Galanin stimulates growth hormone (GH) secretion via GH-releasing factor (GRF) in conscious rats.

abstract：:The protective potency of ischemic preconditioning decreases with increasing age. A key step in ischemic preconditioning is the opening of mitochondrial Ca(2+) sensitive K(+) (mK(Ca)) channels, which causes mild uncoupling of mitochondrial respiration. We hypothesized that aging reduces the effects of mK(Ca) channel o...

journal_title：European journal of pharmacology

authors： Heinen A,Winning A,Schlack W,Hollmann MW,Preckel B,Frässdorf J,Weber NC

更新日期：2008-01-14 00:00:00

abstract：:The corticotropin releasing factor (CRF) family includes CRF and urocortin. The effects of urocortin and CRF (0.3, 1, 3 and 10 nmol/kg, i.v.) relative to those of vehicle (0.9% NaCl) on mean arterial pressure and mean circulatory filling pressure (index of venous tone) were examined in conscious, unrestrained rats tha...

journal_title：European journal of pharmacology

authors： Abdelrahman AM,Lin Lim S,Pang CC

更新日期：2005-03-07 00:00:00

abstract：:Using the curve-shift method, we studied the effects of four doses (0.003, 0.03, 0.3 and 3 mg/kg, s.c.) of granisetron (endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3- carboxamide hydrochloride), a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, on the potentiation of brain stimulatio...

journal_title：European journal of pharmacology

authors： Rompré PP,Injoyan R,Hagan JJ

更新日期：1995-12-20 00:00:00

abstract：:The competitive reversible beta-adrenoceptor antagonist activity of Ro 03-5255 [1-(5-acetylaminobenzfuran-2-yl)-2-isopropylaminoethanol] upon isoprenaline-induced increases of the rate and tension of guinea-pig isolated atria is described. The chlorinated derivative [Ro 03-7894; 1-[5-chloracetylaminobenzfuran-2-yl)-2-...

journal_title：European journal of pharmacology

authors： Nicholson CD,Broadley KJ

更新日期：1978-12-01 00:00:00

abstract：:Apoptosis has received widespread attention for its essential roles in biology, medicine and cancer. We previously found that normal, human papillomavirus (HPV) 16-immortalized and their transformed endocervical cells were increasingly resistant to apoptosis induced by a cancer therapeutic drug. Here, analogously, ano...

journal_title：European journal of pharmacology

authors： Mo B,Pater A

更新日期：2003-04-25 00:00:00

abstract：:The aim of the present investigation was to assess neuroprotection exerted by diazepam (0.1-25 microM) in rat cortical brain slices subjected to oxygen-glucose deprivation and reoxygenation. Neuronal injury and neuroprotection were assessed by measuring the release of glutamate and lactate dehydrogenase and tissue wat...

journal_title：European journal of pharmacology

authors： Ricci L,Valoti M,Sgaragli G,Frosini M

更新日期：2007-04-30 00:00:00

abstract：:Thapsigargin (TG), an inhibitor of Ca(2+) ATPase pumps in the endoplasmic reticulum (ER), inhibits replication of human vascular smooth muscle cell (hVSMC) at low nM concentrations. TG blocks replication of other cell types through promotion of ER stress (ERS). In order to determine whether ERS may mediate the cytosta...

journal_title：European journal of pharmacology

authors： Shukla N,Wan S,Angelini GD,Jeremy JY

更新日期：2013-08-15 00:00:00

abstract：:The aim of this study was to determine the effect of ethanol on cell cycle events during the G(1) and S phases in cultured vascular smooth muscle cells (VSMC). Flow cytometric analysis for the DNA content in rat aortic VSMC indicated that following ethanol treatment, the cell population in the G(0)/G(1) phase increase...

journal_title：European journal of pharmacology

authors： Sayeed S,Cullen JP,Coppage M,Sitzmann JV,Redmond EM

更新日期：2002-06-12 00:00:00

abstract：:Longitudinal organ bath preparations of the rat duodenum, jejunum and ileum were tested for their responsiveness to GABA-receptor agonists. The GABAA-receptor agonists, GABA and 3APS, induced non-adrenergic, non-cholinergic relaxations and/or contractions, although the magnitude and type of response varied depending u...

journal_title：European journal of pharmacology

authors： Krantis A,Harding RK

更新日期：1987-09-11 00:00:00

abstract：:Mouse gastric fundus strips were relaxed by ultraviolet light (UV) irradiation, exogenous nitric oxide (NO), isoproterenol, S-nitrosoglutathione, S-nitroso-L-cysteine and S-nitroso-N-acetyl-penicillamine. Glutathione did not affect relaxations in response to UV irradiation, exogenous NO and isoproterenol while inhibit...

