Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition.

abstract：:The purpose of the present study was to test whether kava extract and its constituents kawain, dihydrokawain, methysticin, dihydromethysticin and yangonin provide protection against ischemic brain damage. To this end, we used a model of focal cerebral ischemia in mice and rats. Ischemia was induced by microbipolar coa...

journal_title：European journal of pharmacology

authors： Backhauss C,Krieglstein J

更新日期：1992-05-14 00:00:00

abstract：:Effects of nicotine, and nicotine+vitamin E on glutathione reductase (Glutathione: NADP(+) oxidoreductase, EC 1.8.1.7) activity in the muscle, heart, lungs, testicles, kidney, stomach, brain and liver tissues were investigated in vivo and also in vitro. The groups were: nicotine [0.5 mg/kg/day, intraperitoneal (i.p.)]...

journal_title：European journal of pharmacology

authors： Erat M,Ciftci M,Gumustekin K,Gul M

更新日期：2007-01-12 00:00:00

abstract：:PK20M (Dmt-D-Lys-Phe-Phe-OH) is a novel modified endomorphin-2 (EM-2) peptide producing strong dose- and time-dependent antinociceptive activity. Yet its prototype, endogenous EM-2, has been reported to trigger respiratory and vascular effects such as apnea and hypotension. The purpose of this study was to investigate...

journal_title：European journal of pharmacology

authors： Wojciechowski P,Kleczkowska P,Mollica A,Stefanucci A,Kaczyńska K

更新日期：2020-10-15 00:00:00

abstract：:In male Swiss mice, muscimol produced myoclonic jerks. A 3 mg/kg (i.p.) dose induced this response in all of the mice tested and the peak response of 73 jerks per min was observed between 27 and 45 min. Increasing the brain serotonin levels by the administration of 5-hydroxytryptophan (80-160 mg/kg) in combination wit...

journal_title：European journal of pharmacology

authors： Menon MK,Vivonia CA

更新日期：1981-07-17 00:00:00

abstract：:This study was designed to investigate the effects of serotonin on changes in intracellular Ca(2+) concentration ([Ca(2+)](i)) in cultured rat heart endothelial cells. Serotonin stimulated a biphasic change in cytosolic Ca(2+) of rat heart endothelial cells: an initial transient increase, which primarily reflects the ...

journal_title：European journal of pharmacology

authors： Lee HZ,Wu CH

更新日期：1999-11-12 00:00:00

abstract：:The mechanisms underlying the hypothermic effect of ethanol have been investigated in rats. At an ambient temperature of 26 degrees C, at which tail skin blood flow will normally be expected to play a role in regulating core temperature, no change in tail cutaneous temperature occurred during the period in which the c...

journal_title：European journal of pharmacology

authors： Lomax P,Bajorek JG,Bajorek TA,Chaffee RR

更新日期：1981-05-22 00:00:00

abstract：:The involvement of dopamine D-1 and D-2 receptor mechanisms was investigated in the forced swimming test with rats. d,1-Sulpiride, a D-2 receptor antagonist, reported to reduce desipramine-induced anti-immobility, did not alter the brain levels of desipramine. In addition, the anti-immobility effect of desipramine was...

journal_title：European journal of pharmacology

authors： Borsini F,Lecci A,Mancinelli A,D'Aranno V,Meli A

更新日期：1988-04-13 00:00:00

abstract：:1,2,3,4-Tetrahydroisoquinoline (TIQ) is an exo- and endogenous amine naturally present in mammalian brain which displays antidepressant-like effect in various animal models: the forced swim test (FST) and chronic mild stress (CMS) paradigm in rats. To elucidate this action we compared the effects of TIQ with imipramin...

journal_title：European journal of pharmacology

authors： Możdżeń E,Papp M,Gruca P,Wąsik A,Romańska I,Michaluk J,Antkiewicz-Michaluk L

更新日期：2014-04-15 00:00:00

abstract：:The pre- and postsynaptic actions of the calcium entry facilitator Bay K 8644 were investigated in the rat isolated vas deferens. Bay K 8644 had no presynaptic effect on adrenergic neurotransmission in the epididymal portion. Bay K 8644 and alpha 1-adrenoceptor agonists potentiated, and the calcium entry blocker nifed...

journal_title：European journal of pharmacology

authors： Hyland L,Warnock P,Docherty JR

更新日期：1984-09-17 00:00:00

abstract：:The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine. CM 57373 and dl-fenfluramine administered orally caused a dose-related reductio...

journal_title：European journal of pharmacology

authors： Miranda GF,Poggesi E,Bianchetti A,Unkovic J,Samanin R

更新日期：1988-05-20 00:00:00

abstract：:Cocaine interacts with sigma receptors, suggesting that these sites are important for many of its behavioral effects. Therefore, two novel sigma receptor ligands, BD1008 (N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine) and BD1063 (1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine), were evaluat...

