Metabotropic receptor mediated afterdepolarization in neocortical neurons.

abstract：:The consequences of the consumption of cannabinoids with other drugs of abuse are of particular medical relevance. Several studies investigated the ability of cannabinoids to induce a locomotor cross-sensitization to other addictive drugs, but results remain inconsistent. Therefore, we investigated in mice the consequ...

journal_title：European journal of pharmacology

authors： Hagues G,Costentin J,Duterte-Boucher D

更新日期：2008-05-31 00:00:00

abstract：:Procaine and procainamide were covalently bound to acryloyl monomers and polymers. The dose-response and time-action parameters of the cardiac antiarrhythmic protection afforded by the prototype drugs and their acryloyl derivatives against chloroform-hypoxia-induced cardiac arrhythmias in unanesthetized mice and epine...

journal_title：European journal of pharmacology

authors： Erker EF,Baker T,Okamoto M,Udenfriend S,Riker WF Jr

更新日期：1985-08-27 00:00:00

abstract：:We investigated the therapeutic effects of OK432 (picibanil; CAS39325-1-4), an immunomodulator that is derived from the Su strain of Streptococcus pyogenes. This agent was administered alone or combined with human interferon-alpha in a murine model of insulin-dependent diabetes mellitus. Interferon-alpha inhibits vira...

journal_title：European journal of pharmacology

authors： Kanda T,Kogure S,Nara M,Tsukui S,Utsugi T,Tomono S,Kawazu S,Nagai R,Kobayashi I

更新日期：1998-01-26 00:00:00

abstract：:Adenosine (10 micrograms kg-1 min-1, infused into the lumen of the left ventricle) and dipyridamole (0.25 mg kg-1 intravenously, a dose that potentiated markedly the fall in arterial pressure in response to bolus doses of adenosine) each reduced the number of extrasystoles which occurred during the first 30 minutes fo...

journal_title：European journal of pharmacology

authors： Wainwright CL,Parratt JR

更新日期：1988-01-12 00:00:00

abstract：:The effect of papaverine on the positive inotropic response to isopreqaline and to calcium was studied on the rabbit isolated papillary muscle; theophylline and the calcium antagonistic D600 were used for comparison. The dose-response curve for isoprenaline was shifted to the left by papaverine (3 times 10- minus 6 to...

journal_title：European journal of pharmacology

authors： Endoh M,Schümann HJ

更新日期：1975-02-01 00:00:00

abstract：:In cases of severe human scorpion envenoming, lung injury is a common finding and frequently the cause of death. In the rat, two distinct mechanisms account for oedema following the intravenous injection of the venom -- acute left ventricular failure resulting from a massive release of catecholamines and an increase i...

journal_title：European journal of pharmacology

authors： Matos IM,Souza DG,Seabra DG,Freire-Maia L,Teixeira MM

更新日期：1999-07-09 00:00:00

abstract：:Mouse myotubes were used to investigate effects of the nondepolarizing neuromuscular blocking drugs pancuronium and atracurium on embryonic-type nicotinic acetylcholine receptor channels. Experiments were performed using patch-clamp techniques in combination with devices for ultra-fast solution exchange at outside--ou...

journal_title：European journal of pharmacology

authors： Löwenick CV,Krampfl K,Schneck H,Kochs E,Bufler J

更新日期：2001-02-09 00:00:00

abstract：:After incubation of rat cortical cell cultures with the human immunodeficiency virus type 1 (HIV-1) coat protein gp120 for 12 h, cells showed fragmentation of DNA at internucleosomal linkers, the characteristic feature of apoptosis. In a quantitative approach, it was determined that the percentage of DNA fragmentation...

journal_title：European journal of pharmacology

authors： Müller WE,Schröder HC,Ushijima H,Dapper J,Bormann J

更新日期：1992-07-01 00:00:00

abstract：:The effects of systemic administration of the full dopamine D1 receptor agonist A-77636 on acetylcholine release in rat frontal cortex and hippocampus were studied using in vivo microdialysis. Administration of A-77636 (4 mumol/kg s.c.) greatly (> 230%) increased both cortical and hippocampal acetylcholine release for...

journal_title：European journal of pharmacology

authors： Acquas E,Day JC,Fibiger HC

更新日期：1994-07-21 00:00:00

abstract：:In the present study we showed that the alpha-adrenoceptor antagonists phentolamine, yohimbine, prazosin, corynanthine and idazoxan, when cumulatively applied in high concentrations (1-100 mumol/l), can increase spontaneous myogenic activity in the rat portal vein. 5-Methyl-urapidil and rauwolscine were ineffective in...

journal_title：European journal of pharmacology

authors： Schwietert R,Wilhelm D,Wilffert B,Van Zwieten PA

更新日期：1992-01-28 00:00:00

abstract：:The ligand preferences of recombinant NR1 homomeric and NR1-NR2 heteromeric NMDA receptors were examined by homogenate binding assay. The binding affinities for most ligands were similar to those reported for native NMDA receptors. The order of affinity for [3H]glutamate was NR1-NR2B > NR1-NR2A approximately NR1-NR2D ...

