Inhibitory effect of ethanol on the 5-hydroxytryptamine-induced Bezold-Jarisch reflex--involvement of peripheral 5-HT3 receptors.

abstract：:The extracellular loops of the adrenoceptors present a potential therapeutic target in the design of highly selective adrenergic drugs. These regions are less conserved than the orthosteric binding site but have to date not been implicated in activation of adrenoceptors. A previously generated homology model identifie...

journal_title：European journal of pharmacology

authors： Campbell AP,MacDougall IJ,Griffith R,Finch AM

更新日期：2014-06-15 00:00:00

abstract：:The kinetics of [3H]dexetimide dissociation from muscarine receptors in bovine cardiac left ventricular and tracheal smooth muscle membranes were studied in the absence and presence of three muscarine antagonists. It was found that [3H]dexetimide dissociation from cardiac muscarine receptors was monophasic and very fa...

journal_title：European journal of pharmacology

authors： Roffel AF,Elzinga CR,Meurs H,Zaagsma J

更新日期：1989-03-07 00:00:00

abstract：:Although the involvement of cannabinoids and the endogenous cannabinoid system in the regulation of the hypothalamo-pituitary-adrenal axis in rodents is well documented, the precise role played by the cannabinoid type one (CB(1)) receptor in this effect has not been fully elucidated. Consequently, we investigated the ...

journal_title：European journal of pharmacology

authors： Wade MR,Degroot A,Nomikos GG

更新日期：2006-12-03 00:00:00

abstract：:In rat neocortical slices activation of glutamate metabotropic receptors with glutamate, quisqualate and 1S,3R-ACPD caused a spike-evoked afterdepolarization which replaced the normal afterhyperpolarization. In some neocortical neurons the afterdepolarization reached action potential threshold causing prolonged self-s...

journal_title：European journal of pharmacology

authors： Greene C,Schwindt P,Crill W

更新日期：1992-07-01 00:00:00

abstract：:Angiotensin II increased the inositol phosphates production (EC50 = 3.4+/-0.7 nM) in Chinese hamster ovary (CHO) cells expressing the cloned human angiotensin AT1 receptor (CHO-AT1 cells). Coincubation with angiotensin AT1 receptor antagonists produced parallel rightward shifts of the concentration-response curve with...

journal_title：European journal of pharmacology

authors： Fierens FL,Vanderheyden PM,De Backer JP,Vauquelin G

更新日期：1999-05-14 00:00:00

abstract：:We have investigated the effects of the ethacrynic acid derivative 4-(2-butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), an inhibitor of the volume-sensitive anion channel (VSAC), on electrical activity and insulin secretion in rat pancreatic beta-cells. DCPIB inhibited whole-cell VSAC curren...

journal_title：European journal of pharmacology

authors： Best L,Yates AP,Decher N,Steinmeyer K,Nilius B

更新日期：2004-04-05 00:00:00

abstract：:Stearoyl-CoA Desaturase 1 (SCD1) is a central enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. SCD1 is an emerging target in obesity and insulin resistance due to the improved metabolic profile obtained when the enzyme is genetically inactivated. Here, we have investiga...

journal_title：European journal of pharmacology

authors： Issandou M,Bouillot A,Brusq JM,Forest MC,Grillot D,Guillard R,Martin S,Michiels C,Sulpice T,Daugan A

更新日期：2009-09-15 00:00:00

abstract：:A series of neurochemical studies evaluated the selectivity of the depletions of norepinephrine produced by intraventricular injections of xylamine. Brain monoamines were assayed by liquid chromatography with electrochemical detection. With ether anesthesia, bilateral injections of 50 or 100 micrograms xylamine reduce...

journal_title：European journal of pharmacology

authors： Geyer MA,Gordon J,Adams LM

更新日期：1984-04-20 00:00:00

abstract：:Histamine levels are elevated in inflammatory bowel disease. We investigated the mechanism by which histamine affects electrolyte transport in the mouse cecum. Using the Ussing-chamber voltage clamp technique, histamine was found to cause a transient concentration-dependent increase in short-circuit current, a measure...

journal_title：European journal of pharmacology

authors： Homaidan FR,Tripodi J,Zhao L,Burakoff R

更新日期：1997-07-23 00:00:00

abstract：:The cGMP response and the accumulation of inositol monophosphate (IP) induced by carbachol were compared in slices of different rat brain structures. Basal cGMP and the responses of cGMP to carbachol appeared dependent on the concentration of added Ca2+, suggesting that distinct Ca(2+)-mediated and Ca(2+)-sensitive mu...

