Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells.

abstract：:Pyrethroid insecticides have been reported to increase transmembrane sodium influx and inhibit ion-dependent ATPases in insect, squid, and toad nerve tissues. Since changes in sarcolemmal ion fluxes and inhibition of membrane-bound ATPases can alter myocardial contractility, the effects of a potent synthetic pyrethroi...

journal_title：European journal of pharmacology

authors： Berlin JR,Akera T,Brody TM,Matsumura F

更新日期：1984-03-02 00:00:00

abstract：:The purpose of this study was to investigate whether the selective angiotensin AT2 receptor ligands, CGP 42112B (Nic-Tyr-(N alpha-benzoyloxycarbonyl-Arg)Lys-His-Pro-Ile-OH) and PD 123319 ((s)-1-[[4-(dimethylamino)-3-methyl-phenyl]methyl]-5-(diphenylacetyl+ ++)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]-pyridine-6-carboxylic...

journal_title：European journal of pharmacology

authors： Macari D,Whitebread S,Cumin F,De Gasparo M,Levens N

更新日期：1994-06-23 00:00:00

abstract：:Lycopene has attracted significant research interest due to its beneficial therapeutic effects, which include anti-oxidant, neuro-protective and anti-cancer effects, but the mechanisms of its beneficial action are not clear so far. The present study was carried out to elucidate the neuroprotective effect of lycopene a...

journal_title：European journal of pharmacology

authors： Prakash A,Kumar A

更新日期：2014-10-15 00:00:00

abstract：:To investigate the mechanism underlying sulpiride-induced catalepsy, we simultaneously examined cataleptic behavior and the kinetics of the dopamine receptor antagonist, sulpiride of dopamine, and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), using in vivo voltammetry. After intrastriatal administrat...

journal_title：European journal of pharmacology

authors： Horikawa HP,Nakazato T,Hikosaka O

更新日期：1997-05-12 00:00:00

abstract：:Free radical production contributes to the early ischemic response and the neuroinflammatory response to injury initiates the second wave of cell death following ischemic stroke. Edaravone is a free radical scavenger, and borneol has shown anti-inflammatory effect. We investigated the synergistic effect of these two d...

journal_title：European journal of pharmacology

authors： Wu HY,Tang Y,Gao LY,Sun WX,Hua Y,Yang SB,Zhang ZP,Liao GY,Zhou QG,Luo CX,Zhu DY

更新日期：2014-10-05 00:00:00

abstract：:In this study we have investigated the functional activity of GR127935 (2-methyl-1,2,4 oxadiazol-3-yl)-biphenyl-[4-carboxylic acid 4-methoxy-3-(4-methyl-piperazine-1-yl]-amide) at human 5-HT1D alpha and 5-HT1D beta receptors which have been expressed in a Chinese Hamster Ovary (CHO) cell line. Using [35S] GTP gamma S ...

journal_title：European journal of pharmacology

authors： Watson JM,Burton MJ,Price GW,Jones BJ,Middlemiss DN

更新日期：1996-10-31 00:00:00

abstract：:This work investigates the actions of LASSBio-1289, (E)-N-methyl-N'-(thiophen-3-methylene)benzo[d][1,3]dioxole-5-carbohydrazide, on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats. Two weeks following the MCT injection, LASSBio-1289 (50 or 75mg/kg, p.o.) or vehicle was administrated once dail...

journal_title：European journal of pharmacology

authors： Pereira SL,Kummerle AE,Fraga CA,Barreiro EJ,Rocha Nde N,Ferraz EB,do Nascimento JH,Sudo RT,Zapata-Sudo G

更新日期：2013-02-28 00:00:00

abstract：:By using acutely dissociated dorsal raphe nucleus neurons (DRN) from young mice, direct and anti-opioid effects of Neuropeptide FF (NPFF) receptors were measured. The NPFF analog 1 DMe (10 µM) had no effect on resting Ca2+ channels but reduced the magnitude of Ca2+ transients induced by depolarization in 83.3% neurons...

journal_title：European journal of pharmacology

authors： Ding Z,Zajac JM

更新日期：2014-10-05 00:00:00

abstract：:The goal of our study was to determine whether GPR55 agonists, O-1602, could reverse the cyclophosphamide (CYP)-induced changes in cystometric and inflammatory parameters, indicative of the development of bladder inflammation and overactivity. If confirmed, the stimulation of novel cannabinoid receptor - GPR55, could ...

journal_title：European journal of pharmacology

authors： Wróbel A,Zapała Ł,Zapała P,Piecha T,Radziszewski P

更新日期：2020-09-05 00:00:00

abstract：:The site of the analgesic action of AD-1211, the less active stereoisomer, and its pharmacological features were investigated. AD-1211, as well as pentazocine and morphine, blocked the reflex hypertension caused by injection of both bradykinin and bradykinin plus PGE1 into the splenic artery of dogs. In the rat or mou...

