Guinea-pig tracheal epithelium and endothelin.

abstract：:The binding of [3H]LSD to serotonergic sites in human brain was studied. The pharmacological profile of [3H]LSD binding in frontal cortex differed to that in hippocampus. Analysis of the inhibition of [3H]LSD binding by serotonin and spiperone was consistent with the presence of two binding sites, which differed in ph...

journal_title：European journal of pharmacology

authors： Cross AJ

更新日期：1982-08-13 00:00:00

abstract：:Neuropathic pain is among the most common and difficult-to-treat types of chronic pain and is associated with sodium channel malfunction. The sodium channel blocker ralfinamide has exhibited potent analgesic effects in several preclinical pain models and in patients with mixed neuropathic pain syndromes (Phase II tria...

journal_title：European journal of pharmacology

authors： Liang X,Yu G,Su R

更新日期：2018-03-15 00:00:00

abstract：:Pharmacological strategies aimed at co-activating peroxisome proliferator-activated receptor-gamma (PPAR-γ)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway have shown promising results in alleviating myocardial injury. The aim of the study was to evaluate the role of chrysin, a PPAR-γ agonist, in ischemia-r...

journal_title：European journal of pharmacology

authors： Rani N,Arya DS

更新日期：2020-09-15 00:00:00

abstract：:Slices of rat kidney cortex were incubated in [3H]noradrenaline, then placed in a flow cell and subjected to electrical field stimulation. At a stimulation frequency of 5 Hz, both the alpha 2-adrenoceptor antagonist idazoxan (0.1 microM) and the alpha 1-adrenoceptor antagonist prazosin (0.1 microM) significantly enhan...

journal_title：European journal of pharmacology

authors： Murphy TV,Majewski H

更新日期：1989-10-10 00:00:00

abstract：:The distribution of P2-purinoceptors in pre-capillary resistance vessels was studied in vitro, using Krebs perfused rabbit ears and in vivo, in autoperfused hindquarters, intestinal and renal vasculatures of pentobarbitone anaesthetised cats. ATP (10(-10)-10(-6) mol i.a.) caused dose-dependent vasodilatation which, in...

journal_title：European journal of pharmacology

authors： Taylor EM,Parsons ME,Wright PW,Pipkin MA,Howson W

更新日期：1989-02-28 00:00:00

abstract：:Conscious guinea-pigs received platelet activating factor (PAF, 0.03-0.25 microgram/kg, i.v.) and colloidal carbon (C, tracer for microvascular leakage). Fifteen min later the animal was killed and C-labelled microvessels (leakage) were detected in the mucosal/submucosal region of tracheal and bronchial sections. PAF ...

journal_title：European journal of pharmacology

authors： O'Donnell SR,Barnett CJ

更新日期：1987-06-26 00:00:00

abstract：:This study investigates the relationship between the rate of phorbol ester-induced contraction of intact rat aorta and protein kinase C activation, as assessed by the translocation of protein kinase C from the cytosolic to the particulate fraction. Aorta was exposed to Ca(2+)-free physiologic salt solution prior to ph...

journal_title：European journal of pharmacology

authors： Bazan E,Campbell AK,Rapoport RM

更新日期：1995-08-15 00:00:00

abstract：:The role of the endogenous corticotropin-releasing hormone (CRH) system in the regulation of heart rate, PQ interval (a measure of vagal activity), gross activity and release of adrenocorticotropic hormone (ACTH), noradrenaline and adrenaline into the blood during conditioned fear was studied in freely moving rats. In...

journal_title：European journal of pharmacology

authors： Nijsen MJ,Croiset G,Diamant M,Stam R,Kamphuis PJ,Bruijnzeel A,de Wied D,Wiegant VM

更新日期：2000-02-11 00:00:00

abstract：:Kinins are known to be potent releasers of histamine. In the present study, the B2 antagonist analogues of bradykinin (BK) and kallidin (KD): [( Thi6,9,D-Phe8]KD, [Thi5,8,D-Phe7]BK) were also found to be potent releasers of histamine from rat mast cells and not to exert any antagonistic effect. Similarly, two B1 recep...

journal_title：European journal of pharmacology

authors： Devillier P,Renoux M,Drapeau G,Regoli D

更新日期：1988-04-27 00:00:00

abstract：:The present study aimed to determine whether nefiracetam, N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide, a cognition enhancer, has an effect on learning and memory function in sustained cerebral ischemia, and whether the effect, if any, may accompany modification of the cholinergic or gamma-aminobutyric ac...

journal_title：European journal of pharmacology

authors： Fukatsu T,Miyake-Takagi K,Nagakura A,Omino K,Okuyama N,Ando T,Takagi N,Furuya Y,Takeo S