journal_title：European journal of pharmacology

authors： Tonnaer JA,Cheung CL,De Boer T

更新日期：1991-07-12 00:00:00

abstract：:We evaluated the anti-exudative effects (Evan's blue) of mu-, delta- and kappa-opioid receptor agonists in a rat model of carrageenan-induced acute inflammation. The contribution of different components was assessed after the administration of: cyclosporine A, capsaicin, 6-hydroxydopamine, compound 48/80, and specific...

journal_title：European journal of pharmacology

authors： Romero A,Planas E,Poveda R,Sánchez S,Pol O,Puig MM

更新日期：2005-03-28 00:00:00

abstract：:Recombinant P2X2 receptor was observed by atomic force microscope in the aqueous phase. The P2X2 receptor was expressed in an insect cell line, and recombinant proteins were prepared under native conditions. The membrane fractions were extracted, and histidine-tagged receptor protein was purified from the fractions by...

journal_title：European journal of pharmacology

authors： Nakazawa K,Yamakoshi Y,Tsuchiya T,Ohno Y

更新日期：2005-08-22 00:00:00

abstract：:The neuroprotective effects of erythropoietin on 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress and apoptosis in cultured PC12 cells as well as the underlying mechanism were investigated. Treatment of PC12 cells with MPP(+) caused the loss of cell viability, which was associated with the elevation in ap...

journal_title：European journal of pharmacology

authors： Wu Y,Shang Y,Sun S,Liu R

更新日期：2007-06-14 00:00:00

abstract：:It was previously demonstrated that the central nicotinic acetylcholine receptor antagonist mecamylamine perfused in the ventral tegmental area (VTA) counteracts the elevation of extracellular dopamine levels in the nucleus accumbens after systemic ethanol, as measured by in vivo microdialysis. In the present study we...

journal_title：European journal of pharmacology

authors： Ericson M,Molander A,Löf E,Engel JA,Söderpalm B

更新日期：2003-04-25 00:00:00

abstract：:Corticotropin-releasing factor (CRF) regulates the hypothalamic-pituitary-adrenal axis, coordinates the mammalian stress response, and acting primarily via the CRF(1) receptor, has been strongly implicated in the pathophysiology of depression and anxiety. Furthermore, the behavioral and autonomic activation that occur...

journal_title：European journal of pharmacology

authors： Skelton KH,Oren D,Gutman DA,Easterling K,Holtzman SG,Nemeroff CB,Owens MJ

更新日期：2007-09-24 00:00:00

abstract：:The biotransformation of arachidonic acid leads to two important groups of inflammatory mediators, the leukotrienes and the prostaglandins. Hyperalgesic effects have been demonstrated for prostaglandins in a variety of animal models but the effects of leukotrienes on inflammatory pain are less well documented. Using t...

journal_title：European journal of pharmacology

authors： Schweizer A,Brom R,Glatt M,Bray MA

更新日期：1984-10-01 00:00:00

abstract：:Effects of chelerythrine and bisindolylmaleimide I on action potential duration and on voltage-activated K(+) and Ca(2+) currents in rat ventricular myocytes were studied using perforated patch-clamp technique. The action potentials were markedly prolonged after application of 20 microM chelerythrine or 100 nM bisindo...

journal_title：European journal of pharmacology

authors： Voutilainen-Myllylä S,Tavi P,Weckström M

更新日期：2003-04-11 00:00:00

abstract：:To investigate the mechanism underlying sulpiride-induced catalepsy, we simultaneously examined cataleptic behavior and the kinetics of the dopamine receptor antagonist, sulpiride of dopamine, and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), using in vivo voltammetry. After intrastriatal administrat...

journal_title：European journal of pharmacology

authors： Horikawa HP,Nakazato T,Hikosaka O

更新日期：1997-05-12 00:00:00

abstract：:Hydrolysis of ([3H]Leu5)-enkephalin into the tripeptide [3H]Tyr-Gly-Gly can be detected using particulate fractions from a variety of peripheral organs. In some tissues, e.g. exocrine and endocrine glands, this dipeptidyl carboxypeptidase ("enkephalinase") activity is even higher than in brain. ...

journal_title：European journal of pharmacology

authors： Llorens C,Schwartz JC

更新日期：1981-01-05 00:00:00

abstract：:After incubation of rat cortical cell cultures with the human immunodeficiency virus type 1 (HIV-1) coat protein gp120 for 12 h, cells showed fragmentation of DNA at internucleosomal linkers, the characteristic feature of apoptosis. In a quantitative approach, it was determined that the percentage of DNA fragmentation...

journal_title：European journal of pharmacology

authors： Müller WE,Schröder HC,Ushijima H,Dapper J,Bormann J

更新日期：1992-07-01 00:00:00

abstract：:The effects of the alpha 2-adrenoceptor antagonist idazoxan on 5-hydroxytryptamine (5-HT) neuronal firing and release have been investigated. Idazoxan, administered i.v. (10 micrograms/kg and 0.5 mg/kg) increased dorsal raphe nucleus (DRN)-5-HT neuronal firing rate in a dose-dependent fashion. At the higher dose, a vo...

