Effect of hypoxia on contraction and 45Ca2+ uptake induced by the thromboxane mimetic U46619 in sheep coronary artery.

abstract：:Angiogenesis is critical for re-establishing blood supply to the ischemic myocardium after acute myocardial infarction (AMI). This study aimed to investigate the effects of morroniside on angiogenesis after AMI and explored associated proangiogenic mechanisms. A rat model of AMI was established by ligation of the left...

journal_title：European journal of pharmacology

authors： Liu T,Sun F,Cui J,Zheng S,Li Z,Guo D,Tian X,Zhu Z,Zheng W,Wang Y,Wang W

更新日期：2020-04-05 00:00:00

abstract：:We studied the effects of 2-(allyl-1-piperazinyl)-4-n-amyloxyquinazoline fumarate (KB-5666) on brain edema and histological neuronal damage in rats with focal ischemia and on lipid peroxidation in brain homogenates and brain mitochondria in vitro. KB-5666 (3-100 microM) inhibited lipid peroxidation in brain homogenate...

journal_title：European journal of pharmacology

authors： Hara H,Kogure K,Kato H,Ozaki A,Sukamoto T

更新日期：1991-05-02 00:00:00

abstract：:The disruption of redox state homeostasis, the overexpression of lipogenic transcription factors and enzymes, and the increase in lipogenic precursors induced by sweetened beverages are determinants of the development of nonalcoholic fatty liver disease. This study evaluated the action of nicotinamide (NAM) on the exp...

journal_title：European journal of pharmacology

authors： Mejía SÁ,Gutman LAB,Camarillo CO,Navarro RM,Becerra MCS,Santana LD,Cruz M,Pérez EH,Flores MD

更新日期：2018-01-05 00:00:00

abstract：:A series of 2-O-alkylated tyrosine analogues of lysine-vasopressin and desamino-lysine and arginine-vasopressin were synthesized and tested for antidiuretic activity in the water-loaded anaesthetized rat. The analogues displayed only weak antidiuretic activities. When they were infused in the rats together with lysine...

journal_title：European journal of pharmacology

authors： Melin P,Lundin S,Vilhardt H,Lindeberg G,Larsson LE,Pliska V

更新日期：1980-10-17 00:00:00

abstract：:Experiments were performed in isolated guinea pig hearts, perfused at constant volume. Left ventricular pressure, left ventricular dp/dtmax, coronary vascular pressure and coronary venous pO2 were measured continuously. Indomethacin (1.4 X 10(-6) M) increased coronary vascular resistance by 15% over control (p less th...

journal_title：European journal of pharmacology

authors： Schrör K,Krebs R,Nookhwun C

更新日期：1976-09-01 00:00:00

abstract：:Glucocorticoids can reverse hemodynamic disturbances and dependence on catecholamines in septic shock. The relevant beneficial mechanisms of steroids in septic shock are unknown, although inducible nitric oxide synthase could account for them. The aim of this study was to compare the effects of dexamethasone, a glucoc...

journal_title：European journal of pharmacology

authors： Mansart A,Bollaert PE,Levy B,Nicolas MB,Mallié JP

更新日期：2003-08-15 00:00:00

abstract：:We have used cannabinoid CB knock-out mice in a two-trial object recognition test to assess the role of cannabinoid CB receptors in memory. Cannabinoid CB1 knock-out mice are able to retain memory for at least 48 h after the first trial whereas the wild-type controls lose their capacity to retain memory after 24 h. Th...

journal_title：European journal of pharmacology

authors： Reibaud M,Obinu MC,Ledent C,Parmentier M,Böhme GA,Imperato A

更新日期：1999-08-20 00:00:00

abstract：:Antipsychotic drugs are traditionally classified as typical or atypical on the basis of their property to cause or not to cause extrapyramidal side-effects. A widely accepted selectivity for the mesolimbic, vs. the nigrostriatal, dopaminergic system is postulated to underlie the existence of fewer or no extrapyramidal...

journal_title：European journal of pharmacology

authors： Melis M,Gessa GL,Diana M

更新日期：1998-12-18 00:00:00

abstract：:Pulmonary hypertension is a progressive disease of various origins that is associated with right ventricular dysfunction. In the present study, the protective effect of diosgenin was investigated in monocrotaline-induced pulmonary hypertension in rats. Pulmonary hypertension was induced by a single subcutaneous inject...

journal_title：European journal of pharmacology

authors： Ahmed LA,Obaid AA,Zaki HF,Agha AM

更新日期：2014-10-05 00:00:00

abstract：:The cerebellum receives indolaminergic fibers influencing Purkinje cell discharges. Data from our laboratories have demonstrated an endogenous release of serotonin (5-HT) and a Na(+)-dependent uptake and Ca(2+)-dependent release of [3H]5-HT from slices, homogenates and synaptosomal fractions of the rat cerebellar mole...

