In vivo effects of fenoldopam on autonomic nervous system after inhibition or activation of ganglionic transmission.

abstract：:Hops (Humulus lupulus L.), a major component of beer, contain potentially neuroactive compounds that made it useful in traditional medicine as a sleeping aid. The present study aims to investigate the individual components in hops acting as allosteric modulators in GABAA receptors and bring further insight into the mo...

journal_title：European journal of pharmacology

authors： Benkherouf AY,Logrén N,Somborac T,Kortesniemi M,Soini SL,Yang B,Salo-Ahen OMH,Laaksonen O,Uusi-Oukari M

更新日期：2020-04-15 00:00:00

abstract：:The pharmacological profile of the opioid antagonist norbinaltorphimine has been characterised in vitro and in vivo. In vitro, norbinaltorphimine reversibly antagonised the effects of kappa agonists with pA2 values of 10.2-10.4. Norbinaltorphimine was much less potent as an antagonist at mu and delta receptors, pA2 va...

journal_title：European journal of pharmacology

authors： Birch PJ,Hayes AG,Sheehan MJ,Tyers MB

更新日期：1987-12-15 00:00:00

abstract：:The autoradiographic distribution of putative brain adrenomedullin receptors was investigated using [125I]human adrenomedullin(13-52) as a new radioligand. Specific [125I]human adrenomedullin(13-52) binding sites were very discretely distributed in the rat brain with enrichment seen in the choroid plexus and linings o...

journal_title：European journal of pharmacology

authors： Juaneda C,Dumont Y,Chabot JG,Quirion R

更新日期：2001-06-08 00:00:00

abstract：:The pruritogenic potency of tryptase and its involvement in anti-pruritic effect of intravenous nafamostat mesilate (NFM) were studied in mice. An intradermal injection of tryptase (0.05-1 ng/site) elicited scratching in ICR mice, while chymase was without effects at doses of 0.05-50 ng/site. The dose-response curve o...

journal_title：European journal of pharmacology

authors： Ui H,Andoh T,Lee JB,Nojima H,Kuraishi Y

更新日期：2006-01-13 00:00:00

abstract：:Galloyl group-containing catechins, such as epigallocatechin-3 gallate, inhibit receptor tyrosine kinase activity of several growth factor receptors. This study investigated the effects of epigallocatechin-3 gallate, as compared to epicatechin, on vascular endothelial growth factor-induced intracellular signaling and ...

journal_title：European journal of pharmacology

authors： Neuhaus T,Pabst S,Stier S,Weber AA,Schrör K,Sachinidis A,Vetter H,Ko YD

更新日期：2004-01-12 00:00:00

abstract：:Galantamine is a drug in clinical use for the treatment of Alzheimer's disease, but its mechanism(s) of action remains controversial. Here we addressed the question whether galantamine could potentiate neurotransmitter release by inhibiting small conductance Ca2+ -activated K+ channels (KCa2). Galantamine potentiated ...

journal_title：European journal of pharmacology

authors： Alés E,Gullo F,Arias E,Olivares R,García AG,Wanke E,López MG

更新日期：2006-10-24 00:00:00

abstract：:The increase of cytoplasmic Ca2+ concentration (Delta[Ca2+]c) in response to antigenic stimulation is a critical step of signals activating immune responses. In addition, the voltage-gated K+ channels (Kv) in T lymphocytes draw attention as an effective target of immune-modulation. Caffeic acid phenethyl ester (CAPE),...

journal_title：European journal of pharmacology

authors： Nam JH,Shin DH,Zheng H,Kang JS,Kim WK,Kim SJ

更新日期：2009-06-10 00:00:00

abstract：:Dynorphin (1-100 nM) dose dependently inhibited both spontaneous and electrically evoked endogenous dopamine (DA) release from slices of the nucleus accumbens of untreated rats. When this inhibitory effect was compared, it was significantly reduced in rats pretreated (for 9 days) with methamphetamine (6 mg/kg per day ...

journal_title：European journal of pharmacology

authors： Yokoo H,Yamada S,Yoshida M,Tanaka M,Nishi S

更新日期：1992-11-03 00:00:00

abstract：:Cordycepin, (3'-deoxyadenosine), a bioactive compound of Cordyceps militaris, has been shown to exhibit many pharmacological actions, such as anti-inflammatory, antioxidative and anticancer activities. Little is known about the neuroprotective action of cordycepin as well as its molecular mechanisms. In this study, co...

journal_title：European journal of pharmacology

authors： Cheng Z,He W,Zhou X,Lv Q,Xu X,Yang S,Zhao C,Guo L

更新日期：2011-08-16 00:00:00

abstract：:Rat anococcygeus muscles were isolated 4 h after treatment with either E. coli endotoxin (20 mg kg-1 i.p.) or saline. The contractile responses of the muscle to electrical field stimulation, and to the alpha 1-adrenoceptor agonist cirazoline were impaired by endotoxin treatment. Inhibition of the L-arginine pathway wi...

