Interaction of thyrotropin-releasing hormone (TRH) and serotonin in cardiovascular control.

abstract：:In isolated heart muscle, the compound R56865 (N-[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2- benzothiazolamine) has been shown to protect against intoxication by cardiac glycosides. We studied the influence of R56865 on various membrane currents in single isolated ventricular cardiomyocytes of the guinea-...

journal_title：European journal of pharmacology

authors： Himmel HM,Wilhelm D,Ravens U

更新日期：1990-10-09 00:00:00

abstract：:Administration of dihydrocapsaicin to rats resulted in a dose-dependent (0.5-10 mg/kg s.c.) hypothermia. Dihydrocapsaicin was approximately 65% more effective in producing hypothermia than capsaicin. Desensitization and cross-tolerance occurred to the hypothermic effects of both capsaicin and dihydrocapsaicin. Repeate...

journal_title：European journal of pharmacology

authors： Miller MS,Brendel K,Buck SH,Burks TF

更新日期：1982-09-24 00:00:00

abstract：:MPC-1304 is a novel Ca2+ entry blocker of the 1,4-dihydropyridine type. In the present study, the effect of oral administration of MPC-1304 on alpha-adrenoceptor-mediated pressor responses was examined in pithed rats and compared with that of nifedipine. Drugs were administered orally to conscious animals before pithi...

journal_title：European journal of pharmacology

authors： Ichihara K,Okumura K,Mori H,Nagasaka M

更新日期：1993-07-20 00:00:00

abstract：:Cultured retina cells released accumulated [3H]GABA (gamma-aminobutyric acid) when stimulated by L-glutamate, N-methyl-D-aspartate (NMDA) and kainate. In the absence of Mg2+, dopamine at 200 microM (IC50 60 microM), inhibited in more than 50% the release of [3H]GABA induced by L-glutamate and NMDA, but not by kainate....

journal_title：European journal of pharmacology

authors： Do Nascimento JL,Kubrusly RC,Reis RA,De Mello MC,De Mello FG

更新日期：1998-02-05 00:00:00

abstract：:The goal of our study was to determine whether GPR55 agonists, O-1602, could reverse the cyclophosphamide (CYP)-induced changes in cystometric and inflammatory parameters, indicative of the development of bladder inflammation and overactivity. If confirmed, the stimulation of novel cannabinoid receptor - GPR55, could ...

journal_title：European journal of pharmacology

authors： Wróbel A,Zapała Ł,Zapała P,Piecha T,Radziszewski P

更新日期：2020-09-05 00:00:00

abstract：:In human erythroleukemia (HEL) cells, stimulation of alpha2-adrenoceptors by adrenaline or neuropeptide Y Y1 receptors by neuropeptide Y, concomitantly inhibit cAMP accumulation and stimulate mobilization of Ca2+ from intracellular stores via pertussis toxin-sensitive G-proteins. Treatment of HEL cells in chemically-d...

journal_title：European journal of pharmacology

authors： Michel MC

更新日期：1998-05-01 00:00:00

abstract：:By far the most attention has been paid to the deleterious actions of nonsteroidal anti-inflammatory drugs (NSAIDs), including isoform selective agents that inhibit cyclooxygenase (COX), on the upper gastrointestinal tract, particularly the gastric and duodenal mucosa. However, recent studies confirm a relatively high...

journal_title：European journal of pharmacology

authors： Whittle BJ

更新日期：2004-10-01 00:00:00

abstract：:Rings of canine bronchi were suspended for isometric tension recording. Contractions produced by exogenously added acetylcholine were inhibited by pirenzepine and pancuronium. The pKB values were 6.76 for pirenzepine (calculated at 10(-6) M) and 5.30 and 5.13 for pancuronium (calculated at 10(-5) and 3 X 10(-5) M, res...

journal_title：European journal of pharmacology

authors： O'Rourke ST,Flavahan NA,Vanhoutte PM

更新日期：1987-08-04 00:00:00

abstract：:Substituted benzamides such as metoclopramide, cisapride, zacopride, renzapride or BRL 20627, stimulate intestinal motility in various species. As they are antagonists at 5-HT3 and agonists at 5-HT4 receptors and as both mechanisms could potentially contribute to their gastrointestinal prokinetic effect, the underlyin...

journal_title：European journal of pharmacology

authors： Buchheit KH,Buhl T

更新日期：1991-11-26 00:00:00

abstract：:20(S)-Protopanaxadiol (PPD), a metabolite of ginsenosides, has been demonstrated to possess cytotoxic effects on several cancer cell lines. The molecular mechanism is, however, not well understood. In this study, we have shown that PPD inhibits cell growth and induces apoptosis in human hepatocarcinoma HepG2 cells. PP...

