当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Ca2+ channel blockade prevents lysergic acid diethylamide-induced changes in dopamine and serotonin metabolism.

Ca2+ channel blockade prevents lysergic acid diethylamide-induced changes in dopamine and serotonin metabolism.

Abstract：

:To investigate the effect of a single and multiple administration of lysergic acid diethylamide (LSD) on cerebral metabolism of dopamine and serotonin, male Wistar rats were treated with low and high doses (0.1 and 2.0 mg/kg i.p.) of LSD and the levels of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-methoxytyramine, serotonin and 5-hydroxyindoleacetic acid were assayed by HPLC in the nucleus accumbens, striatum and frontal cortex. Some rats received nifedipine, 5 mg/kg i.p., before each injection of LSD to assess the effect of a Ca2+ channel blockade. High-dose LSD treatment (8 x 2 mg/kg per day) caused a strong stimulation of dopamine metabolism in the nucleus accumbens and striatum, and serotonin metabolism in the nucleus accumbens: the changes were observed 24 (but not 1 h) after the last dose. The changes induced by the low-dose treatment (8 x 0.1 mg/kg per day) had a different pattern, suggesting the release of dopamine from vesicles to cytoplasm. Co-administration of nifedipine completely prevented the LSD-induced biochemical changes. The results suggest that Ca2+ channel blocking agents may prevent development of some behavioral consequences of chronically used LSD.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Antkiewicz-Michaluk L,Románska I,Vetulani J

doi

10.1016/s0014-2999(97)01025-x

subject

Has Abstract

pub_date

1997-07-30 00:00:00

pages

9-14

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(97)01025-X

journal_volume

332

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity.

    abstract：:Clinical use of gentamicin over prolonged periods is limited because of dose- and time-dependent nephrotoxicity. Primarily, lysosomal phospholipidosis, intracellular oxidative stress and heightened inflammation have been implicated. Hydrogen sulphide is an endogenously produced signal transduction molecule with strong...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2012.04.030

    authors： Dam VP,Scott JL,Ross A,Kinobe RT

    更新日期：2012-06-15 00:00:00

  • Ro 15-4513, like anxiogenic beta-carbolines, increases dopamine metabolism in the prefrontal cortex of the rat.

    abstract：:The effects of Ro 15-4513, FG 7142 and beta-CCM on the activity of the mesocortical dopaminergic system were examined by measuring the changes in the content of the principal dopamine (DA) metabolite, dihydroxyphenylacetic acid (DOPAC) in the prefrontal cortex of the rat. Ro 15-4513 increased the DOPAC content in the ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90148-3

    authors： Giorgi O,Corda MG,Biggio G

    更新日期：1988-10-26 00:00:00

  • Effects of inorganic cations on K(+)-, 5-hydroxytryptamine- and noradrenaline-induced contractions of the isolated rat jugular vein and aorta.

    abstract：:We investigated the inhibitory effects of 1 mM of the inorganic cations, La3+, Cd2+, Mn2+, Ni2+ and Co2+ on contractions induced by K+ (100 mM) and 5-hydroxytryptamine (5-HT, 10(-5) M) in the isolated rat jugular vein and on contractions induced by K+ (100 mM), 5-HT (10(-5] and noradrenaline (NA, 10(-5) M) in the rat ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(90)90634-i

    authors： Gouw MA,Wilffert B,Van Zwieten PA

    更新日期：1990-08-28 00:00:00

  • Infusion of D-cycloserine into temporal-hippocampal areas and restoration of mnemonic function in rats with disrupted glutamatergic temporal systems.

    abstract：:Partial transections of the fiber connections between the temporal cortex and the lateral entorhinal cortex at a site of the white matter corresponding to the perirhinal cortex result in impaired visual memory accompanied by reduced concentrations of glutamate in both the temporal cortex and lateral entorhinal cortex....

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)83019-1

    authors： Myhrer T,Paulsen RE

    更新日期：1997-06-05 00:00:00

  • Naltrexone-reversible effects of flunitrazepam on locomotor activity and passive avoidance behaviour in mice.

    abstract：:Some behavioural effects of flunitrazepam were investigated in two sets of experiments in C57BL/6 mice. In the first set, flunitrazepam administration (0.025 or 0.05 mg/kg) enhanced the locomotor activity of mice. In the second set, memory impairments were observed following posttraining (immediately or 30 min, but no...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(84)90376-5

    authors： Castellano C,Filibeck U,Pavone F

    更新日期：1984-09-03 00:00:00

  • Differential venous effects of isoprenaline in conscious rats.