journal_title：European journal of pharmacology

authors： Laurie DJ,Seeburg PH

更新日期：1994-08-16 00:00:00

abstract：:The adenosine A(2A) receptor in the basal ganglia is involved in the control of movement and plays a role in movement disorders such as Parkinsonism. Developing ligands to evaluate that receptor by noninvasive methods such as positron emission tomography has a high priority. In vitro radioligand binding guides the sel...

journal_title：European journal of pharmacology

authors： Sihver W,Schulze A,Wutz W,Stüsgen S,Olsson RA,Bier D,Holschbach MH

更新日期：2009-08-15 00:00:00

abstract：:We investigated the effects of KF19514 (5-phenyl-3-(3-pyridyl)methyl-3H-imidazo[4,5-c][1,8]naphthyridin-4 (5H)-one) on bronchoconstriction and allergic inflammation in guinea pigs and on tumor necrosis factor-alpha production in mice. KF19514 inhibited phosphodiesterase 4 (IC50 = 0.40 microM) and phosphodiesterase 1 (...

journal_title：European journal of pharmacology

authors： Manabe H,Akuta K,Sejimo H,Kawasaki H,Nukui E,Ichimura M,Kase H,Kawakita T,Suzuki F,Kitamura S,Sato S,Ohmori K

更新日期：1997-07-30 00:00:00

abstract：:Vascular hypertrophy occurs during chronic hypertension and contributes to the elevation of peripheral vascular resistance in hypertension. In this study, we examined whether acute pressure overloading of the vascular wall produces activation of mitogen-activated protein (MAP) kinases, enzymes believed to be involved ...

journal_title：European journal of pharmacology

authors： Kubo T,Hosokawa H,Kambe T,Fukumori R

更新日期：2000-03-17 00:00:00

abstract：:Cathelicidins are a class of gene-encoded multifunctional factors in host defence systems. They have recently attracted a great deal of attention as promising drug candidates. Cathelicidins are well studied in vertebrates, yet no studies have been reported concerning gecko cathelicidin. Recently, we identified a novel...

journal_title：European journal of pharmacology

authors： Cai S,Lu C,Liu Z,Wang W,Lu S,Sun Z,Wang G

更新日期：2021-01-05 00:00:00

abstract：:Baicalin has been reported to protect against liver injury in iron-overload mice, however, the mechanisms underlying the hepatoprotective properties of baicalin are poorly understood. In this study, we systematically studied the protective effect of baicalin on iron overload induced liver injury, as well as the underl...

journal_title：European journal of pharmacology

authors： Zhang Y,Huang Y,Deng X,Xu Y,Gao Z,Li H

更新日期：2012-04-05 00:00:00

abstract：:Cytochrome P450 2J2 (CYP2J2) is highly expressed in human tumors and carcinoma cell lines, and has been implicated in the pathogenesis of human cancers. The aim of this study was to identify a compound that could inhibit the activity of CYP2J2, and to examine its anticancer activity. To identify CYP2J2 inhibitors, 10 ...

journal_title：European journal of pharmacology

authors： Jeon YJ,Kim JS,Hwang GH,Wu Z,Han HJ,Park SH,Chang W,Kim LK,Lee YM,Liu KH,Lee MY

更新日期：2015-10-05 00:00:00

abstract：:Recently, we reported that intracerebroventricularly (i.c.v.) administered (±)-epibatidine (a non-selective agonist of nicotinic acetylcholine receptors) elevates plasma noradrenaline and adrenaline through brain nicotinic acetylcholine receptor-mediated mechanisms in rats. In the present study, we characterized the r...

journal_title：European journal of pharmacology

authors： Shimizu T,Tanaka K,Hasegawa T,Yokotani K

更新日期：2011-03-11 00:00:00

abstract：:We previously described two novel peptides, Ca2+-like peptide (CALP) 1 and CALP2, which interact with Ca2+-binding EF hand motifs, and therefore have the characteristics to define the role of the Ca2+-sensing regulatory protein calmodulin in asthma. In the present study, the effects of the calcium-like peptides were i...

journal_title：European journal of pharmacology

authors： Ten Broeke R,Brandhorst MC,Leusink-Muis T,Villain M,De Clerck F,Blalock JE,Nijkamp FP,Folkerts G

更新日期：2003-08-22 00:00:00

abstract：:C-type natriuretic peptide (CNP) is the major natriuretic peptide in the brain and its mRNA has been reported in the central nervous system, which supports local synthesis and its role as a neuromodulator. The aim of the present work was to study the effect of centrally applied CNP on pancreatic secretion. Rats were f...

