Angiotensin II AT1 receptors in rat superior cervical ganglia: characterization and stimulation of phosphoinositide hydrolysis.

abstract：:Three apparently distinct pertussis toxin (PTX)-sensitive substrates, with Mrs of 39, 40 and 41 kDa, were identified in membranes prepared from the sino-atrial (SA) node and right atrium of bovine heart. Based on their biochemical characterization, the effects of guanine nucleotides/MgCl2 on their PTX-catalyzed [32P]A...

journal_title：European journal of pharmacology

authors： Braun AP,Gupta RC,Sulakhe PV

更新日期：1990-07-31 00:00:00

abstract：:The effects of antagonists of N-methyl-D-aspartate (NMDA) on the capsaicin-induced cough reflex in rats were studied. Intracisternal (i. cist.) injection of MK-801, a non-competitive antagonist of NMDA, significantly decreased the number of coughs in a dose-dependent manner. The competitive antagonists of NMDA, 2-DL-a...

journal_title：European journal of pharmacology

authors： Kamei J,Tanihara H,Igarashi H,Kasuya Y

更新日期：1989-09-13 00:00:00

abstract：:The opioid properties of endomorphin derivatives containing a C-terminal alcoholic(-ol) function were compared to the parent amidated compounds in isolated organs (longitudinal muscle strip of guinea-pig ileum and mouse vas deferens). Similar data were also generated for the mu-opioid receptor selective agonist synthe...

journal_title：European journal of pharmacology

authors： Al-Khrasani M,Orosz G,Kocsis L,Farkas V,Magyar A,Lengyel I,Benyhe S,Borsodi A,Rónai AZ

更新日期：2001-06-01 00:00:00

abstract：:27-O-Caffeoyl myricerone (50-235) is a nonpeptide endothelin receptor antagonist which is highly selective for the endothelin ETA receptor subtype. In order to determine which functional groups in 50-235 are essential for its activity, we examined the potencies of 50-235 and its derivatives to inhibit [125I]endothelin...

journal_title：European journal of pharmacology

authors： Mihara S,Sakurai K,Nakamura M,Konoike T,Fujimoto M

更新日期：1993-10-15 00:00:00

abstract：:The mucociliary activity of the rabbit maxillary sinus is increased after exposure to airway irritants such as cigarette smoke and capsaicin. This effect is partly due to a cholinergic reflex but involves an atropine-resistant response probably mediated by the release of tachykinins such as substance P or neurokinin A...

journal_title：European journal of pharmacology

authors： Lindberg S,Dolata J

更新日期：1993-02-16 00:00:00

abstract：:1-(Meta-chloro)phenylpiperazine (m-CPP) is a 5-HT receptor agonist which has been purported to be relatively selective for the 5-HT2C receptor. In particular, the hypolocomotion produced by m-CPP has been suggested to be mediated by 5-HT2C receptors. m-CPP binds with high affinity to 5-HT1 as well as 5-HT2 receptors, ...

journal_title：European journal of pharmacology

authors： Gleason SD,Shannon HE

更新日期：1998-01-12 00:00:00

abstract：:The effect of dimethyl sulfoxide (DMSO) on the slow ventral root potential, which is related to nociceptive transmission, was investigated in the isolated spinal cord of a newborn rat. DMSO at 0.3-1% (v/v) enhanced the slow ventral root potential, but not mono- and polysynaptic reflex discharges. DMSO at 1% also enhan...

journal_title：European journal of pharmacology

authors： Kubota K,Fujibayashi K,Saito K

更新日期：1998-06-19 00:00:00

abstract：:The influence of ethanol (0.5, 1.0 and 2.0 g/kg i.p.) on the Bezold-Jarisch reflex in urethane-anaesthetized rats was studied. 5-Hydroxytryptamine (serotonin; 5-HT; 1, 3, 10 and 30 micrograms/kg i.v.) and capsaicin (1, 3 and 10 micrograms/kg i.v.) reflexly decreased heart rate in a dose-dependent manner. The 5-HT3 rec...

journal_title：European journal of pharmacology

authors： Malinowska B,Göthert M,Godlewski G,Wróbel B,Bönisch H,Buczko W

更新日期：1995-05-26 00:00:00

abstract：:A deamination product of histidine, urocanic acid, accumulates in the skin of mammals as trans-urocanic acid. Ultraviolet (UV) irradition converts it to the cis-isomer that is an important mediator in UV-induced immunosuppression. We have recently shown that urocanic acid interferes with the agonist binding to GABA(A)...

journal_title：European journal of pharmacology

authors： Uusi-Oukari M,Soini SL,Heikkilä J,Koivisto A,Neuvonen K,Pasanen P,Sinkkonen ST,Laihia JK,Jansén CT,Korpi ER

更新日期：2000-07-14 00:00:00

abstract：:The use of antipsychotic medication has consistently been associated with serious side effects including weight gain and metabolic abnormalities. Strategies for mitigating these side effects have been tested, yet effective interventions have not been identified. The current study tested whether two recently identified...

