Abstract:
:Rat anococcygeus muscles were isolated 4 h after treatment with either E. coli endotoxin (20 mg kg-1 i.p.) or saline. The contractile responses of the muscle to electrical field stimulation, and to the alpha 1-adrenoceptor agonist cirazoline were impaired by endotoxin treatment. Inhibition of the L-arginine pathway with L-NG-nitro arginine methylester (3 x 10(-5) M) failed to restore responsiveness to either electrical field stimulation or to cirazoline. Endotoxin impaired inhibitory responses to electrical field stimulation in preparations precontracted with cirazoline. Responsiveness to sodium nitroprusside was also impaired by endotoxin under these conditions. These results show an impairment by endotoxin of both contractile and inhibitory responses of the rat anococcygeus muscle to electrical field stimulation. The impairment appears to be post-junctional. In contrast to the findings in vascular smooth muscle, the endotoxin-induced impairment of contractile responses does not appear to involve the L-arginine pathway.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Guc MO,Furman BL,Parratt JRdoi
10.1016/0014-2999(91)90285-xsubject
Has Abstractpub_date
1991-09-24 00:00:00pages
397-401issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(91)90285-Xjournal_volume
202pub_type
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