HOE 140, a new highly potent and long-acting bradykinin antagonist in conscious rats.

abstract：:We have previously demonstrated that treatment with L-cis diltiazem reduced cardiac infarct size in vivo. To examine the effect of L-cis diltiazem on Ca(2+) overload induced by ischemia/reperfusion, we used a model for Ca(2+) overload produced by metabolic inhibition in isolated guinea pig myocytes. Intracellular Ca(2...

journal_title：European journal of pharmacology

authors： Nishida M,Urushidani T,Sakamoto K,Nagao T

更新日期：1999-12-03 00:00:00

abstract：:We have studied the effects of withdrawal from chronic clonidine treatment in the adult male spontaneously hypertensive rat (SHR). SHR received clonidine, 0.1 mg X kg-1 X day-1 i.v. for 10 days. Clonidine was delivered via osmotic minipumps. After 7 days of treatment there was a 16.5 +/- 2.5 mm Hg fall in mean arteria...

journal_title：European journal of pharmacology

authors： Atkinson J,Lambas-Senas L,Parker M,Boillat N,Luthi P,Sonnay M,Seccia M,Renaud B

更新日期：1986-02-11 00:00:00

abstract：:We compared the cumulative dose-response relations of verapamil (0.1, 0.2 and 0.4 mg kg(-1)) in different R/S enantiomer ratios (100/0, 90/10, 80/20, 50/50 and 20/80) on the electrophysiological and hemodynamic characteristics of the heart using the conscious dogs. A reduction of mean arterial pressure occurred with 2...

journal_title：European journal of pharmacology

authors： Takahata O,Krolikowski JG,McCallum JB,Lathrop DA,Bosnjak ZJ

更新日期：1998-08-21 00:00:00

abstract：:RES-701-1 (cyclic (Gly1-Asp9)(Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp-Trp-Phe- Phe-Asn-Tyr-Tyr-Trp)), a peptide isolated from Streptomyces sp., has been reported to inhibit the endothelin ETB receptor. We examined the effects of this peptide on the blood vessels and the small intestine. In isolated rat aorta without endot...

journal_title：European journal of pharmacology

authors： Karaki H,Sudjarwo SA,Hori M,Tanaka T,Matsuda Y

更新日期：1994-09-12 00:00:00

abstract：:The goals of the present study were: (1) to investigate the binding properties of (R)- and (S)-procyclidine and two achiral derivatives of muscarinic M1, M2 and M4 receptor subtypes and (2) to identify the interactions which allow these receptors to discriminate between the two stereoisomers. (R)-Procyclidine showed a...

journal_title：European journal of pharmacology

authors： Waelbroeck M,Camus J,Tastenoy M,Lambrecht G,Mutschler E,Tacke R,Christophe J

更新日期：1990-09-18 00:00:00

abstract：:The effects of itasetron (endo-N-8-methyl-8-azabicyclo-[3.2.1.]-octo-3-yl) -2,3-dihydro-2-oxo-1 H-benzimidazole-1-carboxamide hydrochloride), a 5-HT3 receptor antagonist, on discrete memory abilities of the aged rat were assessed by using the multiple choice avoidance behavioral task. Chronic treatment with itasetron ...

journal_title：European journal of pharmacology

authors： Pitsikas N,Borsini F

更新日期：1996-09-12 00:00:00

abstract：:The present study describes the effects of halothane on morphine activity in the isolated left atria of the rat. Concentration-response curves were obtained for the negative inotropic effects of morphine on electrically stimulated left atria. Morphine significantly decreased the contractile force, with an inhibitory c...

journal_title：European journal of pharmacology

authors： Laorden ML,Hernandez J,Carceles MD,Miralles FS,Puig MM

更新日期：1990-01-17 00:00:00

abstract：:The study investigated the effects of dopamine D1-like receptor stimulation on the autonomic nervous system. Fenoldopam (20 microg/kg) was injected i.v. in conscious sinoaortic denervated dogs, that is, surgically deprived of baroreflex pathways. In barodenervated dogs, fenoldopam (20 microg/kg) induced arterial hypot...

journal_title：European journal of pharmacology

authors： Vernejoul F,Damase-Michel C,Montastruc JL,Tran MA

更新日期：2002-05-31 00:00:00

abstract：:Experiments were performed to provide a quantitative description of the barbiturate withdrawal syndrome. Physical dependence was produced in 63 cats by 'maximally tolerable' dosing with sodium pentobarbital. After 5 weeks of chronic treatment each animal was placed in an activity monitoring cage and observed closely f...

journal_title：European journal of pharmacology

authors： Okamoto M,Rosenberg HC,Boisse NR

更新日期：1976-11-01 00:00:00

abstract：:To investigate the putative rewarding effects of atomoxetine, a non-stimulant medication for Attention-deficit/hyperactivity disorder (ADHD), we conducted conditioned place preference (CPP) tests in an animal model of ADHD, the spontaneously hypertensive rat (SHR). The effects of drug pre-exposure were also evaluated,...