journal_title：European journal of pharmacology

authors： McCracken KA,Bowen WD,Matsumoto RR

更新日期：1999-01-15 00:00:00

abstract：:Hypovolemic shock was produced in rats by withdrawing about 50% of the estimated total blood volume. Following mean arterial pressure stabilization in the range of 22-23 mm Hg, the rats were given an i.v. bolus injection of L-6-ketopiperidine-2-carbonyl-L-leucyl-L-proline amide (RGH-2202) to be compared with thyrotrop...

journal_title：European journal of pharmacology

authors： Coppi G,Falcone A

更新日期：1990-06-21 00:00:00

abstract：:Nitric oxide (10 ppm) inhaled by pigs before or during endotoxin shock induced by an infusion of E. coli lipopolysaccharide. Nitric oxide inhalation selectively attenuated pulmonary hypertension during endotoxin infusion without influencing mean arterial blood pressure and cardiac output. Upon cessation of nitric oxid...

journal_title：European journal of pharmacology

authors： Weitzberg E,Rudehill A,Lundberg JM

更新日期：1993-03-16 00:00:00

abstract：:The characteristics of the prefrontal cortex regulation of dopamine release in the rat dorsolateral striatum were investigated in focusing on the corticostriatal pathway, using dual-probe microdialysis in combination with simple behavioral procedures. Intracortical perfusion of the GABA(A) receptor antagonist bicucull...

journal_title：European journal of pharmacology

authors： Matsumoto M,Kanno M,Togashi H,Ueno K,Otani H,Mano Y,Yoshioka M

更新日期：2003-12-15 00:00:00

abstract：:To examine whether low concentrations of endothelin-1 potentiate the vasoconstrictor response to adrenergic stimulation, we recorded the isometric response of rings of rabbit pulmonary artery to electrical stimulation and noradrenaline. Endothelin-1 (10(-10) M) potentiated the contractions induced by electrical stimul...

journal_title：European journal of pharmacology

authors： Vila JM,Medina P,Segarra G,Aldasoro M,Noguera I,Lluch S

更新日期：2001-02-16 00:00:00

abstract：:The effect of dimethyl sulfoxide (DMSO) on the slow ventral root potential, which is related to nociceptive transmission, was investigated in the isolated spinal cord of a newborn rat. DMSO at 0.3-1% (v/v) enhanced the slow ventral root potential, but not mono- and polysynaptic reflex discharges. DMSO at 1% also enhan...

journal_title：European journal of pharmacology

authors： Kubota K,Fujibayashi K,Saito K

更新日期：1998-06-19 00:00:00

abstract：:Chlorpropamide and phenformin inhibited (Na+ - K+)-ATPase and stimulated a high affinity cyclic AMP-phosphodiesterase of isolated liver plasma membrane when tested in vitro. In addition, the two drugs decreased the intracellular cyclic AMP content of isolated hepatocytes without being effective on plasma membrane-boun...

journal_title：European journal of pharmacology

authors： Luly P,Baldini P,Cocco C,Incerpi S,Tria E

更新日期：1977-11-15 00:00:00

abstract：:We investigated the role of K(ATP) channel on acute urinary retention (AUR) induced bladder dysfunction. Eight-week-old female Sprague-Dawley rats were divided into seven groups: a sham-operated control group, an AUR group, and five AUR groups treated with: two different K(ATP) channel openers namely nicorandil (3 or ...

journal_title：European journal of pharmacology

authors： Ohmasa F,Saito M,Shimizu S,Taniguchi S,Dimitriadis F,Satoh I,Kinoshita Y,Satoh K

更新日期：2010-06-10 00:00:00

abstract：:The TxA2 receptor antagonist properties of SQ 27,427 [a cyclohexylcarbinol-7-oxabicyclo(2.2.1)heptenoic acid analog] were studied in vitro both in the human platelet and various isolated smooth muscle preparations. SQ 27,427 was found to be a potent inhibitor of human platelet aggregation induced by arachidonic acid, ...

journal_title：European journal of pharmacology

authors： Harris DN,Greenberg R,Phillips MB,Michel IM,Goldenberg HJ,Haslanger MF,Steinbacher TE

更新日期：1984-08-03 00:00:00

abstract：:Effluents from perfused acetylcholine-relaxed endothelium segments of rabbit aorta (or canin femoral artery) contained endothelium-derived relaxing factors (EDRF) which dilated the endothelium-free segments of rabbit femoral artery (or side branches of canine femoral artery). The half-life of EDRF was 24 +/- 3 s for t...

journal_title：European journal of pharmacology

authors： Förstermann U,Trogisch G,Busse R

更新日期：1984-11-27 00:00:00

abstract：:Salidroside, an active constituent from the root of Rhodiola rosea L., has multiple pharmacological effects, such as anti-cancer, anti-inflammatory and anti-oxidative properties, etc. However, its protective effect on bone tissue via regulating calcium homeostasis is yet to be determined. This study was performed to i...

