Decreased levels of preprotachykinin-A and tachykinin NK1 receptor mRNA in specific region of the rat striatum after electroconvulsive stimuli.

abstract：:Edaravone is a potent scavenger of hydroxyl radicals and attenuates oxidative damage-related neurodegenerative diseases. Previous studies suggest that oxidative stress plays a key role in the pathogenesis of diabetes. The present study examined the effect of edaravone on diabetes in multiple low-dose streptozotocin-tr...

journal_title：European journal of pharmacology

authors： Fukudome D,Matsuda M,Kawasaki T,Ago Y,Matsuda T

更新日期：2008-03-31 00:00:00

abstract：:Antiarrhythmic drugs have been considered to be transported by the organic cation transport system. The purpose of this study was to elucidate the molecular mechanism underlying the transport of antiarrhythmic drugs using cells from the second segment of the proximal tubule (S2) cells of mice expressing human-organic ...

journal_title：European journal of pharmacology

authors： Hasannejad H,Takeda M,Narikawa S,Huang XL,Enomoto A,Taki K,Niwa T,Jung SH,Onozato ML,Tojo A,Endou H

更新日期：2004-09-19 00:00:00

abstract：:Prostaglandin E2 increases bradykinin-induced spike activity from polymodal nociceptors of the skin and deep tissues in animals, suggesting sensitization of these receptors. To see whether these neurophysiological observations in animals correspond with increased pain intensity in humans, and whether also vascular noc...

journal_title：European journal of pharmacology

authors： Kindgen-Milles D

更新日期：1995-12-29 00:00:00

abstract：:Type 2 diabetes is increasing at epidemic proportions throughout the world, and diabetic nephropathy is the principal cause of end stage renal failure. Approximately 40% of patients with type 2 diabetes may progress to nephropathy and a good metabolic control can prevent the development of diabetic renal injury. The a...

journal_title：European journal of pharmacology

authors： Louro TM,Matafome PN,Nunes EC,da Cunha FX,Seiça RM

更新日期：2011-02-25 00:00:00

abstract：:We have investigated the effect of 2(4-((2-carboxymethyl)phenyl)ethylamino)-5'-N-ethylcarboxamidoadenosine (CGS 21680), a potent and selective agonist at adenosine A2A receptors, on pulmonary inflammation induced by allergen challenge in the ovalbumin-sensitised, Brown Norway rat. Aerosol administration of ovalbumin (...

journal_title：European journal of pharmacology

authors： Fozard JR,Ellis KM,Villela Dantas MF,Tigani B,Mazzoni L

更新日期：2002-03-08 00:00:00

abstract：:Chronic lithium treatment was examined for effects on the blood pressure of spontaneously hypertensive rats (SHRs). Treated rats were allowed continuous access to a pelleted lithium diet (1.7 g LiCl (40 mmol)/kg diet) for 21 days. Control SHRs were fed a similar diet lacking the lithium. Two groups of control rats wer...

journal_title：European journal of pharmacology

authors： Koda LY,Shoemaker WJ,Baetge G,Bloom FE

更新日期：1981-12-17 00:00:00

abstract：:Stimulation of [35S]GTPgammaS binding by serotonin (5-hydroxytryptamine, 5-HT) receptor ligands was characterized in rat hippocampal membranes. The optimized assay contained 30-50 microg protein, 300 microM GDP and 0.1 nM [35S]GTPgammaS, incubated at 37 degrees C for 20 min. At 10 microM, the 5-HT1A receptor agonist R...

journal_title：European journal of pharmacology

authors： Alper RH,Nelson DL

更新日期：1998-02-19 00:00:00

abstract：:Kisspeptin (KP), the endogenous ligand of GPR54, is a mammalian amidated neurohormone, which belongs to the RF-amide peptide family. However, in contrast with the related members of the RF-amide family, little information is available regarding its role in the gastrointestinal motility. With regard to the recent data ...

journal_title：European journal of pharmacology

authors： Jiang J,Jin W,Peng Y,He Z,Wei L,Li S,Wang X,Chang M,Wang R

更新日期：2017-01-05 00:00:00

abstract：:Multiple myeloma is an incurable hematological malignancy. Different studies demonstrated the occurrence of genetic and epigenetic alterations in multiple myeloma. Histone lysine methylation has emerged as a central epigenetic change in the organization of eukaryotic chromatin with far-reaching implications for the re...

journal_title：European journal of pharmacology

authors： Zhao F,Chen Y,Zeng L,Li R,Zeng R,Wen L,Liu Y,Zhang C

更新日期：2010-11-10 00:00:00

abstract：:The anti-ulcer activity of calcitonin gene-related peptide (CGRP) was inhibited, in a dose-dependent manner, by pretreatment with NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase. Our results suggest that endogenous nitric oxide is involved in the anti-ulcer activity of CGRP. ...

