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Increase in renal phorbol ester receptors in rats with cyclosporine A-induced nephrotoxicity.

Abstract：

:Treatment of rats with cyclosporine A (50 mg/kg i.p.) for 4 days resulted in the impairment of renal function. Renal membrane and soluble phorbol ester receptor densities were significantly higher in cyclosporine A-treated rats compared to vehicle-treated rats. These data suggest that increased phorbol ester receptor (protein kinase C) may be involved in the increased renal vascular resistance associated with cyclosporine A-induced nephrotoxicity.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Nambi P,Pullen M,Wu HL,Brooks DP

doi

10.1016/0014-2999(91)90396-8

subject

Has Abstract

pub_date

1991-03-19 00:00:00

pages

167-9

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(91)90396-8

journal_volume

195

pub_type

杂志文章

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