Abstract:
:Loss of body weight was proved to be a convenient and reliable way to predict the degree of reserpine-induced amine depletion after i.p. injections of reserpine (2.5, 5 and 10 mg/kg) and it thus helps reduce variability. Two populations of animals were sharply distinguished lying on either side of the 5% cutoff point within the first 24 hr. One group (approximately 20% of all animals) lost less than 5% of their body weight, showed absence of physiological and behavioural effects, a moderate 5-HT depletion and a moderate 5-HIAA increase. These animals were called 'partially reserpinized'. Another group always lost 5% or more of body weight, exhibited the reserpine syndrome as well as a larger extent of 5-HT depletion and 5-HIAA increase. This group comprised 'reserpinized' rats. There were significant correlations between the percent weight loss and the degree of 5-HT depletion and 5-HIAA increase in the group of 'partially reserpinized' animals. The two groups differed also in the time course of amine changes. Dose had no effect in the differentiation of the two groups but did affect the extent of amine depletion. When reserpine was given i.v. or s.c., all animals were 'reserpinized'. The phenomenon of partial reserpinization is discussed.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Halaris AE,Freedman DXdoi
10.1016/0014-2999(75)90327-1keywords:
subject
Has Abstractpub_date
1975-05-01 00:00:00pages
93-101issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(75)90327-1journal_volume
32pub_type
杂志文章abstract::Increasing stimulation frequency and monensin were utilized in attempts to enhance Na+ influx and thereby elicit the maximum rate of ouabain-sensitive 86Rb+ uptake in rat atrial muscle. Increasing stimulation frequency between 0 and 9 Hz enhanced the rate of ouabain-sensitive 86Rb+ uptake, whereas the uptake rate appe...
journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(86)90338-9
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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更新日期:1990-09-21 00:00:00
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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更新日期:1983-04-08 00:00:00
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更新日期:1995-08-25 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:1984-03-23 00:00:00
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更新日期:2000-07-28 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:1994-06-02 00:00:00
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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