Inhibitory actions of ropivacaine on tumor necrosis factor-alpha-induced leukocyte adhesion and tissue accumulation in vivo.

abstract：:Phenylalanine and tyrosine reportedly decrease blood pressure in conscious restrained rats. However, tyrosine has recently been found to increase blood pressure in anesthetized animals, questioning the generality of findings obtained in restrained animals. The present study therefore evaluated the effects of phenylala...

journal_title：European journal of pharmacology

authors： Yourick DL,Tessel RE

更新日期：1989-01-31 00:00:00

abstract：:Ocular ischemic syndrome is likely stem from retinal ischemia, and which causes visual disorder. The pathological mechanism of ocular ischemic syndrome is still unknown, therefore the optimal treatment for ocular ischemic syndrome remains to be established. Then, this study aimed to evaluate the effects of tissue-deri...

journal_title：European journal of pharmacology

authors： Masuda T,Shimazawa M,Ishizuka F,Nakamura S,Tsuruma K,Hara H

更新日期：2014-09-05 00:00:00

abstract：:Fat tissue plays an important role in the regulation of inflammatory processes. Increased visceral fat has been associated with a higher production of cytokines that triggers a low-grade inflammatory response, which eventually may contribute to the development of insulin resistance. In the present study, we investigat...

journal_title：European journal of pharmacology

authors： Alarcon-Aguilar FJ,Almanza-Perez J,Blancas G,Angeles S,Garcia-Macedo R,Roman R,Cruz M

更新日期：2008-12-03 00:00:00

abstract：:The characteristics of [3H](+)-pentazocine and [3H]1,3-di(2-tolyl) guanidine (DTG) binding to mouse whole brain, cortex, cerebellum and spinal cord membranes were investigated in radioreceptor assays. [3H](+)-Pentazocine bound to a single, high affinity site (Kd = 1.2-1.6 nM) with increasing density along the neuraxis...

journal_title：European journal of pharmacology

authors： Kovács KJ,Larson AA

更新日期：1995-10-16 00:00:00

abstract：:Increasing evidence indicates that brain inflammation is involved in the pathogenesis of neuropsychiatric diseases. Mast cells (MCs) are located perivascularly close to neurons and microglia, primarily in the leptomeninges, thalamus, hypothalamus and especially the median eminence. Corticotropin-releasing factor (CRF)...

journal_title：European journal of pharmacology

authors： Theoharides TC,Stewart JM,Panagiotidou S,Melamed I

更新日期：2016-05-05 00:00:00

abstract：:Ten beta-adrenoceptor blocking drugs varying in lipophilicity and beta-adrenoceptor blocking potency were examined for inhibitory effects on synaptosomal [3H]noradrenaline uptake. All compounds produced a concentration-dependent inhibition of noradrenaline uptake, but were at least one order of magnitude less potent t...

journal_title：European journal of pharmacology

authors： Street JA,Walsh A

更新日期：1984-07-13 00:00:00

abstract：:Spinorphin has been isolated from the bovine spinal cord as an endogenous inhibitor of enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase), and tynorphin has been synthesized as a more potent inhibitor of dipeptidyl aminopeptidase III. In this s...

journal_title：European journal of pharmacology

authors： Yamazaki T,Honda M,Yamamoto Y,Hazato T,Ono H

更新日期：2001-02-16 00:00:00

abstract：:The regulation of acetylcholine (ACh) lifetime by acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BuChE, EC 3.1.1.8) was evaluated in vitro in canine tracheal smooth muscle preparations. Selective inhibition of AChE by low concentrations of 1,5-bis(N-allyl-N,N-dimethyl-4-ammoniumphenyl)-pentane-3-on...

journal_title：European journal of pharmacology

authors： Adler M,Reutter SA,Moore DH,Filbert MG

更新日期：1991-11-19 00:00:00

abstract：:We investigated the effect of sevoflurane (fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl) ethylether) on intracellular calcium concentration ([Ca2+]i) and nitric oxide (NO) release from cultured porcine aortic endothelial cells using fura-2 fluorometry, and direct (ESR spectrometry with NO-trapping by 2-(4-carboxyph...

journal_title：European journal of pharmacology

authors： Az-ma T,Fujii K,Yuge O

更新日期：1995-03-15 00:00:00

abstract：:Large doses of dexamphetamine, methylamphetamine and MPTP failed to induce the formation of 6-hydroxydopamine (6-OHDA) in rat striatum. The potent dopamine (DA) releasing actions of these drugs and of the MPTP metabolite MPP+ were shown by intracerebral dialysis of DA in conscious rats but 6-OHDA was not detectable in...