journal_title：European journal of pharmacology

authors： Guc MO,Furman BL,Parratt JR

更新日期：1991-09-24 00:00:00

abstract：:Long-term therapy with L-3,4-dihydroxyphenylalanine (L-DOPA) in parkinsonian patients is known to lead to dyskinesia within a few years, and repeated administration of L-DOPA is also likely to alter the expression of kappa opioid receptors in the basal ganglia, especially the striatum and substantia nigra pars reticul...

journal_title：European journal of pharmacology

authors： Ikeda K,Yoshikawa S,Kurokawa T,Yuzawa N,Nakao K,Mochizuki H

更新日期：2009-10-12 00:00:00

abstract：:Cultured chick hepatocytes were used to investigate the hepatotoxicity of methotrexate alone and in combination with paracetamol. Treatment with methotrexate alone at concentrations as high as 1 mg/ml resulted in no toxicity in cultured chick hepatocytes, as indicated by no detachment of cells and no effect on protein...

journal_title：European journal of pharmacology

authors： Lindenthal J,Sinclair JF,Howell S,Cargill I,Sinclair PR,Taylor T

更新日期：1993-04-01 00:00:00

abstract：:To determine the role of protein kinase C in the regulation of intestinal fluid transport, experiments were performed with the rat jejunum in vivo, using the active phorbol ester, 4-beta-phorbol 12-myristate 13-acetate (PMA), as stimulator of protein kinase C. Intraluminally administered PMA dose dependently reversed ...

journal_title：European journal of pharmacology

authors： Beubler E,Hinterleitner T,Horina G

更新日期：1990-07-17 00:00:00

abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was incidentally administered to pregnant marmosets during the whole gestational period, except for the last 15 days before term. The infant monkeys were killed 5 months after birth, and dopamine and its metabolites were measured in the striatum and the nucleus accum...

journal_title：European journal of pharmacology

authors： Pérez-Otaño I,Oset C,Trinidad Herrero M,Luquin MR,Kupsch A,Oertel W,Obeso JA,Del Río J

更新日期：1992-07-07 00:00:00

abstract：:This study examined whether a clinically relevant concentration of the volatile anaesthetic halothane modifies the endothelium-dependent relaxation produced by acetylcholine (3 nM-10 microM), histamine (1 pM-0.1 microM) and anti-human immunoglobulin E (1:1000) in human isolated pulmonary arteries submaximally precontr...

journal_title：European journal of pharmacology

authors： Higueras J,Sarría B,Ortiz JL,Cortijo J,Maruenda A,Barberá M,Morcillo EJ

更新日期：1997-05-20 00:00:00

abstract：:Clozapine has improved efficacy relative to typical antipsychotics in schizophrenia treatment, particularly regarding emotional symptoms. However, the mechanisms underlying its therapeutic benefits remain unclear. Using a methamphetamine-sensitised rat model, we measured changes in dopamine levels in the amygdalae in ...

journal_title：European journal of pharmacology

authors： Kawano M,Oshibuchi H,Kawano T,Muraoka H,Tsutsumi T,Yamada M,Inada K,Ishigooka J

更新日期：2016-06-15 00:00:00

abstract：:Unlike classical antipsychotic drugs, clozapine activates the hypothalamo-pituitary-adrenal axis and induces a specific regional pattern of Fos-protein expression in the rat forebrain. Whether corticosterone plays a role in the clozapine-induced Fos response is the subject of this study. Some rats were adrenalectomize...

journal_title：European journal of pharmacology

authors： Sebens JB,Middelveld RJ,Koch T,Ter Horst GJ,Korf J

更新日期：2001-04-06 00:00:00

abstract：:A single electroconvulsive shock produced analgesia (expressed as prolongation of hot-plate latency) in Wistar rats 45 min after the shock. The analgesic action was prevented by administration of nifedipine, 5 mg/kg i.p., 15 min before the electroconvulsive shock, while nifedipine injection after electroconvulsive sho...

journal_title：European journal of pharmacology

authors： Antkiewicz-Michaluk L,Michaluk J,Vetulani J

更新日期：1994-03-11 00:00:00

abstract：:We investigated the effect of probucol, a lipid-lowering agent with antioxidant properties, on HCl plus ethanol-induced gastric mucosal injury and on the healing of acetic acid-induced gastric ulcers in rats. When the free radical-scavenging activity of probucol was measured by an electron spin resonance technique, th...

journal_title：European journal of pharmacology

authors： Ito M,Suzuki Y,Ishihara M,Suzuki Y

更新日期：1998-08-07 00:00:00

abstract：:Removal of the epithelium increased the responsiveness of isolated guinea-pig trachea to the contractile effects of endothelin. This phenomenon was observed in the presence of indomethacin (5 microM), captopril (10 microM), bacitracin (20 micrograms/ml) or leupeptin (50 microM), but was inhibited by phosphoramidon (10...