    abstract：:The role beta-adrenoceptors in the control of venous tone is not clear. This study examines the dose-response effects of isoprenaline, a non-selective beta-adrenoceptor agonist, on mean circulatory filling pressure (MCFP), an index of body venous tone, in conscious and unrestrained rats. Dose-response curves of isopre...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(90)94196-5

    authors： Abdelrahman A,Pang CC

    更新日期：1990-11-13 00:00:00

  • Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs.

    abstract：:We evaluated roles of kinins in allergen-induced nasal blockage and sneezing, and development of nasal hyperresponsiveness to leukotriene D4 in a Japanese cedar pollen-induced allergic rhinitis model of guinea pigs. Sensitised guinea pigs were repeatedly challenged by pollen inhalation once every week. Neither a brady...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(03)02185-x

    authors： Sugahara S,Nabe T,Mizutani N,Takenaka H,Kohno S

    更新日期：2003-08-29 00:00:00

  • Tolerance to morphine at the mu-opioid receptor differentially induced by cAMP-dependent protein kinase activation and morphine.

    abstract：:Human neuroblastoma SH-SY5Y cells express endogenous mu-opioid receptor and develop cellular tolerance to morphine after prolonged (>/=4 h) treatment with morphine. Treatment with forskolin (25 microM, 12 h), an adenylyl cyclase activator, also desensitized mu-opioid receptor response to morphine (10 microM) by 38% (P...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(99)00881-x

    authors： Wang Z,Sadée W

    更新日期：2000-02-18 00:00:00

  • Effect of cetiedil analogs on acetylcholine and choline fluxes in synaptosomes and vesicles.

    abstract：:Cetiedil is a potent blocker of acetylcholine and choline fluxes. Several analogs of this compound have been synthesized and their effect on acetylcholine (ACh) and choline fluxes in synaptosomes and on ACh uptake in synaptic vesicles have been studied. The effects of these analogs were compared to those of other drug...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90355-5

    authors： Gaudry-Talarmain YM,Diebler MF,Robba M,Lancelot JC,Lesbats B,Israël M

    更新日期：1989-08-03 00:00:00

  • Effects of the optical isomers of verapamil on electrophysiological properties of the heart in conscious dogs.

    abstract：:We compared the cumulative dose-response relations of verapamil (0.1, 0.2 and 0.4 mg kg(-1)) in different R/S enantiomer ratios (100/0, 90/10, 80/20, 50/50 and 20/80) on the electrophysiological and hemodynamic characteristics of the heart using the conscious dogs. A reduction of mean arterial pressure occurred with 2...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00480-4

    authors： Takahata O,Krolikowski JG,McCallum JB,Lathrop DA,Bosnjak ZJ

    更新日期：1998-08-21 00:00:00

  • Dopaminergic receptors in cat brain. Action of triton X-100 on [3H]spiroperidol binding and localization in relation to the synaptic region.

    abstract：:[3H]Spiroperidol binding was used to assay dopaminergic receptors in synaptosomal membranes isolated from basal ganglia of cat brain. In addition to the usual filtration, a special centrifugation technique was developed which has some advantages for ligands with high non-specific binding. The specific binding to contr...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90568-4

    authors： Jimenez Aguilar C,De Robertis E

    更新日期：1982-04-08 00:00:00

  • Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological mechanisms.

    abstract：:The nuclear transcription factors kappaB (NF-kappaB) function as key regulators of physiological processes in the central nervous system. Aberrant regulation of NF-kappaB can underlie neurological disorders associated with neurodegeneration. A large number of studies have reported a dual role of NF-kappaB in regulatin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2006.06.027

    authors： Pizzi M,Spano P

    更新日期：2006-09-01 00:00:00

  • Effects of barbiturate anesthetics and ketamine on the force-frequency relation of cardiac muscle.

    abstract：:The effects of ketamine and barbiturates (pentobarbital, thiopental, methohexital) were studied in an isolated rabbit Langendorff preparation. All agents tested depressed contractility. Ketamine, as well as the lipophilic barbiturates (thiopental, methohexital), caused a relatively greater depression at higher pacing ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(79)90025-6

    authors： Davies AE,McCans JL

    更新日期：1979-10-26 00:00:00

  • Receptor affinity and pharmacological potency of a series of narcotic analgesic, anti-diarrheal and neuroleptic drugs.

    abstract：:A series of 26 drugs was tested for in vitro binding to opiate receptors in the presence and absence of 0.1 M NaCl. The results were correlated with assays for in vivo pharmacological potency. Highly significant correlation was found between binding in the presence and absence of sodium ions and analgesic potency. For...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(77)90334-x

    authors： Stahl KD,van Bever W,Janssen P,Simon EJ

    更新日期：1977-12-01 00:00:00

  • Galanin decreases the activity of locus coeruleus neurons in vitro.

