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Attenuation of the inhibitory effect of dynorphin on dopamine release in the rat nucleus accumbens by repeated treatment with methamphetamine.

Abstract：

:Dynorphin (1-100 nM) dose dependently inhibited both spontaneous and electrically evoked endogenous dopamine (DA) release from slices of the nucleus accumbens of untreated rats. When this inhibitory effect was compared, it was significantly reduced in rats pretreated (for 9 days) with methamphetamine (6 mg/kg per day i.p.) relative to rats treated with saline. These findings indicate that dynorphin inhibits DA release from the nucleus accumbens, and that treatment with methamphetamine reduces the modulatory action of dynorphin on DA release. It is possible that repeated administration of methamphetamine leads to attenuation of the inhibition of DA release from the nucleus accumbens via presynaptic dynorphin-sensitive receptors.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Yokoo H,Yamada S,Yoshida M,Tanaka M,Nishi S

doi

10.1016/0014-2999(92)90461-c

keywords:

subject

Has Abstract

pub_date

1992-11-03 00:00:00

pages

43-7

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(92)90461-C

journal_volume

222

pub_type

杂志文章

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