journal_title：European journal of pharmacology

authors： Belanoff JK,Blasey CM,Clark RD,Roe RL

更新日期：2011-03-25 00:00:00

abstract：:We examined whether the proteinase-activated receptor-2 (PAR2) agonist, H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SLIGRL-NH2), could induce scratching behavior in mice. Intradermal injections of SLIGRL-NH2 (10-50 microg) evoked dose dependent scratching. This behavior peaked near 5 min and returned to preinjection levels within ...

journal_title：European journal of pharmacology

authors： Shimada SG,Shimada KA,Collins JG

更新日期：2006-01-20 00:00:00

abstract：:The effect of acute exposure to micromolar concentrations of kainic acid was studied in rat cerebellar astroglial cultures consisting of two antigenically and functionally distinct subpopulations of astrocytes. Kainate (20-100 microM) released [3H]GABA preaccumulated by A2B5-positive stellate astrocytes in a concentra...

journal_title：European journal of pharmacology

authors： Gallo V,Suergiu R,Levi G

更新日期：1986-12-16 00:00:00

abstract：:Cutaneous arteries show enhanced contraction in response to cooling, which is suggested to be mediated via α2C-adrenoceptors. We have previously shown that α1-adrenoceptors are also involved in the enhanced contraction in cooling conditions. In the present study, we aimed to identify the α1-adrenoceptor subtype involv...

journal_title：European journal of pharmacology

authors： Ishida H,Saito SY,Ishikawa T

更新日期：2018-11-05 00:00:00

abstract：:The integrity of endothelial cell monolayers, a critical requirement for barrier maintenance, is needed for the prevention of edema formation. To investigate the mechanisms by which 2-phenyl-4-quinolone (YT-1) provided protection against serotonin-induced exudation, rat heart endothelial cell cultures were used. In th...

journal_title：European journal of pharmacology

authors： Lee HZ

更新日期：1997-09-24 00:00:00

abstract：:The inhibitory effect of forskolin-stimulated 3',5'-cyclic monophosphate (c-AMP) synthesis in isolated rat adipocytes has been measured for eight typical adenosine receptor agonists. The percent inhibition was evaluated using concentrations of each compound corresponding to 100 times their Ki, inhibitory binding const...

journal_title：European journal of pharmacology

authors： Borea PA,Varani K,Dalpiaz A,Capuzzo A,Fabbri E,IJzerman AP

更新日期：1994-03-15 00:00:00

abstract：:The administration of radioactive angiotensin I to the retrogradely perfused feline adrenal gland caused a brisk discharge of catecholamines. Recovery of the labelled decapeptide and metabolites in the adrenal effluent fluid was complete in 5 min. Radioimmunoassay of this perfusate revealed that most of the peptide re...

journal_title：European journal of pharmacology

authors： Ackerly JA,Felger TS,Peach MJ

更新日期：1976-07-01 00:00:00

abstract：:The effects of angiotensin I-converting enzyme (ACE) inhibitors and bradykinin (BK) on prostacyclin (PGI2) production in isolated arterial tissue were investigated. Rings of rat abdominal aorta were incubated in Krebs-Ringer bicarbonate buffer and PGI2 generation was assessed by the determination of its stable hydroly...

journal_title：European journal of pharmacology

authors： Hoffmann G,Pietsch R,Göbel BO,Weisser B,Bönner G,Vetter H,Düsing R

更新日期：1990-03-13 00:00:00

abstract：:In pentobarbital (35.0 mg/kg) anaesthetised dogs, bolus injections of prazosin into the femoral artery (3.0--300.0 microgram) provoked a dose-related fall in the vascular resistance of the innervated hind limb. In contrast to papaverine, prazosin failed to produce the same effect in dogs under spinal anaesthesia even ...

journal_title：European journal of pharmacology

authors： Cavero I,Fenard S,Gomeni R,Lefevre F,Roach AG

更新日期：1978-06-01 00:00:00

abstract：:The function of multidrug resistance-associated protein 2 (Mrp2) in the intestine and liver, as well as intestinal Mrp2 expression, was analyzed in CCl(4)-induced acute hepatic failure rats with hyperbilirubinemia. The plasma level of bilirubin glucuronides, endogenous Mrp2-substrates, was 26 microM at 24 h after CCl(...

journal_title：European journal of pharmacology

authors： Yokooji T,Murakami T,Yumoto R,Nagai J,Takano M

更新日期：2006-09-28 00:00:00

abstract：:Vervet monkeys were pharmacologically treated acutely and with repeated dose loading to alter serotonergic systems to assess the role of serotonin in the regulation of the hypothalamus-pituitary-thyroid axis. Acute L-tryptophan administration failed to alter basal levels of thyroid hormones but did decrease the TRH-in...