journal_title：European journal of pharmacology

authors： Garratt JC,Crespi F,Mason R,Marsden CA

更新日期：1991-01-25 00:00:00

abstract：:The beta 1- and beta 2-adrenoceptor agonist and thromboxane A2 (TXA2) antagonist properties of trimetoquinol (TMQ, I) and 1-benzyl substituted TMQ analogues [3'-iodo-4',5'-dimethoxy TMQ, II; 3',5'-diiodo-4'-dimethoxy TMQ, III; 3',4'-dimethoxy-5'-nitro TMQ, IV; 3',4'-dimethoxy-5'-amino TMQ; V; and 3',4'-dimethoxy TMQ, ...

journal_title：European journal of pharmacology

authors： Shams G,Romstedt KJ,Gerhardt MA,Harrold MW,Miller DD,Feller DR

更新日期：1990-08-02 00:00:00

abstract：:Chronic administration of amphetamine to cats (twice daily, in doses increasing from 5 to 15 mg/kg over a 10-day period) elicited a number of behaviors e.g., limb flicking, abortive grooming, and excessive head shaking, which were originally proposed as an animal behavioral model for studying the actions of hallucinog...

journal_title：European journal of pharmacology

authors： Trulson ME,Crisp T

更新日期：1984-04-06 00:00:00

abstract：:Three naturally occurring peptides, pGlu-Glu-Pro amide, pGlu-Phe-Pro amide and pGlu-Gln-Pro amide, with similar structures to thyrotropin releasing hormone (TRH) have recently been identified but no studies of their in vivo activities have been reported previously. We describe here the ability of pGlu-Phe-Pro amide an...

journal_title：European journal of pharmacology

authors： Cremades A,Peñafiel R,Rausell V,Del Rio-Garcia J,Smyth DG

更新日期：1998-09-25 00:00:00

abstract：:Antidepressant activity of partial agonists at strychnine-insensitive glycine receptors, 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine, was studied in a chronic mild stress model of depression. In this model, a substantial decrease in consumption of a palatable sucrose solution is observed over time in r...

journal_title：European journal of pharmacology

authors： Papp M,Moryl E

更新日期：1996-12-05 00:00:00

abstract：:Pigs were subjected to acute, intermittent hypoxia (fraction of inhaled O2 0.1, n = 10). The increase in mean pulmonary artery pressure during hypoxia was not altered after i.v. administration of the selective endothelin ETB receptor antagonist BQ-788 (N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma-methylleucyl-D -1- me...

journal_title：European journal of pharmacology

authors： Holm P,Liska J,Franco-Cereceda A

更新日期：1997-03-26 00:00:00

abstract：:The study compared the efficacy of acute versus chronic metrifonate treatment to improve initial and reversal learning of the water maze spatial navigation task in medial septal-lesioned rats. Acute oral administration of 30 mg/kg metrifonate at 30 min, but not at 150 or 360 min, before training improved the initial a...

journal_title：European journal of pharmacology

authors： Riekkinen M,Schmidt BH,Riekkinen P Jr

更新日期：1997-11-05 00:00:00

abstract：:Depression is very common in asthmatic patients and may increases risk for morbidity and mortality. The present work aimed to investigate the protective effect of fluoxetine, on behavioral and biochemical changes, associated with ovalbumin (OVA) - induced bronchial asthma and depression in rats. Rats were sensitized w...

journal_title：European journal of pharmacology

authors： Sherkawy MM,Abo-Youssef AM,Salama AAA,Ismaiel IE

更新日期：2018-10-15 00:00:00

abstract：:Recent studies suggest that endocannabinoid signaling is modulated by 17β-estradiol (17Eβ) however it is unclear if this applies to the cardiovascular actions of anandamide, a major endocannabinoid. This study examined the in vitro effects of 17Eβ on vasorelaxation to anandamide in myograph-mounted small mesenteric ar...

journal_title：European journal of pharmacology

authors： Ho WS

更新日期：2013-02-15 00:00:00

abstract：:DNA methylation is considered as a potential cause of aberrations in regulation of gene expression during carcinogenesis. Therefore, changes in DNA methylation patterns may be targets for chemoprevention. In the present study, we investigated effects of all-trans retinoic acid (ATRA), vitamin D(3), and resveratrol alo...

journal_title：European journal of pharmacology

authors： Stefanska B,Rudnicka K,Bednarek A,Fabianowska-Majewska K

更新日期：2010-07-25 00:00:00