journal_title：European journal of pharmacology

authors： Nakamura H,Ishii K,Yokoyama Y,Imazu C,Shimoda A,Kadokawa T,Shimizu M

更新日期：1984-11-13 00:00:00

abstract：:The D-1 receptor agonist, SKF 38393 (2 mg/kg s.c.), failed to elicit contralateral turning when administered to drug-naive rats 17 days after unilateral 6-hydroxydopamine (6-OHDA) lesioning of the medial forebrain bundle, while it elicited intense contralateral turning 90 days post-lesioning. On the other hand the D-1...

journal_title：European journal of pharmacology

authors： Morelli M,Fenu S,Garau L,Di Chiara G

更新日期：1989-03-21 00:00:00

abstract：:The loss of cholinergic neurons and synapses relates to the severity of dementia in several neurodegenerative pathologies; and the vesicular acetylcholine transporter (VAChT) provides a reliable biomarker of cholinergic function. We recently characterized and (11)C-labeled a new VAChT inhibitor, (-)-TZ659. Here we rep...

journal_title：European journal of pharmacology

authors： Liu H,Jin H,Li J,Zhang X,Kaneshige K,Parsons SM,Perlmutter JS,Tu Z

更新日期：2015-04-05 00:00:00

abstract：:The pH dependence of the facilitation by dopamine (10 microM), 5-hydroxytryptamine (10 microM), adenosine (1 and 100 microM), Zn2+ (10 microM) and Cd2+ (1 mM) of P2X2 purinoceptor/channels was tested by expressing these channels in Xenopus oocytes. In a pH range between 6.0 and 8.5, concentration-response curves for a...

journal_title：European journal of pharmacology

authors： Nakazawa K,Liu M,Inoue K,Ohno Y

更新日期：1997-10-22 00:00:00

abstract：:The aim of this study was to correlate mineralocorticoid action and steroid structure. Inasmuch as Na(+) retention follows a parabolic dose-response curve for most pregnanesteroids, the second-order coefficient of the function was used as a representative factor for this bipartite biological effect. The C(3)=O/D angle...

journal_title：European journal of pharmacology

authors： Piwien-Pilipuk G,Kanelakis KC,Galigniana MD

更新日期：2002-11-15 00:00:00

abstract：:Several reports suggest that enteric cholinergic neurons are subject to a tonic inhibitory modulation, whereas few studies are available concerning the role of facilitatory pathways. Glutamate, the main excitatory neurotransmitter in the central nervous system (CNS), has recently been described as an excitatory neurot...

journal_title：European journal of pharmacology

authors： Giaroni C,Zanetti E,Chiaravalli AM,Albarello L,Dominioni L,Capella C,Lecchini S,Frigo G

更新日期：2003-08-22 00:00:00

abstract：:Tamsulosin (10(-10)-10(-9) M) or prazosin (10(-9)-10(-8) M) concentration dependently blocked the tension responses to electrical field stimulation (0.3 ms duration, 80 V and 20 Hz) in human hyperplastic prostate with lC50 values of (1.93 +/- 0.26) x 10(-10) M and (2.11 +/- 0.21) x 10(-9) M, respectively. The relative...

journal_title：European journal of pharmacology

authors： Chueh SC,Guh JH,Chen J,Lai MK,Ko FN,Teng CM

更新日期：1996-06-03 00:00:00

abstract：:Platelet aggregation induced in mice or rats by i.v. ADP can be antagonized by oral administration of suloctidil. This effect on platelet behaviour appears to be sufficient to reduce the rate of thrombotic occlusion of the femoral artery in the dog and to protect the rat against occurrence of thrombophlebitis. ...

journal_title：European journal of pharmacology

authors： Roba J,Claeys M,Lambelin G

更新日期：1976-06-01 00:00:00

abstract：:The effect of chronic treatment (21 days s.c.) with SCH 23390 and haloperidol on spontaneously active DA neurones in substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) was studied in rats by means of single unit recording techniques. The specific DA D-1 receptor antagonist SCH 23390 was injected twi...

journal_title：European journal of pharmacology

authors： Skarsfeldt T

更新日期：1988-01-12 00:00:00

abstract：:Chronic, spaced electroconvulsive shock (ECS, 6 treatments at 72 h intervals) produced a moderate (16%) increase in the density of [3H]prazosin binding sites to rat cerebral cortical membranes. The increase was of borderline significance (0.1 greater than P greater than 0.05) and KD was not affected. The effect was si...

journal_title：European journal of pharmacology

authors： Pilc A,Rokosz-Pelc A,Vetulani J

更新日期：1984-03-02 00:00:00

abstract：:A previous report showed that transforming growth factor-beta1 (TGF-beta1) can induce heme oxygenase-1 (HO-1) expression, attenuate cellular injury, and maintain tissue homeostasis. In this study, we investigated the involvement of phosphoinositide-3-OH-kinase (PI3K)/Akt and the nuclear factor-kappaB (NF-kappaB) signa...

