Abstract:
:Langendorff preparations of Sprague-Dawley rat hearts were perfused with calcium-free Krebs solution of pH 7.48 (control), 7.26 (acidosis) or 7.69 (alkalosis) containing either adrenaline or potassium. The responses of the force of contraction, coronary perfusion pressure and heart rate to graded doses of calcium preceded by a single dose of verapamil were measured. Contractile responsiveness to calcium was reduced during acidosis in both adrenaline- and potassium-stimulated hearts but was increased or reduced during alkalosis with adrenaline- or potassium stimulation, respectively. The efficacy of verapamil as a calcium antagonist increased during acidosis or alkalosis in both adrenaline- and potassium-stimulated hearts. In conclusion, acidosis or alkalosis inhibits potassium-stimulated contractions of the heart and enhances the effects of verapamil on potassium- and adrenaline-mediated contractions. Acidosis inhibits and alkalosis enhances adrenaline-stimulated contractions.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Achike FI,Dai Sdoi
10.1016/0014-2999(91)90411-ikeywords:
subject
Has Abstractpub_date
1991-04-10 00:00:00pages
77-83issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(91)90411-Ijournal_volume
196pub_type
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journal_title:European journal of pharmacology
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