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Cardiac and hemodynamic effects of S(-)- and (R(+)-DPI 201-106 and of racemic DPI 201-106 in conscious dogs.

Abstract：

:The cardiac and hemodynamic effects of (+/-)-DPI 201-106 (0.6 mg/kg), S(-)-DPI (0.3 mg/kg), R(+)-DPI (0.3 mg/kg), and their vehicle were compared in chronically implanted conscious dogs. (+/-)-DPI and S(-)-DPI induced qualitatively and quantitatively similar effects, increasing LV dP/dt, cardiac output and stroke volume and reducing total peripheral resistance. In contrast, R(+)-DPI decreased only stroke volume. It is concluded that (a) the positive inotropic effects of (+/-)-DPI in vivo are caused by its S(-) enantiomer, and (b) the peripheral vasodilating effects of (+/-)-DPI may not be linked to the drug's calcium antagonist properties.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Gérard JL,Berdeaux A,Giudicelli JF

doi

10.1016/0014-2999(90)90625-g

subject

Has Abstract

pub_date

1990-08-10 00:00:00

pages

321-3

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(90)90625-G

journal_volume

184

pub_type

杂志文章

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