journal_title：European journal of pharmacology

authors： Zhu GY,Li YW,Tse AK,Hau DK,Leung CH,Yu ZL,Fong WF

更新日期：2011-10-01 00:00:00

abstract：:The regulation of the 5-HT2 receptor-mediated head twitch response and of 5-HT2 receptor binding in the frontal cortex was studied in rats treated repeatedly with the 5-HT2 agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) (2.5 mg/kg, s.c.). Four injections in 24 h produced a near maximal reduction in the ...

journal_title：European journal of pharmacology

authors： Leysen JE,Janssen PF,Niemegeers CJ

更新日期：1989-04-12 00:00:00

abstract：:The hypothesis that morphine acts on the serotonergic system to produce analgesia is based on the previous observations that (1) lesions and stimulation of midbrain raphe nuclei after the threshold to nociceptive stimuli; (2) morphine alters the turnover of serotonin (5-hydroxytryptamine; 5-HT). Microiontophoretic exp...

journal_title：European journal of pharmacology

authors： Haigler HJ

更新日期：1978-10-15 00:00:00

abstract：:Forskolin inhibited the response to electrical field stimulation (0.1 Hz) and antagonised contractile responses to noradrenaline in the isolated rat vas deferens. The inhibition of the response to electrical stimulation (IC50 0.1 microM) was not affected by either propranolol or yohimbine. Both isoprenaline and forsko...

journal_title：European journal of pharmacology

authors： Hovevei-Sion D,Finberg JP,Bomzon A,Youdim MB

更新日期：1983-11-25 00:00:00

abstract：:Liver failure altered P-glycoprotein (P-gp) function and expression at blood-brain barrier (BBB), partly owing to hyperammonemia. We aimed to examine the effects of partial portal vein ligation (PVL) plus chronic hyperammonemia (CHA) on P-gp function and expression at rat BBB. Experimental rats included sham-operation...

journal_title：European journal of pharmacology

authors： Zhou Y,Zhou J,Li P,Xie Q,Sun B,Li Y,Chen Y,Zhao K,Yang T,Zhu L,Xu J,Liu X,Liu L

更新日期：2019-03-05 00:00:00

abstract：:The actions of carbachol were studied on the firing response of neostriatal neurons recorded intracellularly from in vitro slice preparations of the rat brain. Carbachol (1-10 microM) reversibly reduced the afterhyperpolarization in neostriatal neurons. This effect was accompanied by an increase in both firing frequen...

journal_title：European journal of pharmacology

authors： Pineda JC,Bargas J,Flores-Hernández J,Galarraga E

更新日期：1995-08-15 00:00:00

abstract：:In rats, surgical injury of the neocortex enhances the level of procholecystokinin-mRNA in the ipsilateral cortex. This increase in procholecystokinin gene expression was significantly reduced by the blockers of catecholamine re-uptake nomifensine (4 mg/kg), cocaine (5 mg/kg) and (+)-oxaprotiline (1.5 mg/kg) given i.m...

journal_title：European journal of pharmacology

authors： Mondeh JD,Olenik C,Götz E,Uhl A,Meyer DK

更新日期：1993-08-10 00:00:00

abstract：:CGS7184 (ethyl 1-[[(4-chlorophenyl)amino]oxo]-2-hydroxy-6-trifluoromethyl-1H-indole-3-carboxylate) is a synthetic large-conductance Ca(2+)-activated potassium (BK(Ca)) channel opener. The existing literature suggests that potassium channels are involved in cardioprotection, particularly during ischemia-reperfusion eve...

journal_title：European journal of pharmacology

authors： Wrzosek A,Tomaskova Z,Ondrias K,Lukasiak A,Szewczyk A

更新日期：2012-09-05 00:00:00

abstract：:Severe depletion of 5-hydroxytryptamine (5-HT) by para-chlorophenylalanine (pCPA, 150 mg/kg per day x3) did not alter the hypophagic effect of d-fenfluramine (1-3 mg/kg i.p.) 1 h after food presentation in 24-h food-deprived rats, and moderately and comparably increased the hypophagic effects of its metabolite, d-norf...

journal_title：European journal of pharmacology

authors： Gibson EL,Kennedy AJ,Curzon G

更新日期：1993-09-21 00:00:00

abstract：:In this study the desensitizing power of increasing concentrations of resiniferatoxin applied topically to the bladder mucosa, and the irritating properties of the most effective desensitizing dose, were determined with the aid of the spinal expression of the proto-oncogene c-fos. Desensitization was assessed by the d...

journal_title：European journal of pharmacology

authors： Avelino A,Cruz F,Coimbra A

更新日期：1999-07-28 00:00:00

abstract：:The myocardial effects of g-strophanthin and the partial beta 1-adrenoceptor agonist xamoterol were compared to the effects of isoprenaline in the isolated spontaneously beating rabbit heart. Xamoterol and g-strophanthin both produced a distinct maximum increase in contractility as shown by the increase in isotonic co...