journal_title：European journal of pharmacology

authors： Rollema H,De Vries JB,Westerink BH,Van Putten FM,Horn AS

更新日期：1986-12-02 00:00:00

abstract：:The bronchial smooth muscle of the rat was examined for contractile responses to excitatory amino acids. The nerve-mediated contraction induced by electrical field stimulation was enhanced by exogenous L-glutamate (L-Glu). The apparent affinity (ED50) of L-Glu was 3.5 +/- 0.1 mM. Both tetrodotoxin and hemicholinium-3 ...

journal_title：European journal of pharmacology

authors： Aas P,Tansø R,Fonnum F

更新日期：1989-05-02 00:00:00

abstract：:Myocardial pH was measured continuously with a micro pH electrode inserted into the left ventricular wall in dogs. Anterior descending coronary flow was reduced to about 1/3 of the original flow by partial occlusion of the coronary artery. Myocardial pH decreased from 7.50--7.60 to 7.06--7.24 after partial occlusion. ...

journal_title：European journal of pharmacology

authors： Abiko Y,Sakai K

更新日期：1980-06-27 00:00:00

abstract：:Langendorff preparations of Sprague-Dawley rat hearts were perfused with calcium-free Krebs solution of pH 7.48 (control), 7.26 (acidosis) or 7.69 (alkalosis) containing either adrenaline or potassium. The responses of the force of contraction, coronary perfusion pressure and heart rate to graded doses of calcium prec...

journal_title：European journal of pharmacology

authors： Achike FI,Dai S

更新日期：1991-04-10 00:00:00

abstract：:The spontaneous and electrically evoked activity was examined in guinea-pig, ferret and marmoset urinary bladder. Electrical field stimulation of detrusor strips in vitro induced a rapid, frequency-dependent contraction with a maximum response at 40 Hz. This contraction was partly decreased by either atropine (0.29 mi...

journal_title：European journal of pharmacology

authors： Moss HE,Burnstock G

更新日期：1985-08-27 00:00:00

abstract：:The muscarinic agonists, xanomeline and carbachol, displayed similar intrinsic activities in stimulating neuronal nitric oxide synthase at muscarinic M1 receptors in Chinese hamster ovary (CHO) cells, with xanomeline being more potent. Pre-incubation (1 h) with 1 microM xanomeline, followed by extensive washing, resul...

journal_title：European journal of pharmacology

authors： Christopoulos A,El-Fakahany EE

更新日期：1997-09-03 00:00:00

abstract：:The new antisecretory drug, telenzepine (4,9-dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno-[3,4 - b][1,5]benzodiazepin-10-one), was investigated for its inhibition of functionally intact muscarinic receptors involved in gastric acid secretion in rabbit fundic glands, perfused mouse stomach in vitro, p...

journal_title：European journal of pharmacology

authors： Eltze M,Gönne S,Riedel R,Schlotke B,Schudt C,Simon WA

更新日期：1985-06-07 00:00:00

abstract：:The insulin-like growth factor-1 receptor (IGF-1 receptor) is a receptor tyrosine kinase, highly homologous to the insulin receptor. In contrast to the insulin receptor, which is mostly involved in metabolic pathways, the IGF-1 system plays a pivotal role in normal and neoplastic cell growth through anti-apoptotic, pr...

journal_title：European journal of pharmacology

authors： Steiner L,Blum G,Friedmann Y,Levitzki A

更新日期：2007-05-07 00:00:00

abstract：:UTP causes IL-6 production in HaCaT keratinocytes, which is partially inhibited by PD98059, a mitogen-activated protein kinase kinase (MEK) inhibitor, suggesting that a pathway other than the extracellular signal-regulated kinase (ERK) pathway is involved in the production. In the present study, we examined the involv...

journal_title：European journal of pharmacology

authors： Kobayashi D,Ohkubo S,Nakahata N

更新日期：2007-11-14 00:00:00

abstract：:In strips of pig coronary arteries incubated in oxygenated Krebs-bicarbonate solution at 37 degrees C, dotarizine blocked the phasic contractions evoked by 5-HT (0.5 microM) or K+ depolarization (35 mM K+) with an IC50 of 0.22 and 3.7 microM, respectively. Flunarizine inhibited both types of contractions with IC50 val...

journal_title：European journal of pharmacology

authors： Montiel C,Herrero CJ,García-Palomero E,Renart J,García AG,Lomax RB

更新日期：1997-08-06 00:00:00

abstract：:The binding characteristics of [3H]gabapentin, the radiolabelled analogue of the novel anticonvulsant gabapentin (1-(aminomethyl)cyclohexaneacetic acid) were studied using purified synaptic plasma membranes prepared from rat cerebral cortex. In 10 mM HEPES buffer [3H]gabapentin bound to a single population of sites wi...

