic properties of the selective 5-HT(1A) receptor agonist, alnespirone (S-20499), with those of buspirone, a 5-HT(1A) receptor agonist exhibiting potent alpha(2)-adrenoceptor antagonist properties via its principal ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(02)02814-5

    authors： Astier B,Lambás Señas L,Soulière F,Schmitt P,Urbain N,Rentero N,Bert L,Denoroy L,Renaud B,Lesourd M,Muñoz C,Chouvet G

    更新日期：2003-01-10 00:00:00

  • Analgesic effects of cyclazocine and morphine microinjected into the rat dorsomedial hypothalamus demonstrated by the bradykinin-induced flexor reflex test.

    abstract：:The analgesic effect of cyclazocine microinjected into the diencephalon of rats was studied by using the bradykinin-induced flexor reflex test. The dorsal portion of the medial hypothalamic area was sensitive to cyclazocine with respect to the production of analgesia (ED50 2.6 micrograms/rat). Microinjections of morph...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90119-0

    authors： Kawajiri S,Satoh M

    更新日期：1985-04-23 00:00:00

  • Sigma-1 receptor stimulation with fluvoxamine activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding.

    abstract：:In the present study, we investigated the vasculoprotective effect of sigma-1 receptor stimulation with fluvoxamine on pressure overload hypertrophy-induced vascular injury in the thoracic aorta and defined mechanisms underlying that activity. Wistar rats underwent bilateral ovariectomy, and two weeks later were furth...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2010.10.055

    authors： Bhuiyan MS,Tagashira H,Fukunaga K

    更新日期：2011-01-15 00:00:00

  • Intravascular substance P dilates cerebral parenchymal vessels through a specific tachykinin NK1 receptor in cats.

    abstract：:The role of substance P in the cerebral parenchymal circulation was examined in 19 anesthetized cats. The local cerebral blood volume in the temporoparietal cortex was measured by our photoelectric method. Cerebral blood volume reflects the cumulative dimensions of the parenchymal microvessels. Intravenous injection o...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(96)00725-x

    authors： Kobari M,Tomita M,Tanahashi N,Yokoyama M,Takao M,Fukuuchi Y

    更新日期：1996-12-19 00:00:00

  • Synergistic interaction of gabapentin and oxcarbazepine in the mouse maximal electroshock seizure model--an isobolographic analysis.

    abstract：:The anticonvulsant effects produced by mixtures of oxcarbazepine and gabapentin (two second-generation antiepileptic drugs) in numerous fixed-ratio combinations of 1:1, 1:2, 1:5, 1:10, 1:15, and 1:20 were examined isobolographically in the mouse maximal electroshock seizure model. Results displayed that mixtures of bo...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.03.046

    authors： Luszczki JJ,Andres MM,Czuczwar SJ

    更新日期：2005-05-16 00:00:00

  • Pharmacological modulation of bradykinin-, acetylcholine- and calcium ionophore A23187-induced relaxation of rabbit pulmonary arterial segments.

    abstract：:Bradykinin (BK; 10(-10)-10(-7) M) relaxes phenylephrine-contracted rabbit isolated pulmonary arterial rings. The mechanical destruction of the endothelial layer obliterates acetylcholine (ACh) and A23187-induced relaxation without influencing BK-, isoproterenol-, sodium nitroprusside- and papaverine-induced relaxation...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90219-6

    authors： Chand N,Mahoney TP Jr,Diamantis W,Sofia RD

    更新日期：1987-06-04 00:00:00

  • Effects of dopamine D1 and dopamine D2 receptor agonists on coronary and peripheral hemodynamics.

    abstract：:This study evaluated the coronary dopamine receptors by using the dopamine D1 receptor agonist fenoldopam, dopamine D2 receptor agonist propylbutyldopamine, and their selective antagonists SCH23390 and domperidone. Left circumflex coronary flow (CF), coronary perfusion pressure at constant flow, left ventricular hemod...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(90)94126-i

    authors： Zhao RR,Fennell WH,Abel FL

    更新日期：1990-11-06 00:00:00

  • Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors.

