Antiplatelet and antithrombogenic effects of suloctidil.

abstract：:We investigated the endothelin production and endothelin receptor activity of pericardial mesothelial cells obtained from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. The pericardial mesothelial cells were maintained in vitro and the production of endothelin-1 by these cells was evaluated by usin...

journal_title：European journal of pharmacology

authors： Kuwahara M,Kuwahara M

更新日期：1998-04-24 00:00:00

abstract：:Mitiglinide (KAD-1229), a new anti-diabetic drug, is thought to stimulate insulin secretion by closing the ATP-sensitive K+ (K(ATP)) channels in pancreatic beta-cells. However, its selectivity for the various K(ATP) channels is not known. In this study, we examined the effects of mitiglinide on various cloned K(ATP) c...

journal_title：European journal of pharmacology

authors： Sunaga Y,Gonoi T,Shibasaki T,Ichikawa K,Kusama H,Yano H,Seino S

更新日期：2001-11-09 00:00:00

abstract：:Antibodies against the neurite outgrowth inhibitor Nogo-A enhance axonal regeneration following spinal cord injury. However, antibodies directed against myelin components can also enhance CNS inflammation. The present study was designed to assess the efficacy of DNA vaccination for generating antibodies against Nogo-A...

journal_title：European journal of pharmacology

authors： Bourquin C,van der Haar ME,Anz D,Sandholzer N,Neumaier I,Endres S,Skerra A,Schwab ME,Linington C

更新日期：2008-06-24 00:00:00

abstract：:In rabbits, i.v. delta9-tetrahydrocannabinol (delta9-THC) at 0.5 mg/kg was challenged with i.v. arecoline (0.025 mg/kg), nicotine (0.02 mg/kg) or physostigmine (PHYSO, 0.05 mg/kg), and observations were made on quantified EEG and behavior. The cholinomimetics effectively reversed the cortical and hippocampal EEG alter...

journal_title：European journal of pharmacology

authors： Jones BC,Consroe PF,Laird HE 2nd

更新日期：1976-08-01 00:00:00

abstract：:Huperzine A, a promising therapeutic agent for Alzheimer's disease, was examined for its potential to antagonize the deleterious neurochemical, structural, and cognitive effects of infusing beta-amyloid protein-(1-40) into the cerebral ventricles of rats. Daily intraperitoneal administration of huperzine A for 12 cons...

journal_title：European journal of pharmacology

authors： Wang R,Zhang HY,Tang XC

更新日期：2001-06-15 00:00:00

abstract：:Three important features must be considered when proposing therapeutic strategies in liver cirrhosis: inflammation, oxidative stress and fibrogenesis. Pirfenidone is a synthetic molecule which oxidative action has not been tested in cirrhosis. Cirrhosis was induced in rats by ligation of the common bile duct or carbon...

journal_title：European journal of pharmacology

authors： Salazar-Montes A,Ruiz-Corro L,López-Reyes A,Castrejón-Gómez E,Armendáriz-Borunda J

更新日期：2008-10-24 00:00:00

abstract：:The present study examined patterns of analgesia by intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of the serotonin 5-HT3 receptor agonist, 2-methylserotonin (1-100 micrograms) against acute thermal, mechanical or formalin-induced chemo-inflammatory pain in male rats. Neither i.c.v. or i.t. 2-me...

journal_title：European journal of pharmacology

authors： Giordano J

更新日期：1991-06-25 00:00:00

abstract：:The K562 cell line has been proposed as a useful experimental system to identify anti-tumor compounds acting by inducing terminal erythroid differentiation. K562 cells exhibit a low proportion of hemoglobin-synthesizing cells under standard cell growth conditions, but are able to undergo terminal erythroid differentia...

journal_title：European journal of pharmacology

authors： Brognara E,Lampronti I,Breveglieri G,Accetta A,Corradini R,Manicardi A,Borgatti M,Canella A,Multineddu C,Marchelli R,Gambari R

更新日期：2011-12-15 00:00:00

abstract：:Homovanillic acid (HVA) was measured in rat caudate and pre-frontal cortex 3 h following a single dose of a variety of neuroleptics. Thioridazine, haloperidol, fluphenazine, and metoclopramide increased HVA levels in caudate more than in pre-frontal cortex; whereas sulpiride and clozapine produced greater increases in...

journal_title：European journal of pharmacology

authors： Bowers MB Jr

更新日期：1984-03-16 00:00:00

abstract：:We have examined the effect of ropivacaine, a local anesthetic, on leukocyte-endothelium interactions induced by tumor necrosis factor-alpha (TNF-alpha) in vivo by the use of intravital microscopy in the mouse cremaster microcirculation. It was found that ropivacaine markedly reduced venular leukocyte adhesion and tis...