journal_title：European journal of pharmacology

authors： Hay DW

更新日期：1989-11-21 00:00:00

abstract：:Recombinant human GABA(A) receptors were investigated in vitro by coexpression of cDNAs coding for alpha1, beta2, and gamma2 subunits in the baculovirus/Sf-9 insect cell system. We report that a single amino acid exchange (isoleucine 121 to valine 121) in the N-terminal, extracellular part of the alpha1 subunit induce...

journal_title：European journal of pharmacology

authors： Westh-Hansen SE,Rasmussen PB,Hastrup S,Nabekura J,Noguchi K,Akaike N,Witt MR,Nielsen M

更新日期：1997-06-25 00:00:00

abstract：:We investigated whether or not insulin and cAMP-elevating agents induce the proliferation of adult rat hepatocytes during the early and late phases of primary culture. Adult rat hepatocytes synthesized a significant amount of DNA when cultured in the presence of 10(-7) M insulin for 3 h. Under these conditions, the nu...

journal_title：European journal of pharmacology

authors： Kimura M,Ogihara M

更新日期：1997-05-26 00:00:00

abstract：:The effect of intracutaneous adrenaline and noradrenaline (5 X 10(-12) and 5 X 10(-11) mol) was examined on the oedema (Evans blue dye leakage) response of rats to several inflammatory agents. The catecholamines reduced the oedema response to all agents tested except prostaglandin E1 (PGE1) which was significantly pot...

journal_title：European journal of pharmacology

authors： O'Duffy G,Chahl LA

更新日期：1979-08-15 00:00:00

abstract：:We have studied the pharmacological effects of (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) and the enantiomers of (RS)-2-amino-3-(3-hydroxy-1,2, 5-thiadiazol-4-yl)propionic acid (TDPA) on cloned human excitatory amino acid transporter subtypes 1, 2 and 3 (EAAT1-3) expressed in Cos-7 cells. Wh...

journal_title：European journal of pharmacology

authors： Bräuner-Osborne H,Hermit MB,Nielsen B,Krogsgaard-Larsen P,Johansen TN

更新日期：2000-10-06 00:00:00

abstract：:Major depression is a highly prevalent disorder and is predicted to be the second leading cause of disease burden by 2020. Although many antidepressant drugs are currently available, they are far from optimal. Approximately 50% of patients do not respond to initial first line antidepressant treatment, while approximat...

journal_title：European journal of pharmacology

authors： O'Leary OF,Dinan TG,Cryan JF

更新日期：2015-04-15 00:00:00

abstract：:Morphine produces a state dependent learning. The hippocampus is involved in this kind of learning. Gap junctions (GJs) are involved in some of the effects of morphine and exist in different areas of the hippocampus. We investigated the effects of blocking GJ channels of the hippocampal CA1 area, by means of pre-test ...

journal_title：European journal of pharmacology

authors： Beheshti S,Hosseini SA,Noorbakhshnia M,Eivani M

更新日期：2014-12-15 00:00:00

abstract：:Gastric lesions were provoked in all rats that had received intraperitoneally a single dose of the dopamine antagonists haloperidol, metoclopramide or domperidone 24 h before. Dose-dependence was demonstrated for haloperidol. This drug induced gastric lesions as early as 90 min after its application. The ulcerogenic e...

journal_title：European journal of pharmacology

authors： Sikirić P,Geber J,Ivanović D,Suchanek E,Gjuris V,Tućan-Foretić M,Mise S,Cvitanović B,Rotkvić I

更新日期：1986-11-12 00:00:00

abstract：:Endothelium injury is a primary event in atherogenesis, which is followed by monocyte infiltration, macrophage differentiation, and smooth muscle cell migration. Peroxisome proliferator-activated receptors (PPARs) are transcription factors now recognized as important mediators in the inflammatory response. The aim of ...

journal_title：European journal of pharmacology

authors： Rival Y,Benéteau N,Taillandier T,Pezet M,Dupont-Passelaigue E,Patoiseau JF,Junquéro D,Colpaert FC,Delhon A

更新日期：2002-01-25 00:00:00

abstract：:We studied the effects of synthetic porcine big endothelin (ET), a putative 39-residue intermediate deduced from cDNA sequence analysis, on receptor binding activity in cultured rat vascular smooth muscle cells as well as its vasoconstrictive activity in rat pulmonary artery. Big ET was about two orders of magnitude l...

journal_title：European journal of pharmacology

authors： Hirata Y,Kanno K,Watanabe TX,Kumagaye S,Nakajima K,Kimura T,Sakakibara S,Marumo F

更新日期：1990-02-06 00:00:00

abstract：:In rabbits, i.v. delta9-tetrahydrocannabinol (delta9-THC) at 0.5 mg/kg was challenged with i.v. arecoline (0.025 mg/kg), nicotine (0.02 mg/kg) or physostigmine (PHYSO, 0.05 mg/kg), and observations were made on quantified EEG and behavior. The cholinomimetics effectively reversed the cortical and hippocampal EEG alter...

journal_title：European journal of pharmacology

authors： Jones BC,Consroe PF,Laird HE 2nd

更新日期：1976-08-01 00:00:00