journal_title：European journal of pharmacology

authors： Ogülener N,Ergün Y

更新日期：2002-08-30 00:00:00

abstract：:Agonists of adenosine A1 receptors have been frequently proposed as candidates for clinical development in treatment of cerebral ischemia and stroke. Numerous experimental studies have shown that pre- and postischemic administration of these drugs results in a very significant reduction of postischemic brain damage. H...

journal_title：European journal of pharmacology

authors： Von Lubitz DK,Beenhakker M,Lin RC,Carter MF,Paul IA,Bischofberger N,Jacobson KA

更新日期：1996-04-29 00:00:00

abstract：:We have investigated the cardiac and pressor responses to (±)-ephedrine and (-)-ephedrine in pentobarbitone anaesthetized male wistar rats. The tachycardiac responses to (±)- and (-)-ephedrine were similar, but pressor responses to (-)-ephedrine (10 mg/kg) were significantly greater than those to (±)-ephedrine, and fo...

journal_title：European journal of pharmacology

authors： Alsufyani HA,Docherty JR

更新日期：2018-04-15 00:00:00

abstract：:Endothelial differentiation gene (EDG) receptors are a new family of eight G protein-coupled receptors for the lysophospholipids lysophosphatitic acid and sphingosine-1-phosphate. In the present experiments, the expression of EDG receptors in rat and human alveolar macrophages was studied by reverse transcription-poly...

journal_title：European journal of pharmacology

authors： Hornuss C,Hammermann R,Fuhrmann M,Juergens UR,Racké K

更新日期：2001-10-19 00:00:00

abstract：:Studies were designed to examine the influence of endothelin type A receptor (ETA) blockade on the hypertensive and renal response to 4 day treatment with the nitric oxide (NO) synthase inhibitor, L-nitroarginine methyl ester (L-NAME), and cyclosporine. In the first series of experiments, male Sprague-Dawley rats main...

journal_title：European journal of pharmacology

authors： Pollock DM,Polakowski JS,Opgenorth TJ,Pollock JS

更新日期：1998-04-03 00:00:00

abstract：:The present study was carried out to investigate the possibility that noradrenaline (NA) and neuropeptide Y (NPY) are co-released after afferent vagal or saphenous stimulation (1, 5, 10 and 20 Hz) in chloralose-anaesthetized dogs. Electrical stimulation of the vagus elicited an increase in plasma NA levels for the 5, ...

journal_title：European journal of pharmacology

authors： Montastruc P,Damase-Michel C,Tavernier G,Tran MA,Montastruc JL

更新日期：1992-03-17 00:00:00

abstract：:Co-dergocrine (Hydergine), an ergot preparation composed of four dihydrogenated peptide ergot alkaloids (dihydroergocornine, dihydroergocristine, dihydro-alpha-ergokryptine, dihydro-beta-ergokryptine, 3:3:2:1), has been reported to exert in vivo effects suggesting an interaction with dopaminergic systems. The present ...

journal_title：European journal of pharmacology

authors： Markstein R

更新日期：1982-12-24 00:00:00

abstract：:In cats anaesthetized with chloralose--urethane (70/100 mg/kg) a somato-sympathetic reflex increase of blood pressure and heart rate was evoked by electrical stimulation of sensory fibres running within the tibial nerve. I.V. injection of 30 microgram/kg of the alpha-adrenoceptor agonist clonidine caused a reflex inhi...

journal_title：European journal of pharmacology

authors： Walland A

更新日期：1978-01-15 00:00:00

abstract：:The effects of intraperitoneal injections of two opioid antagonists on plasma corticosterone levels in stressed mice was investigated. The effects of the mu-opioid receptor antagonist naloxone was dependent on the dose used. Low doses (0.5 and 1 mg/kg) potentiated the elevation of plasma corticosterone observed in sal...

journal_title：European journal of pharmacology

authors： Kitchen I,Rowan KM

更新日期：1984-05-18 00:00:00

abstract：:Androgens relax several smooth muscles, including the airways. They also contract ileum and myocardium via nongenomic mechanisms. To find out whether androgens modulate airway smooth muscles in different species and further assess their mechanism of action, regarding the role of beta-adrenoceptors, polyamines and extr...

journal_title：European journal of pharmacology

authors： Bordallo J,de Boto MJ,Meana C,Velasco L,Bordallo C,Suárez L,Cantabrana B,Sánchez M

更新日期：2008-12-28 00:00:00

abstract：:The effects of FG5893 were evaluated by several different methods; rats were used as experimental animals. Receptor binding studies revealed that FG5893 (2-(4-(4,4-bis(4-fluorophenyl)butyl)-1-piperazinyl)-3-pyridinecarboxy lic acid methyl ester) binds with high affinity to both 5-HT1A (Ki = 0.7 nM) and 5-HT2A receptor...