journal_title：European journal of pharmacology

authors： Chen XF,Li XL,Yang M,Song Y,Zhang Y

更新日期：2018-01-15 00:00:00

abstract：:The effect of KC 2450 (racemic 3,5-cis-3-methylamino-2,3,4,5-tetrahydro-1-benzoxepine-5-ol hydrochloride) on lower esophageal sphincter pressure in pentobarbital-anesthetized dogs was determined and compared to the effect of metoclopramide. The ED20 value (i.e. the dose that increased lower esophageal sphincter pressu...

journal_title：European journal of pharmacology

authors： Fowler PJ,Nelson AH,Price WJ,Sarau HM,Grous M,Lombardi DM,Barone FC,Ormsbee HS 3rd

更新日期：1987-10-13 00:00:00

abstract：:The effects of procaine, mepivacaine and phenylbutazone on pain perception in the equine were studied using two behavioral assays of nociception; the thermal evoked hoof withdrawal reflex and skin twitch reflex. Pain perception threshold was measured as the latency from onset of thermal stimuli to reflex withdrawal of...

journal_title：European journal of pharmacology

authors： Kamerling SG,Dequick DJ,Weckman TJ,Sprinkle FP,Tobin T

更新日期：1984-12-15 00:00:00

abstract：:Given the differences in the dopamine neurotransmission between the shell and the core of the nucleus accumbens, as well as the differential involvement of these two domains in oral behaviour of rats, it was decided to determine whether or not dopamine D1 and/or dopamine D2 receptors differentially direct oral behavio...

journal_title：European journal of pharmacology

authors： Cools AR,Miwa Y,Koshikawa N

更新日期：1995-11-03 00:00:00

abstract：:Using 3H-ligands and radioactive microspheres we studied the binding characteristics and the effects on the distribution of carotid arterial blood flow of n-(3-acetylaminophenyl)piperazine hydrochloride (BEA 1654). The compound had a Ki value of 32 nM (5-HT: 8 nM) on 5-HT1 but no or very weak affinity for 5-HT2, alpha...

journal_title：European journal of pharmacology

authors： Verdouw PD,Jennewein HM,Mierau J,Saxena PR

更新日期：1985-01-08 00:00:00

abstract：:In urethane-anesthetized rats the intrathecal (i.t.) injection of 100 nmol anandamide produced a hypotensive effect (-19.3+/-1.6 mm Hg; n=6) that was mimicked by i.t. administration of 0.25 nmol calcitonin gene-related peptide (CGRP; -26.2+/-1.8 mm Hg, n=4). Both effects were antagonized either by the CGRP receptor an...

journal_title：European journal of pharmacology

authors： García Mdel C,Adler-Graschinsky E,Celuch SM

更新日期：2006-02-17 00:00:00

abstract：:The anticonvulsant compound oxcarbazepine and its principal 10-monohydroxy metabolite protected potently against electroshock-induced tonic hindlimb extension. Maximal plasma concentrations depended on dose and were reached < or = 1 h after an oral dose of oxcarbazepine and < 2 h after monohydroxy derivative. In mice,...

journal_title：European journal of pharmacology

authors： Wamil AW,Schmutz M,Portet C,Feldmann KF,McLean MJ

更新日期：1994-12-27 00:00:00

abstract：:We report the cloning, molecular characterization, and pharmacological characterization of the canine 5-HT2A and 5-HT2B receptors. The canine and human 5-HT2A receptors share 93% amino acid homology. The canine and human 5-HT2B receptors are also highly conserved (87% homology) with the exception of the carboxyl termi...

journal_title：European journal of pharmacology

authors： Bonaventure P,Nepomuceno D,Miller K,Chen J,Kuei C,Kamme F,Tran DT,Lovenberg TW,Liu C

更新日期：2005-04-25 00:00:00

abstract：:Baicalein, a naturally occurring flavone, has been proved as a promising chemopreventive compound for many chronic human diseases. The aim of this work was to investigate whether treatment with baicalein prevented nonalcoholic steatohepatitis (NASH) induced by methionine-choline-deficient (MCD) diet. Rats were divided...

journal_title：European journal of pharmacology

authors： Xin HG,Zhang BB,Wu ZQ,Hang XF,Xu WS,Ni W,Zhang RQ,Miao XH

更新日期：2014-09-05 00:00:00

abstract：:Colorectal cancer (CRC) has become one of the major factors of tumor-related morbidity and mortality in the world because of its poor prognosis and consequences of metastatic spread. Currently, chemoprevention has been considered as a way of preventing cancer who takes advantage of plant phytochemicals and synthetic c...

journal_title：European journal of pharmacology

authors： Zhu Y,Yang Q,Liu H,Song Z,Chen W

更新日期：2020-11-15 00:00:00