Adenosine contracts the isolated rat tail artery by releasing endogenous 5-hydroxytryptamine.

abstract：:The antagonist potencies of SCH 23390 and domperidone have been determined at vascular and neuronal dopamine receptors in the rabbit isolated splenic artery and rectococcygeus muscle, respectively. SCH 23390 was a potent, competitive antagonist at vascular (pA2 = 10.65) but not neuronal (pA2 less than 6.0) receptors. ...

journal_title：European journal of pharmacology

authors： Hilditch A,Drew GM

更新日期：1985-10-08 00:00:00

abstract：:Di-isobutyryl apomorphine (5 mg/kg i.p.) and lergotrile (5 mg/kg i.p.) produce long lasting turning behaviour in rats with 6-hydroxydopamine lesions at the level of the substantia nigra. Haloperidol (1.5 and 3.0 mg/kg p.o.) blocks the rotational behaviour due to the apomorphine ester but has no effect on lergotrile tu...

journal_title：European journal of pharmacology

authors： Tye NC,Horsman L,Wright FC,Large BT,Pullar IA

更新日期：1977-09-01 00:00:00

abstract：:We have previously found that the induction of long-term potentiation in the synaptic pathway from the basolateral amygdala to the dentate gyrus (BLA-DG LTP) is regulated by L-type Ca(2+) channels, dopamine D(2) receptors and GABAergic inhibition. In the present study, we investigated possible relations among the thre...

journal_title：European journal of pharmacology

authors： Abe K,Fujimoto T,Niikura Y,Akaishi T,Misawa M

更新日期：2009-03-15 00:00:00

abstract：:Diabetes mellitus is associated with an increased risk of cardiovascular disease. Endothelial dysfunction (i.e. decreased endothelium-dependent vasorelaxation) plays a key role in the pathogenesis of diabetic vascular disease. The present study was undertaken to determine whether diabetes induced by streptozotocin alt...

journal_title：European journal of pharmacology

authors： Fatehi-Hassanabad Z,Imen-Shahidi M,Fatehi M,Farrokhfall K,Parsaeei H

更新日期：2006-03-27 00:00:00

abstract：:The novel antiepileptic drug levetiracetam has been shown to reverse anxiogenic effects of benzodiazepine withdrawal in mice tested in an elevated plus-maze without altering the behaviour of normal mice in this model. This could suggest that the effect of levetiracetam is dependent upon the level of stress/anxiety of ...

journal_title：European journal of pharmacology

authors： Lamberty Y,Falter U,Gower AJ,Klitgaard H

更新日期：2003-05-23 00:00:00

abstract：:A deamination product of histidine, urocanic acid, accumulates in the skin of mammals as trans-urocanic acid. Ultraviolet (UV) irradition converts it to the cis-isomer that is an important mediator in UV-induced immunosuppression. We have recently shown that urocanic acid interferes with the agonist binding to GABA(A)...

journal_title：European journal of pharmacology

authors： Uusi-Oukari M,Soini SL,Heikkilä J,Koivisto A,Neuvonen K,Pasanen P,Sinkkonen ST,Laihia JK,Jansén CT,Korpi ER

更新日期：2000-07-14 00:00:00

abstract：:Complete control of emesis caused by cyclophosphamide (CPA) is of immense interest to both patients and physicians. Serotonin 5-HT3- and tachykinin NK1-receptor antagonists are widely used antiemetics in clinic, but they fail to completely control CPA-induced emesis. New antiemetic targets for the full control of CPA-...

journal_title：European journal of pharmacology

authors： Alkam T,Chebolu S,Darmani NA

更新日期：2014-01-05 00:00:00

abstract：:Drugs differentially affecting catecholaminergic neurotransmission mechanisms were injected into isolated mice to assess effects on aggression. L-DOPA in combination with a peripheral decarboxylase inhibitor produced a dose-dependent decrease in the number of fights and average fight durations accompanied by an increa...

journal_title：European journal of pharmacology

authors： Hodge GK,Butcher LL

更新日期：1975-03-01 00:00:00

abstract：:It is known that low-dose aspirin is effective in coronary artery therapy, although it has not yet been clarified how it exerts its action. Here, we report that treatment of coronary artery patients with 100 mg/day of aspirin does not attenuate thrombin generation, but reduces free thrombin by favouring the formation ...

journal_title：European journal of pharmacology

authors： Di Micco B,Colonna G,Di Micco P,Di Micco G,Russo BM,Macalello MA,Ragone R

更新日期：2003-01-26 00:00:00

abstract：:Rhesus monkeys were trained to discriminate saline from an injection of ketamine. In tests of stimulus generalization, phencyclidine (PCP) produced dose-related ketamine-appropriate responding in each monkey. Two monohydroxylated PCP metabolites also produced ketamine-like discriminative effects, although only at cons...