journal_title：European journal of pharmacology

authors： Morley JE,Raleigh MJ,Brammer GL,Yuwiler A,Geller E,Flannery J,Hershman JM

更新日期：1980-10-17 00:00:00

abstract：:Prenatal exposure to different doses (0.25, or 0.5 or 1.0 mg/kg corresponding to 1/320 th or 1/160 th or 1/80 th of LD50) of deltamethrin to the pregnant Wistar rats from gestation day 5 to 21 were found to produce a dose dependent increase in the activity of cytochrome P450 (CYP) dependent 7-ethoxyresorufin-O-deethyl...

journal_title：European journal of pharmacology

authors： Johri A,Yadav S,Singh RL,Dhawan A,Ali M,Parmar D

更新日期：2006-08-21 00:00:00

abstract：:The administration to mice of 1-methyl-4-(2'-methylphenyl)-1,2,3, 6-tetrahydropyridine (2'-CH3-MPTP), a substituted analog of the dopaminergic neurotoxin MPTP caused even more dopaminergic toxicity than MPTP itself. Under conditions in which MPTP was relatively ineffective (i.e. two injections per day of 0.113 mmol/kg...

journal_title：European journal of pharmacology

authors： Youngster SK,Duvoisin RC,Hess A,Sonsalla PK,Kindt MV,Heikkila RE

更新日期：1986-03-18 00:00:00

abstract：:Results from lesion studies show that selective damage to the temporal cortex or lateral entorhinal cortex impairs visual memory, whereas damage to the hippocampal region does not affect retention of a visual discrimination task. Major input pathways of the above structures use glutamate as neurotransmitter. The gluta...

journal_title：European journal of pharmacology

authors： Myhrer T,Andersen JM

更新日期：2001-10-12 00:00:00

abstract：:The open field is a very popular animal model of anxiety-like behavior. An overview of the literature on the action elicited by effective or putative anxiolytics in animal subjected to this procedure indicates that classical treatments such as benzodiazepine receptor full agonists or 5-HT(1A) receptor full or partial ...

journal_title：European journal of pharmacology

authors： Prut L,Belzung C

更新日期：2003-02-28 00:00:00

abstract：:Prostaglandin D2 (PGD2) and the selective DP receptor agonist BW 245C have been previously shown to lower intraocular pressure in rabbits, while PGD2, but not BW 245C, caused plasma extravasation, eosinophil infiltration, and goblet cell depletion. In these present studies definition of the ocular pharmacology of pros...

journal_title：European journal of pharmacology

authors： Woodward DF,Spada CS,Hawley SB,Williams LS,Protzman CE,Nieves AL

更新日期：1993-01-19 00:00:00

abstract：:Amphetamine elicits its locomotor-activating and drug-reinforcing effects by releasing the catecholamines dopamine and norepinephrine into the synapse. Amphetamine is a substrate of the plasmalemmal transporters for both dopamine and norepinephrine. As such, it binds to the transporters in conjunction with Na+ and Cl-...

journal_title：European journal of pharmacology

authors： Gnegy ME

更新日期：2003-10-31 00:00:00

abstract：:Polygonum tinctorium Lour. (P. tinctorium) is known to have the ability to suppress inflammation. We attempted to isolate the active compounds from P. tinctorium based on their inhibitory effects on the production of interferon-gamma, which is a well-known inflammatory cytokine. We thus isolated indirubin, an isomer o...

journal_title：European journal of pharmacology

authors： Kunikata T,Tatefuji T,Aga H,Iwaki K,Ikeda M,Kurimoto M

更新日期：2000-12-20 00:00:00

abstract：:T-kinin and its putative carboxypeptidase product des-Arg(11)-T-kinin are members of the kinin family that are unique to the rat. Primary cultures of rat bladder smooth muscle cells were used to investigate the pharmacology of these peptides. Calcium imaging experiments showed that rat bladder smooth muscle cells resp...

journal_title：European journal of pharmacology

authors： Davis C,Burgess G

更新日期：2002-08-23 00:00:00

abstract：:Synthesized pyridine compound derivatives (SK94, SK126) from a natural lead source were administered to mice to test for possible anti-TNF alpha and anti-inflammatory activities. Lipopolysaccharide (LPS)-induced TNF alpha production was analyzed in the endothelial cells, Raw 264.7 cells, and serum of normal mice after...

journal_title：European journal of pharmacology

authors： Choi B,Kim J,Lee ES,Bang D,Sohn S

更新日期：2011-04-25 00:00:00

abstract：:Breast cancer comes second among the causes of cancer deaths of women. Although new generation hormone therapy is a promising strategy, re-occurrence or emergence of drug resistance limits the success. According to the theory of cancer stem cells (CSCs); CSCs are immortal, tumor inducing and self renewing pluripotent ...

journal_title：European journal of pharmacology

authors： Kars MD,Yıldırım G

更新日期：2019-04-05 00:00:00