Effects of L-glutamic acid and kainic acid on central cardiovascular control.

abstract：:Dopamine hyperpolarizes growth hormone-producing cells (GHC) in the CNS of Lymnaea stagnalis. This effect of dopamine was mimicked by the D-2 receptor agonist LY 141865 and antagonized by the D-2 receptor antagonists (-)-sulpiride and YM 09151-2. SKF 38393, a selective D-1 receptor agonist, increased the excitability ...

journal_title：European journal of pharmacology

authors： Stoof JC,De Vlieger TA,Lodder JC

更新日期：1984-11-13 00:00:00

abstract：:In the present studies, we have examined the effects of two new Ca(2+) channel blockers, LY042826 (N-[2-[(2-methylphenyl)(phenyl)methoxy]ethyl]-1-butanamine hydrochloride) and LY393615 (N-[[5, 5-bis(4-fluorophenyl)tetrahydro-2-furanyl]methyl]-1-butanamine hydrochloride) in the gerbil model of global and the endothelin...

journal_title：European journal of pharmacology

authors： Hicks CA,Ward MA,O'Neill MJ

更新日期：2000-11-24 00:00:00

abstract：:Evidence for an analgesic interaction between delta-9-tetrahydrocannabinol (Delta(9)-THC) and morphine was sought using an experimental pain model applied to normal volunteers. The study incorporated a double blinded, four treatment, four period, four sequence, crossover design. Subjects received Delta(9)-THC 5 mg ora...

journal_title：European journal of pharmacology

authors： Roberts JD,Gennings C,Shih M

更新日期：2006-01-13 00:00:00

abstract：:The effects of the delta2-opioid receptor agonist, deltorphin II, on extracellular levels of dopamine in the rat nucleus accumbens were investigated in awake animals by in vivo brain microdialysis. In agreement with previous studies, perfusion of deltorphin II (50.0 nmol) into the nucleus accumbens significantly incre...

journal_title：European journal of pharmacology

authors： Murakawa K,Hirose N,Takada K,Suzuki T,Nagase H,Cools AR,Koshikawa N

更新日期：2004-04-26 00:00:00

abstract：:St. John's wort (Hypericum perforatum L.) is widely used for the treatment of mild to moderately severe depression. However, the nature of its active principles and the exact mode of antidepressant action are still unknown. It has been suggested repeatedly in preclinical and clinical studies that the content of the ac...

journal_title：European journal of pharmacology

authors： Simmen U,Bobirnac I,Ullmer C,Lübbert H,Berger Büter K,Schaffner W,Schoeffter P

更新日期：2003-01-05 00:00:00

abstract：:The NMDA receptor is coupled to a cation-selective ion channel, which has been implicated in important brain functions such as long-term potentiation and burst firing, and in neuronal death associated with stroke and epilepsy. We have investigated the binding properties of [3H]MK-801, which binds selectively to the op...

journal_title：European journal of pharmacology

authors： von Euler G,Liu Y

更新日期：1993-05-15 00:00:00

abstract：:Melatonin protection against in vitro kainic acid-induced oxidative damage in rat brain is shown. Brain disrupted cell homogenates were incubated with different concentrations of kainate and with or without different concentrations of melatonin. The concentration of malonaldehyde and 4-hydroxyalkenals was measured as ...

journal_title：European journal of pharmacology

authors： Melchiorri D,Reiter RJ,Chen LD,Sewerynek E,Nisticò G

更新日期：1996-06-03 00:00:00

abstract：:The effect of chlorogenic acid on the sleep-wakefulness cycle in rats was investigated in comparison with those of caffeic acid (the metabolite of chlorogenic acid) and dihydrocaffeic acid (the metabolite of caffeic acid). A significant prolongation of sleep latency was observed with chlorogenic acid and caffeic acid ...

journal_title：European journal of pharmacology

authors： Shinomiya K,Omichi J,Ohnishi R,Ito H,Yoshida T,Kamei C

更新日期：2004-11-19 00:00:00

abstract：:3,5-Dihydroxyphenylglycine (DHPG), (S)-3-hydroxyphenylglycine and (S)-4-carboxy-3-hydroxyphenylglycine (S-4C3HPG) stimulated phosphoinositide hydrolysis in neonatal rat cortical slices, but with lower maximal effect, in comparison with 2S,1'S,2'S-2-(2'-carboxycyclopropyl)glycine (L-CCG I) or (1S,3R)-1-aminocyclo-penta...

journal_title：European journal of pharmacology

authors： Schaffhauser H,de Barry J,Muller H,Heitz MP,Gombos G,Mutel V

更新日期：1997-09-10 00:00:00

abstract：:We examined whether danazol has a direct action on ovarian steroid secretion and/or uterine prostaglandin (PG) F2 alpha catabolic activity in immature rats in which the first ovulation was induced and in adult ovariectomized rats. The preovulatory surge of estradiol and progesterone was markedly suppressed together wi...

