当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells.

Intradermal application of nociceptin increases vascular permeability in rats: the possible involvement of histamine release from mast cells.

Abstract：

:Intradermal application of nociceptin was used to investigate its in vivo effect on the inflammatory response in rats. Intradermal nociceptin (5 pmol/site-5 nmol/site) increased vascular permeability in a dose-dependent manner. The increased vascular permeability by nociceptin (5 nmol/site) was dose-dependently inhibited by the histamine H1 receptor antagonist pyrilamine (50 pmol/site-5 nmol/site). In rat peritoneal mast-cell preparation, nociceptin (10(-8)-10(-4) M) dose-dependently stimulated histamine release. The effect of nociceptin (10(-5) M) occurred rapidly (within 30 s) and was inhibited by pertussis toxin, Ca2+, but was not sensitive to naloxone, a classical opioid receptor antagonist. These characteristics are in agreement with features of the opioid-receptor-like 1 (ORL1) receptor, a non-classical opioid receptor linked to a pertussis toxin-sensitive G protein. Taken together, these data suggest that nociceptin, likely acting via the ORL1 receptor at the site of inflammation, might be critical for the enhancement of the inflammatory response by stimulating histamine release from mast cells.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Kimura T,Kitaichi K,Hiramatsu K,Yoshida M,Ito Y,Kume H,Yamaki K,Suzuki R,Takagi K

doi

10.1016/s0014-2999(00)00746-9

keywords:

subject

Has Abstract

pub_date

2000-11-03 00:00:00

pages

327-32

issue

3

eissn

0014-2999

issn

1879-0712

pii

S0014299900007469

journal_volume

407

pub_type

杂志文章

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