journal_title：European journal of pharmacology

authors： Zhang XW,Thorlacius H

更新日期：2000-03-24 00:00:00

abstract：:The effects of i.v. injected delta9-tetrahydrocannabinol (delta9-THC) on behaviour, body temperature and levels of brain monoamines, measured spectrophotofluorimetrically, of the rat were determined. Doses of delta9-THC in the range of 0.05--5.0 mg/kg produced biphasic changes in behaviour, body temperature and levels...

journal_title：European journal of pharmacology

authors： Taylor DA,Fennessy MR

更新日期：1977-11-15 00:00:00

abstract：:The spontaneous firing rate of the noradrenergic neurons of the locus coeruleus and of the serotonergic neurons of the dorsal raphe was recorded with extracellular microelectrodes in chloral hydrate-anesthetized rats. A quantitative comparison of the effect of five tricyclic antidepressants, of tranylcypromine and of ...

journal_title：European journal of pharmacology

authors： Scuvée-Moreau JJ,Dresse AE

更新日期：1979-08-01 00:00:00

abstract：:The influence of (+/-)-tamsulosin, a selective alpha 1A-adrenoceptor antagonist, on the positive inotropic effect and the accumulation of inositol phosphates that are induced via alpha 1-adrenoceptors was studied in comparison with that of another alpha 1A-adrenoceptor ligand oxymetazoline in the rabbit ventricular my...

journal_title：European journal of pharmacology

authors： Yang HT,Endoh M

更新日期：1996-10-03 00:00:00

abstract：:Despite ample in vitro evidence that myofilament Ca(2+)-responsiveness of stunned myocardium is decreased, in vivo data are inconclusive. Conversely, while Ca(2+)-sensitizing agents increase myofilament Ca(2+)-responsiveness in vitro, it has been questioned whether this also occurs in vivo. We therefore tested in open...

journal_title：European journal of pharmacology

authors： de Zeeuw S,Trines SA,Krams R,Duncker DJ,Verdouw PD

更新日期：2000-09-01 00:00:00

abstract：:The effects of thyrotropin-releasing hormone (TRH), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) and L-5-hydroxytryptophan (5-HTP) were studied on the monosynaptic reflex (MSR) and the polysynaptic reflex (PSR) in acute and chronic spinal rats. Radioimmunoassay showed that while chronic spinal transection (for 2 weeks)...

journal_title：European journal of pharmacology

authors： Nagano N,Ono H,Ozawa M,Fukuda H

更新日期：1988-05-10 00:00:00

abstract：:It has been shown previously that both forms of interleukin-1, 1 alpha and 1 beta, produce dose-dependent relaxation of the rat gastric fundus in vitro, accompanied by an increased production and release of eicosanoids. This effect appears to be mediated, at least in part, by leukotrienes, since the inhibition of 5-li...

journal_title：European journal of pharmacology

authors： Montuschi P,Tringali G,Mirtella A,Parente L,Preziosi P,Navarra P

更新日期：1995-02-24 00:00:00

abstract：:Organ culture is an in vitro method for investigating cellular mechanisms involved in upregulation of vasocontractile G-protein coupled receptors. We hypothesize that mitogen-activated-protein kinase (MEK) and/or extracellular-signal-regulated kinase (ERK) specific inhibitors will attenuate the G-protein coupled recep...

journal_title：European journal of pharmacology

authors： Sandhu H,Ansar S,Edvinsson L

更新日期：2010-10-10 00:00:00

abstract：:Recent studies suggest that non-steroidal anti-inflammatory drugs have central sites of action which contribute to their analgesic efficacy. In the present study microinjections of the non-steroidal anti-inflammatory drug, dipyrone, were made into the medullary nucleus raphe magnus of lightly pentobarbital-anesthetize...

journal_title：European journal of pharmacology

authors： Jones SL

更新日期：1996-12-27 00:00:00

abstract：:The effect of simultaneous topical application of adrenergic agonists was investigated on the polydipsia caused by direct carbachol (CCh) stimulation of the rat brain. In addition, fluid selection (4-choice arrangement) was studied. Noradrenaline and isoprenaline fully antagonized the CCh effect after either intracere...

journal_title：European journal of pharmacology

authors： Schmidt P,Zámbó K,Decsi L,Nagy J

更新日期：1981-10-15 00:00:00

abstract：:Antagonists, but not agonists, of the 5-HT3 receptor are useful therapeutic agents, and it is possible that partial agonists may also be potentially useful in the clinic. Here we show that 5-fluorotryptamine (5-FT) is a partial agonist at both 5-HT3A and 5-HT3AB receptors with an Rmax (Imax/Imax 5-HT) of 0.64 and 0.45...

