RO 15-4513 does not protect rats against the lethal effects of ethanol.

abstract：:To explore the possibility that raloxifene might influence an adipocyte differentiation and lipogenesis, we studied the effects of raloxifene on the expression of adiponectin and other peroxisome proliferator-activated receptor gamma targeting genes using the 3T3-L1 adipocytes. With standard adipogenic inducers, we ad...

journal_title：European journal of pharmacology

authors： Murase Y,Kobayashi J,Nohara A,Asano A,Yamaaki N,Suzuki K,Sato H,Mabuchi H

更新日期：2006-05-24 00:00:00

abstract：:The effects of seganserin, a specific 5HT2 antagonist, on human sleep were assessed in two experiments and compared to the effects of temazepam and sleep deprivation. During daytime recovery sleep after sleep deprivation, seganserin did not significantly enhance visually scored slow wave sleep (SWS, stages 3 + 4) or t...

journal_title：European journal of pharmacology

authors： Dijk DJ,Beersma DG,Daan S,van den Hoofdakker RH

更新日期：1989-11-21 00:00:00

abstract：:Cerebral ischemia/reperfusion (I/R) is a lethal and disabling disease. Studies have suggested that hyperglycemia is a risk factor for cerebral I/R. Baicalin is a natural bioactive flavonoid extracted from Scutellaria baicalensis Georgi with neuroprotective activity. In the present study, we investigated the effects of...

journal_title：European journal of pharmacology

authors： Li S,Sun X,Xu L,Sun R,Ma Z,Deng X,Liu B,Fu Q,Qu R,Ma S

更新日期：2017-11-15 00:00:00

abstract：:Levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide, ucb L059) is a novel potential antiepileptic agent presently in clinical development with unknown mechanism of action. The finding that its anticonvulsant activity is highly stereoselective (Gower et al., 1992) led us to investigate the presence of specific b...

journal_title：European journal of pharmacology

authors： Noyer M,Gillard M,Matagne A,Hénichart JP,Wülfert E

更新日期：1995-11-14 00:00:00

abstract：:The effects of intracisternal injections of [Lys8]vasopressin and [Arg8]vasopressin (25, 50, 100, 200 mU/kg) and related compounds oxytocin (25, 50, 100, 200 mU/kg), felypressin (25, 50, 100, 200 mU/kg) and vasotocin (100, 200, 400, 800 ng/kg) on the acute neurogenic pressor responses to afferent vagal stimulation (5,...

journal_title：European journal of pharmacology

authors： Montastruc P,Dang Tran L,Montastruc JL

更新日期：1985-11-19 00:00:00

abstract：:Hydrolysis of ([3H]Leu5)-enkephalin into the tripeptide [3H]Tyr-Gly-Gly can be detected using particulate fractions from a variety of peripheral organs. In some tissues, e.g. exocrine and endocrine glands, this dipeptidyl carboxypeptidase ("enkephalinase") activity is even higher than in brain. ...

journal_title：European journal of pharmacology

authors： Llorens C,Schwartz JC

更新日期：1981-01-05 00:00:00

abstract：:Visfatin is a novel adipokine involved in the process of atherosclerosis. We assessed the effect of rosuvastatin on plasma visfatin levels in patients with primary hyperlipidemia. Eighty hyperlipidemic patients without evidence of cardiovascular disease were randomized to receive either rosuvastatin 10 mg/day or thera...

journal_title：European journal of pharmacology

authors： Kostapanos MS,Derdemezis CS,Filippatos TD,Milionis HJ,Kiortsis DN,Tselepis AD,Elisaf MS

更新日期：2008-01-14 00:00:00

abstract：:The effects of H 25 and H 74 on ouabain-resistant 86Rb+ influx were tested in beta-cell-rich mouse pancreatic islets. Both H 25, which is considered to be a specific inhibitor of Na+, K+, Cl- co-transport, and H 74, a specific inhibitor of K+, Cl- co-transport, reduced the ouabain-resistant 86Rb+ influx. The specific ...

journal_title：European journal of pharmacology

authors： Sandström PE,Sehlin J

更新日期：1993-07-20 00:00:00

abstract：:The activation of C-fibers in the airways induces coughing, mucus production and bronchoconstriction, which are also symptoms of airway diseases. In this study, we evaluated the role of the C-fibers and the TRPV1 (transient receptor potential vanilloid 1) receptor in an experimental mouse model of allergic airway infl...

journal_title：European journal of pharmacology

authors： Rogerio AP,Andrade EL,Calixto JB

更新日期：2011-07-15 00:00:00

abstract：:We investigated the role of interleukin-1 in the induction of a Ca(2+)-independent nitric oxide (NO) synthase by bacterial endotoxin in vivo. In anaesthetized rats, pretreatment with interleukin-1 receptor antagonist (interleukin-1ra; 16 mg kg-1 i.v., followed by an infusion of 2.4 mg kg-1 h-1) ameliorated the delayed...