journal_title：European journal of pharmacology

authors： Beas-Zárate C,Morales-Villagran A,Tapia-Arizmendi G,Feria-Velasco A

更新日期：1991-05-30 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD), a chronic progressive liver disease, covers a series of liver damage encompassing steatosis, nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis. However, there are no approved therapies for NAFLD. Herein, we characterize the pharmacological profile of ZLY16 ((E)-2-(4-...

journal_title：European journal of pharmacology

authors： Zhou Z,Deng L,Hu L,Ren Q,Cai Z,Wang B,Li Z,Zhang L

更新日期：2020-09-05 00:00:00

abstract：:We examined the feasibility of coupling the 5-HT(6) receptor to a Ca(2+) signaling read-out using a chimeric G-protein, comprising of G(alphaq) with the C-terminal five amino acids from G(alphas), to facilitate assays on the fluorometric imaging plate reader (FLIPR). Using a transient transfection assay in human embry...

journal_title：European journal of pharmacology

authors： Zhang JY,Nawoschik S,Kowal D,Smith D,Spangler T,Ochalski R,Schechter L,Dunlop J

更新日期：2003-07-04 00:00:00

abstract：:Two major effector systems are frequently implicated in the immune and endothelial cell alternations associated with inflammation. They include the enhanced production of reactive oxygen species and diminished bioavailability of nitric oxide (NO). Importantly, these processes can be regulated by endogenously produced ...

journal_title：European journal of pharmacology

authors： Pekarova M,Kubala L,Martiskova H,Bino L,Twarogova M,Klinke A,Rudolph TK,Kuchtova Z,Kolarova H,Ambrozova G,Kuchta R,Kadlec J,Lojek A

更新日期：2013-08-05 00:00:00

abstract：:We investigated intracellular Ca2+ regulation in pancreatic acinar cells from rats with diabetes induced by a single injection of streptozotocin (80 mg/kg). Experiments were performed 2 days and 7 days after the injection of streptozotocin. The density of muscarinic receptors, measured by [3H]N-methyl scopolamine bind...

journal_title：European journal of pharmacology

authors： Komabayashi T,Sawada H,Izawa T,Kogo H

更新日期：1996-03-18 00:00:00

abstract：:The extracts of Phellodendron amurense (P. amurense) have been shown to contain many active ingredients e.g. flavone glycosides and to exert a wide range of physiological activities including anti-tumor activity. However, the effects of phellamurin (Phe), a plant flavonone glycoside from the leaves of P. amurense, on ...

journal_title：European journal of pharmacology

authors： Zhang H,Jiang H,Zhang H,Liu J,Hu X,Chen L

更新日期：2019-09-05 00:00:00

abstract：:Dinitrosyl iron complexes (DNIC) with glutathione exert a cytotoxic effect on endometrioid tumours in rats with surgically induced experimental endometriosis. Intraperitoneal treatment of rats (Group 1) with DNIC (12.5μmoles/kg, daily, for 12 days), beginning with day 4 after the surgical operation (implantation of tw...

journal_title：European journal of pharmacology

authors： Burgova EN,Tkachev NА,Adamyan LV,Mikoyan VD,Paklina OV,Stepanyan AA,Vanin AF

更新日期：2014-03-15 00:00:00

abstract：:Glioma is a kind of lethal malignant tumor, and lacks efficient therapies. Combination therapy has been claimed to be a promising approach to combat cancer, due to its increased anti-cancer effects and reduced side effects. This study aimed to investigate the anti-cancer effect and mechanism of combining imatinib with...

journal_title：European journal of pharmacology

authors： Lu J,Hu Y,Qian R,Zhang Y,Yang X,Luo P

更新日期：2020-05-05 00:00:00

abstract：:Molecules regulating cell death constitute prominent therapeutic targets. The pro-apoptotic role of serine protease inhibitors prompted us to search for novel modulators of this process. We have tested some recently synthesized antithrombotic compounds for their potential to induce apoptotic cell death. Cell based ana...

journal_title：European journal of pharmacology

authors： Celhar T,Batista Napotnik T,Obreza A,Zega A,Anderluh PS,Kikelj D,Mlinaric-Rascan I

更新日期：2009-01-05 00:00:00

abstract：:The sciatic nerve in the right thigh was divided in 40 rats and the nerve stumps then sewn together with two microsutures. The treated animals, 20 rats, had daily subcutaneous administration of a bovine cortex ganglioside mixture. The controls, 20 rats, received the solvent alone. At 21 days after nerve division it wa...

journal_title：European journal of pharmacology

authors： Kleinebeckel D

更新日期：1982-05-21 00:00:00

abstract：:Oxyntomodulin is a hormone and a growth factor. It activates two receptors, the Glucagon-like peptide 1 (GLP-1) and the glucagon receptor. GLP-1 mimetics are on the market as treatments for type 2 diabetes and are well tolerated. These drugs have shown neuroprotective properties in animal models of neurodegenerative d...