journal_title：European journal of pharmacology

authors： Solomon RE,Herling S,Woods JH

更新日期：1982-08-27 00:00:00

abstract：:In rat neocortical slices activation of glutamate metabotropic receptors with glutamate, quisqualate and 1S,3R-ACPD caused a spike-evoked afterdepolarization which replaced the normal afterhyperpolarization. In some neocortical neurons the afterdepolarization reached action potential threshold causing prolonged self-s...

journal_title：European journal of pharmacology

authors： Greene C,Schwindt P,Crill W

更新日期：1992-07-01 00:00:00

abstract：:We have used in situ hybridization to study the localization of mRNA encoding the beta 2-adrenoceptor in tissue sections of the human and rat lung and compared this with the distribution of beta 2-receptor binding sites using receptor autoradiography. To localize beta 2-receptor mRNA, a [32P]labeled antisense RNA prob...

journal_title：European journal of pharmacology

authors： Hamid QA,Mak JC,Sheppard MN,Corrin B,Venter JC,Barnes PJ

更新日期：1991-02-25 00:00:00

abstract：:In strips of pig coronary arteries incubated in oxygenated Krebs-bicarbonate solution at 37 degrees C, dotarizine blocked the phasic contractions evoked by 5-HT (0.5 microM) or K+ depolarization (35 mM K+) with an IC50 of 0.22 and 3.7 microM, respectively. Flunarizine inhibited both types of contractions with IC50 val...

journal_title：European journal of pharmacology

authors： Montiel C,Herrero CJ,García-Palomero E,Renart J,García AG,Lomax RB

更新日期：1997-08-06 00:00:00

abstract：:Although an inhibition of action potential conduction in nerve fibers possibly contributes to at least a part of antinociception produced by analgesics and the adjuvants, it has not been fully examined yet how the conduction inhibition differs in extent among their drugs. We investigated the effects of various antidep...

journal_title：European journal of pharmacology

authors： Hirao R,Fujita T,Sakai A,Kumamoto E

更新日期：2018-01-15 00:00:00

abstract：:The anti-migraine drug, eletriptan [(R)-3-(1-methyl-2-pyrrolidinylmethyl)-5-[2-(phenylsulphonyl )ethyl]-1 H-indole; UK-116,044], is a novel 5-HT(1B/1D) receptor agonist. In this paper, the regional vasoconstrictor profile of eletriptan, in comparison with sumatriptan, was examined in the anaesthetised dog. The inhibit...

journal_title：European journal of pharmacology

authors： Gupta P,Butler P,Shepperson NB,McHarg A

更新日期：2000-06-09 00:00:00

abstract：:We have confirmed our earlier finding that most red wines are able to bring about 5-hydroxytryptamine (5-HT, serotonin) release from platelets in vitro. Platelets from individual subjects manifested varying degrees of releasing ability but responded to different wines with a similar rank ordering. There was a high cor...

journal_title：European journal of pharmacology

authors： Pattichis K,Louca LL,Jarman J,Sandler M,Glover V

更新日期：1995-01-13 00:00:00

abstract：:The thromboxane mimetic U46619 (11 alpha,9 alpha-epoxymethano PGH2) increased 45Ca2+ uptake in sheep coronary artery rings. A larger increase occurred in endothelium-denuded than in endothelium-inact rings (increase in 45Ca2+ uptake: endothelium intact = 9.6 +/- 3.8, endothelium-denuded = 33.2 +/- 8.1 nmol g-1), in ag...

journal_title：European journal of pharmacology

authors： Dalen T,Vestereng M,Wadsworth R,Kane K

更新日期：1994-08-03 00:00:00

abstract：:The administration of the synthetic and stable opioid peptide[D-Ala2,MePhe4,Met(O)5o1]enkephalin (FK 33-824) at the dose of 0.2 mg/kg i.v. induced a rise in plasma levels of prolactin in the rat, an effect which was prevented by 1 mg/kg i.v. of the opiate antagonist naloxone. A simultaneous i.v. injection of 20 microg...

journal_title：European journal of pharmacology

authors： Ferri S,Cocchi D,Locatelli V,Spampinato S,Muller E

更新日期：1982-01-22 00:00:00

abstract：:Troxypyrrolidinium, a choline uptake inhibitor, reduced but failed to abolish responses of the rat urinary bladder to electrical stimulation at 1-100 Hz although it reduced acetylcholine output during stimulation at 10 Hz to a level similar to that of spontaneous release. Inhibition of the response to stimulation was ...

journal_title：European journal of pharmacology

authors： Choo LK,Mitchelson F

更新日期：1980-02-08 00:00:00

abstract：:Resveratrol pretreatment can protect the heart by inducing pharmacological preconditioning. Whether resveratrol protects the heart when applied at reperfusion remains unknown. We examined the effect of resveratrol on myocardial infarct size when given at reperfusion and investigated the mechanism underlying the effect...