    abstract：:In an in vitro model for mitogenic activity in cloned Chinese hamster ovary (CHO) cells expressing rat dopamine D2 or D3 receptors, the EC50D2/EC50D3 ratios for the agonists, apomorphine, (+)-3-hydroxy-N-n-propyl-phenylpiperidine ((+)-3-PPP), quinpirole, R-(+)-7-hydroxy-2-(di-n-propylamino)tetralin (R-(+)-7-OH-DPAT) a...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(94)90718-8

    authors： Svensson K,Carlsson A,Huff RM,Kling-Petersen T,Waters N

    更新日期：1994-10-03 00:00:00

  • Neuroprotection of taurine against reactive oxygen species is associated with inhibiting NADPH oxidases.

    abstract：:It is well established that taurine shows potent protection against glutamate-induced injury to neurons in stroke. The neuroprotection may result from multiple mechanisms. Increasing evidences suggest that NADPH oxidases (Nox), the primary source of superoxide induced by N-methyl-d-aspartate (NMDA) receptor activation...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.03.006

    authors： Han Z,Gao LY,Lin YH,Chang L,Wu HY,Luo CX,Zhu DY

    更新日期：2016-04-15 00:00:00

  • MDIMP, a novel cardiac Ca(2+) channel blocker with atrial selectivity.

    abstract：:In cardiac muscle cells both T-and L-type Ca(2+) channels (TTCCs and LTCCs, respectively) are expressed, and the latter are relevant to a process known as excitation-contraction coupling (ECC). Evidence obtained from docking studies suggests that isoindolines derived from α-amino acids bind to the LTCC CaV1.2. In the ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.04.027

    authors： Santamaria-Herrera MA,Ríos-Pérez EB,de la Rosa JA,García-Castañeda M,Osornio-Garduño DS,Ramos-Mondragón R,Mancilla-Percino T,Avila G

    更新日期：2016-06-15 00:00:00

  • Contractile actions of imidazoline alpha-adrenoceptor agonists and effects of noncompetitive alpha1-adrenoceptor antagonists in human vas deferens.

    abstract：:The contractile actions of imidazoline alpha-adrenoceptor agonists were investigated in human vas deferens longitudinal and circular muscle. The effects of phenoxybenzamine were studied in comparison to dibenamine and SZL-49 (4-amino-6,7-dimethoxy-2-quinazolinyl-4-(2-bicyclo[2,2,2]octa-2,5-dienylcarbonyl-2-piperazine)...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(03)01346-3

    authors： Amobi N,Guillebaud J,Kaisary A,Lloyd-Davies RW,Turner E,Smith IC

    更新日期：2003-02-21 00:00:00

  • Effects of brain mineralocorticoid receptor blockade on blood pressure and renal functions in DOCA-salt hypertension.

    abstract：:In normotensive rats, we have previously demonstrated a role of brain mineralocorticoid receptors in blood pressure and renal function control. In the present study, the coordinate cardiovascular and renal effects of brain mineralocorticoid receptor blockade were examined by intracerebroventricular (i.c.v.) administra...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)01586-2

    authors： Rahmouni K,Sibug RM,De Kloet ER,Barthelmebs M,Grima M,Imbs JL,De Jong W

    更新日期：2002-02-02 00:00:00

  • Pharmacological properties of homomeric and heteromeric GluR1o and GluR3o receptors.

    abstract：:Homomeric and heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunits GluR1o and GluR3o were expressed in Spodoptera frugiperda (Sf9) insect cells. Membranes containing the recombinant receptors showed a doublet of bands of the expected size (99-109 kDa) after western immunoblotting w...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00668-2

    authors： Nielsen BS,Banke TG,Schousboe A,Pickering DS

    更新日期：1998-11-06 00:00:00

  • Cannabinoid CB(1) receptor upregulation in a rat model of chronic neuropathic pain.

    abstract：:Although cannabinoids are known to be more effective analgesics against chronic rather than acute pain, the mechanism underlying this phenomenon is still unclear. We report now that contralateral thalamic cannabinoid CB(1) receptors are upregulated after unilateral axotomy of the tibial branch of the sciatic nerve, a ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)00798-1

    authors： Siegling A,Hofmann HA,Denzer D,Mauler F,De Vry J

    更新日期：2001-03-09 00:00:00

  • Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. PPARgamma regulates several metabolic pathways by binding to sequence-specific PPAR response elements in the promoter region of target genes, including lipid bi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2005.12.048

    authors： Belvisi MG,Hele DJ,Birrell MA

    更新日期：2006-03-08 00:00:00

  • Quantitative autoradiography of [3H]piquindone binding sites (dopamine D2 receptors) in rat brain.