journal_title：European journal of pharmacology

authors： dela Peña IC,Ahn HS,Ryu JH,Shin CY,Park IH,Cheong JH

更新日期：2011-09-30 00:00:00

abstract：:Specific binding of [3H]imipramine to its recognition sites in frontal cortex and levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) as well as uptake of serotonin by crude synaptosomal (P2) fraction were determined in a group of rats chronically (for 21 days) treated with differen...

journal_title：European journal of pharmacology

authors： Hrdina PD

更新日期：1987-06-19 00:00:00

abstract：:The distribution of P2-purinoceptors in pre-capillary resistance vessels was studied in vitro, using Krebs perfused rabbit ears and in vivo, in autoperfused hindquarters, intestinal and renal vasculatures of pentobarbitone anaesthetised cats. ATP (10(-10)-10(-6) mol i.a.) caused dose-dependent vasodilatation which, in...

journal_title：European journal of pharmacology

authors： Taylor EM,Parsons ME,Wright PW,Pipkin MA,Howson W

更新日期：1989-02-28 00:00:00

abstract：:Scopolamine, a non-selective muscarinic receptor antagonist has widespread central nervous system effects. Muscarinic receptors located in the central nervous system play a vital role in the modulation of impulsivity. The objective of the current study was to evaluate the effect of scopolamine on impulsivity using dif...

journal_title：European journal of pharmacology

authors： Jayarajan P,Nirogi R,Shinde A

更新日期：2013-11-15 00:00:00

abstract：:Cocaine and several sigma receptor ligands inhibit dopamine uptake via a common site. This is evidenced by a concentration-dependent inhibition of dopamine uptake and displacement of the binding of [3H]WIN 35,428 (also called CFT), a cocaine analog with high affinity for the dopamine transporter. Since several sigma r...

journal_title：European journal of pharmacology

authors： Izenwasser S,Newman AH,Katz JL

更新日期：1993-10-19 00:00:00

abstract：:Ulcerative colitis (UC), as an autoimmune disease, has been troubling human health for many years. Up to now, the available treatments remain unsatisfactory. Rhizoma Coptidis has been widely applied to treat gastrointestinal diseases in China for a long time, and coptisine (COP) is identified as one of its major activ...

journal_title：European journal of pharmacology

authors： Wang Y,Liu J,Huang Z,Li Y,Liang Y,Luo C,Ni C,Xie J,Su Z,Chen J,Li C

更新日期：2021-01-25 00:00:00

abstract：:A deamination product of histidine, urocanic acid, accumulates in the skin of mammals as trans-urocanic acid. Ultraviolet (UV) irradition converts it to the cis-isomer that is an important mediator in UV-induced immunosuppression. We have recently shown that urocanic acid interferes with the agonist binding to GABA(A)...

journal_title：European journal of pharmacology

authors： Uusi-Oukari M,Soini SL,Heikkilä J,Koivisto A,Neuvonen K,Pasanen P,Sinkkonen ST,Laihia JK,Jansén CT,Korpi ER

更新日期：2000-07-14 00:00:00

abstract：:We investigated whether estrogen protects the ischemic myocardium in oophorectomized female rabbits fed with a cholesterol-enriched diet, whether the addition of a progestin compound attenuates the beneficial effect of estrogen and whether raloxifene also limits myocardial necrosis. We treated 32 female oophorectomize...

journal_title：European journal of pharmacology

authors： Sbarouni E,Iliodromitis EK,Bofilis E,Kyriakides ZS,Kremastinos DT

更新日期：2003-04-25 00:00:00

abstract：:The thromboxane A2/prostaglandin endoperoxide (TXA2/PGH2) receptor antagonist activity of CV-4151, a potent TXA2 synthetase inhibitor, was examined. CV-4151 inhibited guinea pig and human platelet aggregation induced by U-44069 with IC50 values of 1.2 +/- 0.3 X 10(-5) and 1.9 +/- 0.4 X 10(-5) M, respectively, and inhi...

journal_title：European journal of pharmacology

authors： Imura Y,Terashita Z,Shibouta Y,Nishikawa K

更新日期：1988-03-15 00:00:00

abstract：:Schild plots for (-)-propranolol, timolol and IPS 339, but not penbutolol or carazolol, as antagonists of isoproterenol in the isolated, field-stimulated rat vas deferens exhibited biphasic curves indicating the presence of both high and low affinity sites for these agents in this preparation. Schild plots determined ...

journal_title：European journal of pharmacology

authors： Lotti VJ,Kling P,Cerino D

更新日期：1982-10-22 00:00:00

abstract：:We have developed a model of ischaemia-reperfusion injury in C57BL/6 mice involving ischaemia for 0.5 to 2.5 h with an elastic tourniquet on one hind limb and reperfusion for 24 h, analogous to a well-established model of ischaemia-reperfusion injury in the rat. Viability was assessed in tissue homogenates of the gast...