journal_title：European journal of pharmacology

authors： Xi J,Wang H,Mueller RA,Norfleet EA,Xu Z

更新日期：2009-02-14 00:00:00

abstract：:The pharmacologic profile of Ib, 5-n-butyl-4-{4-[2-(1H-tetrazole-5-yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6-dichloridephenyl)-3H-1,2,4-triazol-3-one, a novel nonpeptide angiotensin AT(1) receptor antagonist, was investigated by receptor-binding studies, functional in vitro assays with rabbit and rat aorta, ...

journal_title：European journal of pharmacology

authors： Wu J,Wang Q,Guo J,Hu Z,Yin Z,Xu J,Wu X

更新日期：2008-07-28 00:00:00

abstract：:In incubation medium containing Na+ as the only cation, the specific binding of [3H]cocaine to a membrane preparation obtained from rat striatum reached a maximal level for 10 mM Na+, whereas higher concentrations decreased its affinity. The specific binding of [3H]cocaine was inhibited monophasically by GBR 12783, ma...

journal_title：European journal of pharmacology

authors： Saadouni S,Refahi-Lyamani F,Costentin J,Bonnet JJ

更新日期：1994-07-15 00:00:00

abstract：:The extracts of Phellodendron amurense (P. amurense) have been shown to contain many active ingredients e.g. flavone glycosides and to exert a wide range of physiological activities including anti-tumor activity. However, the effects of phellamurin (Phe), a plant flavonone glycoside from the leaves of P. amurense, on ...

journal_title：European journal of pharmacology

authors： Zhang H,Jiang H,Zhang H,Liu J,Hu X,Chen L

更新日期：2019-09-05 00:00:00

abstract：:The influence of inflammatory cells on airway reactivity was investigated on arachidonic acid-induced relaxations of guinea-pig trachea and on arachidonic acid metabolism in guinea-pig tracheal epithelial cells. The presence of either eosinophils or neutrophils (1.0 x 10(7) cells/ml), from bronchoalveolar lavage, decr...

journal_title：European journal of pharmacology

authors： Prié S,Conroy DM,Gleich GJ,Sirois P

更新日期：1996-12-19 00:00:00

abstract：:Increased motor activity and poor performance in the active avoidance test were observed in the offspring of rats treated with dl-propranolol or sotalol during pregnancy, but not with atenolol and d-propranolol. All substances were administered in drinking water from days 8-22 of gestation. A significant increase in t...

journal_title：European journal of pharmacology

authors： Speiser Z,Gordon I,Rehavi M,Gitter S

更新日期：1991-03-19 00:00:00

abstract：:Experiments were designed to determine whether or not ketanserin (R 41 468) antagonizes the augmentation by 5-hydroxytryptamine of contractions evoked in isolated arteries by non-adrenergic vasoconstrictor substances. Rings of rabbit femoral arteries were studied under isometric conditions in organ chambers filled wit...

journal_title：European journal of pharmacology

authors： Van Nueten JM,Janssen PA,De Ridder A,Vanhoutte PM

更新日期：1982-02-05 00:00:00

abstract：:Using the ex vivo chick embryo retina to study the efficacy of antagonists in blocking the excitotoxic effects of excitatory amino acid agonists, we previously identified phencyclidine as the most powerful known anti-excitotoxin. Here we show that MK-801 is 5 times more powerful than phencyclidine as an anti-excitotox...

journal_title：European journal of pharmacology

authors： Olney J,Price M,Salles KS,Labruyere J,Frierdich G

更新日期：1987-09-23 00:00:00

abstract：:Due to the limited results achieved in the clinical treatment of heart failure, a new inotropic strategy of myosin motor activation has been developed. The lead molecule of myosin activator agents is omecamtiv mecarbil, which binds directly to the heavy chain of the cardiac β-myosin and enhances cardiac contractility ...

journal_title：European journal of pharmacology

authors： Nánási P Jr,Gaburjakova M,Gaburjakova J,Almássy J

更新日期：2017-08-15 00:00:00

abstract：:The rate of release of enkephalin from rat striatal slices increased 7--10 fold in response to depolarization by 50 mM potassium ions in vitro. The potassium-evoked release of enkephalins was abolished in a calcium deficient medium. Uptake studies indicated that the potassium-stimulated efflux was not due to the inhib...

journal_title：European journal of pharmacology

authors： Osborne H,Höllt V,Herz A

更新日期：1978-03-15 00:00:00

abstract：:Ryanodine at nanomolar concentrations suppressed the earlier of two contraction components which can be produced in guinea-pig papillary muscles, in the presence of noradrenaline (3 microM) at a low contraction frequency (0.2 Hz). However, test contractions elicited shortly after a steady state contraction showed an u...

journal_title：European journal of pharmacology

authors： Vierling W

更新日期：1988-01-19 00:00:00