journal_title：European journal of pharmacology

authors： Szabó C,Wu CC,Gross SS,Thiemermann C,Vane JR

更新日期：1993-11-30 00:00:00

abstract：:Ovarian cancer is the leading cause of death among gynecologic cancer patients. Although platinum-based chemotherapy as a frontline treatment for ovarian cancer has been widely used in clinical settings, its clinical efficacy is not satisfactory due to the resistance of ovarian cancer cells to apoptosis. Therefore, it...

journal_title：European journal of pharmacology

authors： Pang HF,Li XX,Zhao YH,Kang JK,Li JY,Tian W,Wang CM,Hou HX,Li DR

更新日期：2020-11-05 00:00:00

abstract：:Sham and electrolytic lesions of the dorsal, median, and dorsal + median raphe nuclei were made in different groups of rats. One week later, daily oral treatment with ethanol (5 g/kg p.o. for 25 days) was started. This treatment produced tolerance to the hypothermic and motor impairing (moving belt test) effects of et...

journal_title：European journal of pharmacology

authors： Lê AD,Kalant H,Khanna JM

更新日期：1982-06-04 00:00:00

abstract：:The development of anticonvulsant tolerance with RO 16-6028, a benzodiazepine receptor partial agonist, was assessed in mice using an i.v. infusion of pentylenetetrazol as the convulsive stimulus. In contrast to other benzodiazepines tested previously in this seizure model the anticonvulsant protection afforded by RO ...

journal_title：European journal of pharmacology

authors： Haigh JR,Feely M

更新日期：1988-03-01 00:00:00

abstract：:Oxidative stress plays an important role in auditory dysfunction. Exogenous cell therapy has brought new hopes for repairing mammalian inner ear hair cells. However, poor cell viability of transplanted cells under oxidative stress conditions has limited their therapeutic potential. The adipocytokine apelin-13 was isol...

journal_title：European journal of pharmacology

authors： Niknazar S,Abbaszadeh HA,Peyvandi H,Rezaei O,Forooghirad H,Khoshsirat S,Peyvandi AA

更新日期：2019-06-15 00:00:00

abstract：:Slices of rat kidney cortex were incubated in [3H]noradrenaline, then placed in a flow cell and subjected to electrical field stimulation. At a stimulation frequency of 5 Hz, both the alpha 2-adrenoceptor antagonist idazoxan (0.1 microM) and the alpha 1-adrenoceptor antagonist prazosin (0.1 microM) significantly enhan...

journal_title：European journal of pharmacology

authors： Murphy TV,Majewski H

更新日期：1989-10-10 00:00:00

abstract：:Opioid agonists and antagonists can regulate the density of mu-opioid receptors in whole animal and in cell culture. High intrinsic efficacy agonists (e.g., etorphine), but not lower intrinsic efficacy agonists (e.g., morphine), produce mu-opioid receptor down-regulation and can alter the abundance of mu-opioid recept...

journal_title：European journal of pharmacology

authors： Yoburn BC,Purohit V,Patel K,Zhang Q

更新日期：2004-09-13 00:00:00

abstract：:Adenosine (10(-4)-10(-3) M) contracted the isolated rat tail artery. This effect exhibited rapidly developing tachyphylaxis. Methysergide (10(-7) M) prevented the contractile response to adenosine and 5-hydroxytryptamine (5-HT) without affecting that to noradrenaline. Pretreatment of rats with parachlorophenylalanine ...

journal_title：European journal of pharmacology

authors： Brown CM,Collis MG

更新日期：1981-12-03 00:00:00

abstract：:Although muscarinic M(2) and M(3) receptors are known to be important for regulation of gastric and small intestinal motility, muscarinic receptor subtypes regulating colonic function remain to be investigated. The aim of this study was to characterize muscarinic receptors involved in regulation of colonic contractili...

journal_title：European journal of pharmacology

authors： Kondo T,Nakajima M,Teraoka H,Unno T,Komori S,Yamada M,Kitazawa T

更新日期：2011-11-16 00:00:00

abstract：:The present study shows that the GABAB positive allosteric modulators (PAMs) CGP7930 and GS39783 stimulate extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) signalling in cells that do not express functional GABAB receptors. In human SH-SY5Y neuroblastoma cells, CGP7930 and GS39783 induced a time- and co...

journal_title：European journal of pharmacology

authors： Olianas MC,Dedoni S,Onali P

更新日期：2017-01-05 00:00:00

abstract：:Herbacetin is an active flavonol (a type of flavonoid) that has various biologic effects such as antioxidant, antitumor, and anti-inflammatory activities. However, one of its novel effects remains to be investigated, that is, the induction of osteoclastogenesis by the receptor activator of nuclear factor-κB ligand (RA...