journal_title：European journal of pharmacology

authors： Clementi G,Caruso A,Prato A,De Bernardis E,Fiore CE,Amico-Roxas M

更新日期：1994-04-21 00:00:00

abstract：:Nitric oxide (NO) is continuously produced in the lung and can be measured in exhaled gas of different species. To investigate a possible neuro-humoral regulation of pulmonary NO production in vivo we injected veratrine, an activator of Na(+) channels known to activate the sympathoadrenal system, in anaesthetized, mec...

journal_title：European journal of pharmacology

authors： Adding LC,Agvald P,Artlich A,Gustafsson LE

更新日期：2001-01-12 00:00:00

abstract：:Two splice variants of the pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor (PACAP receptor and PACAP/HOP receptor isoform) were stably expressed in Chinese hamster ovary (CHO) cells that did not express constitutively receptors for this family of peptides. The PACAP/HOP receptor protein had ...

journal_title：European journal of pharmacology

authors： Ciccarelli E,Svoboda M,De Neef P,Di Paolo E,Bollen A,Dubeaux C,Vilardaga JP,Waelbroeck M,Robberecht P

更新日期：1995-02-15 00:00:00

abstract：:This study shows that in spontaneously hypertensive rats (SHR) of 14-weeks-old, the sympathetically-induced, but not noradrenaline-induced tachycardic response are higher than age-matched Wistar normotensive rats. Furthermore, in SHR the sympathetically-induced tachycardic response was: (1) unaffected by moxonidine (3...

journal_title：European journal of pharmacology

authors： Cobos-Puc LE,Sánchez-López A,Centurión D

更新日期：2016-11-15 00:00:00

abstract：:Histogranin, was co-purified with bombesin-like immunoreactive peptides from bovine adrenal medulla. Its structure, H-Met-Asn-Tyr-Ala-Leu-Lys-Gly-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-COOH, was determined by gas-phase Edman degradation. It was in accordance with its amino acid composition and corresponded to a 15 amino acid...

journal_title：European journal of pharmacology

authors： Lemaire S,Shukla VK,Rogers C,Ibrahim IH,Lapierre C,Parent P,Dumont M

更新日期：1993-05-15 00:00:00

abstract：:The uptake and release of 3H-dopamine was studied in slices of corpus striatum and substantia nigra in the presence of nialamide. High potassium triggered the outflow of tritium in both brain structures and this release was potentiated by GABA in a dose related fashion, whereas the spontaneous overflow of radioactivit...

journal_title：European journal of pharmacology

authors： Starr MS

更新日期：1979-01-15 00:00:00

abstract：:We investigated whether estrogen protects the ischemic myocardium in oophorectomized female rabbits fed with a cholesterol-enriched diet, whether the addition of a progestin compound attenuates the beneficial effect of estrogen and whether raloxifene also limits myocardial necrosis. We treated 32 female oophorectomize...

journal_title：European journal of pharmacology

authors： Sbarouni E,Iliodromitis EK,Bofilis E,Kyriakides ZS,Kremastinos DT

更新日期：2003-04-25 00:00:00

abstract：:Inhibition of intrathecal substance P-elicited behavior by mu-, delta- and kappa-opioids was compared. In both the substance P behavioral test and the tail flick antinociceptive test, intrathecal [D-Ala2, Met5]enkephalinamide and [D-Ala2, D-Leu5]enkephalin (DADL) were equipotent, morphine and ethylketazocine were less...

journal_title：European journal of pharmacology

authors： Hylden JL,Wilcox GL

更新日期：1982-12-17 00:00:00

abstract：:The pharmacological nature of nicotine-induced contraction in the rat basilar artery is poorly understood. The purpose of this study was to investigate the endothelium dependency and involvement of arachidonic acid metabolites in nicotine-induced contraction in the rat basilar artery. The rat basilar artery was remove...

journal_title：European journal of pharmacology

authors： Ji X,Nishihashi T,Trandafir CC,Wang A,Shimizu Y,Kurahashi K

更新日期：2007-12-22 00:00:00

abstract：:The mechanism by which dibutyryl cyclic AMP (db-cAMP) induces vasodilatation was examined in isolated rat aorta. The contraction induced by norepinephrine (NE) was more sensitive to the inhibitory effect of db-cAMP than that induced by high K+, and the contraction induced by lower concentrations of each stimulant was ...

journal_title：European journal of pharmacology

authors： Abe A,Karaki H

更新日期：1992-02-18 00:00:00

abstract：:Osteoporosis is a reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation. Therefore, components involved in BMP activation are good targets for the development of anti-osteoporo...

journal_title：European journal of pharmacology

authors： Tang CH,Yang RS,Chien MY,Chen CC,Fu WM

更新日期：2008-01-28 00:00:00

abstract：:We studied the effects of inhaled formoterol (0.75 mg/ml, 60 breaths = 26 micrograms), a long-acting beta 2-adrenoceptor agonist, or of the more short-acting drug, salbutamol (25 mg/ml, 60 breaths = 875 micrograms), on acute airflow obstruction and airway microvascular leakage (MVL) induced by inhaled histamine in ane...