journal_title：European journal of pharmacology

authors： Suman-Chauhan N,Webdale L,Hill DR,Woodruff GN

更新日期：1993-02-15 00:00:00

abstract：:Diabetic nephropathy is a progressive kidney disorder and is pathologically characterized by thickened glomerular and tubular basement membranes, accumulation of the extracellular matrix and increased mesangial hypertrophy. Growing evidence has suggested that diabetic nephropathy is induced by multiple factors, such a...

journal_title：European journal of pharmacology

authors： Ni WJ,Ding HH,Tang LQ

更新日期：2015-08-05 00:00:00

abstract：:Rats were injected with 15 mg/kg (i.p.) mianserin or vehicle (saline) for 4, 10 or 21 days and 5-HT2 receptor binding and mRNA levels measured. Treatment with mianserin induced a substantial decrease in 5-HT2 radioligand binding (44-59% decrease; P less than 0.05 vs. control). No changes in the amount of 5-HT2 or, as ...

journal_title：European journal of pharmacology

authors： Roth BL,Ciaranello RD

更新日期：1991-06-19 00:00:00

abstract：:Recent studies show that 8-iso-prostaglandin F(2alpha), a member of F(2)-isoprostane family, acts as a vasoconstrictor via TP receptor activation; and its local release may contribute to an abnormal vasomotor tone associated with hypercholesterolemia. The purpose of this study was to examine whether ramatroban, a TP r...

journal_title：European journal of pharmacology

authors： Ishizuka T,Matsui T,Kurita A

更新日期：2003-05-02 00:00:00

abstract：:The pathological changes of parasympathetic nerves are considered as an independent prognostic factor of the survival rate for patients with chronic liver disease. The non-selective muscarinic acetylcholine receptors (mAchR) agonists and antagonists can affect the proliferation of hepatocytes, but little is known abou...

journal_title：European journal of pharmacology

authors： Luo L,Xi C,Xu T,Zhang G,Qun E,Zhang W

更新日期：2017-07-15 00:00:00

abstract：:The Langendorff-perfused rabbit heart preparation has been used to study the interaction of isolated rabbit neutrophils with regionally ischaemic myocardium. Short durations of regional ischaemia (10-60 min) and subsequent reperfusion (30 min) of the hearts with neutrophils resulted in a significant time-dependent acc...

journal_title：European journal of pharmacology

authors： Lad N,Williams TJ,Booth RF

更新日期：1992-11-17 00:00:00

abstract：:The amyloid precursor protein (APP) has been mainly studied in its role in the production of amyloid β peptides (Aβ), because Aβ deposition is a hallmark of Alzheimer's disease. Although several studies suggest APP has physiological functions, it is still controversial. We previously reported that APP increased glial ...

journal_title：European journal of pharmacology

authors： Kwak YD,Marutle A,Dantuma E,Merchant S,Bushnev S,Sugaya K

更新日期：2011-01-10 00:00:00

abstract：:Nerve growth factor (NGF) is known to regulate the development and survival of select populations of neurons via its binding/activation of the TrkA and p75(NTR) receptors. However, in some physiological circumstances NGF dysregulation can result in debilitating pathologies, including diabetic neuropathies, interstitia...

journal_title：European journal of pharmacology

authors： Eibl JK,Strasser BC,Ross GM

更新日期：2013-05-15 00:00:00

abstract：:The G protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor and is associated with angiotensin-(1-7) signaling. We investigated the effect of Mas-deficiency on blood pressure regulation under physiological conditions and salt load using radiotelemetry. Mas-knockout mice and t...

journal_title：European journal of pharmacology

authors： Heringer-Walther S,Gembardt F,Perschel FH,Katz N,Schultheiss HP,Walther T

更新日期：2012-08-15 00:00:00

abstract：:The effects of GABA on depolarization-induced (26 mM K+) release of radiolabeled dopamine (DA) and acetylcholine (ACh) from slices of rat caudate nucleus were examined with a superfusion method. GABA, in concentrations of 10(-5)--10(-3) M, dose-dependently enhanced the release of DA, either accumulated by high-affinit...

journal_title：European journal of pharmacology

authors： Stoof JC,Den Breejen EJ,Mulder AH

更新日期：1979-07-15 00:00:00

abstract：:Hypoglycemia developed in fasted rats during forced swimming. This hypoglycemia was mostly abolished by phentolamine, an alpha-adrenolytic agent, or by hexamethonium; was potentiated by propranolol, a beta-adrenolytic agent, of by 5-methoxyindole-2-carboxylic acid, a gluconeogenic inhibitor; and was not affected by an...

journal_title：European journal of pharmacology

authors： Yajima M,Hosokawa T,Ui M

更新日期：1977-03-07 00:00:00