journal_title：European journal of pharmacology

authors： Sabbatini ME,Rodríguez MR,Corbo NS,Vatta MS,Bianciotti LG

更新日期：2005-11-07 00:00:00

abstract：:Lipoprotein lipase (LPL) is the rate-controlling enzyme for the accumulation of triacylglycerol into adipocytes, which acts by digesting it into glycerol and fatty acids. In this study, we found that treatment with (+)-JQ1, an inhibitor of the bromodomain and extra-terminal (BET) family proteins, for 4 days from the e...

journal_title：European journal of pharmacology

authors： Inoue T,Hariya N,Imamochi Y,Dey A,Ozato K,Goda T,Kubota T,Mochizuki K

更新日期：2019-09-05 00:00:00

abstract：:The aim of this study was to investigate the relaxation effect of farrerol on rat aortic vascular smooth muscle cells (VSMCs) and its underlying mechanism. VSMCs were cultured primarily and were used to examine the relaxation effect of farrerol. Cells surface and length were measured by dynamic observation, or by rhod...

journal_title：European journal of pharmacology

authors： Qin X,Hou X,Zhang K,Li Q

更新日期：2019-06-15 00:00:00

abstract：:Pharmacological properties of oxime reactivators, not related to its ability to regenerate or reactivate nerve agent-inhibited acetylcholinesterase located at nerve synapses, have been reported to be important in protecting against poisoning by the nerve agent soman. Such non-reactivation effects have thus far been as...

journal_title：European journal of pharmacology

authors： Loke WK,Sim MK,Go ML

更新日期：2005-10-03 00:00:00

abstract：:Rats were treated with ethanol in the drinking fluid 2 X 1 h daily for 83 weeks. [3H]Muscimol, [3H]quinuclidinyl benzilate ( [3H]QNB) and [3H]nicotine binding was measured in selected brain areas 7, 14 and 21 days after withdrawal of ethanol. A significant increase (P less than 0.05) when compared to controls was foun...

journal_title：European journal of pharmacology

authors： Nordberg A,Wahlström G,Eriksson B

更新日期：1985-09-24 00:00:00

abstract：:Fabry disease (FD) is an X-linked metabolic storage disorder arising from the deficiency of lysosomal α-galactosidase A, which leads to the gradual accumulation of glycosphingolipids, mainly globotriaosylceramide (Gb3), throughout the body. Pain in the extremities is an early symptom of FD; however, the underlying pat...

journal_title：European journal of pharmacology

authors： Sugimoto J,Satoyoshi H,Takahata K,Muraoka S

更新日期：2021-01-20 00:00:00

abstract：:In urethane-anesthetized rats, the effects of intravenous injections of morphine, levorphanol, dextrorphan, pentazocine and naloxone were studied studied on the activity in nerve fibres of the cervical sympathetic trunk, and on mean arterial blood pressure and heart rate. Impulse frequency in sympathetic nerve fibres ...

journal_title：European journal of pharmacology

authors： Jurna I,Rummel W

更新日期：1984-05-18 00:00:00

abstract：:Proliferation and migration of vascular smooth muscle cells (VSMCs) play crucial roles in the development of vascular restenosis. Our previous study showed that CCN4, namely Wnt1 inducible signaling pathway protein 1 (WISP1), significantly promotes proliferation and migration of rat VSMCs, but its mechanism remains un...

journal_title：European journal of pharmacology

authors： Lu S,Liu H,Lu L,Wan H,Lin Z,Qian K,Yao X,Chen Q,Liu W,Yan J,Liu Z

更新日期：2016-10-05 00:00:00

abstract：:Cholecystokinin (CCK) shows a potent influence on gastric secretion and motility but its role in gastric mucosal integrity has been little examined. In this study we found that exogenous CCK octapeptide protected gastric mucosa against ethanol-induced gastric injury but was ineffective against aspirin-induced damage. ...

journal_title：European journal of pharmacology

authors： Konturek SJ,Brzozowski T,Pytko-Polonczyk J,Drozdowicz D

更新日期：1995-01-24 00:00:00

abstract：:Human podocytes (hPC) are essential for maintaining normal kidney function and dysfunction or loss of hPC play a pivotal role in the manifestation and progression of chronic kidney diseases including diabetic nephropathy. Previously, α-Lipoic acid (α-LA), a licensed drug for treatment of diabetic neuropathy, was shown...

journal_title：European journal of pharmacology

authors： Leppert U,Gillespie A,Orphal M,Böhme K,Plum C,Nagorsen K,Berkholz J,Kreutz R,Eisenreich A

更新日期：2017-09-05 00:00:00

abstract：:We have investigated, by using the whole-cell patch-clamp technique, the Ca2+ channel antagonist properties of eliprodil in cultured cerebellar granule cells which are known to express L-, N-, P- as well as Q- and R-type Ca2+ channels. Eliprodil maximally antagonized 50% of the voltage-dependent Ba2+ current with an I...

journal_title：European journal of pharmacology

authors： Biton B,Godet D,Granger P,Avenet P

更新日期：1997-04-04 00:00:00