Abstract:
:Agonists of adenosine A1 receptors have been frequently proposed as candidates for clinical development in treatment of cerebral ischemia and stroke. Numerous experimental studies have shown that pre- and postischemic administration of these drugs results in a very significant reduction of postischemic brain damage. However, only a few studies determined the impact of cerebral ischemia and drug treatment on postischemic recovery of spatial memory. The present paper demonstrates that preischemic i.p. administration of adenosine amine congener (ADAC) at 100 micrograms/kg in gerbils results in a significant (P < 0.05) reduction of postischemic mortality and hippocampal, cortical and striatal morbidity. Postischemic Morris' water maze tests show that preischemic treatment with ADAC also leads to a very significant (P < 0.001) reduction of postischemic spatial memory loss. Our results indicate feasibility of further consideration of adenosine A1 receptor agonists as a clinically applicable acute treatment of brain ischemia. Recent development of neuroprotective adenosine A1 receptor agonists that are free of cardiovascular side effects supports such development.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Von Lubitz DK,Beenhakker M,Lin RC,Carter MF,Paul IA,Bischofberger N,Jacobson KAdoi
10.1016/0014-2999(96)00101-xsubject
Has Abstractpub_date
1996-04-29 00:00:00pages
43-8issue
1-3eissn
0014-2999issn
1879-0712pii
0014-2999(96)00101-Xjournal_volume
302pub_type
杂志文章abstract::Statins are the most common type of medicine used to treat hypercholesterolemia; however, they are associated with a low incidence of myotoxicity such as myopathy and rhabdomyolysis. The mechanisms for the adverse effects remain to be fully elucidated for safer chronic use and drug development. The results of our earl...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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