journal_title：European journal of pharmacology

authors： Li L,Sapkota M,Kim SW,Soh Y

更新日期：2016-04-15 00:00:00

abstract：:Drugs known to interact with Na+ channels were compared as antagonists of Ca2+-induced contractions of K+-depolarized taenia preparations from guinea-pig caecum. Tetracaine (apparent pA2 5.3 +/- 0.2), quinidine (5.2 +/- 0.1) quinine (5.1 +/- 0.1), d-propranolol (4.7 +/- 0.1), 1-propranolol (4.7 +/- 0.1), lignocaine (4...

journal_title：European journal of pharmacology

authors： Spedding M,Berg C

更新日期：1985-01-22 00:00:00

abstract：:The characteristics of [3H](+)-pentazocine and [3H]1,3-di(2-tolyl) guanidine (DTG) binding to mouse whole brain, cortex, cerebellum and spinal cord membranes were investigated in radioreceptor assays. [3H](+)-Pentazocine bound to a single, high affinity site (Kd = 1.2-1.6 nM) with increasing density along the neuraxis...

journal_title：European journal of pharmacology

authors： Kovács KJ,Larson AA

更新日期：1995-10-16 00:00:00

abstract：:The aim of the present study was to further characterize [3H]clonidine binding in the ventrolateral medulla of the human brainstem, the region involved in the vasodepressor effect of imidazoline drugs of the clonidine type. Under basal conditions, [3H]clonidine can bind both to the imidazoline receptors and to the alp...

journal_title：European journal of pharmacology

authors： Bricca G,Greney H,Zhang J,Dontenwill M,Stutzmann J,Belcourt A,Bousquet P

更新日期：1994-01-01 00:00:00

abstract：:The present study examined the adverse effects of delta-9-tetrahydrocannabinol (i.p injection in albino mice) on free radical damage of testicular lipids (lipid peroxidation) at low doses and the role of antioxidant enzymes defense system at high dose and particularly at the withdrawal of the drug after applying highe...

journal_title：European journal of pharmacology

authors： Mandal TK,Das NS

更新日期：2009-04-01 00:00:00

abstract：:Sodium was measured in rat pancreatic islet exposed to tolbutamide, glipizide, diazoxide or sulfisomidine. When added to a medium with physiologically balanced cations these sulphonamides induced a significant rise of the islet content of sodium. The insulin-releasing compounds, tolbutamide and glipizide, had effects ...

journal_title：European journal of pharmacology

authors： Ali L,Wesslén N,Hellman B

更新日期：1988-12-13 00:00:00

abstract：:The effect of KC 2450 (racemic 3,5-cis-3-methylamino-2,3,4,5-tetrahydro-1-benzoxepine-5-ol hydrochloride) on lower esophageal sphincter pressure in pentobarbital-anesthetized dogs was determined and compared to the effect of metoclopramide. The ED20 value (i.e. the dose that increased lower esophageal sphincter pressu...

journal_title：European journal of pharmacology

authors： Fowler PJ,Nelson AH,Price WJ,Sarau HM,Grous M,Lombardi DM,Barone FC,Ormsbee HS 3rd

更新日期：1987-10-13 00:00:00

abstract：:Gender-related differences in susceptibility to stress and stress-related disorders such as depression, and in response to treatment with antidepressants have been observed, but the underlying molecular mechanisms are still unknown. Considering the role of glucocorticoid hormones in the systemic reaction against stres...

journal_title：European journal of pharmacology

authors： Elaković I,Brkljacić J,Matić G

更新日期：2009-04-17 00:00:00

abstract：:After recovery from a first intraplantar or intrathoracic stimulation with bradykinin, repeated daily provocation with this peptide resulted in a progressive loss of its ability to cause paw or pleural oedema, reaching 0-20% of the control within seven and four consecutive provocations, respectively. The phenomenon wa...

journal_title：European journal of pharmacology

authors： Martins MA,Pasquale CP,Bozza PT,Silva PM,Faria Neto HC,COrdeiro RS

更新日期：1992-09-10 00:00:00

abstract：:Endothelial dysfunction ensuing inhibition of nitric oxide synthase (NOS) was investigated in male Sprague-Dawley rats given N(omega)-nitro-L-arginine methyl ester (L-NAME) in drinking water for 8 weeks. Age-matched rats served as controls. L-NAME-treated rats, as compared to control animals, showed: (1) a clear-cut i...

journal_title：European journal of pharmacology

authors： De Gennaro Colonna V,Rossoni G,Rigamonti A,Bonomo S,Manfredi B,Berti F,Muller E

更新日期：2002-08-16 00:00:00

abstract：:Loss of body weight was proved to be a convenient and reliable way to predict the degree of reserpine-induced amine depletion after i.p. injections of reserpine (2.5, 5 and 10 mg/kg) and it thus helps reduce variability. Two populations of animals were sharply distinguished lying on either side of the 5% cutoff point ...

journal_title：European journal of pharmacology

authors： Halaris AE,Freedman DX

更新日期：1975-05-01 00:00:00