更新日期：2002-10-18 00:00:00

abstract：:The effects of protein kinase C (PKC) activators on gamma-aminoburyric acid (GABA) rho 1 receptor function were studied in rho 1 -expressing Xenopus oocytes. The PKC activator phorbol 12-myristate 13-acetate (PMA) but not the inactive analog phorbol 12-mono-myristate inhibited the GABA-gated chloride currents. Mezerei...

journal_title：European journal of pharmacology

authors： Kusama T,Sakurai M,Kizawa Y,Uhl GR,Murakami H

更新日期：1995-11-30 00:00:00

abstract：:In isolated heart muscle, the compound R56865 (N-[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2- benzothiazolamine) has been shown to protect against intoxication by cardiac glycosides. We studied the influence of R56865 on various membrane currents in single isolated ventricular cardiomyocytes of the guinea-...

journal_title：European journal of pharmacology

authors： Himmel HM,Wilhelm D,Ravens U

更新日期：1990-10-09 00:00:00

abstract：:The purpose of our study was to determine whether a toxic arrhythmogenic dose of digitalis administered to an in vivo preparation would affect the neuronal uptake of norepinephrine, serotonin and dopamine in brain tissue and norepinephrine in cardiac tissue. This was investigated by intoxicating anesthetized cats with...

journal_title：European journal of pharmacology

authors： Helke CJ,Kellar KJ,Gillis RA

更新日期：1978-11-01 00:00:00

abstract：:The effect of antipsychotics on electrically evoked dopamine efflux in the rat nucleus accumbens core and shell was investigated, using in vitro fast cyclic voltammetry. In the nucleus accumbens core, the dopamine D2/D3 receptor agonist, (+/-)7-OH-DPAT ((+/-)-2-dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene), i...

journal_title：European journal of pharmacology

authors： Roberts C,Cummins R,Gnoffo Z,Kew JN

更新日期：2006-03-18 00:00:00

abstract：:Ischemia reperfusion (I/R) injury is a cellular damage in a hypoxic organ following the restoration of oxygen delivery. It may occur during organ transplantation, trauma and hepatectomies. Nitric oxide (NO) effects during hepatic I/R are complicated. The iNOS-derived NO has a deleterious effect, whereas eNOS-derived N...

journal_title：European journal of pharmacology

authors： Atef Y,El-Fayoumi HM,Abdel-Mottaleb Y,Mahmoud MF

更新日期：2017-11-15 00:00:00

abstract：:The investigation examined the mechanism of the increase in brain tryptophan concentration of rats treated with d-amphetamine. Certain well recognised influences upon brain tryptophan have been excluded as responsible. Thus, the effect is not associated with changes in the plasma concentrations of NEFA or free tryptop...

journal_title：European journal of pharmacology

authors： Fernando JC,Curzon G

更新日期：1978-06-15 00:00:00

abstract：:For the development of efficient pulmonary delivery systems for protein and peptide drugs, it is important to understand their transport mechanisms in alveolar epithelial cells. In this study, the uptake mechanism for FITC-insulin in cultured alveolar epithelial cell line RLE-6TN was elucidated. FITC-insulin uptake by...

journal_title：European journal of pharmacology

authors： Oda K,Yumoto R,Nagai J,Katayama H,Takano M

更新日期：2011-12-15 00:00:00

abstract：:The effect of two serotonin precursors, 5-hydroxytryptophan (5-OH-TRP) and indolepyruvic acid (IPA), a tryptophan ketoanalogue, on rat pineal indole metabolism during the light-dark cycle was investigated. 5-OH-TRP drastically increased the production of 5-hydroxyindoleacetic acid at a dose of only 10 mg/kg, whereas 5...

journal_title：European journal of pharmacology

authors： Ferretti C,Blengio M,Ghi P,Genazzani E

更新日期：1990-10-23 00:00:00

abstract：:Oxyntomodulin, a hormone released from jejuno-ileum and composed of the glucagon sequence extended by a C-terminal octapeptide displays original tissue specificity for the gastric mucosa. The aim of this study was to compare the effect of oxyntomodulin on histamine (0.4 mg/kg per h)-stimulated gastric acid secretion i...

journal_title：European journal of pharmacology

authors： Carles-Bonnet C,Jarrousse C,Niel H,Martinez J,Bataille D

更新日期：1991-10-15 00:00:00

abstract：:The ability of the kappa-opioid receptor agonist U69593 to attenuate the sensitization and cross-sensitization which develops to the conditioned rewarding effects of morphine and cocaine was examined using an unbiased place-preference conditioning procedure. The influence of U69593 treatment upon sensitization and cro...

journal_title：European journal of pharmacology

authors： Shippenberg TS,LeFevour A,Thompson AC

更新日期：1998-03-12 00:00:00

abstract：:The receptor for gonadotropin-releasing hormone (GnRH) belongs to the G-protein-coupled receptors, and its stimulation activates extracellular signal-regulated protein kinase (ERK). In the present study, we first examined the actions of GnRH on the ErbB family using two types of cultured gonadotroph cells. As reported...