journal_title：European journal of pharmacology

authors： Albinsson A,Björk A,Svartengren J,Klint T,Andersson G

更新日期：1994-08-22 00:00:00

abstract：:Cynaropicrin, a sesquiterpene lactone from Saussurea lappa, has been reported to possess immunomodulatory effects on cytokine release, nitric oxide production and immunosuppressive effects. In this study, we have examined cytotoxic effect of cynaropicrin against several types of cell lines such as macrophages, eosinop...

journal_title：European journal of pharmacology

authors： Cho JY,Kim AR,Jung JH,Chun T,Rhee MH,Yoo ES

更新日期：2004-05-25 00:00:00

abstract：:The distribution of P2-purinoceptors in pre-capillary resistance vessels was studied in vitro, using Krebs perfused rabbit ears and in vivo, in autoperfused hindquarters, intestinal and renal vasculatures of pentobarbitone anaesthetised cats. ATP (10(-10)-10(-6) mol i.a.) caused dose-dependent vasodilatation which, in...

journal_title：European journal of pharmacology

authors： Taylor EM,Parsons ME,Wright PW,Pipkin MA,Howson W

更新日期：1989-02-28 00:00:00

abstract：:Previous studies have shown that sertindole (1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl ]-2 imidazolidinone), an atypical antipsychotic drug that is a potent 5-HT2A and dopamine D2 receptor antagonist, preferentially affects mesocorticolimbic rather than mesostriatal dopamine neurons. Usin...

journal_title：European journal of pharmacology

authors： Watanabe M,Hagino Y

更新日期：1999-02-12 00:00:00

abstract：:More recently, arsenic trioxide (ATO), was integrated into acute promyelocytic leukemia (APL) treatment, showing high efficacy and tolerability in patients with both ATRA-sensitive and ATRA-resistant APL. ATO could induce apoptosis at relatively high concentrations (0.5 to 2.0 micromol/L) and partial differentiation a...

journal_title：European journal of pharmacology

authors： Safa M,Mousavizadeh K,Noori S,Pourfathollah A,Zand H

更新日期：2014-08-05 00:00:00

abstract：:Two reserpine dosage schedules were applied to Wistar rats (a) 5 mg/kg i.p. 6 hr before sacrifice and (b) 5 mg/kg i.p. at 36, 24 and 12 hr prior to sacrifice. Control animals were correspondingly sham-injected. The coeliac-mesenteric ganglion complex was removed and processed either for the Falck-Hillarp fluorescence ...

journal_title：European journal of pharmacology

authors： Lever JD,Presley R,Santer RM,Lu KS

更新日期：1975-12-01 00:00:00

abstract：:Effects of histamine receptor ligands on the glibenclamide-sensitive K+ currents induced by K+ channel openers, cromakalim and Y-26763, were examined in follicle-enclosed Xenopus oocytes. Histamine H1 receptor antagonists, promethazine, dimethindene and chlorpheniramine all decreased cromakalim-induced K+ currents wit...

journal_title：European journal of pharmacology

authors： Sakuta H

更新日期：1994-01-01 00:00:00

abstract：:The administration of morphine and fentanyl by continuous intravenous infusion has been shown to produce analgesic tolerance and physical dependence in human neonates. In animals, daily repeated morphine bolus injections is a common method of inducing neonatal rat tolerance and dependence. Yet this method differs from...

journal_title：European journal of pharmacology

authors： Thornton SR,Wang AF,Smith FL

更新日期：1997-12-11 00:00:00

abstract：:We hypothesized that uncompetitive NMDA glutamate receptor antagonists memantine (2,5-dimethyl-1-adamantanamine), and amino-alkyl-cyclohexane compounds: MRZ 2/579 (1-amino-1,3,3,5,5-pentamethylcyclohexane HCl), MRZ 2/600 (1-amino-1-ethyl-3,3,5,5-tetramethylcyclohexane HCl), and MRZ 2/615 (1-amino-1,3,5,5-tetramethyl-3...

journal_title：European journal of pharmacology

authors： Fourie J,Escobar MR,Sitar DS

更新日期：2002-09-27 00:00:00

abstract：:The comparative dromotropic activity of timolol (TML) and propranolol (PPL) was studied by means of His bundle electrograms in two groups of pentobarbital-anesthetized dogs: group I, 7 non-atropinized dogs; group II, 8 atropinized dogs. beta-Blocking agents were injected in 4 cumulative doses in each dog at 3 days' in...

journal_title：European journal of pharmacology

authors： Jaillon P,Heckle J,Weissenburger J,Cheymol G

更新日期：1978-01-15 00:00:00

abstract：:The adenosine-receptor modulation of noradrenaline release was compared in prostatic and epididymal portions of rat vas deferens. In both portions, tritium overflow elicited by electrical stimulation (100 pulses/8 Hz) was reduced by the adenosine A(1) receptor agonist, N(6)-cyclopentyladenosine, and enhanced by the no...

journal_title：European journal of pharmacology

authors： Queiroz G,Diniz C,Gonçalves J

更新日期：2002-07-12 00:00:00