journal_title：European journal of pharmacology

authors： Kogo H,Takasaki K,Yatabe Y,Nishikawa M,Takeo S,Tamura K

更新日期：1992-01-28 00:00:00

abstract：:MPC-1304 is a novel Ca2+ entry blocker of the 1,4-dihydropyridine type. In the present study, the effect of oral administration of MPC-1304 on alpha-adrenoceptor-mediated pressor responses was examined in pithed rats and compared with that of nifedipine. Drugs were administered orally to conscious animals before pithi...

journal_title：European journal of pharmacology

authors： Ichihara K,Okumura K,Mori H,Nagasaka M

更新日期：1993-07-20 00:00:00

abstract：:Increasing stimulation frequency and monensin were utilized in attempts to enhance Na+ influx and thereby elicit the maximum rate of ouabain-sensitive 86Rb+ uptake in rat atrial muscle. Increasing stimulation frequency between 0 and 9 Hz enhanced the rate of ouabain-sensitive 86Rb+ uptake, whereas the uptake rate appe...

journal_title：European journal of pharmacology

authors： Kennedy RH,Seifen E,Kafiluddi R

更新日期：1986-09-23 00:00:00

abstract：:Galectins are carbohydrate-binding proteins and these have very high affinity for β-galactoside containing glycoproteins and glycolipids. Amongst sixteen types of galectin, the role of galectin 1, 3, 9 and 12 is defined in the development and progression of different types of leukemia including acute myeloid leukemia,...

journal_title：European journal of pharmacology

authors： Zheng Y,Feng W,Wang YJ,Sun Y,Shi G,Yu Q

更新日期：2019-02-05 00:00:00

abstract：:The purpose of this study was to examine the influence of ageing on the alterations in binding characteristics of adrenoceptors and membrane phospholipid fatty acids in rat heart following repeated administration of epinephrine. The maximal number of binding sites (Bmax) and dissociation constant (Kd) of [3H]prazosin ...

journal_title：European journal of pharmacology

authors： Benediktsdóttir VE,Skúladóttir GV,Gudbjarnason S

更新日期：1995-05-26 00:00:00

abstract：:The effects of RX 781094, a new and potent alpha 2-adrenoceptor antagonist, on locus coeruleus (LC) unit activity were examined. Low doses of RX 781094 produced suppression of spontaneous LC unit activity which could be reversed with yohimbine. The increase in LC firing produced by WB 4101 could also be reversed with ...

journal_title：European journal of pharmacology

authors： Goldstein JM,Knobloch LC,Malick JB

更新日期：1983-07-15 00:00:00

abstract：:The suppression of pro-inflammatory cytokine-induced inflammation responses is an attractive pharmacological target for the development of therapeutic strategies for inflammatory bowel disease (IBD). In the present study, we evaluated the anti-inflammatory properties of flavonoid isoliquiritigenin (ISL) in intestinal ...

journal_title：European journal of pharmacology

authors： Chi JH,Seo GS,Cheon JH,Lee SH

更新日期：2017-02-05 00:00:00

abstract：:Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high attrition rates of drugs in Phase II/III rates means that a relatively small number of drugs reach the market, despite showing efficacy in pre-clinical models. Th...

journal_title：European journal of pharmacology

authors： McNamee K,Williams R,Seed M

更新日期：2015-07-15 00:00:00

abstract：:ATP, ADP, adenosine and AMP, but not adenine, inosine, or GMP, caused dose-related intestinal contractions when injected as intra-arterial bolus doses in vascularly perfused isolated segments of dog small bowel. The stimulatory effects of these agents were decreased by receptor densitization during exposure to high co...

journal_title：European journal of pharmacology

authors： Northway MG,Burks TF

更新日期：1980-07-11 00:00:00

abstract：:After recovery from a first intraplantar or intrathoracic stimulation with bradykinin, repeated daily provocation with this peptide resulted in a progressive loss of its ability to cause paw or pleural oedema, reaching 0-20% of the control within seven and four consecutive provocations, respectively. The phenomenon wa...

journal_title：European journal of pharmacology

authors： Martins MA,Pasquale CP,Bozza PT,Silva PM,Faria Neto HC,COrdeiro RS

更新日期：1992-09-10 00:00:00

abstract：:On exposure to triphosphatic nucleotides vas deferens DDT1 MF-2 smooth muscle cells responded with an outward K+ current as measured with the whole-cell patch clamp configuration. The rank order of potency was: ATP greater than UTP greater than TTP greater than CTP = GTP. The responses evoked by these agonists were bl...