journal_title：European journal of pharmacology

authors： Liu W,Li Y,Jalewa J,Saunders-Wood T,Li L,Hölscher C

更新日期：2015-10-15 00:00:00

abstract：:The imidazopyridines EMD 35993 and EMD 41717 antagonized the anticonflict actions of diazepam and chlordiazepoxide in rodent models which are predictive for anxiolytic action in man. In contrast to other described benzodiazepine antagonists, these compounds did not antagonize either the anticonvulsant or muscle relaxa...

journal_title：European journal of pharmacology

authors： Skolnick P,Paul S,Crawley J,Lewin E,Lippa A,Clody D,Irmscher K,Saiko O,Minck KO

更新日期：1983-04-08 00:00:00

abstract：:The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves. Stimu...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Liska J

更新日期：1998-05-15 00:00:00

abstract：:To investigate the effect of a single and multiple administration of lysergic acid diethylamide (LSD) on cerebral metabolism of dopamine and serotonin, male Wistar rats were treated with low and high doses (0.1 and 2.0 mg/kg i.p.) of LSD and the levels of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-...

journal_title：European journal of pharmacology

authors： Antkiewicz-Michaluk L,Románska I,Vetulani J

更新日期：1997-07-30 00:00:00

abstract：:Administration of the 5-HT1C/5-HT2 receptor agonist 1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI, 0.125-2.0 mg/kg i.v.) triggered dose-dependent increases in plasma glucose; plasma insulin levels remained unchanged. Pretreatment with the 5-HT1C/5-HT2 receptor antagonists LY 53857, ritanserin, or the mixed 5-HT2...

journal_title：European journal of pharmacology

authors： Chaouloff F,Laude D,Baudrie V

更新日期：1990-10-23 00:00:00

abstract：:St. John's wort (Hypericum perforatum L.) is widely used for the treatment of mild to moderately severe depression. However, the nature of its active principles and the exact mode of antidepressant action are still unknown. It has been suggested repeatedly in preclinical and clinical studies that the content of the ac...

journal_title：European journal of pharmacology

authors： Simmen U,Bobirnac I,Ullmer C,Lübbert H,Berger Büter K,Schaffner W,Schoeffter P

更新日期：2003-01-05 00:00:00

abstract：:In this study we aimed to test central administration of CDP-choline on serum ghrelin, leptin, glucose and corticosterone levels in rats. Intracerebroventricular (i.c.v.) 0.5, 1.0 and 2.0 µmol CDP-choline and saline were administered to male Wistar-Albino rats. For the measurement of serum leptin and ghrelin levels, b...

journal_title：European journal of pharmacology

authors： Kiyici S,Basaran NF,Cavun S,Savci V

更新日期：2015-10-05 00:00:00

abstract：:The binding of tritium-labelled BIBP3226, N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine amide, to human neuroblastoma SK-N-MC cells was investigated. [3H]BIBP3226 reversibly binds to neuropeptide Y receptors of the Y1 subtype expressed in SK-N-MC cells with a KD of 2.1 +/- 0.3 nM (mean +/- S.E.M., n = 3)...

journal_title：European journal of pharmacology

authors： Entzeroth M,Braunger H,Eberlein W,Engel W,Rudolf K,Wienen W,Wieland HA,Willim KD,Doods HN

更新日期：1995-05-24 00:00:00

abstract：:The effect of noradrenaline on 5-hydroxytryptamine (5-HT) release from isolated mouse ileal tissues was investigated. Noradrenaline, but not isoprenaline, at 1 microM stimulated 5-HT release, an effect which was inhibited by yohimbine, an alpha(2)-adrenoceptor antagonist, but not by bunazosin, an alpha(1)-adrenoceptor...

journal_title：European journal of pharmacology

authors： Hirafuji M,Ogawa T,Kato K,Hamaue N,Endo T,Parvez H,Minami M

更新日期：2001-12-07 00:00:00

abstract：:Dipeptidyl peptidase IV (DPP IV) is the primary inactivator of glucoregulatory incretin hormones. This has lead to development of DPP IV inhibitors as a new class of agents for the treatment of type 2 diabetes. Recent reports indicate that other antidiabetic drugs, such as metformin, may also have inhibitory effects o...

journal_title：European journal of pharmacology

authors： Duffy NA,Green BD,Irwin N,Gault VA,McKillop AM,O'Harte FP,Flatt PR

更新日期：2007-07-30 00:00:00

abstract：:[123I]Iodobenzofuran ([123I]IBF) is a new single photon emission computed tomography (SPECT) tracer for visualization of the dopamine D2 receptors. A tracer constant infusion paradigm was developed to measure the binding potential, density (Bmax) and affinity (KD) of the dopamine D2 receptor in baboons. Three baboons ...

journal_title：European journal of pharmacology

authors： Laruelle M,al-Tikriti MS,Zea-Ponce Y,Zoghbi SS,Baldwin RM,Charney DS,Hoffer PB,Kung HF,Innis RB

更新日期：1994-09-22 00:00:00