    abstract：:(-)Piquindone is a new antipsychotic pyrroloisoquinoline derivative that binds to dopamine D2 receptors. We used in vitro quantitative autoradiography to determine the distribution of [3H](-)piquindone binding sites in rat forebrain. [3H](-)Piquindone binding to brain slices was sodium dependent, saturable and of high...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(86)90259-1

    authors： Nock B,Sedvall G,Mcewen BS

    更新日期：1986-03-04 00:00:00

  • Augmentation with a 5-HT(1A), but not a 5-HT(1B) receptor antagonist critically depends on the dose of citalopram.

    abstract：:Pharmacokinetic and pharmacodynamic parameters of the selective serotonin reuptake inhibitor 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-5-phtalancarbonitril (citalopram) were determined in order to find optimal conditions for augmentation of its effect on extracellular serotonin [5-hydroxytryptamine (5-HT)] through ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00247-8

    authors： Cremers TI,de Boer P,Liao Y,Bosker FJ,den Boer JA,Westerink BH,Wikström HV

    更新日期：2000-05-26 00:00:00

  • Decreased levels of preprotachykinin-A and tachykinin NK1 receptor mRNA in specific region of the rat striatum after electroconvulsive stimuli.

    abstract：:The effects of electroconvulsive stimuli on the expression of mRNAs coding for preprotachykinin-A and the substance P-sensitive tachykinin NK1 receptor were examined in subregions of the rat striatum. In the electroconvulsive stimuli-treated animals, a 43% decrease in preprotachykinin-A mRNA was detected in the dorso-...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(96)00861-8

    authors： Zachrisson O,Mathé AA,Lindefors N

    更新日期：1997-01-29 00:00:00

  • ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes.

    abstract：:N-[3-(1H-Imidazol-4-ylmethyl)phenyl]ethanesulfonamide, maleate (ABT-866) is a novel alpha(1)-adrenoceptor agent with mixed pharmacological properties in vitro. Compared to phenylephrine, ABT-866 demonstrates intrinsic activity at the alpha(1A)-adrenoceptor subtype present in the rabbit urethra (pD(2) = 6.22, with 80% ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(02)01976-3

    authors： Buckner SA,Milicic I,Daza AV,Meyer MD,Altenbach RJ,Williams M,Sullivan JP,Brioni JD

    更新日期：2002-08-02 00:00:00

  • Prulifloxacin: in vitro (HERG current) and in vivo (conscious dog) assessment of cardiac risk.

    abstract：:Prulifloxacin, a new thiazeto-quinoline derivative with antibiotic properties, was evaluated for cardiac risk both in vitro on the ether-à-go-go-related gene (HERG) K+ channel, and in vivo in the conscious dog monitored by telemetry. HERG current was measured from stably transfected human embryonic kidney (HEK) 293 ce...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(03)02180-0

    authors： Lacroix P,Crumb WJ,Durando L,Ciottoli GB

    更新日期：2003-09-05 00:00:00

  • Central injection of CDP-choline suppresses serum ghrelin levels while increasing serum leptin levels in rats.

    abstract：:In this study we aimed to test central administration of CDP-choline on serum ghrelin, leptin, glucose and corticosterone levels in rats. Intracerebroventricular (i.c.v.) 0.5, 1.0 and 2.0 µmol CDP-choline and saline were administered to male Wistar-Albino rats. For the measurement of serum leptin and ghrelin levels, b...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2015.07.014

    authors： Kiyici S,Basaran NF,Cavun S,Savci V

    更新日期：2015-10-05 00:00:00

  • Mechanisms underlying ATP-induced endothelium-dependent contractions in the SHR aorta.