journal_title：European journal of pharmacology

authors： Knight KR,Zhang B,Morrison WA,Stewart AG

更新日期：1997-08-13 00:00:00

abstract：:The present study investigated the mechanisms involved in the antinociception produced by the triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene (TTHL) in mice. TTHL administered by intra-gastric (i.g.) gavage inhibited glutamate-induced nociception with an ID(50) of 19.0 (13.2-27.5) mg/kg. This action started 60 min (in...

journal_title：European journal of pharmacology

authors： Longhi-Balbinot DT,Martins DF,Lanznaster D,Silva MD,Facundo VA,Santos AR

更新日期：2011-02-25 00:00:00

abstract：:Studies have shown a cardioprotective role of thyroid hormones (THs) in cardiac remodeling after acute myocardial infarction (MI). However, there is no data in the literature examining the influence of TH administration on the aortic tissue in an animal model of MI. This study aimed to evaluate the effects of thyroid ...

journal_title：European journal of pharmacology

authors： Ortiz VD,de Castro AL,Campos C,Fernandes RO,Bonetto JHP,Siqueira R,Conzatti A,Fernandes TRG,Belló-Klein A,Araujo ASR

更新日期：2016-11-15 00:00:00

abstract：:Our data indicate that estrogens and progesterone can regulate the number of GABA receptors (as detected by [3H]muscimol binding assay) in rat brain. Both hormones act in selected areas. The extent of the effect (up to 160% increase) and the number of areas responsive suggest that sex hormones may play a very importan...

journal_title：European journal of pharmacology

authors： Maggi A,Perez J

更新日期：1984-08-03 00:00:00

abstract：:We have studied the effects of selective and non-selective adenosine receptor agonists and antagonists in audiogenic-seizure-sensitive DBA/2 mice, an animal model of generalized reflex epilepsy. With the exception of the adenosine A3 receptor agonist, N6-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine (IB-MECA), all th...

journal_title：European journal of pharmacology

authors： De Sarro G,De Sarro A,Di Paola ED,Bertorelli R

更新日期：1999-04-29 00:00:00

abstract：:In 36 healthy subjects of various ages (14-76 years) the number of alpha 2-adrenergic receptors in platelets - as determined by [3H]yohimbine binding - and plasma catecholamine levels were measured. A highly significant negative correlation (r = -0.666, P less than 0.001) between the number of alpha 2-adrenergic recep...

journal_title：European journal of pharmacology

authors： Brodde OE,Anlauf M,Graben N,Bock KD

更新日期：1982-07-09 00:00:00

abstract：:Two highly selective mu-opioid receptor agonists, endomorphin-1 and endomorphin-2, have been identified and postulated to be endogenous ligands for mu-opioid receptors. Intrathecal (i.t.) administration of endomorphin-1 and endomorphin-2 at doses from 0.039 to 5 nmol dose-dependently produced antinociception with the ...

journal_title：European journal of pharmacology

authors： Sakurada S,Hayashi T,Yuhki M,Orito T,Zadina JE,Kastin AJ,Fujimura T,Murayama K,Sakurada C,Sakurada T,Narita M,Suzuki T,Tan-no K,Tseng LF

更新日期：2001-09-21 00:00:00

abstract：:Interleukin-1 beta stimulates corticotropin-releasing factor (CRF) secretion from the hypothalamus involving the activation of prostaglandins. This study investigated the possibility that nitric oxide (NO) acts as a mediator of interleukin-1-induced CRF release. An in vitro rat hypothalami continuous perifusion system...

journal_title：European journal of pharmacology

authors： Sandi C,Guaza C

更新日期：1995-02-14 00:00:00

abstract：:Inflammation, closely associated with obesity, is emerging as an important risk factor for the pathophysiological development of atherosclerosis and diabetes mellitus. Fat balance is critical in the aetiology of obesity. Lipoprotein lipase is an important enzyme in lipid metabolism. The aim of this study was to invest...

journal_title：European journal of pharmacology

authors： Cai M,Yin W,Li Q,Liao D,Tsutsumi K,Hou H,Liu Y,Zhang C,Li J,Wang Z,Xiao J

更新日期：2006-07-01 00:00:00

abstract：:Vagal motor outflow from the dorsal vagal complex is important in the regulation of intestinal motility. The aim of our study was to test the hypothesis that within the dorsal vagal complex, tonic GABA(A)-receptor mediated neurotransmission modulates intestinal motility. The GABA(A) receptor antagonist, bicuculline (m...

journal_title：European journal of pharmacology

authors： Greenwood-Van Meerveld B,Barron KW

更新日期：1998-04-10 00:00:00

abstract：:We used two experimental models to prove that resveratrol (trans-3,4',5-trihydroxystilbene) reduces cardiac ischemic-reperfusion injury by means of a nitric oxide- and adenosine-dependent mechanism. (1). ACUTE EX VIVO: resveratrol (10 microM, 10 min) infusion in Langendorff-perfused normoxic rat hearts significantly i...

journal_title：European journal of pharmacology

authors： Bradamante S,Barenghi L,Piccinini F,Bertelli AA,De Jonge R,Beemster P,De Jong JW

更新日期：2003-03-28 00:00:00