journal_title：European journal of pharmacology

authors： Tokuyama K,Lötvall JO,Löfdahl CG,Barnes PJ,Chung KF

更新日期：1991-01-25 00:00:00

abstract：:Intracellular accumulation of Mn2+ augmented the contractions induced by norepinephrine and acetylcholine in the guinea pig isolated vas deferens. Contractions repeatedly induced by norepinephrine, acetylcholine, or a high concentration of K+ decreased depending on the incubation time in Ca(2+)-free medium. The rate o...

journal_title：European journal of pharmacology

authors： Tsunobuchi-Ushijima H,Gomi Y

更新日期：1996-01-11 00:00:00

abstract：:In rats, tolerance to the analgesic effect of intraventricular substance P (SP) develops quickly. In rats made tolerant to [D-Ala2, D-Leu5]enkephalin the analgesic efficacy of SP is reduced significantly. The latter result suggests some overlap in the sites of action of SP and [D-Ala2,D-Leu5] enkephalin. Since SP seem...

journal_title：European journal of pharmacology

authors： Naranjo JR,Fernandez-Tome MP,Del Rio J

更新日期：1984-02-10 00:00:00

abstract：:Recently, it has been shown that release of cytochrome c from the mitochondria to the cytosol is required for activation of the caspase-3-dependent cascade in apoptosis, and also for alpha-synuclein aggregation. In the present study, we examined the effects of talipexole and pramipexole on the release of cytochrome c ...

journal_title：European journal of pharmacology

authors： Kakimura J,Kitamura Y,Takata K,Kohno Y,Nomura Y,Taniguchi T

更新日期：2001-04-06 00:00:00

abstract：:The present study aimed to determine whether nefiracetam, N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide, a cognition enhancer, has an effect on learning and memory function in sustained cerebral ischemia, and whether the effect, if any, may accompany modification of the cholinergic or gamma-aminobutyric ac...

journal_title：European journal of pharmacology

authors： Fukatsu T,Miyake-Takagi K,Nagakura A,Omino K,Okuyama N,Ando T,Takagi N,Furuya Y,Takeo S

更新日期：2002-10-18 00:00:00

abstract：:Extracellular diadenosine polyphosphates (ApnA) are recently considered as an endogenous signaling compounds with transmitter-like activity which present in numerous tissues, including heart. It has been demonstrated previously that extracellular ApnA cause alteration of the heart functioning via purine receptors in d...

journal_title：European journal of pharmacology

authors： Pakhomov N,Pustovit K,Potekhina V,Filatova T,Kuzmin V,Abramochkin D

更新日期：2018-02-05 00:00:00

abstract：:The effects of intracisternal injections of [Lys8]vasopressin and [Arg8]vasopressin (25, 50, 100, 200 mU/kg) and related compounds oxytocin (25, 50, 100, 200 mU/kg), felypressin (25, 50, 100, 200 mU/kg) and vasotocin (100, 200, 400, 800 ng/kg) on the acute neurogenic pressor responses to afferent vagal stimulation (5,...

journal_title：European journal of pharmacology

authors： Montastruc P,Dang Tran L,Montastruc JL

更新日期：1985-11-19 00:00:00

abstract：:The possibility of a role of hypothalamic growth hormone (GH)-releasing factor (GRF) in GH secretion induced by centrally administered galanin was investigated in freely moving male rats. Intracerebroventricular (i.c.v.) injection of synthetic galanin (0.4 or 2 micrograms/rat) elicited a dose-related increase in plasm...

journal_title：European journal of pharmacology

authors： Murakami Y,Kato Y,Koshiyama H,Inoue T,Yanaihara N,Imura H

更新日期：1987-04-29 00:00:00

abstract：:Capsaicin (1-3 microM) and electrical stimulation of mesenteric nerves in the presence of hexamethonium and guanethidine antidromically stimulate extrinsic sensory nerve fibers to produce a specific slow depolarizing response of myenteric neurons and a contractile response of muscles in the isolated guinea-pig ileum, ...

journal_title：European journal of pharmacology

authors： Takaki M,Namba T,Fujii W,Suga H

更新日期：1993-06-11 00:00:00

abstract：:Oenanthotoxin (OETX) and dihydro-OETX are polyacetylenic diols occurring in Oenanthe crocata and are known to exert proconvulsant effects. We have recently demonstrated that these compounds downregulated GABAergic currents (Appendino et al., 2009) and that OETX induced open channel block and allosterically modulated G...

journal_title：European journal of pharmacology

authors： Wyrembek P,Negri R,Appendino G,Mozrzymas JW

更新日期：2012-05-15 00:00:00