Abstract：
:Chlorin derivatives have been known for their biological activities. Especially due to their advanced electron transfer capacity they have been used as photodynamic therapy agent both at clinical and laboratory scales. Photodynamic therapy (PDT) against cancer or an infectious disease aims the development of less side effect on the patient since the activation of the inert drug molecule will start only after the light treatment. In order to increase our library of photodynamic therapy agents, we generated a set of chlorin derivatives and tested their PDT potential on the immune system cells; macrophages. Macrophages are known for their primary role as an inflammatory cell type that have been found in the inflamed tissues of the patients with autoimmune and inflammatory disorders as well as in the tumor environment as tumor associated macrophages. Our derivatives had anti-inflammatory PDT potential in the presence of a danger mimic but they lacked immunostimulatory effect. Moreover, these cells' ability to eliminate an infectious agent or present the danger molecules to the other immune cells were tested by phagocytosis assay in the presence of our compounds. Chlorin derivatives were able to differentially regulate the phagocytic activity of the mammalian macrophages.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Ayaz F,Ocakoglu Kdoi
10.1016/j.ejphar.2020.172980subject
Has Abstractpub_date
2020-04-15 00:00:00pages
172980eissn
0014-2999issn
1879-0712pii
S0014-2999(20)30072-8journal_volume
873pub_type
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