journal_title：European journal of pharmacology

authors： Bower KS,Price KL,Sturdee LE,Dayrell M,Dougherty DA,Lummis SC

更新日期：2008-02-12 00:00:00

abstract：:The effect of diazoxide, verapamil and compound D600 on calcium and isoproterenol dose-response relationships was investigated in isolated rabbit atrial preparations. All three agents shifted calcium dose-force relationships parallel and to the right. D600 acted as a competitive antagonist of calcium, as a plot of log...

journal_title：European journal of pharmacology

authors： Bristow MR,Green RD

更新日期：1977-10-01 00:00:00

abstract：:The novel substituted benzamide eticlopride, (S)-(-)-5-chloro-3-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxy salicylamide hydrochloride (A38503; FLB 131), was radiolabelled to high specific activity and used for in vivo receptor binding studies in the rat brain. Intravenous injections of [3H]eticlopride resulted...

journal_title：European journal of pharmacology

authors： Köhler C,Hall H,Gawell L

更新日期：1986-01-21 00:00:00

abstract：:Recent studies have suggested that hydrogen sulfide (H2S), an important endogenous signaling gaseous molecule, participates in relaxation of smooth muscle. Nevertheless, the mechanism of this relaxation effect on respiratory system is still unclear. The present study aims to investigate the physiological function as w...

journal_title：European journal of pharmacology

authors： Huang J,Luo YL,Hao Y,Zhang YL,Chen PX,Xu JW,Chen MH,Luo YF,Zhong NS,Xu J,Zhou WL

更新日期：2014-10-15 00:00:00

abstract：:The dopamine D4 receptor is a potential target for novel antipsychotic drugs. Most available compounds with affinity for the dopamine D4 receptor also bind to dopamine D2 receptors. This report describe the affinity of the 5-HT2A receptor antagonist RP 62203 (fananserin) for the human dopamine D4 receptor. Fananserin ...

journal_title：European journal of pharmacology

authors： Heuillet E,Petitet F,Mignani S,Malleron JL,Lavayre J,Néliat G,Doble A,Blanchard JC

更新日期：1996-10-24 00:00:00

abstract：:Impaired ventricular repolarization can lead to long QT syndrome (LQT), a proarrhythmic disease with high risk of developing lethal ventricular tachyarrhythmias. The compound ICA-105574 is a recently developed hERG activator and it enhances IKr current with very high potency by removing the channel inactivation. The p...

journal_title：European journal of pharmacology

authors： Meng J,Shi C,Li L,Du Y,Xu Y

更新日期：2013-10-15 00:00:00

abstract：:The aims of the present study were to examine the effect of adenosine monophosphate-activated protein kinase (AMPK) activation on airway smooth muscle cells (ASMCs) proliferation and to address its potential mechanisms. Platelet derived growth factor (PDGF) activated phosphatidylinositol 3-kinase (PI3K)/protein kinase...

journal_title：European journal of pharmacology

authors： Liu L,Pan Y,Song Y,Su X,Ke R,Yang L,Gao L,Li M

更新日期：2016-11-15 00:00:00

abstract：:The NMDA receptor is coupled to a cation-selective ion channel, which has been implicated in important brain functions such as long-term potentiation and burst firing, and in neuronal death associated with stroke and epilepsy. We have investigated the binding properties of [3H]MK-801, which binds selectively to the op...

journal_title：European journal of pharmacology

authors： von Euler G,Liu Y

更新日期：1993-05-15 00:00:00

abstract：:In bovine aortic endothelial cells (BAEC), pertussis toxin (PTx) ADP-ribosylated two major substrates with apparent molecular masses of 40 and 41 kDa, whereas cholera toxin (CTx) ADP-ribosylated two other substrates of 44 and 50 kDa. [alpha-32P]GTP bound to three bands in the 22-27 kDa range. Immunoblot analysis revea...

journal_title：European journal of pharmacology

authors： Gil-Longo J,Dufour MN,Guillon G,Lugnier C

更新日期：1993-10-15 00:00:00

abstract：:A 5-min period of cerebral ischemia induced in rats by the four-vessel occlusion method increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) assessed by a working memory procedure applied in a three-panel runway task. The protein kinase C (PKC) i...

journal_title：European journal of pharmacology

authors： Ohno M,Yamamoto T,Watanabe S

更新日期：1991-10-29 00:00:00

abstract：:Several structural analogs of mazindol were tested as inhibitors of the uptake of [3H] dopamine in rat neostriatum, of [3H] norepinephrine in rat occipital cortex and of [3H] serotonin in whole rat brain. A rather wide range of potencies was observed but a number of the drugs were even more potent than mazindol as upt...

journal_title：European journal of pharmacology

authors： Heikkila RE,Babington RG,Houlihan WJ

更新日期：1981-05-08 00:00:00