journal_title：European journal of pharmacology

authors： Omoto Y,Higa-Nakamine S,Higa A,Yamamoto H

更新日期：2017-03-15 00:00:00

abstract：:Longitudinal organ bath preparations of the rat duodenum, jejunum and ileum were tested for their responsiveness to GABA-receptor agonists. The GABAA-receptor agonists, GABA and 3APS, induced non-adrenergic, non-cholinergic relaxations and/or contractions, although the magnitude and type of response varied depending u...

journal_title：European journal of pharmacology

authors： Krantis A,Harding RK

更新日期：1987-09-11 00:00:00

abstract：:Exploring the importance of nanofibrous scaffold with traditionally important medicine as a wound dressing material prevents infection and aids in faster healing of wounds. In the present study, the Collagen (COL) from the marine fish skin was extracted and employed for coating the Poly(3-hydroxybutyric acid) (P)-Gela...

journal_title：European journal of pharmacology

authors： Ramanathan G,Muthukumar T,Tirichurapalli Sivagnanam U

更新日期：2017-11-05 00:00:00

abstract：:We investigated the effects of ginsenosides, the active ingredient of ginseng, on neuronal or muscle-type nicotinic acetylcholine receptor channel activity expressed in Xenopus oocytes after injection of cRNA encoding bovine neuronal alpha3beta4, alpha7 or human muscle alphabetadeltavarepsilon subunits. Treatment with...

journal_title：European journal of pharmacology

authors： Choi S,Jung SY,Lee JH,Sala F,Criado M,Mulet J,Valor LM,Sala S,Engel AG,Nah SY

更新日期：2002-05-03 00:00:00

abstract：:Inhaled corticosteroids (ICS) are recommended treatments for all degrees of asthma severity and in combination with bronchodilators are indicated for COPD patients with a history of frequent exacerbations. However, the long-term side effects of glucocorticoids (GCs) may include increased risk of respiratory infections...

journal_title：European journal of pharmacology

authors： Marcellini A,Swieboda D,Guedán A,Farrow SN,Casolari P,Contoli M,Johnston SL,Papi A,Solari R

更新日期：2021-02-15 00:00:00

abstract：:Glutamatergic abnormalities are involved in several psychiatric disorders. Clinical evidence demonstrates altered glutamatergic neurotransmission in patients suffering from obsessive-compulsive disorder. MGS0039, (1R,2R,3R,5R,6R)-2-amino-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, is ...

journal_title：European journal of pharmacology

authors： Shimazaki T,Iijima M,Chaki S

更新日期：2004-10-06 00:00:00

abstract：:The cardiac and hemodynamic effects of (+/-)-DPI 201-106 (0.6 mg/kg), S(-)-DPI (0.3 mg/kg), R(+)-DPI (0.3 mg/kg), and their vehicle were compared in chronically implanted conscious dogs. (+/-)-DPI and S(-)-DPI induced qualitatively and quantitatively similar effects, increasing LV dP/dt, cardiac output and stroke volu...

journal_title：European journal of pharmacology

authors： Gérard JL,Berdeaux A,Giudicelli JF

更新日期：1990-08-10 00:00:00

abstract：:Nausea and vomiting are among the most common and distressing consequences of cytotoxic chemotherapies. Nausea and vomiting can be acute (0-24h) or delayed (24-72 h) after chemotherapy administration. The introduction of 5-HT(3) receptor antagonists in the 90s was a major advance in the prevention of acute emesis. The...

journal_title：European journal of pharmacology

authors： Rojas C,Slusher BS

更新日期：2012-06-05 00:00:00

abstract：:Intravenous (i.v.) administration of cytidine-5'-diphosphate choline (CDP-choline) (100, 250 and 500 mg/kg) increased blood pressure in normal rats and reversed hypotension in haemorrhagic shock. Choline (54 mg/kg; i.v.), at the dose equimolar to 250 mg/kg CDP-choline decreased blood pressure of rats in both condition...

journal_title：European journal of pharmacology

authors： Savci V,Goktalay G,Cansev M,Cavun S,Yilmaz MS,Ulus IH

更新日期：2003-05-09 00:00:00

abstract：:The potent analgesic responses elicited by systemic administration of RB101, N-[(R,S)-2-benzyl-3[(S)(2-amino-4-methylthio)butyldithio]-1-oxopro pyl]- 1-oxopropyl]-L-phenylalanine benzyl ester, a prodrug able to inhibit enkephalin-degrading enzymes completely after in vivo bioactivation, has made it possible to investi...

journal_title：European journal of pharmacology

authors： Noble F,Turcaud S,Fournié-Zaluski MC,Roques BP

更新日期：1992-11-13 00:00:00