    abstract：:In mature spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats, acetylcholine, the calcium ionophore A 23187 and ATP release endothelium-derived contracting factor (EDCF), cyclooxygenase (COX) derivatives that activate thromboxane-endoperoxide (TP) receptors on vascular smooth muscle. The EDCFs released by ace...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2006.10.050

    authors： Gluais P,Vanhoutte PM,Félétou M

    更新日期：2007-02-05 00:00:00

  • Influence of psychotomimetics and lisuride on synaptosomal dopamine release in the nucleus accumbens of rats.

    abstract：:In superfusion experiments with a crude synaptosomal fraction from the nucleus accumbens of rats, lysergic acid diethylamide, mescaline and N,N-dimethyltryptamine (representing different chemical classes of psychotomimetics) produced a concentration-related inhibition of K+-evoked [3H]dopamine release whereas spontane...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(83)90140-1

    authors： Hetey L,Schwitzkowsky R,Oelssner W

    更新日期：1983-09-30 00:00:00

  • Mechanism of osthole inhibition of vascular Ca(v)1.2 current.

    abstract：:Osthole is a coumarin extracted from Cnidium monnieri (L.) Cusson. The medicinal plant is widely used in Vietnamese as well as Chinese traditional medicine as a vasodilating and antihypertensive agent. Here we have tested the proposition that the block of Ca(v)1.2 channels is mainly responsible for its vascular activi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2012.01.038

    authors： Fusi F,Sgaragli G,Ha le M,Cuong NM,Saponara S

    更新日期：2012-04-05 00:00:00

  • Comparison of caffeine-induced locomotor activity between adolescent and adult rats.

    abstract：:Caffeine is the psychostimulant drug most consumed in the world. This drug is present in food, beverages and medicines marketed for individuals of all ages. In spite of this, caffeine effects on adolescents are poorly understood. The aim of this study was to evaluate the differences on caffeine-induced locomotor stimu...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2011.03.052

    authors： Marin MT,Zancheta R,Paro AH,Possi AP,Cruz FC,Planeta CS

    更新日期：2011-06-25 00:00:00

  • [125I]thienylphencyclidine, a novel ligand for the NMDA receptor.

    abstract：:We have monitored the binding of [125I]thienylphencyclidine ([125I]TCP), a novel high affinity radioiodinated ligand that specifically recognizes the NMDA (N-methyl-D-aspartate) receptor in rat brain membranes. [125I]TCP binds with an affinity of about 30 nM, and recognizes a similar number of binding sites to previou...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(92)90082-7

    authors： Reynolds IJ,Rothermund K,Rajdev S,Fauq AH,Kozikowski AP

    更新日期：1992-05-12 00:00:00

  • Resveratrol attenuates high fat diet-induced mouse cardiomyopathy through upregulation of estrogen related receptor-α.

    abstract：:Resveratrol reportedly promotes the improvement of cardiac dysfunction and other cardiovascular diseases. Studies demonstrate resveratrol exhibits a set of benefits, including anti-oxidative property, anti-apoptosis and anti-inflammation. However, the molecular mediators of resveratrol-induced cardiac benefits are sti...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2018.10.018

    authors： Lu Y,Lu X,Wang L,Yang W

    更新日期：2019-01-15 00:00:00

  • Comparative effects of four migraine prophylactic drugs on an isolated extracranial artery.

    abstract：:Clonidine and methysergide constrict the rabbit auricular artery by activating smooth muscle alpha-adrenoceptors. Clonidine inhibits and methysergide enhances responses to stimulation of the sympathetic nerves. Both drugs sensitise the artery to a variety of vasoconstrictor stimuli, although not to potassium chloride....

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(76)90264-8

    authors： Fozard JR

    更新日期：1976-03-01 00:00:00

  • Relaxant influence of phosphodiesterase inhibitors in the cat gastric fundus.

    abstract：:The breakdown of the relaxation-inducing second messengers cAMP and cGMP is mediated by phosphodiesterases. Inhibitors of functionally present phosphodiesterases can be expected to induce relaxation by increasing the basic amount of cAMP and/or cGMP. In the cat gastric fundus, vinpocetine, which has some selectivity f...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(95)00009-a

    authors： Barbier AJ,Lefebvre RA

    更新日期：1995-03-24 00:00:00