    abstract：:A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the firing of 14 out of 19 neurons in a concentration-dependent manner. The observed effect was quite variable, ranging f...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90481-0

    authors： Seutin V,Verbanck P,Massotte L,Dresse A

    更新日期：1989-05-19 00:00:00

  • 8-Hydroxy-2-(di-n-propylamino)tetralin, a 5-HT1A receptor agonist, impairs performance in a passive avoidance task.

    abstract：:The effects of various subcutaneous doses (30, 100 and 300 micrograms/kg) of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a serotonin (5-HT)1A receptor agonist, were studied on the performance of rats in a one-trial passive avoidance task. When administered 30 min before the training trial and the retention tes...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90533-a

    authors： Carli M,Tranchina S,Samanin R

    更新日期：1992-02-11 00:00:00

  • Inhibitors of arachidonate-regulated calcium channel signaling suppress triggered activity induced by the late sodium current.

    abstract：:Disturbances in myocyte calcium homeostasis are hypothesized to be one cause for cardiac arrhythmia. The full development of this hypothesis requires (i) the identification of all sources of arrhythmogenic calcium and (ii) an understanding of the mechanism(s) through which calcium initiates arrhythmia. To these ends w...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2013.12.020

    authors： Wolkowicz P,Umeda PK,Sharifov OF,White CR,Huang J,Mahtani H,Urthaler F

    更新日期：2014-02-05 00:00:00

  • Pharmacological modulation of bradykinin-, acetylcholine- and calcium ionophore A23187-induced relaxation of rabbit pulmonary arterial segments.

    abstract：:Bradykinin (BK; 10(-10)-10(-7) M) relaxes phenylephrine-contracted rabbit isolated pulmonary arterial rings. The mechanical destruction of the endothelial layer obliterates acetylcholine (ACh) and A23187-induced relaxation without influencing BK-, isoproterenol-, sodium nitroprusside- and papaverine-induced relaxation...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90219-6

    authors： Chand N,Mahoney TP Jr,Diamantis W,Sofia RD

    更新日期：1987-06-04 00:00:00

  • pH dependence of facilitation by neurotransmitters and divalent cations of P2X2 purinoceptor/channels.

    abstract：:The pH dependence of the facilitation by dopamine (10 microM), 5-hydroxytryptamine (10 microM), adenosine (1 and 100 microM), Zn2+ (10 microM) and Cd2+ (1 mM) of P2X2 purinoceptor/channels was tested by expressing these channels in Xenopus oocytes. In a pH range between 6.0 and 8.5, concentration-response curves for a...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01293-4

    authors： Nakazawa K,Liu M,Inoue K,Ohno Y

    更新日期：1997-10-22 00:00:00

  • Motor depressant effects mediated by dopamine D2 and adenosine A2A receptors in the nucleus accumbens and the caudate-putamen.

    abstract：:We compared hypolocomotion and catalepsy mediated by striatal dopamine D2 and adenosine A2A receptors using microinfusions of the adenosine A2A receptor agonist 2-p-(2-carboxyethyl) phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride (CGS21680) and the dopamine D2 receptor antagonist raclopride into the nucleu...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)00040-x

    authors： Hauber W,Münkle M

    更新日期：1997-04-04 00:00:00

  • Pharmacological evidence for the involvement of the opioid system in the antidepressant-like effect of adenosine in the mouse forced swimming test.

    abstract：:This study investigated the involvement of the opioid system in the antidepressant-like effect of adenosine in the forced swimming test. The effect of adenosine (10 mg/kg, i.p.) was prevented by the pretreatment of mice with naloxone (1 mg/kg, i.p., a nonselective opioid receptor antagonist), naltrindole (3 mg/kg, i.p...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.08.026

    authors： Kaster MP,Budni J,Santos AR,Rodrigues AL

    更新日期：2007-12-08 00:00:00

  • The interleukin-8 receptor: a potential target for antipsoriatic therapy?

    abstract：:Interleukin-8 is assumed to play a central role in the pathogenesis of psoriasis. Since an increased expression of the interleukin-8 receptor has been observed both in polymorphonuclear leukocytes and in affected psoriatic epidermis, we were interested in whether the interleukin-8 receptor could be a molecular target ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(94)90490-1

    authors： Kemény L,Kenderessy AS,Olasz E,Michel G,Ruzicka T,Farkas B,Dobozy A

    更新日期：1994-06-13 00:00:00

  • Amelioration of brain damage after focal ischemia in the rat by a novel inhibitor of lipid peroxidation.