journal_title：European journal of pharmacology

authors： Vigholt Sørensen E,Nielsen-Kudsk F

更新日期：1986-06-24 00:00:00

abstract：:Novel insulinotropic agent nateglinide stimulates insulin via binding to sulfonylurea receptor and closing the ATP-dependent K+ (K(ATP)) channels in pancreatic beta-cells, leading to an increase in [Ca(2+)](i) for exocytosis. The voltage-dependent Ca(2+) channel and the delayed rectifier K+ (Kv) channels are also pres...

journal_title：European journal of pharmacology

authors： Hu S,Wang S

更新日期：2001-09-14 00:00:00

abstract：:Statins have been demonstrated to elicit a broad range of cellular events resulting in an attenuation of the inflammatory response and enhanced protection to the components of the vessel wall. The present study was designed to examine the effect of pitavastatin on pathways associated with the proinflammatory gene, ear...

journal_title：European journal of pharmacology

authors： Lamon BD,Summers BD,Gotto AM Jr,Hajjar DP

更新日期：2009-03-15 00:00:00

abstract：:To investigate the abnormal function of T and B lymphocytes involved in collagen-induced arthritis in DBA/1 mice and the regulation role of TACI-Ig on T and B lymphocytes, collagen-induced arthritis models were established in DBA/1 mice. Mice were divided randomly into eight groups, including normal, collagen-induced ...

journal_title：European journal of pharmacology

authors： Liu Y,Zhang L,Wu Y,Tong T,Zhao W,Li P,Huang M,Wang W,Fang J,Wei W

更新日期：2011-03-11 00:00:00

abstract：:The models currently used to assess antinociceptive efficacy in animals are far from ideal. Those procedures that detect both opioid agonists and mixed agonist-antagonists fail to differentiate between them unless the noxious stimulus is adjusted. Furthermore, changes in the sensitivity of the test often result in pos...

journal_title：European journal of pharmacology

authors： Pizziketti RJ,Pressman NS,Geller EB,Cowan A,Adler MW

更新日期：1985-12-10 00:00:00

abstract：:Anorexia and muscle wasting are frequently observed in cancer patients and influence their clinical outcome. The better understanding of the mechanisms underlying behavioral changes and altered metabolism yielded to the development of specialized nutritional support, which enhances utilization of provided calories and...

journal_title：European journal of pharmacology

authors： Laviano A,Seelaender M,Sanchez-Lara K,Gioulbasanis I,Molfino A,Rossi Fanelli F

更新日期：2011-09-01 00:00:00

abstract：:The effects of two predominant dopamine D2-like receptor agonists, talipexole (6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo [4,5-d]-azepine dihydrochloride, B-HT 920 CL2) and pramipexole (S(-)2-amino-4,5,6,7-tetrahydro-6-propyl-aminobenzothiazole dihydrochloride, SND 919 CL2Y), were studied alone and in combination ...

journal_title：European journal of pharmacology

authors： Domino EF,Ni L,Zhang H,Kohno Y,Sasa M

更新日期：1997-05-01 00:00:00

abstract：:Histamine and serotonin levels in gastric secretion and the effects of pharmacological antagonists were studied in rats in which stomach ulceration was induced by electrical vagal stimulation. Electrical vagal stimulation (2 and 5 V) produced a graded increase in haemorrhagic glandular mucosal ulcers. NaHCO3 perfusion...

journal_title：European journal of pharmacology

authors： Cho CH,Hung KM,Ogle CW

更新日期：1985-04-02 00:00:00

abstract：:The vasodilatory role of calcitonin gene-related peptide in activating K+ channels was examined in isolated, suffused human uterine arteries. Calcitonin gene-related peptide produced a concentration-dependent relaxation of norepinephrine (1 microM)-induced contractions. Calcitonin gene-related peptide was antagonized ...

journal_title：European journal of pharmacology

authors： Nelson SH,Suresh MS,Dehring DJ,Johnson RL

更新日期：1993-10-05 00:00:00

abstract：:The effect of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) on central monoamine neurons in mice was investigated using histo- and biochemical techniques. NMPTP (2 X 10 mg/kg i.v.) produced a rapid and long-lasting reduction (-30%) of striatal dopamine, while the dopamine levels were only transiently reduced in...

journal_title：European journal of pharmacology

authors： Hallman H,Olson L,Jonsson G

更新日期：1984-01-13 00:00:00

abstract：:N6-2-(4-Aminophenyl)ethyl-adenosine (APNEA, a non-selective agonist of the adenosine A3 receptors), at the subprotective dose of 1 mg/kg against electroconvulsions, significantly potentiated the anticonvulsive action of phenobarbital, diphenylhydantoin and valproate against maximal electroshock, being ineffective at l...

journal_title：European journal of pharmacology

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1997-05-30 00:00:00