journal_title：European journal of pharmacology

authors： Van der Zee L,Nelemans A,Den Hertog A

更新日期：1992-05-14 00:00:00

abstract：:The effect of antiepileptic drug di-n-propylacetamide (DPM) on 5-hydroxytryptamine (5-HT) turnover in rat brain and 5-hydroxyindoleacetic acid (5-HIAA) in cat cerebrospinal fluid (CSF) was investigated. DPM (200 mg/kg) increased brain 5-HIAA without altering the 5-HT level. DPM augmented the accumulation of 5-HT induc...

journal_title：European journal of pharmacology

authors： Whitton PS,Oresković D,Marković Z,Skarpa D,Bulat M

更新日期：1983-07-15 00:00:00

abstract：:One of the best known bioactive triterpenoids is oleanolic acid, a widespread 3-hydroxy-17-carboxy oleanane-type compound. In order to determine whether further oxidation of carbon 3 affects anti-inflammatory activity in mice, different tests were carried out on oleanolic acid and its 3-oxo-analogue oleanonic acid, wh...

journal_title：European journal of pharmacology

authors： Giner-Larza EM,Máñez S,Recio MC,Giner RM,Prieto JM,Cerdá-Nicolás M,Ríos JL

更新日期：2001-09-28 00:00:00

abstract：:Vascular hypertrophy occurs during chronic hypertension and contributes to the elevation of peripheral vascular resistance in hypertension. In this study, we examined whether acute pressure overloading of the vascular wall produces activation of mitogen-activated protein (MAP) kinases, enzymes believed to be involved ...

journal_title：European journal of pharmacology

authors： Kubo T,Hosokawa H,Kambe T,Fukumori R

更新日期：2000-03-17 00:00:00

abstract：:Flesinoxan acts as a full 5-HT1A receptor agonist and displays anxiolytic and anti-depressant properties. 5-HT1A receptor agonists, including flesinoxan, increase corticosterone (B) levels in the blood and reduces 5-HT1A receptor mRNA expression in the hippocampus. In this study, we examined whether the 5-HT1A recepto...

journal_title：European journal of pharmacology

authors： Sibug RM,Compaan JC,Meijer OC,Van der Gugten J,Olivier B,De Kloet ER

更新日期：1998-07-24 00:00:00

abstract：:The vasodepressor actions of the cyclic endoperoxides PGG2 and PGH2 were compared with those of their products PGD2 and PGE2 using anaesthetised normotensive and genetically hypertensive rats. Given into the aortic arch of normotensives PGE2 was approximately 6 times more potent than PGH2 and 11 times more potent tha...

journal_title：European journal of pharmacology

authors： Armstrong JM,Boura AL,Hamberg M,Samuelsson B

更新日期：1976-10-01 00:00:00

abstract：:The psychotropic actions of crude ginseng saponins, pure ginsenoside Rb1 (GS-Rb1) and ginsenoside Rg1 (GS-Rg1) obtained from the root of Panax ginseng, were evaluated from their effects on agonistic behavior in mice. A resident-intruder test situation was used. When the resident mouse was treated with crude ginseng sa...

journal_title：European journal of pharmacology

authors： Yoshimura H,Watanabe K,Ogawa N

更新日期：1988-02-09 00:00:00

abstract：:The effects of beta-chlornaltrexamine (CNA, 5 mg/kg s.c.) on social conflict analgesia and brain opioid binding were investigated in mice at different times after the administration of the alkylating antagonist. The specific binding of [3H]etorphine to high-affinity binding sites and the stress-induced analgesia of at...

journal_title：European journal of pharmacology

authors： Lazega D,Frischknecht HR,Waser PG,Siegfried B

更新日期：1988-10-18 00:00:00

abstract：:In two separate research centres the ability of RO 15-4513 to protect rats against the lethal effects of ethanol (7.5 and 15 g/kg) was investigated. In neither study did RO 15-4513 offer protection against ethanol-induced lethality or the loss of righting reflex caused by these doses of ethanol. These data fail to rep...

journal_title：European journal of pharmacology

authors： Nutt DJ,Lister RG,Rusche D,Bonetti EP,Reese RE,Rufener R

更新日期：1988-06-22 00:00:00

abstract：:We explored the effects of contractile arrest maintained for 24-72 h in the presence of 2,3-butanedione monoxime or a Ca(2+) channel blocker (nifedipine or verapamil) on contractile activity, Ca(i)(2+) transients, and myofibrillar protein content and ultrastructure in long-term cultures of spontaneously beating adult ...

journal_title：European journal of pharmacology

authors： Horackova M,Byczko Z,Morash B

更新日期：2000-09-22 00:00:00

abstract：:The effect of genistein, a tyrosine kinase inhibitor, on nitroglycerin-induced relaxation was examined in rat aortic rings contracted by phenylephrine. In rat aortic rings, genistein (10(-5) M and 3x10(-5) M), a tyrosine kinase inhibitor, but not daidzein, an analogue of genistein, increased relaxation induced by nitr...

journal_title：European journal of pharmacology

authors： Satake N,Imanishi M,Shibata S

更新日期：1999-07-21 00:00:00