Abstract：
:Infusion of tryptamine (1-4 mug/ml) through the pulmonary circulation of rat isolated lung perfused with Krebs solution caused release of a mixture of spasmogens contracting isolated smooth muscle preparations. One component of this mixture had biological activity comparable to E-type prostaglandins. Other components included a slow reacting substance comparable to SRS-A and a rabbit aorta-contracting substance comparable to RCS. Infusions of 5-hydroxytryptamine, acetylcholine and histamine (0.5-2 mug/ml) also caused release. Release induced by the tryptamines but not that by acetylcholine and histamine was prevented by methysergide whereas acetylcholine-induced release was prevented by hyoscine which did not affect tryptamine-induced release. The tryptamines and histamine released spasmogens from dog isolated lungs but only histamine was effective in guinea-pig lungs. We conclude that amine-induced release from isolated lungs is a fairly general phenomenon and that it may represent an endocrine function of lung.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Alabaster VA,Bakhle YSdoi
10.1016/0014-2999(76)90238-7keywords:
subject
Has Abstractpub_date
1976-02-01 00:00:00pages
349-60issue
2eissn
0014-2999issn
1879-0712pii
0014-2999(76)90238-7journal_volume
35pub_type
杂志文章abstract：:Olanzapine and clozapine produce robust increases in hippocampal acetylcholine release during acetylcholinesterase inhibition, while other antipsychotics, including thioridazine, have only small effects. Since thioridazine binds with similar high affinities to muscarinic receptors as olanzapine and clozapine, muscarin...
journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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更新日期：1996-12-30 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2001-11-30 00:00:00
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journal_title：European journal of pharmacology
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更新日期：1991-12-12 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2001-08-17 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2013-11-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(92)90096-m
更新日期：1992-04-07 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(76)90296-x
更新日期：1976-01-01 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1999-04-29 00:00:00
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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更新日期：2017-01-05 00:00:00
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journal_title：European journal of pharmacology
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更新日期：1995-11-03 00:00:00
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1990-05-16 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章,评审
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更新日期：2015-07-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1983-02-18 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1991-01-03 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(82)90527-1
更新日期：1982-01-08 00:00:00
abstract：:Most currently prescribed antidepressants act by selectively increasing the synaptic availability of serotonin or norepinephrine, or through action on both serotonin and norepinephrine. However, most therapies require several weeks of treatment before improvement of symptoms is observed and not all patients respond to...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2006.10.004
更新日期：2007-01-19 00:00:00