    abstract：:We studied the effects of 2-(allyl-1-piperazinyl)-4-n-amyloxyquinazoline fumarate (KB-5666) on brain edema and histological neuronal damage in rats with focal ischemia and on lipid peroxidation in brain homogenates and brain mitochondria in vitro. KB-5666 (3-100 microM) inhibited lipid peroxidation in brain homogenate...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(91)90367-y

    authors： Hara H,Kogure K,Kato H,Ozaki A,Sukamoto T

    更新日期：1991-05-02 00:00:00

  • Differential effects of aminochlorin derivatives on the phagocytic and inflammatory potentials of mammalian macrophages.

    abstract：:Chlorin derivatives have been known for their biological activities. Especially due to their advanced electron transfer capacity they have been used as photodynamic therapy agent both at clinical and laboratory scales. Photodynamic therapy (PDT) against cancer or an infectious disease aims the development of less side...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.172980

    authors： Ayaz F,Ocakoglu K

    更新日期：2020-04-15 00:00:00

  • The distribution of 5-HT3 recognition sites in the marmoset brain.

    abstract：:The distribution of the binding of [3H]GR65630 (0.2 nM) to putative 5-HT3 recognition sites in the brain of the common marmoset was assessed using autoradiography. Specific binding was heterogeneously distributed with the highest densities found in discrete nuclei of the lower medulla (nucleus tractus solitarii, dorsa...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(92)90609-8

    authors： Jones DN,Barnes NM,Costall B,Domeney AM,Kilpatrick GJ,Naylor RJ,Tyers MB

    更新日期：1992-04-29 00:00:00

  • Dopamine agonist-induced hyperglycemia in rats: structure-activity relationships and mechanisms of action.

    abstract：:The concentration of blood glucose was measured in rats after administration of a number of drugs characterized as dopamine agonists. Compounds that cause release of dopamine, or agents that block the reuptake of dopamine, did not elevate blood glucose. Some direct dopamine receptor stimulants (lergotrile, bromocripti...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(83)90234-0

    authors： Schmidt MJ,Root MA,Hall JL

    更新日期：1983-06-03 00:00:00

  • Herbacetin inhibits RANKL-mediated osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.

    abstract：:Herbacetin is an active flavonol (a type of flavonoid) that has various biologic effects such as antioxidant, antitumor, and anti-inflammatory activities. However, one of its novel effects remains to be investigated, that is, the induction of osteoclastogenesis by the receptor activator of nuclear factor-κB ligand (RA...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.02.057

    authors： Li L,Sapkota M,Kim SW,Soh Y

    更新日期：2016-04-15 00:00:00

  • A role for endothelin ETA receptors in regulation of renal function in spontaneously hypertensive rats.

    abstract：:While there is evidence to suggest that endothelin-1 is involved in regulation of kidney function and blood pressure, the importance of endothelin ETA receptors in this area has not been clearly defined. The novel, non-peptide endothelin ETA receptor antagonist, BMS-182874, (5-(dimethylamino)-N-(3,4- dimethyl-5-isoxaz...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(95)00537-4

    authors： Bird JE,Webb ML,Giancarli MR,Chao C,Dorso CR,Asaad MM

    更新日期：1995-12-27 00:00:00

  • Analgesic effects of cyclazocine and morphine microinjected into the rat dorsomedial hypothalamus demonstrated by the bradykinin-induced flexor reflex test.

    abstract：:The analgesic effect of cyclazocine microinjected into the diencephalon of rats was studied by using the bradykinin-induced flexor reflex test. The dorsal portion of the medial hypothalamic area was sensitive to cyclazocine with respect to the production of analgesia (ED50 2.6 micrograms/rat). Microinjections of morph...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90119-0

    authors： Kawajiri S,Satoh M

    更新日期：1985-04-23 00:00:00

  • Role of 5-hydroxytryptamine and mast cells in the tachykinin-induced contraction of rat trachea in vitro.

    abstract：:The in vivo bronchoconstrictor effect of tachykinins in Fisher 344 rats is accompanied by release into the airways of 5-hydroxytryptamine (5-HT). 5-HT is possibly derived from mast cells. In the present study the presumed mast cell-tachykinin interaction was studied in isolated trachea from Fisher 344 rats. Contractio...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)81929-2

    authors： Joos GF,Lefebvre RA,Bullock GR,Pauwels RA

    更新日期：1997-11-12 00:00:00