journal_title：European journal of pharmacology

authors： Lin CC,Chiang LL,Lin CH,Shih CH,Liao YT,Hsu MJ,Chen BC

更新日期：2007-04-10 00:00:00

abstract：:The interaction of phencyclidine, dexoxadrol, their analogs and stereoisomers with phencyclidine receptors was compared to their ability to induce stereotyped behavior and ataxia after i.c.v. administration to rats. The order of potency for binding to phencyclidine receptors revealed that among the stereoisomers of ph...

journal_title：European journal of pharmacology

authors： Contreras PC,Rice KC,Jacobson AE,O'Donohue TL

更新日期：1986-02-11 00:00:00

abstract：:Ezetimibe represents a new lipid lowering agent which inhibits cholesterol absorption. It effectively reduces low-density lipoprotein cholesterol when administered either alone or in combination with statins. However, its effect on cardiovascular mortality remains under question since it failed to demonstrate any sign...

journal_title：European journal of pharmacology

authors： Kalogirou M,Tsimihodimos V,Elisaf M

更新日期：2010-05-10 00:00:00

abstract：:Male mice from 14 strains were injected i.p. with tremorine (3.0 mg/kg) or oxotremorine (0.15 or 0.1 mg/kg). Large inter-strain differences in the degree and duration of the subsequent hypothermia were noted. 2 strains, BALB/c and Simpson, were particularly sensitive to the hypothermic effect of oxotremorine. The offs...

journal_title：European journal of pharmacology

authors： Lush IE,Andrews KM

更新日期：1978-05-01 00:00:00

abstract：:Aripiprazole is the first dopamine D(2)/D(3) receptor partial agonist approved for use in the treatment of psychiatric disorders including schizophrenia, bipolar disorder, and unipolar depression in the US. Aripiprazole has demonstrated a relatively favorable side effect profile compared to other commonly prescribed a...

journal_title：European journal of pharmacology

authors： Tadori Y,Forbes RA,McQuade RD,Kikuchi T

更新日期：2009-04-01 00:00:00

abstract：:The analgesic activity of dothiepin (an antidepressant interacting with serotonin receptors) was studied (double-blind) in humans. A significant increase in nociceptive flexion reflex threshold and subjective pain threshold was observed after a 14-day dothiepin treatment. The effects of dothiepin on diffuse noxious in...

journal_title：European journal of pharmacology

authors： Sandrini G,Ruiz L,Capararo M,Danilov A,Beretta A,Nappi G

更新日期：1993-10-12 00:00:00

abstract：:The functional role of metabotropic glutamate (mGlu) receptors in the rat dentate gyrus was investigated. By using extracellular recording techniques in slices, it was found that the depression induced by the mGlu receptor agonist (1S,3R)-1-amino-cyclopentane-1,3-dicarboxylate (ACPD) was mediated through the mGlu grou...

journal_title：European journal of pharmacology

authors： Ugolini A,Bordi F

更新日期：1995-12-29 00:00:00

abstract：:The effect of the kappa-opioid receptor agonist, bremazocine, on plasma oxytocin levels in rats was measured by a sensitive radioimmunoassay. Initially, a decrease in plasma oxytocin levels was seen 30 min after injection. This was in accordance with the bremazocine inhibition of oxytocin release after submaximal elec...

journal_title：European journal of pharmacology

authors： Grell S,Fjalland B,Christensen JD

更新日期：1989-07-04 00:00:00

abstract：:Deprenyl, used clinically in Parkinson's disease, has multiple pharmacological effects which make it a good candidate to treat neurotoxicity. Thus, we investigated deprenyl's ability to attenuate methamphetamine-induced dopamine neurotoxicity. We also examined deprenyl's effect in changing markers associated with psyc...

journal_title：European journal of pharmacology

authors： Davidson C,Chen Q,Zhang X,Xiong X,Lazarus C,Lee TH,Ellinwood EH

更新日期：2007-11-14 00:00:00

abstract：:Abnormal proliferation and hypertrophy of vascular smooth muscle (VSMC), as the main structural component of the vasculature, is an important pathological mechanism of hypertension. Recently, increased levels of arginine vasopressin (AVP) and copeptin, the C-terminal fragment of provasopressin, have been shown to corr...

journal_title：European journal of pharmacology

authors： Zhang L,Wang X,Cao H,Chen Y,Chen X,Zhao X,Xu F,Wang Y,Woo AY,Zhu W

更新日期：2016-12-05 00:00:00

abstract：:We investigated whether intracerebroventricular (i.c.v.) infusion of the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine (N-Arg), impairs learning in male Sprague-Dawley rats (2-3 months old) in a 14-unit T-maze. Rats were pretrained in one-way active avoidance to a criterion of 13/15 avoidances of foot shock...

journal_title：European journal of pharmacology

authors： Ingram DK,Spangler EL,Kametani H,Meyer RC,London ED

更新日期：1998-01-02 00:00:00