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Species-dependent differences in the nature of endothelium-derived vascular relaxing factor.

Abstract：

:Effluents from perfused acetylcholine-relaxed endothelium segments of rabbit aorta (or canin femoral artery) contained endothelium-derived relaxing factors (EDRF) which dilated the endothelium-free segments of rabbit femoral artery (or side branches of canine femoral artery). The half-life of EDRF was 24 +/- 3 s for the rabbit and 49 +/- 5 s for the canine system. Nordihydroguaiaretic acid was less effective against the formation of canine EDRF than of rabbit EDRF. These findings suggest species differences in the nature of EDRF.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Förstermann U,Trogisch G,Busse R

doi

10.1016/0014-2999(84)90071-2

subject

Has Abstract

pub_date

1984-11-27 00:00:00

pages

639-43

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(84)90071-2

journal_volume

106

pub_type

杂志文章

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